Caveolae and Caveolins in the Cardiovascular System

Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

2001 • 1,517 citations

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

1998 • 1,502 citations

Lipid Rafts

2003 • 1,485 citations

Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER

2001 • 1,236 citations

Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.

1998 • 1,191 citations

Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities

2001 • 1,144 citations

Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice

2000 • 1,020 citations

Caveolins, Liquid-Ordered Domains, and Signal Transduction

1999 • 1,016 citations

Co-purification and Direct Interaction of Ras with Caveolin, an Integral Membrane Protein of Caveolae Microdomains

1996 • 1,006 citations

Caveolae: From Cell Biology to Animal Physiology

2002 • 977 citations

Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells

1993 • 961 citations

Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability

2001 • 960 citations

VIP21/caveolin is a cholesterol-binding protein.

1995 • 892 citations

Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors

2003 • 839 citations

Dissecting the Interaction between Nitric Oxide Synthase (NOS) and Caveolin

1997 • 808 citations

Acylation Targets Endothelial Nitric-oxide Synthase to Plasmalemmal Caveolae

1996 • 798 citations

Microvascular Permeability

1999 • 769 citations

Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms

2002 • 754 citations

A detergent-free method for purifying caveolae membrane from tissue culture cells.

1995 • 732 citations

Expression of Caveolin-3 in Skeletal, Cardiac, and Smooth Muscle Cells

1996 • 692 citations

Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling.

1996 • 677 citations

Endothelial Nitric Oxide Synthase Targeting to Caveolae

1996 • 670 citations

Dynamin at the Neck of Caveolae Mediates Their Budding to Form Transport Vesicles by GTP-driven Fission from the Plasma Membrane of Endothelium

1998 • 657 citations

Direct Interaction of Endothelial Nitric-oxide Synthase and Caveolin-1 Inhibits Synthase Activity

1997 • 647 citations

Evidence for a Regulated Interaction between Heterotrimeric G Proteins and Caveolin

1995 • 612 citations

Lipid Rafts and Caveolae as Portals for Endocytosis: New Insights and Common Mechanisms

2003 • 589 citations

Multiple Functions of Caveolin-1

2002 • 579 citations

The plasma membrane

1983 • 561 citations

In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation

2000 • 558 citations

Differential Targeting of β-Adrenergic Receptor Subtypes and Adenylyl Cyclase to Cardiomyocyte Caveolae

2000 • 514 citations

Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough?

2001 • 495 citations

VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro.

1995 • 465 citations

Caveolin-3 Null Mice Show a Loss of Caveolae, Changes in the Microdomain Distribution of the Dystrophin-Glycoprotein Complex, and T-tubule Abnormalities

2001 • 450 citations

Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice

2002 • 434 citations

Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species

2000 • 429 citations

Hydroxy-Methylglutaryl–Coenzyme A Reductase Inhibition Promotes Endothelial Nitric Oxide Synthase Activation Through a Decrease in Caveolin Abundance

2001 • 418 citations

Cholesterol Depletion of Caveolae Causes Hyperactivation of Extracellular Signal-related Kinase (ERK)

1998 • 375 citations

Gp60 Activation Mediates Albumin Transcytosis in Endothelial Cells by Tyrosine Kinase-dependent Pathway

1997 • 371 citations

Caveolin‐mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo

1998 • 371 citations

Segregation of Heterotrimeric G Proteins in Cell Surface Microdomains

2001 • 370 citations

Role of GTP Hydrolysis in Fission of Caveolae Directly from Plasma Membranes

1996 • 370 citations

Oxidized Low Density Lipoprotein Displaces Endothelial Nitric-oxide Synthase (eNOS) from Plasmalemmal Caveolae and Impairs eNOS Activation

1999 • 357 citations

Signal transduction of a G protein-coupled receptor in caveolae: colocalization of endothelin and its receptor with caveolin.

1994 • 333 citations

Caveolin versus Calmodulin

1997 • 324 citations

Caveolin-2-Deficient Mice Show Evidence of Severe Pulmonary Dysfunction without Disruption of Caveolae

2002 • 318 citations

Microvascular Hyperpermeability in Caveolin-1 (−/−) Knock-out Mice

2002 • 311 citations

High Density Lipoprotein Prevents Oxidized Low Density Lipoprotein-induced Inhibition of Endothelial Nitric-oxide Synthase Localization and Activation in Caveolae

2000 • 308 citations

In Situ Flow Activates Endothelial Nitric Oxide Synthase in Luminal Caveolae of Endothelium with Rapid Caveolin Dissociation and Calmodulin Association

1998 • 307 citations

Caveolae: anchored, multifunctional platforms in the lipid ocean

2003 • 301 citations

MORPHOMETRIC DATA ON THE ENDOTHELIUM OF BLOOD CAPILLARIES

1974 • 291 citations

Caveolin-3 Knock-out Mice Develop a Progressive Cardiomyopathy and Show Hyperactivation of the p42/44 MAPK Cascade

2002 • 283 citations

Regulation of Vascular Endothelial Growth Factor Receptor-2 Activity by Caveolin-1 and Plasma Membrane Cholesterol

2003 • 275 citations

Organized Endothelial Cell Surface Signal Transduction in Caveolae Distinct from Glycosylphosphatidylinositol-anchored Protein Microdomains

1997 • 274 citations

The Vesiculo–Vacuolar Organelle (VVO): A New Endothelial Cell Permeability Organelle

2001 • 271 citations

Hsp90 and Caveolin Are Key Targets for the Proangiogenic Nitric Oxide–Mediated Effects of Statins

2001 • 266 citations

Caveolae: mining little caves for new cancer targets

2003 • 260 citations

Interaction of Neuronal Nitric-oxide Synthase with Caveolin-3 in Skeletal Muscle

1997 • 257 citations

Bradykinin Sequesters B2 Bradykinin Receptors and the Receptor-coupled Gα Subunits Gαq and Gαiin Caveolae in DDT1 MF-2 Smooth Muscle Cells

1997 • 256 citations

Receptor Number and Caveolar Co-localization Determine Receptor Coupling Efficiency to Adenylyl Cyclase

2001 • 254 citations

Caveolae from luminal plasmalemma of rat lung endothelium: microdomains enriched in caveolin, Ca(2+)-ATPase, and inositol trisphosphate receptor.

1995 • 250 citations

Palmitoylation of Endothelial Nitric Oxide Synthase Is Necessary for Optimal Stimulated Release of Nitric Oxide: Implications for Caveolae Localization

1996 • 243 citations

Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice

2003 • 239 citations

Cellular Stress Induces the Tyrosine Phosphorylation of Caveolin-1 (Tyr14) via Activation of p38 Mitogen-activated Protein Kinase and c-Src kinase

2001 • 236 citations

Caveolar Localization Dictates Physiologic Signaling of β2-Adrenoceptors in Neonatal Cardiac Myocytes

2002 • 236 citations

Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts

2003 • 229 citations

Distinction between signaling mechanisms in lipid rafts vs. caveolae

2001 • 226 citations

Genetic Ablation of Caveolin-1 Confers Protection Against Atherosclerosis

2003 • 217 citations

Recruitment of endothelial caveolae into mechanotransduction pathways by flow conditioning in vitro

2003 • 216 citations

Targeting endothelium and its dynamic caveolae for tissue-specific transcytosisin vivo: A pathway to overcome cell barriers to drug and gene delivery

2002 • 214 citations

Organization of G Proteins and Adenylyl Cyclase at the Plasma Membrane

1997 • 211 citations

Hsp90 Ensures the Transition from the Early Ca2+-dependent to the Late Phosphorylation-dependent Activation of the Endothelial Nitric-oxide Synthase in Vascular Endothelial Growth Factor-exposed Endothelial Cells

2001 • 210 citations

Cholesterol Depletion Inhibits Epidermal Growth Factor Receptor Transactivation by Angiotensin II in Vascular Smooth Muscle Cells

2001 • 209 citations

Caveolin-1/3 Double-Knockout Mice Are Viable, but Lack Both Muscle and Non-Muscle Caveolae, and Develop a Severe Cardiomyopathic Phenotype

2002 • 204 citations

Caveolin-deficient mice: insights into caveolar function human disease

2001 • 202 citations

Vesicle formation and trafficking in endothelial cells and regulation of endothelial barrier function

2002 • 198 citations

Caveolae: Static inpocketings of the plasma membrane, dynamic vesicles or plain artifact?

1988 • 197 citations

Cellular cholesterol efflux

2001 • 193 citations

Caveolin-deficient mice: insights into caveolar function human disease

2001 • 193 citations

Rapid Mechanotransduction in Situ at the Luminal Cell Surface of Vascular Endothelium and Its Caveolae

1998 • 191 citations

Modulation of the Endothelial Nitric-oxide Synthase-Caveolin Interaction in Cardiac Myocytes

1998 • 186 citations

The First 35 Amino Acids and Fatty Acylation Sites Determine the Molecular Targeting of Endothelial Nitric Oxide Synthase into the Golgi Region of Cells: A Green Fluorescent Protein Study

1997 • 184 citations

Plasma Membrane Cholesterol Is a Key Molecule in Shear Stress-dependent Activation of Extracellular Signal-regulated Kinase

1998 • 182 citations

Chronic shear induces caveolae formation and alters ERK and Akt responses in endothelial cells

2003 • 179 citations

Ignition of Calcium Sparks in Arterial and Cardiac Muscle Through Caveolae

2000 • 171 citations

Caveolin-3 deficiency causes muscle degeneration in mice

2000 • 168 citations

Structure and function of endothelial caveolae

2002 • 167 citations

Caveolin-1 Expression Enhances Endothelial Capillary Tubule Formation

2002 • 166 citations

Angiogenesis Activators and Inhibitors Differentially Regulate Caveolin-1 Expression and Caveolae Formation in Vascular Endothelial Cells

1999 • 163 citations

Rosuvastatin Decreases Caveolin-1 and Improves Nitric Oxide–Dependent Heart Rate and Blood Pressure Variability in Apolipoprotein E ^−/− Mice In Vivo

2003 • 163 citations

Modulation of cardiac contraction, relaxation and rate by the endothelial nitric oxide synthase (eNOS): lessons from genetically modified mice

2003 • 160 citations

Transgenic overexpression of caveolin-3 in skeletal muscle fibers induces a Duchenne-like muscular dystrophy phenotype

2000 • 154 citations

VEGF-induced permeability increase is mediated by caveolae.

1999 • 154 citations

Caveolin-1 Null (−/−) Mice Show Dramatic Reductions in Life Span

2003 • 150 citations

Protein Kinase A and G Protein-coupled Receptor Kinase Phosphorylation Mediates β-1 Adrenergic Receptor Endocytosis through Different Pathways

2003 • 150 citations

Activated Protein Kinase C Isoforms Target to Cardiomyocyte Caveolae

1999 • 148 citations

Interaction between Caveolin-1 and the Reductase Domain of Endothelial Nitric-oxide Synthase

1998 • 144 citations

Opposing Effects of Reactive Oxygen Species and Cholesterol on Endothelial Nitric Oxide Synthase and Endothelial Cell Caveolae

1999 • 141 citations

Endothelial vesicles in the blood-brain barrier: are they related to permeability?

2000 • 136 citations

Caveolin-1 Knockout Mice Show an Impaired Angiogenic Response to Exogenous Stimuli

2003 • 131 citations

Biosynthesis and Palmitoylation of Endothelial Nitric Oxide Synthase: Mutagenesis of Palmitoylation Sites, Cysteines-15 and/or -26, Argues against Depalmitoylation-Induced Translocation of the Enzyme

1995 • 127 citations

Mass spectrometric characterization of proteins extracted from Jurkat T cell detergent-resistant membrane domains

2001 • 122 citations

Codistribution of NOS and caveolin throughout peripheral vasculature and skeletal muscle of hamsters

1999 • 121 citations

Caveolin Interacts with the Angiotensin II Type 1 Receptor during Exocytic Transport but Not at the Plasma Membrane

2003 • 121 citations

Cholesteryl Ester Is Transported from Caveolae to Internal Membranes as Part of a Caveolin-Annexin II Lipid-Protein Complex

2002 • 117 citations

The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation

2003 • 106 citations

Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling

2000 • 100 citations

Bradykinin activates the Janus-activated kinase/signal transducers and activators of transcription (JAK/STAT) pathway in vascular endothelial cells: localization of JAK/STAT signalling proteins in plasmalemmal caveolae

2000 • 99 citations

Caveolin-1 Can Regulate Vascular Smooth Muscle Cell Fate by Switching Platelet-Derived Growth Factor Signaling From a Proliferative to an Apoptotic Pathway

2003 • 95 citations

Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase.

1994 • 94 citations

The convergence of haemodynamics, genomics, and endothelial structure in studies of the focal origin of atherosclerosis

2002 • 94 citations

Caveolin-1 regulates contractility in differentiated vascular smooth muscle

2004 • 87 citations

Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species

2000 • 84 citations

Influence of Caveolin, Cholesterol, and Lipoproteins on Nitric Oxide Synthase Implications for Vascular Disease

2001 • 80 citations

Heterologous Desensitization Mediated by G Protein-specific Binding to Caveolin

2000 • 79 citations

Src-induced Phosphorylation of Caveolin-2 on Tyrosine 19

2002 • 74 citations

Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling

2003 • 72 citations

Developmental Changes in β₂-Adrenergic Receptor Signaling in Ventricular Myocytes: the Role of Gi proteins and Caveolae Microdomains

2003 • 72 citations

Activation of Protein Phosphorylation by Oxidants in Vascular Endothelial Cells: Identification of Tyrosine Phosphorylation of Caveolin

1997 • 71 citations

Transgenic overexpression of caveolin-3 in the heart induces a cardiomyopathic phenotype

2003 • 64 citations

Bradykinin activates the Janus-activated kinase/signal transducers and activators of transcription (JAK/STAT) pathway in vascular endothelial cells: localization of JAK/STAT signalling proteins in plasmalemmal caveolae

2000 • 63 citations

Segmental Differentiation of Permeability, Protein Glycosylation, and Morphology of Cultured Bovine Lung Vascular Endothelium

1994 • 59 citations

Class B Scavenger Receptors, Caveolae and Cholesterol Homeostasis

1999 • 54 citations

Expression of caveolae on the surface of rat arterial smooth muscle cells is dependent on the phenotypic state of the cells.

1997 • 52 citations

Inhibition of GTP-dependent vesicle trafficking impairs internalization of plasmalemmal eNOS and cellular nitric oxide production

2003 • 44 citations

Caveolae and Cholesterol Distribution in Vascular Smooth Muscle Cells of Different Phenotypes

2002 • 39 citations

Internalization of caveolin-1 scaffolding domain facilitated by Antennapedia homeodomain attenuates PAF-induced increase in microvessel permeability

2004 • 38 citations

Caveolin-1 and Caveolae Act as Regulators of Mitogenic Signaling in Vascular Smooth Muscle Cells

2003 • 22 citations

Deleted Work

1955 • 0 citations