The role of ADAMs in disease pathophysiology

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

NF-κB functions as a tumour promoter in inflammation-associated cancer

2004 • 2,370 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

Multiple essential functions of neuregulin in development

1995 • 1,236 citations

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

1999 • 1,115 citations

Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness

2002 • 1,108 citations

A Novel Proteolytic Cleavage Involved in Notch Signaling

2000 • 1,080 citations

IgE in allergy and asthma today

2008 • 1,074 citations

The ADAM metalloproteinases

2008 • 1,066 citations

ADAMs: key components in EGFR signalling and development

2005 • 1,056 citations

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

2004 • 965 citations

Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

1998 • 922 citations

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

2002 • 727 citations

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

2002 • 657 citations

ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and β-catenin translocation

2005 • 630 citations

Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment

2000 • 545 citations

A metalloprotease-disintegrin, MDC9/meltrin-gamma /ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor

1998 • 523 citations

ADAMs in cancer cell proliferation and progression

2007 • 509 citations

Neuregulins Promote Survival and Growth of Cardiac Myocytes

1998 • 493 citations

The ADAMs: signalling scissors in the tumour microenvironment

2008 • 493 citations

ADAM10 cleavage of N-cadherin and regulation of cell–cell adhesion and β-catenin nuclear signalling

2005 • 470 citations

Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis

2003 • 460 citations

The many facets of Notch ligands

2008 • 435 citations

Adam Meets Eph: An ADAM Substrate Recognition Module Acts as a Molecular Switch for Ephrin Cleavage In trans

2005 • 434 citations

The EGF receptor family: spearheading a merger of signaling and therapeutics

2007 • 397 citations

Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer

2006 • 376 citations

Tumor Necrosis Factor-α-converting Enzyme Is Required for Cleavage of erbB4/HER4

2000 • 310 citations

ADAM 12-S Cleaves IGFBP-3 and IGFBP-5 and Is Inhibited by TIMP-3

2000 • 309 citations

Essential role of tumor necrosis factor alpha (TNF-alpha) in tumor promotion as revealed by TNF-alpha-deficient mice.

1999 • 308 citations

Putative function of ADAM9, ADAM10, and ADAM17 as APP -secretase

2003 • 291 citations

The Disintegrins ADAM10 and TACE Contribute to the Constitutive and Phorbol Ester-regulated Normal Cleavage of the Cellular Prion Protein

2001 • 285 citations

TACE is required for the activation of the EGFR by TGF-α in tumors

2003 • 270 citations

Neuregulin-1/erbB-Activation Improves Cardiac Function and Survival in Models of Ischemic, Dilated, and Viral Cardiomyopathy

2006 • 259 citations

Emerging roles of ADAM and ADAMTS metalloproteinases in cancer

2007 • 252 citations

Role of Neuregulin-1/ErbB Signaling in Cardiovascular Physiology and Disease

2007 • 252 citations

The Adaptor Protein Fish Associates with Members of the ADAMs Family and Localizes to Podosomes of Src-transformed Cells

2003 • 250 citations

Targeting TACE-dependent EGFR ligand shedding in breast cancer

2007 • 246 citations

Matrix Metalloproteinases as Valid Clinical Target

2006 • 240 citations

Notch tumor suppressor function

2008 • 238 citations

α-Secretase ADAM10 as Well as αAPPs Is Reduced in Platelets and CSF of Alzheimer Disease Patients

2002 • 229 citations

Role of ADAMs in Cancer Formation and Progression

2009 • 221 citations

RGD-independent Binding of Integrin α9β1 to the ADAM-12 and -15 Disintegrin Domains Mediates Cell-Cell Interaction

2000 • 211 citations

Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma

2004 • 205 citations

ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23

2006 • 200 citations

Tumor Necrosis Factor-α Converting Enzyme/ADAM 17 Mediates MUC1 Shedding

2003 • 197 citations

Interaction of metargidin (ADAM-15) with αvβ3 and α5β1 integrins on different haemopoietic cells

1999 • 193 citations

Drug Insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis

2008 • 192 citations

Potential Role for ADAM15 in Pathological Neovascularization in Mice

2003 • 182 citations

Roles of Meltrin β/ADAM19 in the Processing of Neuregulin

2001 • 181 citations

Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells

2006 • 178 citations

TACE/ADAM17 Processing of EGFR Ligands Indicates a Role as a Physiological Convertase

2003 • 178 citations

The Ectodomain Shedding of E-cadherin by ADAM15 Supports ErbB Receptor Activation

2008 • 178 citations

Catalytic Activity of ADAM8, ADAM15, and MDC-L (ADAM28) on Synthetic Peptide Substrates and in Ectodomain Cleavage of CD23

2003 • 176 citations

Cellular roles of ADAM12 in health and disease

2008 • 172 citations

VEGF-A Stimulates ADAM17-Dependent Shedding of VEGFR2 and Crosstalk Between VEGFR2 and ERK Signaling

2008 • 154 citations

Tumor Necrosis Factor-α Is a Potent Endogenous Mutagen that Promotes Cellular Transformation

2006 • 147 citations

Increased expression of ADAM33 and ADAM8 with disease progression in asthma

2007 • 145 citations

Selective Inhibition of ADAM Metalloproteases as a Novel Approach for Modulating ErbB Pathways in Cancer

2007 • 142 citations

NRG-1-induced cardiomyocyte hypertrophy. Role of PI-3-kinase, p70^S6K, and MEK-MAPK-RSK

1999 • 140 citations

ErbB and HB-EGF Signaling in Heart Development and Function

2006 • 134 citations

Essential Role for ADAM19 in Cardiovascular Morphogenesis

2003 • 131 citations

Breaking up the tie: Disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion

2006 • 131 citations

TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha.

1998 • 130 citations

Catalytic Properties of ADAM19

2003 • 125 citations

The Disintegrin ADAM9 Indirectly Contributes to the Physiological Processing of Cellular Prion by Modulating ADAM10 Activity

2005 • 119 citations

ADAMs, cell migration and cancer

2006 • 118 citations

ADAM28 Is Overexpressed in Human Breast Carcinomas: Implications for Carcinoma Cell Proliferation through Cleavage of Insulin-like Growth Factor Binding Protein-3

2006 • 116 citations

Ectodomain shedding of the EGF‐receptor ligand epigen is mediated by ADAM17

2006 • 116 citations

ADAM-17 Expression in Breast Cancer Correlates with Variables of Tumor Progression

2007 • 115 citations

Hypoxia-inducible Factor Mediates Hypoxic and Tumor Necrosis Factor α-induced Increases in Tumor Necrosis Factor-α Converting Enzyme/ADAM17 Expression by Synovial Cells

2007 • 113 citations

Expression and Regulation of the Metalloproteinase ADAM-8 during Human Neutrophil Pathophysiological Activation and Its Catalytic Activity on L-Selectin Shedding

2007 • 113 citations

ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression

2006 • 106 citations

Synergistic Inhibition with a Dual Epidermal Growth Factor Receptor/HER-2/neu Tyrosine Kinase Inhibitor and a Disintegrin and Metalloprotease Inhibitor

2008 • 105 citations

TACE/ADAM-17: A Component of the Epidermal Growth Factor Receptor Axis and a Promising Therapeutic Target in Colorectal Cancer

2008 • 104 citations

Expression and Regulation of a Disintegrin and Metalloproteinase (ADAM) 8 in Experimental Asthma

2004 • 103 citations

TNF-α Convertase Enzyme from Human Arthritis-Affected Cartilage: Isolation of cDNA by Differential Display, Expression of the Active Enzyme, and Regulation of TNF-α

1998 • 99 citations

ADAM10 is essential for proteolytic activation of Notch during thymocyte development

2008 • 99 citations

ADAM15 Supports Prostate Cancer Metastasis by Modulating Tumor Cell–Endothelial Cell Interaction

2008 • 97 citations

Part-Time α-Secretases: The Functional Biology of ADAM 9, 10 and 17

2008 • 96 citations

A secreted form of human ADAM9 has an α-secretase activity for APP

2002 • 96 citations

Selective Modulation of Integrin-mediated Cell Migration by Distinct ADAM Family Members

2005 • 93 citations

Altered Expression of ADAMs ( A D isintegrin A nd M etalloproteinase) in Fibrillating Human Atria

2002 • 93 citations

The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein

2004 • 90 citations

ADAM10 as a Target for Anti-Cancer Therapy

2008 • 89 citations

The biology of integrins.

2007 • 89 citations

ADAM-17 predicts adverse outcome in patients with breast cancer

2008 • 85 citations

ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer

2007 • 85 citations

Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8

2006 • 82 citations

The ADAMs family of proteins: from basic studies to potential clinical applications

2003 • 76 citations

CD23: An overlooked regulator of allergic disease

2007 • 75 citations

ADAM9 Expression is a Significant and Independent Prognostic Marker of PSA Relapse in Prostate Cancer

2007 • 74 citations

Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage

2007 • 73 citations

Integrins, membrane-type matrix metalloproteinases and ADAMs: Potential implications for cardiac remodeling

2005 • 69 citations

Distinct Functions of Natural ADAM-15 Cytoplasmic Domain Variants in Human Mammary Carcinoma

2008 • 66 citations

ADAM‐12 (meltrin α) is involved in chondrocyte proliferation via cleavage of insulin‐like growth factor binding protein 5 in osteoarthritic cartilage

2008 • 65 citations

Comparative localization of ADAMs 10 and 15 in human cerebral cortex normal aging, Alzheimer disease and Down syndrome

2003 • 64 citations

Multiple Acquired Renal Carcinoma Tumor Capabilities Abolished upon Silencing of ADAM17

2006 • 60 citations

ADAM15 decreases integrin αvβ3/vitronectin-mediated ovarian cancer cell adhesion and motility in an RGD-dependent fashion

2004 • 56 citations

(Make) Stick and cut loose—Disintegrin metalloproteases in development and disease

2006 • 55 citations

Increased mRNA expression of ADAMs in renal cell carcinoma and their association with clinical outcome

2004 • 54 citations

Cloning and Expression in Pichia pastoris of Metalloprotease Domain of ADAM 9 Catalytically Active against Fibronectin

2001 • 54 citations

Amyloid-β neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity

2005 • 52 citations

Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates

2006 • 50 citations

Role of ADAM8 in experimental asthma

2005 • 47 citations

Synthesis and structure–activity relationship of a novel, achiral series of TNF-α converting enzyme inhibitors

2006 • 46 citations

An Adam15 amplification loop promotes vascular endothelial growth factor‐induced ocular neovascularization

2008 • 36 citations

Roles of transforming growth factor-α in mammary development and disease

2007 • 31 citations

Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late‐onset Alzheimer's disease

2007 • 31 citations

DNA sequence variations of metalloproteinases: their role in asthma and COPD

2007 • 30 citations

Variation at the ADAM10 gene locus is not associated with Creutzfeldt–Jakob disease

2003 • 7 citations

Deleted Work

1955 • 0 citations