Regulation of Endothelial Barrier Function

Functional rafts in cell membranes

1997 • 9,471 citations

The Protein Kinase Complement of the Human Genome

2002 • 7,708 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

The Acute Respiratory Distress Syndrome

1996 • 5,031 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

The Pathobiology of Diabetic Complications

2005 • 4,849 citations

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases

2003 • 4,348 citations

Structure and function of the blood–brain barrier

2009 • 4,310 citations

The Pathophysiology and Treatment of Sepsis

2003 • 4,027 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Chemokines

2000 • 3,773 citations

Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress

2000 • 3,760 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Structure and function of matrix metalloproteinases and TIMPs

2006 • 3,132 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Neutrophils and immunity: challenges and opportunities

2006 • 2,795 citations

Seven-transmembrane receptors

2002 • 2,571 citations

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

1997 • 2,470 citations

The Blood-Brain Barrier/Neurovascular Unit in Health and Disease

2005 • 2,454 citations

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

Thermodynamic analysis of the permeability of biological membranes to non-electrolytes

1958 • 2,157 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

Advanced Glycation End Products

2006 • 2,077 citations

On the Absorption of Fluids from the Connective Tissue Spaces

1896 • 2,075 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

The endothelial glycocalyx: composition, functions, and visualization

2007 • 1,672 citations

Pathophysiology of ischaemia-reperfusion injury

2000 • 1,664 citations

Signaling Mechanisms Regulating Endothelial Permeability

2005 • 1,632 citations

Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness

2000 • 1,627 citations

Structural Basis of Integrin Regulation and Signaling

2007 • 1,575 citations

Fibrinogen and fibrin structure and functions

2005 • 1,572 citations

Multiple Organ Failure Pathophysiology and Potential Future Therapy

1992 • 1,398 citations

Focal adhesion kinase: the first ten years

2003 • 1,360 citations

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

2009 • 1,341 citations

Protein kinase C activation and the development of diabetic complications.

1998 • 1,328 citations

Regulation, substrates and functions of src

1996 • 1,173 citations

Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities

2001 • 1,144 citations

Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome

2003 • 1,069 citations

ADAMs: key components in EGFR signalling and development

2005 • 1,056 citations

Microvascular fluid exchange and the revised Starling principle

2010 • 1,028 citations

Filtration, Diffusion and Molecular Sieving Through Peripheral Capillary Membranes

1951 • 972 citations

Design and Therapeutic Application of Matrix Metalloproteinase Inhibitors

1999 • 965 citations

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

2004 • 965 citations

Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability

2001 • 960 citations

Abnormalities in Pericytes on Blood Vessels and Endothelial Sprouts in Tumors

2002 • 955 citations

The Role of Nuclear Factor- κ B in Cytokine Gene Regulation

1997 • 948 citations

Passage of Molecules Through Capillary Walls

1953 • 942 citations

Identification of a transformation-specific antigen induced by an avian sarcoma virus

1977 • 931 citations

Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications

2010 • 868 citations

Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation

2006 • 864 citations

Pathophysiological consequences of VEGF-induced vascular permeability

2005 • 848 citations

Integrin signalling at a glance

2008 • 832 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

Activated macrophages induce vascular proliferation

1977 • 818 citations

Micromotion of mammalian cells measured electrically.

1991 • 813 citations

PAR1 Is a Matrix Metalloprotease-1 Receptor that Promotes Invasion and Tumorigenesis of Breast Cancer Cells

2005 • 808 citations

Selective Requirement for Src Kinases during VEGF-Induced Angiogenesis and Vascular Permeability

1999 • 802 citations

Development of Matrix Metalloproteinase Inhibitors in Cancer Therapy

2001 • 788 citations

Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins

2003 • 784 citations

Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology

2004 • 763 citations

Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells

1997 • 731 citations

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

1996 • 718 citations

The Tie-2 ligand Angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies

2004 • 695 citations

Molecular mechanisms of fibrinolysis

2005 • 694 citations

The biology of the receptor for advanced glycation end products and its ligands

2000 • 690 citations

Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis

2001 • 655 citations

Direct Interaction of Endothelial Nitric-oxide Synthase and Caveolin-1 Inhibits Synthase Activity

1997 • 647 citations

Fibrin structure and wound healing

2006 • 641 citations

Caveolin-1 Regulates Transforming Growth Factor (TGF)-β/SMAD Signaling through an Interaction with the TGF-β Type I Receptor

2001 • 638 citations

A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them

2004 • 625 citations

Mechanical Signaling and the Cellular Response to Extracellular Matrix in Angiogenesis and Cardiovascular Physiology

2002 • 612 citations

Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1

1997 • 610 citations

Mice lacking vimentin develop and reproduce without an obvious phenotype

1994 • 603 citations

Metalloproteinases: role in breast carcinogenesis, invasion and metastasis

2000 • 598 citations

Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

2010 • 597 citations

Regulation of Endothelial Junctional Permeability

2008 • 579 citations

Effect of Elevated Left Atrial Pressure and Decreased Plasma Protein Concentration on the Development of Pulmonary Edema

1959 • 555 citations

Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats.

1996 • 551 citations

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 • 550 citations

Intracellular signalling controlling integrin activation in lymphocytes

2005 • 547 citations

Vascular reactions to histamine, histamine‐liberator and leukotaxine in the skin of guinea‐pigs

1952 • 535 citations

Histamine and its receptors

2006 • 526 citations

Inhibitory Phosphorylation Site for Rho-associated Kinase on Smooth Muscle Myosin Phosphatase

1999 • 522 citations

Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation

2003 • 518 citations

EFFECTIVE OSMOTIC PRESSURE OF THE PLASMA PROTEINS AND OTHER QUANTITIES ASSOCIATED WITH THE CAPILLARY CIRCULATION IN THE HINDLIMBS OF CATS AND DOGS

1948 • 507 citations

The Ins and Outs of Leukocyte Integrin Signaling

2009 • 503 citations

Excess Circulating Angiopoietin-2 May Contribute to Pulmonary Vascular Leak in Sepsis in Humans

2006 • 490 citations

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

1994 • 485 citations

Electrical resistance of brain microvascular endothelium

1982 • 478 citations

Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells

1997 • 477 citations

Transcellular Diapedesis Is Initiated by Invasive Podosomes

2007 • 473 citations

ADAM10 cleavage of N-cadherin and regulation of cell–cell adhesion and β-catenin nuclear signalling

2005 • 470 citations

The Nitric Oxide Synthase Family of Proteins

1994 • 465 citations

INTRAVITREAL BEVACIZUMAB (AVASTIN) THERAPY FOR PERSISTENT DIFFUSE DIABETIC MACULAR EDEMA

2006 • 459 citations

Vascular endothelial growth factors and vascular permeability

2010 • 459 citations

Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation.

1995 • 451 citations

Involvement of ROS in BBB dysfunction

2009 • 428 citations

Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function.

1992 • 424 citations

Leukocyte engagement of fibrin(ogen) via the integrin receptor αMβ2/Mac-1 is critical for host inflammatory response in vivo

2004 • 412 citations

Regulation of vascular permeability by vascular endothelial growth factors

2002 • 404 citations

Blocking Platelet-Derived Growth Factor-D/Platelet-Derived Growth Factor Receptor β Signaling Inhibits Human Renal Cell Carcinoma Progression in an Orthotopic Mouse Model

2005 • 398 citations

Therapeutic strategies targeting the endothelial glycocalyx: acute deficits, but great potential

2010 • 398 citations

Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

2008 • 391 citations

Myosin light chain phosphatase: subunit composition, interactions and regulation.

1998 • 391 citations

Nitric Oxide and the Vascular Endothelium

2006 • 384 citations

Focal adhesions: Structure and dynamics

2000 • 380 citations

Endothelial Mitochondria

2007 • 359 citations

Activated Protein C Mediates Novel Lung Endothelial Barrier Enhancement

2005 • 358 citations

Molecular mechanisms of endothelial hyperpermeability: implications in inflammation

2009 • 356 citations

Role of GTPases in control of microvascular permeability

2010 • 351 citations

Phosphorylation of Caveolin by Src Tyrosine Kinases

1996 • 347 citations

Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2

1993 • 338 citations

Shear stress and the endothelial transport barrier

2010 • 338 citations

Reactive oxygen species in acute lung injury

1998 • 336 citations

Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia

2007 • 332 citations

p120 Catenin-Associated Fer and Fyn Tyrosine Kinases Regulate β-Catenin Tyr-142 Phosphorylation and β-Catenin-α-Catenin Interaction

2003 • 329 citations

Mini‐review: Transendothelial migration of leukocytes: through the front door or around the side of the house?

2004 • 329 citations

Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling

2002 • 327 citations

MICRO-INJECTION STUDIES OF CAPILLARY PERMEABILITY

1927 • 326 citations

The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity

1991 • 324 citations

Capillary endothelial surface layer selectively reduces plasma solute distribution volume

2000 • 320 citations

Constitutive and Growth Factor-Regulated Phosphorylation of Caveolin-1 Occurs at the Same Site (Tyr-14) in Vivo: Identification of a c-Src/Cav-1/Grb7 Signaling Cassette

2000 • 320 citations

Oncotic pressures opposing filtration across non‐fenestrated rat microvessels

2004 • 314 citations

Protein kinase C and the development of diabetic vascular complications

2001 • 314 citations

Caveolae and Caveolins in the Cardiovascular System

2004 • 310 citations

Proteoglycans in health and disease: the multiple roles of syndecan shedding

2010 • 302 citations

Capillary fluid filtration. Starling forces and lymph flow.

1981 • 302 citations

Regulation of Tight Junction Permeability and Occludin Phosphorylation by RhoA-p160ROCK-dependent and -independent Mechanisms

2001 • 300 citations

Caveolin regulation of endothelial function

2003 • 297 citations

Pulmonary Endothelial Cell Barrier Enhancement by Sphingosine 1-Phosphate

2004 • 295 citations

The Effect of Ruboxistaurin on Nephropathy in Type 2 Diabetes

2005 • 293 citations

Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)

2004 • 291 citations

The role of integrins in the maintenance of endothelial monolayer integrity.

1991 • 290 citations

Integrins as dynamic regulators of vascular function

1994 • 289 citations

Endothelial Cell-Surface Gp60 Activates Vesicle Formation and Trafficking via Gi-Coupled Src Kinase Signaling Pathway

2000 • 289 citations

Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation

2010 • 288 citations

Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes

2001 • 287 citations

Microvascular Function in Human Diabetes: A Physiological Perspective

1995 • 287 citations

Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.

1996 • 286 citations

Emerging roles for p120-catenin in cell adhesion and cancer

2004 • 280 citations

ADAM10 Regulates Endothelial Permeability and T-Cell Transmigration by Proteolysis of Vascular Endothelial Cadherin

2008 • 279 citations

Identification of a polypeptide encoded by the avian sarcoma virus src gene.

1978 • 266 citations

The actin cytoskeleton in endothelial cell phenotypes

2008 • 266 citations

The vesiculo-vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation

1996 • 266 citations

Tumors and Fibrinogen

2001 • 259 citations

Transport of large molecules from plasma to interstitial fluid and lymph in dogs

1970 • 258 citations

Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxide1

2002 • 257 citations

Molecular sieving characteristics of the cultured endothelial monolayer

1987 • 254 citations

Marimastat as maintenance therapy for patients with advanced gastric cancer: a randomised trial

2002 • 254 citations

Protein Kinase C-α Signals Rho-Guanine Nucleotide Dissociation Inhibitor Phosphorylation and Rho Activation and Regulates the Endothelial Cell Barrier Function

2001 • 253 citations

Fusion of Cells by Flipped SNAREs

2003 • 248 citations

Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor.

2000 • 244 citations

Structural aspects of the permeability of the microvascular endothelium.

1979 • 241 citations

Leukocyte and endothelial cell interactions in sepsis: Relevance of the protein C pathway

2004 • 239 citations

Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain

2009 • 235 citations

Role of Oxidants in Lung Injury During Sepsis

2007 • 235 citations

Protein kinase signaling in the modulation of microvascular permeability

2002 • 234 citations

Evans blue dye as a marker of albumin clearance in cultured endothelial monolayer and isolated lung

1992 • 234 citations

The cell surface: the stage for matrix metalloproteinase regulation of migration

2002 • 232 citations

Ca²⁺ Signaling, TRP Channels, and Endothelial Permeability

2006 • 229 citations

Molecular Mechanisms of Vascular Permeability in Diabetic Retinopathy

1999 • 227 citations

Role of TRPM2 Channel in Mediating H ₂ O ₂ -Induced Ca ²⁺ Entry and Endothelial Hyperpermeability

2007 • 226 citations

Myosin light chain kinase in microvascular endothelial barrier function

2010 • 224 citations

Vascular Endothelial Growth Factor and Diabetic Retinopathy: Role of Oxidative Stress

2005 • 222 citations

Upregulation of vascular endothelial growth factor by H2O2 in rat heart endothelial cells

1998 • 218 citations

The burn edema process: current concepts.

2005 • 218 citations

Ca²⁺ signalling and PKCα activate increased endothelial permeability by disassembly of VE—cadherin junctions

2001 • 216 citations

Integrin–Matrix Interactions in the Cerebral Microvasculature

2006 • 214 citations

Solvent Drag on Non‐electrolytes During Osmotic Flow Through Isolated Toad Skin and Its Response to Antidiuretic Hormone

1957 • 212 citations

Starling: the formulation of his hypothesis of microvascular fluid exchange and its significance after 100 years

1997 • 211 citations

Role of Src-induced Dynamin-2 Phosphorylation in Caveolae-mediated Endocytosis in Endothelial Cells

2004 • 211 citations

Crystal structure of a 30 kDa C-terminal fragment from the γ chain of human fibrinogen

1997 • 211 citations

Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability

2009 • 209 citations

Matrix metalloproteinase inhibitors (MMPIs): the beginning of phase I or the termination of phase III clinical trials.

2003 • 206 citations

High Glucose Concentrations Increase Endothelial Cell Permeability via Activation of Protein Kinase Cα

1997 • 206 citations

Oxidative Stress and Antioxidant Treatment in Diabetes

2004 • 205 citations

Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin

2002 • 202 citations

Myosin light chain kinase in endothelium: molecular cloning and regulation.

1997 • 200 citations

Pathophysiology of the burn wound and pharmacological treatment. The Rudi Hermans Lecture, 1995

1996 • 198 citations

Mitogen-activated protein kinases as glucose transducers for diabetic complications

1999 • 195 citations

Control of lymphatic and hematogenous metastasis of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94).

1996 • 195 citations

Novel role of microtubules in thrombin‐induced endothelial barrier dysfunction

2004 • 192 citations

Streptozotocin-induced diabetes progressively increases blood-brain barrier permeability in specific brain regions in rats

2006 • 192 citations

Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels.

1992 • 191 citations

Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels.

1991 • 191 citations

Effect of Matrix Metalloproteinase Inhibitor Batimastat on Breast Cancer Regrowth and Metastasis in Athymic Mice

1995 • 190 citations

Contribution of host MMP‐2 and MMP‐9 to promote tumor vascularization and invasion of malignant keratinocytes

2004 • 188 citations

Identification and characterization of cell-substratum adhesion receptors on cultured human endothelial cells.

1989 • 186 citations

Bench-to-bedside review: acute respiratory distress syndrome - how neutrophils migrate into the lung.

2004 • 184 citations

Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: Role of Rho‐dependent mechanisms

2004 • 183 citations

THE PASSAGE OF FLUID AND PROTEIN THROUGH THE HUMAN CAPILLARY WALL DURING VENOUS CONGESTION

1932 • 183 citations

Key concepts in immunology

2010 • 183 citations

Endothelial-dependent Mechanisms Regulate Leukocyte Transmigration: A Process Involving the Proteasome and Disruption of the Vascular Endothelial–Cadherin Complex at Endothelial Cell-to-Cell Junctions

1997 • 182 citations

Functional Selectivity of G Protein Signaling by Agonist Peptides and Thrombin for the Protease-activated Receptor-1

2005 • 181 citations

VE-cadherin: adhesion at arm's length

2004 • 180 citations

Molecular mechanisms of thrombin-induced endothelial cell permeability.

2002 • 178 citations

The Ectodomain Shedding of E-cadherin by ADAM15 Supports ErbB Receptor Activation

2008 • 178 citations

Molecular determinants of endothelial transcytosis and their role in endothelial permeability

2007 • 177 citations

The NO cascade, eNOS location, and microvascular permeability

2010 • 177 citations

Transcapillary exchange: role and importance of the interstitial fluid pressure and the extracellular matrix

2010 • 176 citations

Open junctions in the endothelium of the postcapillary venules of the diaphragm.

1978 • 176 citations

Proatherosclerotic Mechanisms Involving Protein Kinase C in Diabetes and Insulin Resistance

2005 • 175 citations

Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors

2000 • 172 citations

Role of RhoA and Rho Kinase in Lysophosphatidic Acid–Induced Endothelial Barrier Dysfunction

2000 • 172 citations

Lysophosphatidic Acid Increases Tight Junction Permeability in Cultured Brain Endothelial Cells

1997 • 172 citations

Microvascular complications of diabetes

2004 • 171 citations

Albumin uptake and transcytosis in endothelial cells in vivo induced by albumin-binding protein

2001 • 171 citations

Release of Abdominal Compartment Syndrome Improves Survival in Patients with Burn Injury

2002 • 170 citations

Fibrinogen and fibrin: scaffold proteins in hemostasis

2007 • 168 citations

Src protein tyrosine kinase family and acute inflammatory responses

2006 • 165 citations

Advances in pathogenesis and management of sepsis

2007 • 165 citations

Platelet‐Fibrinogen Interactions

2001 • 164 citations

Microvascular Dysfunction in Sepsis

2000 • 164 citations

Pulmonary Edema Fluid from Patients with Acute Lung Injury Augments In Vitro Alveolar Epithelial Repair by an IL-1 β -dependent Mechanism

2001 • 164 citations

A New View of Starling's Hypothesis at the Microstructural Level

1999 • 164 citations

Lipid Infusion Impairs Physiologic Insulin-Mediated Capillary Recruitment and Muscle Glucose Uptake In Vivo

2002 • 164 citations

Angiopoietin-1 Opposes VEGF-Induced Increase in Endothelial Permeability by Inhibiting TRPC1-Dependent Ca ² Influx

2005 • 164 citations

Protein kinase C phosphorylates caldesmon₇₇ and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers

1992 • 163 citations

Vascular endothelial growth factor and platelet-derived growth factor are potential angiogenic and metastatic factors in human breast cancer

1996 • 163 citations

Mechanics of vimentin intermediate filaments.

2002 • 158 citations

Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis

2004 • 158 citations

Pathophysiologic Events Related to Thermal Injury of Skin

1990 • 158 citations

Comparison of systemic cytokine levels in patients with acute respiratory distress syndrome, severe pneumonia, and controls

2000 • 158 citations

Regulation of vascular permeability by sphingosine 1-phosphate

2008 • 158 citations

Induction of Endothelial NO Synthase by Hydrogen Peroxide via a Ca ²⁺ /Calmodulin-Dependent Protein Kinase II/Janus Kinase 2–Dependent Pathway

2001 • 157 citations

The Potential Role of PKC β in Diabetic Retinopathy and Macular Edema

2002 • 157 citations

Rho and ROCK Signaling in VEGF‐Induced Microvascular Endothelial Hyperpermeability

2006 • 156 citations

Arg-Gly-Asp peptide increases endothelial hydraulic conductivity: comparison with thrombin response

1995 • 155 citations

Angiopoietin‐1 inhibits endothelial permeability, neutrophil adherence and IL‐8 production

2003 • 154 citations

Differential Effects of Sphingosine 1–Phosphate Receptors on Airway and Vascular Barrier Function in the Murine Lung

2009 • 154 citations

Filariasis and lymphoedema

2009 • 153 citations

Vascular permeability modulation at the cell, microvessel, or whole organ level: towards closing gaps in our knowledge

2010 • 153 citations

Effects of Bradykinin on Permeability and Diameter of Pial Vessels In vivo

1984 • 152 citations

Differential Regulation of Alternatively Spliced Endothelial Cell Myosin Light Chain Kinase Isoforms by p60Src

2001 • 150 citations

Targets for pharmacological intervention of endothelial hyperpermeability and barrier function

2002 • 149 citations

Pathogenesis of edema formation in burn injuries

1992 • 149 citations

Regulation of endothelial barrier function by reactive oxygen and nitrogen species

2008 • 148 citations

Integrins in angiogenesis: multitalented molecules in a balancing act

2003 • 148 citations

Vascular Endothelial Growth Factor Regulates Focal Adhesion Assembly in Human Brain Microvascular Endothelial Cells through Activation of the Focal Adhesion Kinase and Related Adhesion Focal Tyrosine Kinase

2003 • 148 citations

Membrane associated matrix metalloproteinases in metastasis

1999 • 147 citations

Caveolin-1–Deficient Mice Have Increased Tumor Microvascular Permeability, Angiogenesis, and Growth

2007 • 147 citations

Fibrinogen Signal Transduction as a Mediator and Therapeutic Target in Inflammation:Lessons from Multiple Sclerosis

2007 • 146 citations

H2O2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway

2005 • 145 citations

Phosphorylation of Thr695 and Thr850 on the myosin phosphatase target subunit: Inhibitory effects and occurrence in A7r5 cells

2005 • 142 citations

Ca ²⁺ -Dependent Rapid Ca ²⁺ Sensitization of Contraction in Arterial Smooth Muscle

2006 • 142 citations

Complement activation following oxidative stress

1999 • 141 citations

Protein kinase involved in lung injury susceptibility: Evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment

2003 • 135 citations

Measurements of endothelial cell-to-cell and cell-to-substrate gaps and micromechanical properties of endothelial cells during monocyte adhesion

2002 • 134 citations

A Single Human Myosin Light Chain Kinase Gene (MLCK; MYLK)Transcribes Multiple Nonmuscle Isoforms

1999 • 134 citations

Novel Mechanism of Endothelial Nitric Oxide Synthase Activation Mediated by Caveolae Internalization in Endothelial Cells

2006 • 134 citations

Mechanics of fluid movement across single capillaries in the rabbit

1968 • 131 citations

The Coupling of Glucose Metabolism and Perfusion in Human Skeletal Muscle: The Potential Role of Endothelium-Derived Nitric Oxide

1996 • 131 citations

Involvement of site‐specific FAK phosphorylation in sphingosine‐1 phosphate‐ and thrombin‐induced focal adhesion remodeling: role of Src and GIT

2003 • 130 citations

Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats

1999 • 128 citations

Leukocyte transendothelial migration: A junctional affair

2002 • 126 citations

Intercellular Adhesion Molecule-1–Dependent Neutrophil Adhesion to Endothelial Cells Induces Caveolae-Mediated Pulmonary Vascular Hyperpermeability

2008 • 126 citations

Through and beyond the wall: late steps in leukocyte transendothelial migration

1997 • 124 citations

Nitric Oxide Affects Microvascular Permeability in the Intact and Inflamed Vasculature

1995 • 123 citations

p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation

2008 • 123 citations

Role of Myosin Phosphatase Isoforms in cGMP-mediated Smooth Muscle Relaxation

2001 • 121 citations

Matrix metalloproteinases and metastatic cancer.

1998 • 121 citations

The Role of ADAM 15 in Glomerular Mesangial Cell Migration

2002 • 117 citations

Regulation of Cell Adhesion by Protein-tyrosine Phosphatases

2006 • 117 citations

Endothelial focal adhesions and barrier function

2005 • 117 citations

The effect of altering the external calcium concentration and a calcium channel blocker, verapamil, on microvascular leaky sites and dextran clearance in the hamster cheek pouch

1984 • 116 citations

Metalloproteinases and their inhibitors in angiogenesis

2003 • 116 citations

Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo

2004 • 115 citations

Tumor necrosis factor-alpha blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation.

1993 • 114 citations

Angiopoietin-1, Unlike Angiopoietin-2, Is Incorporated into the Extracellular Matrix via Its Linker Peptide Region

2001 • 112 citations

Inhibition of angiogenesis and metastasis in two murine models by the matrix metalloproteinase inhibitor, BMS-275291.

2001 • 112 citations

The Incidence and Impact of Pre-Existing Protein Energy Malnutrition on Outcome in the Elderly Burn Patient Population

2005 • 112 citations

Current Status Of Burn Wound Pathophysiology

2000 • 112 citations

Implications of the three‐dimensional structure of astacin for the structure and function of the astacin family of zinc‐endopeptidases

1993 • 111 citations

Control of repetitive electrical discharges by means of an external electrode

1992 • 111 citations

Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits

2008 • 110 citations

Regulation of endothelial permeability by Src kinase signaling: Vascular leakage versus transcellular transport of drugs and macromolecules

2007 • 109 citations

Fibrin Degradation Products, Fibrin Monomer and Soluble Fibrin in Disseminated Intravascular Coagulation

2001 • 109 citations

Degree of Hypercoagulability and Hyperfibrinolysis is Related to Organ Failure and Prognosis after Burn Trauma

1998 • 107 citations

Regulation of Endothelial Barrier Function by the cAMP-Dependent Protein Kinase

2000 • 107 citations

Fibrin-mediated vascular injury. Identification of fibrin peptides that mediate endothelial cell retraction.

1984 • 105 citations

Tumor Necrosis Factor-α and Angiostatin Are Mediators of Endothelial Cytotoxicity in Bronchoalveolar Lavages of Patients with Acute Respiratory Distress Syndrome

2002 • 104 citations

The Endothelial Receptor Tyrosine Kinase Tie1 Activates Phosphatidylinositol 3-Kinase and Akt To Inhibit Apoptosis

2002 • 103 citations

Transcytosis in the continuous endothelium of the myocardial microvasculature is inhibited by N-ethylmaleimide.

1994 • 102 citations

Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: Role of NADPH oxidase-derived ROS

2007 • 102 citations

Protein Kinase C Activation Contributes to Microvascular Barrier Dysfunction in the Heart at Early Stages of Diabetes

2000 • 101 citations

Structure and functions of the endothelial cell protein C receptor

2004 • 100 citations

Insight into intra- and inter-molecular interactions of PKC: Design of specific modulators of kinase function

2007 • 100 citations

Intersectin Regulates Fission and Internalization of Caveolae in Endothelial Cells

2003 • 98 citations

Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin

2002 • 98 citations

ADAM15 Supports Prostate Cancer Metastasis by Modulating Tumor Cell–Endothelial Cell Interaction

2008 • 97 citations

Cause-effect relation between hyperfibrinogenemia and vascular disease

2003 • 96 citations

Current pharmacotherapy for the treatment of severe burns

2003 • 96 citations

Analysis of the Roles of ICAM-1 in Neutrophil Transmigration Using a Reconstituted Mammalian Cell Expression Model: Implication of ICAM-1 Cytoplasmic Domain and Rho-Dependent Signaling Pathway

2001 • 95 citations

Fibrinogen induces endothelial cell permeability

2007 • 95 citations

Reversibility of increased microvessel permeability in response to VE-cadherin disassembly

2000 • 95 citations

CaM Kinase II-dependent pathophysiological signalling in endothelial cells

2007 • 94 citations

Role of H2O2-activated TRPM2 calcium channel in oxidant-induced endothelial injury

2009 • 94 citations

Introduction: The complexities of leukocyte recruitment

2002 • 93 citations

Analysis of altered capillary pressure and permeability after thermal injury

1987 • 93 citations

Microvascular Solute and Water Transport

2005 • 92 citations

Signal Transduction Pathways in Enhanced Microvascular Permeability

2000 • 92 citations

Dominant regulation of interendothelial cell gap formation by calcium-inhibited type 6 adenylyl cyclase

2002 • 91 citations

Macromolecular transport in the cat mesentery

1975 • 91 citations

Fibrinogen γ chain functions

2003 • 89 citations

Endothelial Transcytotic Machinery Involves Supramolecular Protein–Lipid Complexes

2001 • 88 citations

Elevated Orbital Pressure: Another Untoward Effect of Massive Resuscitation after Burn Injury

2006 • 87 citations

Oxidants and the pathophysiology of burn and smoke inhalation injury

1992 • 87 citations

Identification of Amino Acid Sequences in Fibrinogen γ-Chain and Tenascin C C-terminal Domains Critical for Binding to Integrin αvβ3

2000 • 87 citations

Basal and angiopoietin-1–mediated endothelial permeability is regulated by sphingosine kinase-1

2008 • 87 citations

Regulation of transendothelial permeability by Src Kinase

2008 • 86 citations

ZM323881, a Novel Inhibitor of Vascular Endothelial Growth Factor‐Receptor‐2 Tyrosine Kinase Activity

2002 • 86 citations

Specific Binding of Integrin αvβ3 to the Fibrinogen γ and α_E Chain C-Terminal Domains

1999 • 85 citations

Dynamics of neutrophil extravasation and vascular permeability are uncoupled during aseptic cutaneous wounding

2009 • 84 citations

Diabetes-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1) expression.

2002 • 84 citations

Role of blood cells in ischaemia-reperfusion induced endothelial barrier failure

2010 • 83 citations

Endothelial Barrier Strengthening by Activation of Focal Adhesion Kinase

2003 • 82 citations

Functional significance of differential eNOS translocation

2006 • 82 citations

Mechanisms of Acute Lung Injury/Acute Respiratory Distress Syndrome

2006 • 80 citations

Protein kinase A attenuates endothelial cell barrier dysfunction induced by microtubule disassembly

2004 • 80 citations

Expression of a Novel High Molecular-Weight Myosin Light Chain Kinase in Endothelium

1998 • 78 citations

Src-dependent, neutrophil-mediated vascular hyperpermeability and β-catenin modification

2002 • 78 citations

Effects of H₁antagonists on the cutaneous vascular response to histamine and bradykinin: a study using scanning laser Doppler imaging

1998 • 76 citations

Upregulation of PKC genes and isozymes in cardiovascular tissues during early stages of experimental diabetes

2003 • 76 citations

Novel functions of thrombomodulin in inflammation

2004 • 76 citations

Histamine Effects on Endothelial Cell Fibronectin Interaction Studied by Atomic Force Microscopy

2005 • 75 citations

Vascular endothelial growth factor stimulates differential signaling pathways in in vivo microcirculation

2004 • 74 citations

RhoGDI-1 Modulation of the Activity of Monomeric RhoGTPase RhoA Regulates Endothelial Barrier Function in Mouse Lungs

2007 • 73 citations

H₂O₂-mediated permeability II: importance of tyrosine phosphatase and kinase activity

2001 • 73 citations

Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality

2009 • 73 citations

Tyrosine phosphorylation of vascular endothelial cadherin and the regulation of microvascular permeability

2002 • 72 citations

Role of neutrophil-derived matrix metalloproteinase-9 in tissue regeneration.

2010 • 71 citations

Integrin binding to fibronectin and vitronectin maintains the barrier function of isolated porcine coronary venules

2001 • 71 citations

Forty years in burns research — the postburn inflammatory response

2000 • 70 citations

Current advances in the initial management of major thermal burns

2000 • 70 citations

Role of fibrin D-dimer testing in emergency medicine

2003 • 69 citations

The role of lipids and protein kinase Cs in the pathogenesis of diabetic retinopathy

2004 • 69 citations

Pathophysiologic roles of the fibrinogen gamma chain

2004 • 68 citations

Anti-adhesion Therapy

1997 • 68 citations

GIT1 Mediates Thrombin Signaling in Endothelial Cells

2004 • 67 citations

Diapedesis and the permeability of venous microvessels to protein macromolecules: The impact of leukotriene B4 (LTB4)

1988 • 67 citations

Small GTPases in mechanosensitive regulation of endothelial barrier

2008 • 66 citations

Abnormal capillary permeability and endothelial dysfunction in hypertension with comorbid Metabolic Syndrome

2003 • 66 citations

ADAM‐15: a metalloprotease that mediates inflammation

2007 • 66 citations

The role of cadherin endocytosis in endothelial barrier regulation: involvement of protein kinase C and actin-cadherin interactions.

1998 • 65 citations

Diabetic vascular dysfunction: Links to glucose‐induced reductive stress and VEGF

2002 • 65 citations

Fibrin degradation products. A review of structures found in vitro and in vivo.

2001 • 64 citations

Sequence γ377−395(P2), but Not γ190−202(P1), Is the Binding Site for the α_MI-Domain of Integrin α_Mβ₂ in the γC-Domain of Fibrinogen

2003 • 63 citations

Calcium Antagonists Ameliorate Ischemia-Induced Endothelial Cell Permeability by Inhibiting Protein Kinase C

1999 • 63 citations

Acute modulation of albumin microvascular leakage by advanced glycation end products in microcirculation of diabetic rats in vivo.

1999 • 63 citations

The role of ADAMs in disease pathophysiology

2009 • 63 citations

Burn edema and protein leakage in the rat

1978 • 62 citations

The protein kinase MEK1/2 mediate vascular endothelial growth factor‐ and histamine‐induced hyperpermeability in porcine coronary venules

2004 • 61 citations

Ruboxistaurin, a Protein Kinase C β Inhibitor, as an Emerging Treatment for Diabetes Microvascular Complications

2005 • 61 citations

Endogenous endothelial cell signaling systems maintain vascular stability

2009 • 61 citations

Focal adhesion kinase mediates porcine venular hyperpermeability elicited by vascular endothelial growth factor

2003 • 59 citations

Fibrin(ogen) and its fragments in the pathophysiology and treatment of myocardial infarction

2006 • 59 citations

Molecular basis of mechanical modulation of endothelial cell migration

2005 • 59 citations

A novel advanced glycation index and its association with diabetes and microangiopathy

2005 • 58 citations

THE STRUCTURAL BASIS OF INCREASED VASCULAR PERMEABILITY AFTER GRADED THERMAL INJURY‐LIGHT AND ELECTRON MICROSCOPIC STUDIES*

1968 • 58 citations

The mechanism of the endothelial supporting function of intact platelets

1964 • 57 citations

Novel Therapies for Microvascular Permeability in Sepsis

2007 • 57 citations

Barrier Dysfunction of the Corneal Endothelium in Response to TNF-α: Role of p38 MAP Kinase

2010 • 56 citations

Aggravation of hemorrhagic transformation by early intraarterial infusion of low-dose vascular endothelial growth factor after transient focal cerebral ischemia in rats

2005 • 56 citations

Myosin Light Chain Kinase-Dependent Microvascular Hyperpermeability in Thermal Injury

2003 • 56 citations

Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays

2009 • 55 citations

The integrin complex αvβ3 participates in the adhesion of microvascular endothelial cells to fibronectin

1991 • 55 citations

Involvement of PKCδ and PKD in pulmonary microvascular endothelial cell hyperpermeability

2004 • 55 citations

Myosin Phosphatase Regulatory Pathways

2007 • 55 citations

Phosphotyrosine protein dynamics in cell membrane rafts of sphingosine-1-phosphate-stimulated human endothelium: Role in barrier enhancement

2009 • 55 citations

Endothelial contractile cytoskeleton and microvascular permeability

2009 • 54 citations

Microvascular Perfusion and Transport in the Diabetic Heart

2000 • 53 citations

The coagulation system and pulmonary endothelial function in acute lung injury

2008 • 53 citations

Internalization of eNOS and NO delivery to subcellular targets determine agonist-induced hyperpermeability

2009 • 52 citations

Trends in burn resuscitation: shifting the focus from fluids to adequate endpoint monitoring, edema control, and adjuvant therapies

2004 • 52 citations

Predicting the Severity of Systemic Inflammatory Response Syndrome (SIRS)-Associated Coagulopathy With Hemostatic Molecular Markers and Vascular Endothelial Injury Markers

2007 • 50 citations

Tissue Inhibitor of Metalloproteinase-2 Regulates Matrix Metalloproteinase-2–Mediated Endothelial Barrier Dysfunction and Breast Cancer Cell Transmigration through Lung Microvascular Endothelial Cells

2010 • 49 citations

Increased capillary permeability to albumin in diabetic rat myocardium.

1993 • 49 citations

What's New in Burns and Metabolism

2001 • 49 citations

The Microvasculature in Insulin Resistance and Type 2 Diabetes

2002 • 49 citations

Interactions of constitutive nitric oxide with PAF and thromboxane on rat intestinal vascular integrity in acute endotoxaemia

1994 • 48 citations

Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia‐reperfusion injury in rats

2006 • 48 citations

A ROLE FOR LONG CHAIN MYOSIN LIGHT CHAIN KINASE (MLCK-210) IN MICROVASCULAR HYPERPERMEABILITY DURING SEVERE BURNS

2007 • 48 citations

cGMP in the Vasculature

2008 • 48 citations

Role of CPI-17 in the regulation of endothelial cytoskeleton

2004 • 47 citations

δPKC inhibition or ɛPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification

2009 • 46 citations

Microtubules are involved in transport of macromolecules by vesicles in cultured bovine aortic endothelial cells

1993 • 46 citations

TRPM2 Channel Regulates Endothelial Barrier Function

2009 • 46 citations

The role of the neutrophil in ischaemia-reperfusion injury: potential therapeutic interventions

1998 • 45 citations

Mechanisms for early microvascular injury in obesity and type II diabetes

2004 • 45 citations

Synergistic Antitumor Activity of Ixabepilone (BMS-247550) Plus Bevacizumab in Multiple In vivo Tumor Models

2008 • 44 citations

THE INTERACTION OF SOLUBLE TIE2 WITH ANGIOPOIETINS AND PULMONARY VASCULAR PERMEABILITY IN SEPTIC AND NONSEPTIC CRITICALLY ILL PATIENTS

2010 • 43 citations

A role for endothelial-derived matrix metalloproteinase-2 in breast cancer cell transmigration across the endothelial-basement membrane barrier

2007 • 43 citations

Agonist-induced impairment of glycocalyx exclusion properties: contribution to coronary effects of adenosine

2010 • 43 citations

Regulation of Vascular Genes by Glucose

2005 • 42 citations

Internalization of eNOS via caveolae regulates PAF-induced inflammatory hyperpermeability to macromolecules

2008 • 41 citations

Microtubule stabilization opposes the (TNF-α)-induced loss in the barrier integrity of corneal endothelium

2009 • 41 citations

The endothelial vesicle system in cryofixed frog mesenteric capillaries analysed by ultrathin serial sectioning

1991 • 40 citations

Focal Adhesion Kinase in Neutrophil‐Induced Microvascular Hyperpermeability

2005 • 40 citations

Electron microscopic evidence for the mechanism of blood-retinal barrier breakdown in diabetic rabbits: Comparison with magnetic resonance imaging

1998 • 39 citations

Platelet lipid(s) bound to albumin increases endothelial electrical resistance: mimicked by LPA

2001 • 39 citations

Endogenous protein C activation in patients with severe sepsis

2004 • 39 citations

High D-Glucose Induces Alterations of Endothelial Cell Structure in a Cell-Culture Model

1997 • 38 citations

The COOH-Terminal Globular Domain of Fibrinogen γ Chain Suppresses Angiogenesis and Tumor Growth

2006 • 37 citations

Modulation of Ca2+ transients and tension by intracellular EGTA in intact frog muscle fibers

1997 • 36 citations

Endothelial F-actin Cytoskeleton in the Retinal Vasculature of Normal and Diabetic Rats

2005 • 36 citations

Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: Organization, expression, alternative splicing, and polymorphic marker

1999 • 36 citations

Cross-bridge dephosphorylation and relaxation of vascular smooth muscle

1989 • 36 citations

Role of local production of endothelium-derived nitric oxide on cGMP signaling and S-nitrosylation

2009 • 35 citations

Early changes of endothelial clefts after thermal injury

1975 • 35 citations

A transgenic mouse with vascular endothelial over-expression of the non-muscle myosin light chain kinase-2 isoform is susceptible to inflammatory lung injury: role of sexual dimorphism and age

2008 • 35 citations

Microvascular albumin permeability in isolated perfused lung: effects of EDTA

1985 • 35 citations

Reduced expression of the adherens junction protein cadherin-5 in a diabetic retina

2000 • 34 citations

The Role of Interstitial Starling Forces in the Pathogenesis of Burn Edema

1998 • 33 citations

Small Molecule Inhibitors of Lck: The Search for Specificity within a Kinase Family

2008 • 31 citations

The role of the disintegrin metalloproteinase ADAM15 in prostate cancer progression

2009 • 31 citations

Effects of Glutathione Depletion on Oxidant-Induced Endothelial Cell Injury

1998 • 31 citations

Real‐time monitoring of cAMP levels in living endothelial cells: thrombin transiently inhibits adenylyl cyclase 6

2009 • 30 citations

Segmental differences of microvascular permeability for FITC-dextrans measured in the hamster cheek pouch

1986 • 30 citations

The physiology ofS-nitrosothiols: carrier molecules for nitric oxide

2003 • 30 citations

Fibrinogen-γ C-Terminal Fragments Induce Endothelial Barrier Dysfunction and Microvascular Leak via Integrin-Mediated and RhoA-Dependent Mechanism

2009 • 30 citations

Modulation of a potassium conductance in developing skeletal muscle

1995 • 30 citations

Prostaglandins and sepsis: still a fascinating topic despite almost 40 years of research

2001 • 29 citations

Transvascular Low-Density Lipoprotein Transport in Patients With Diabetes Mellitus (Type 2)

2002 • 27 citations

Role of intracellular calcium in regulation of brain endothelial permeability

1998 • 26 citations

Effects of bradykinin, histamine and serotonin on pulmonary vascular resistance and permeability

1997 • 26 citations

Elevated Plasma Levels of Fibrin Degradation Productsby Granulocyte-Derived Elastase in Patients with Disseminated Intravascular Coagulation

2005 • 25 citations

Microvascular ultrastructure in thermal injury: A reconsideration of the role of mediators

1973 • 24 citations

Spectral Absorption of T-1824 in Plasma of Various Species and Recovery of the Dye by Extraction

1953 • 24 citations

THE 1999 EVERETT IDRIS EVANS MEMORIAL LECTURE Edema Generation Following Thermal Injury

1999 • 23 citations

Spontaneous injury in isolated sheep lungs: role of perfusate leukocytes and platelets

1989 • 23 citations

Elevated cAMP opposes (TNF-alpha)-induced loss in the barrier integrity of corneal endothelium.

2010 • 22 citations

Mediators in thermal injury.

1993 • 22 citations

Experimental determination of the linear correlation between in vivo TV fluorescence intensity and vascular and tissue FITC-Dx concentrations

1991 • 21 citations

Counter Regulatory Effects of PKC _βII and PKC _δ on Coronary Endothelial Permeability

2008 • 21 citations

[Vital microscopy studies on the localization of protein permeability in the terminal stream bed of homoiotherms].

1969 • 21 citations

Biochemical and functional characteristics of integrins: a new family of adhesive receptors present in hematopoietic cells.

1990 • 20 citations

Cellular Aspects of Transvascular Exchange: A 40‐Year Perspective

1994 • 20 citations

High-Glucose-Altered Endothelial Cell Function Involves Both Disruption of Cell-to-Cell Connection and Enhancement of Force Development

2006 • 19 citations

The Utility of D-Dimer Levels in Screening for Thromboembolic Complications in Burn Patients

2002 • 18 citations

Osmosis and Solute–Solvent Drag: Fluid Transport and Fluid Exchange in Animals and Plants

2005 • 18 citations

Proteolytic Activity in Burn Wound Exudates and Comparison of Fibrin Degradation Products and Protease Inhibitors in Exudates and Sera

1994 • 18 citations

Glucose-induced increase in paracellular permeability and disruption of beta-receptor signaling in retinal endothelium.

1998 • 18 citations

Oleic acid-induced lung injury in rabbits: effect of fibrinogen depletion with Arvin

1988 • 17 citations

A densitometric method for determining the filtration coefficients of single capillaries in the frog mesentery

1977 • 17 citations

The Crystal Structure of Fragment Double-D from Cross-Linked Lamprey Fibrin Reveals Isopeptide Linkages across an Unexpected D−D Interface^,

2002 • 16 citations

Changes in capillary permeability in diabetic patients.

1998 • 16 citations

Determining the crystal structure of fibrinogen

2004 • 15 citations

Microvascular heart disease in diabetes mellitus

1997 • 15 citations

Vein Tissue Expression of Matrix Metalloproteinase as Biomarker for Hemodialysis Arteriovenous Fistula Maturation

2010 • 14 citations

The Microvasculature in Type 1 Diabetes

2002 • 12 citations

Microvascular Clearance of Macromolecules in Skeletal Muscle of Spontaneously Diabetic Rats

1993 • 12 citations

Protein Consensus Sequence Motifs

2003 • 10 citations

Effect of H1 antihistamines in a model of mesenteric ischaemia/reperfusion

2008 • 10 citations

Angiogenesis Switch Pathways

2008 • 8 citations

Extravascular fibrinogen degradation in experimental burn wounds: a source of fibrin split products.

1975 • 8 citations

Centripetal Tension and Endothelial Retraction

1994 • 7 citations

Die Ausbreitung von Fluorescenzfarbstoffen in der Hamsterbackentasche

1968 • 5 citations