p53 is required for radiation-induced apoptosis in mouse thymocytes

Antibodies, a laboratory manual

1989 • 12,929 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Antibodies: A laboratory manual

1989 • 4,532 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Handbook of Experimental Immunology.

1968 • 2,480 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

1984 • 1,761 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1987 • 923 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma

1990 • 660 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Handbook of experimental immunology

1986 • 637 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Transgenesis by means of blastocyst-derived embryonic stem cell lines.

1986 • 432 citations

Identification of Deoxyribonuclease II as an Endonuclease Involved in Apoptosis

1993 • 428 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1986 • 285 citations

Programmed death of autoreactive thymocytes

1990 • 224 citations

Activation-induced cell death in T cell hybridomas is due to apoptosis. Morphologic aspects and DNA fragmentation.

1990 • 201 citations

Genetic Analysis of Susceptibility to Radiation-induced Apoptosis of Thymocytes in Mice

1992 • 25 citations

N-terminal Deletions of a Mitochondrial Signal Sequence in Yeast

1989 • 25 citations