The role of lipids and protein kinase Cs in the pathogenesis of diabetic retinopathy

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

Biochemistry and molecular cell biology of diabetic complications

2001 • 8,707 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders

1994 • 3,652 citations

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.

1999 • 2,452 citations

Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis

1999 • 1,494 citations

Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins

1994 • 1,311 citations

Insulin resistance and cardiovascular disease

2000 • 1,280 citations

Glucose autoxidation and protein modification. The potential role of ‘autoxidative glycosylation’ in diabetes

1987 • 1,278 citations

Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions

2001 • 966 citations

IRS proteins and the common path to diabetes

2002 • 907 citations

Lipotoxicity: when tissues overeat

2003 • 878 citations

Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy

2003 • 765 citations

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

1992 • 743 citations

Measurement of Plasma Glucose, Free Fatty Acid, Lactate, and Insulin for 24 h in Patients With NIDDM

1988 • 713 citations

Protein kinase C signaling and oxidative stress

2000 • 691 citations

Vascular Endothelial Growth Factor–Induced Retinal Permeability Is Mediated by Protein Kinase C In Vivo and Suppressed by an Orally Effective β-Isoform–Selective Inhibitor

1997 • 665 citations

Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family

2001 • 662 citations

Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein HuR

1998 • 662 citations

Protein Kinase C as a Molecular Machine for Decoding Calcium and Diacylglycerol Signals

1998 • 646 citations

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca ²⁺ -Dependent Protein Kinase

1984 • 618 citations

Activation of protein kinase C by tyrosine phosphorylation in response to H ₂ O ₂

1997 • 610 citations

Relationship between lactate dehydrogenase and myeloperoxidase levels in human gingival crevicular fluid and clinical and microbial measurements

1988 • 568 citations

Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.

1996 • 567 citations

Early breakdown of the blood-retinal barrier in diabetes.

1975 • 556 citations

The missing link: A single unifying mechanism for diabetic complications

2000 • 517 citations

Diabetic Retinopathy

1998 • 484 citations

Effects of Diabetes and Level of Glycemia on All-Cause and Cardiovascular Mortality: The San Antonio Heart Study

1998 • 484 citations

Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy.

1991 • 483 citations

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover.

2001 • 465 citations

Progression of Incipient Diabetic Retinopathy During Good Glycemic Control

1987 • 453 citations

Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia

1994 • 444 citations

Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy.

1997 • 424 citations

Protein Kinase C–Dependent Increase in Reactive Oxygen Species (ROS) Production in Vascular Tissues of Diabetes

2003 • 419 citations

Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid.

1995 • 411 citations

Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.

1989 • 409 citations

Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters

2002 • 355 citations

Adaptor proteins in protein kinase C-mediated signal transduction

2001 • 352 citations

Activation of Protein Kinase C Triggers Its Ubiquitination and Degradation

1998 • 333 citations

Retinal Vascular Patterns

1963 • 329 citations

The pathogenesis of diabetic retinopathy: old concepts and new questions

2002 • 329 citations

Retinal blood flow in diabetic retinopathy.

1992 • 326 citations

Pathogenesis of Diabetic Retinopathy

1989 • 325 citations

Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats.

1997 • 324 citations

Role of Blood Flow and Impaired Autoregulation in the Pathogenesis of Diabetic Retinopathy

1995 • 311 citations

Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation

1993 • 306 citations

Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?

1998 • 289 citations

Mammalian Diacylglycerol Kinases, a Family of Lipid Kinases with Signaling Functions

1999 • 284 citations

Glucose-Induced Protein Kinase C Activation Regulates Vascular Permeability Factor mRNA Expression and Peptide Production by Human Vascular Smooth Muscle Cells In Vitro

1997 • 276 citations

The relation between expression of vascular endothelial growth factor and breakdown of the blood-retinal barrier in diabetic rat retinas.

1996 • 274 citations

Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.

2000 • 268 citations

Phosphorylation sites of protein kinase C δ in H ₂ O ₂ -treated cells and its activation by tyrosine kinase in vitro

2001 • 251 citations

High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures

1991 • 251 citations

Properties and functions of diacylglycerol kinases

2000 • 245 citations

Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: regulation of glutathione synthesis and efflux

1995 • 241 citations

The retinal blood flow in diabetes

1975 • 230 citations

Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C

1995 • 228 citations

Ocular blood flow and associated functional deviations in diabetic retinopathy

1999 • 224 citations

Increase in Diacylglycerol Mass in Isolated Glomeruli by Glucose From De Novo Synthesis of Glycerolipids

1990 • 219 citations

Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol.

1997 • 218 citations

Regulation of Human Vascular Endothelial Growth Factor mRNA Stability in Hypoxia by Heterogeneous Nuclear Ribonucleoprotein L

1999 • 209 citations

High Glucose Concentrations Increase Endothelial Cell Permeability via Activation of Protein Kinase Cα

1997 • 206 citations

Molecular Cloning of a Novel Human Diacylglycerol Kinase Highly Selective for Arachidonate-containing Substrates

1996 • 205 citations

Early cellular and molecular changes induced by diabetes in the retina

2001 • 204 citations

Diacylglycerol and Phosphatidate Generated by Phospholipases C and D, Respectively, Have Distinct Fatty Acid Compositions and Functions

1997 • 200 citations

AGEs induce oxidative stress and activate protein kinase C-β_IIin neonatal mesangial cells

2000 • 199 citations

The wisconsin epidemiological study of diabetic retinopathy: A review

1989 • 193 citations

Vascular biology of endothelin.

1998 • 188 citations

Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues

1994 • 186 citations

Differential Localization of Protein Kinase C δ by Phorbol Esters and Related Compounds Using a Fusion Protein with Green Fluorescent Protein

1999 • 184 citations

Sublethal Levels of Oxidant Stress Stimulate Multiple Serine/Threonine Kinases and Suppress Protein Phosphatases in Jurkat T Cells

1995 • 181 citations

Activation of the PKC‐isotypes α, β₁, γ, δ, and ε by phorbol esters of different biological activities

1991 • 178 citations

Retinal haemodynamics in patients with early diabetes mellitus.

1996 • 175 citations

Characterization of protein kinase C β isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization

2002 • 167 citations

Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states

2002 • 167 citations

Eyes wide shut: Protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters

2000 • 165 citations

Protein kinase C phosphorylates caldesmon₇₇ and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers

1992 • 163 citations

Molecular Species Analysis of 1,2-Diglycerides Stimulated by α-Thrombin in Cultured Fibroblasts

1989 • 161 citations

Serum concentrations of advanced glycation endproducts are associated with the development of atherosclerosis as well as diabetic microangiopathy in patients with type 2 diabetes

2000 • 158 citations

Characterization of Retinal Leukostasis and Hemodynamics in Insulin Resistance and Diabetes

2003 • 154 citations

Correlation of Fluorescein Angiogram and Retinal Digest in Diabetic Retinopathy

1970 • 152 citations

Total retinal volumetric blood flow rate in diabetic patients with poor glycemic control.

1992 • 148 citations

Regulation of retinal hemodynamics in diabetic rats by increased expression and action of endothelin-1.

1996 • 140 citations

Control of astrocyte Ca2+ oscillations and waves by oscillating translocation and activation of protein kinase C

2001 • 137 citations

Diabetic Retinopathy*

1950 • 137 citations

Ocular vascular endothelial growth factor levels in diabetic rats are elevated before observable retinal proliferative changes

1997 • 136 citations

The Turn Motif Is a Phosphorylation Switch That Regulates the Binding of Hsp70 to Protein Kinase C

2002 • 136 citations

Stabilization of Vascular Endothelial Growth Factor mRNA by Hypoxia-Inducible Factor 1

2002 • 135 citations

Increased expression of placenta growth factor in proliferative diabetic retinopathy.

1998 • 132 citations

High Glucose Induced VEGF Expression via PKC and ERK in Glomerular Podocytes

2002 • 125 citations

Nuclear Lipid Signaling

2002 • 125 citations

Increased serum levels of advanced glycation end-products and diabetic complications

1998 • 125 citations

Subunit-Specific Association of Protein Kinase C and the Receptor for Activated C Kinase with GABA Type A Receptors

1999 • 125 citations

Diabetes-induced vascular dysfunction in the retina: role of endothelins

1999 • 123 citations

Protein Kinase C and Lipid‐Induced Insulin Resistance in Skeletal Muscle

2002 • 121 citations

Expression of the inducible isoform of nitric oxide synthase in the retinas of human subjects with diabetes mellitus

2001 • 120 citations

Diacylglycerol Kinases: Emerging Downstream Regulators in Cell Signaling Systems

2002 • 119 citations

Long-Chain Acyl CoA Regulation of Protein Kinase C and Fatty Acid Potentiation of Glucose-Stimulated Insulin Secretion in Clonalβ -Cells¹

2000 • 118 citations

Selectivity of the diacylglycerol kinase inhibitor 3-{2-(4-[bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone (R59949) among diacylglycerol kinase subtypes

2000 • 118 citations

Breakdown of the Inner and Outer Blood Retinal Barrier in Streptozotocin-Induced Diabetes

1998 • 117 citations

Modulation of Cellular Signals by Calpain

1992 • 117 citations

Role of nitric oxide in modulating permeability of hamster cheek pouch in response to adenosine 5?-diphosphate and bradykinin

1992 • 116 citations

Regulation of platelet protein kinase C by oleic acid. Kinetic analysis of allosteric regulation and effects on autophosphorylation, phorbol ester binding, and susceptibility to inhibition.

1990 • 116 citations

Suppression by prostaglandin E1 of vascular permeability induced by vasoactive inflammatory mediators.

1980 • 114 citations

Interaction of PKC and NOS in signal transduction of microvascular hyperpermeability

1997 • 112 citations

Molecular species analysis of mitogen-stimulated 1,2-diglycerides in fibroblasts. Comparison of alpha-thrombin, epidermal growth factor, and platelet-derived growth factor.

1990 • 110 citations

Bryostatin 1 and phorbol ester down-modulate protein kinase C-alpha and -epsilon via the ubiquitin/proteasome pathway in human fibroblasts.

1997 • 108 citations

Implication of acyl chain of diacylglycerols in activation of different isoforms of protein kinase C

2001 • 108 citations

Role of Protein Kinase C on the Expression of Platelet-Derived Growth Factor and Endothelin-1 in the Retina of Diabetic Rats and Cultured Retinal Capillary Pericytes

2003 • 107 citations

Diabetes-induced elevations in retinal oxidative stress, protein kinase C and nitric oxide are interrelated

2001 • 104 citations

Quantitative analysis of molecular species of diacylglycerol and phosphatidate formed upon muscarinic receptor activation of human SK-N-SH neuroblastoma cells.

1991 • 102 citations

Neural Dysfunction and Metabolic Imbalances in Diabetic Rats: Prevention by Acetyl-<scp>L</scp>-Carnitine

1994 • 101 citations

Protein Kinase C Activation Contributes to Microvascular Barrier Dysfunction in the Heart at Early Stages of Diabetes

2000 • 101 citations

Delayed catabolism of apoB-48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice

2000 • 98 citations

Designing bisubstrate analog inhibitors for protein kinases

2002 • 95 citations

Hyperglycemia Inhibits Vascular Smooth Muscle Cell Apoptosis Through a Protein Kinase C–Dependent Pathway

2000 • 94 citations

Interaction of Endothelin-1 with Vasoactive Factors in Mediating Glucose-Induced Increased Permeability in Endothelial Cells

2000 • 94 citations

Diacylglycerol (DAG)-lactones, a New Class of Protein Kinase C (PKC) Agonists, Induce Apoptosis in LNCaP Prostate Cancer Cells by Selective Activation of PKCα

2002 • 94 citations

Protein kinase C β1 overexpression augments phorbol ester-induced increase in endothelial permeability

1996 • 93 citations

Dynamics of Glucose-induced Membrane Recruitment of Protein Kinase C βII in Living Pancreatic Islet β-Cells

2002 • 92 citations

PKC-beta inhibitor (LY333531) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats.

2000 • 92 citations

Modification of tight junction function by protein kinase C isoforms

2000 • 89 citations

Clinicopathologic Correlations in Diabetic Retinopathy

1977 • 88 citations

Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats.

1997 • 88 citations

Nitric Oxide Synthase Activity in Retinas from Non-Insulin-Dependent Diabetic Goto-Kakizaki Rats: Correlation with Blood–Retinal Barrier Permeability

2000 • 87 citations

Parallel Single-Cell Monitoring of Receptor-Triggered Membrane Translocation of a Calcium-Sensing Protein Module

2002 • 86 citations

Multiple disturbances of free fatty acid metabolism in noninsulin-dependent diabetes. Effect of oral hypoglycemic therapy.

1985 • 86 citations

Functional role of nitric oxide in regulation of ocular blood flow

1999 • 85 citations

Inhibition of Protein Kinase Cα Prevents Endothelial Cell Migration and Vascular Tube Formation In Vitro and Myocardial Neovascularization In Vivo

2002 • 85 citations

Capillary hydraulic conductivity is elevated by cGMP-dependent vasodilators.

1992 • 84 citations

Elevated plasma endothelin‐1 level in streptozotocin‐induced diabetic rats and responsiveness of the mesenteric arterial bed to endothelin‐1

1998 • 79 citations

Expression of vascular endothelial growth factor in response to high glucose in rat mesangial cells

2000 • 78 citations

Hyperglycemia-induced Intracellular Depletion of Ascorbic Acid in Human Mononuclear Leukocytes

1983 • 76 citations

Oxidation-induced persistent activation of protein kinase C in hippocampal homogenates

1992 • 76 citations

From Functional to Microvascular Abnormalities in Early Diabetic Retinopathy

1997 • 75 citations

Isolated preparations of ocular vasculature and their applications in ophthalmic research

2003 • 74 citations

Oxidant-Induced Activation of Protein Kinase C in Uc11mg Cells

1995 • 74 citations

The Clinical Value of Electroretinography

1969 • 70 citations

Constitutive nitric oxide synthase is associated with retinal vascular permeability in early diabetic rats

2001 • 70 citations

Expression of a catalytically inactive form of diacylglycerol kinase α induces sustained signaling through RasGRP

2002 • 69 citations

Advanced glycation end products increase, through a protein kinase C-dependent pathway, vascular endothelial growth factor expression in retinal endothelial cells

2002 • 68 citations

Selective loss of vascular smooth muscle cells in the retinal microcirculation of diabetic dogs.

1994 • 67 citations

Branched Chain Fatty Acids Induce Nitric Oxide-dependent Apoptosis in Vascular Smooth Muscle Cells

2002 • 67 citations

Retinal protein kinase C

1997 • 64 citations

Activation of protein kinase C-δ and C-ϵ by oxidative stress in early diabetic rat kidney

2001 • 61 citations

Diacylglycerol Kinase ε, but Not ζ, Selectively Removes Polyunsaturated Diacylglycerol, Inducing Altered Protein Kinase C Distribution in Vivo

1999 • 59 citations

Protein kinase C isoforms in muscle cells and their regulation by phorbol ester and calpain

1995 • 58 citations

Retinal expression, regulation, and functional bioactivity of prostacyclin-stimulating factor

2000 • 58 citations

Bombesin stimulates distinct time-dependent changes in the sn-1,2-diradylglycerol molecular species profile from Swiss 3T3 fibroblasts as analysed by 3,5-dinitrobenzoyl derivatization and h.p.l.c. separation

1993 • 58 citations

Molecular species analysis of a product of phospholipase D activation. Phosphatidylethanol is formed from phosphatidylcholine in phorbol ester- and bradykinin-stimulated PC12 cells.

1992 • 56 citations

Histamine H1 Receptors Mediate Increased Blood-Retinal Barrier Permeability in Experimental Diabetes

1989 • 53 citations

Purification and Characterization of Diacylglycerol Lipase from Human Platelets

1999 • 51 citations

Permeability of endothelial monolayers to albumin is increased by bradykinin and inhibited by prostaglandins

2001 • 51 citations

Diacylglycerol generated in CHO cell plasma membrane by phospholipase C is used for triacylglycerol synthesis

2001 • 50 citations

Endothelin expression in ocular tissues of diabetic and insulin-treated rats.

1997 • 49 citations

Increased vasodilatory prostaglandin production in the diabetic rat retinal vasculature

1999 • 49 citations

Retinal hemodynamics in proliferative diabetic retinopathy. A laser Doppler velocimetry study.

1993 • 49 citations

Type I Diabetes is Characterized by Insulin Resistance Not Only with Regard to Glucose, but also to Lipid and Aminoacid Metabolism*

1986 • 48 citations

Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity

2002 • 45 citations

Diabetes-induced activation of protein kinase C inhibits store-operated Ca 2+ uptake in rat retinal microvascular smooth muscle

2003 • 45 citations

Neural conduction in visual pathways in newly-diagnosed IDDM patients

1998 • 42 citations

Heterogeneity in Cytosolic Calcium Regulation among Different Microvascular Smooth Muscle Cells of the Rat Retina

2000 • 41 citations

Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.

1987 • 40 citations

Arachidonic Acid Liberated by Diacylglycerol Lipase Is Essential for the Release Mechanism in Chromaffin Cells from Bovine Adrenal Medulla

1990 • 40 citations

Retina accumulates more glucose than does the embryologically similar cerebral cortex in diabetic rats

2000 • 40 citations

Human munc13 Is a Diacylglycerol Receptor that Induces Apoptosis and May Contribute to Renal Cell Injury in Hyperglycemia

1999 • 40 citations

Diurnal and circadian variation of protein kinase C immunoreactivity in the rat retina

2001 • 40 citations

Lipid second messenger regulation: the role of diacylglycerol kinases and their relevance to hypertension

2001 • 38 citations

Diacylglycerol lipase and kinase activities in rat brain microvessels

1985 • 38 citations

Regulatory role of diacylglycerol kinase γ in macrophage differentiation of leukemia cells

2003 • 35 citations

Production of 12-hydroxyeicosatetraenoic acid and vitamin E status in platelets from type I human diabetic subjects

1985 • 35 citations

H2O2-Induced Tyrosine Phosphorylation of Protein Kinase Cδ by a Mechanism Independent of Inhibition of Protein-Tyrosine Phosphatase in CHO and COS-7 Cells

2000 • 35 citations

Down-Regulation of Endothelin-1 Receptors by Protein Kinase C in Streptozotocin Diabetic Rats

1991 • 34 citations

Effects of Perfusion Rate on Permeability of Frog and Rat Mesenteric Microvessels to Sodium Fluorescein

2002 • 34 citations

Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth

2001 • 32 citations

Reversal of abnormal retinal hemodynamics in diabetic rats by acarbose, an α-glucosidase inhibitor

1995 • 30 citations

Epidermal growth factor stimulates distinct diradylglycerol species generation in Swiss 3T3 fibroblasts: evidence for a potential phosphatidylcholine-specific phospholipase C-catalysed pathway

1994 • 30 citations

Vascular Dysfunction Induced by AGE is Mediated by VEGF via Mechanisms Involving Reactive Oxygen Species, Guanylate Cyclase, and Protein Kinase C

2001 • 30 citations

Receptor-Stimulated Phospholipase A₂Liberates Arachidonic Acid and Regulates Neuronal Excitability Through Protein Kinase C

2001 • 30 citations

Association of the calpain-10 gene with microvascular function

2002 • 29 citations

Effect of cis-unsaturated fatty acids on the activity of protein kinases and protein phosphorylation in macrophage tumor (AK-5) cells in vitro

1999 • 29 citations

Diacylglycerol lipase activity in human platelet intracellular and surface membranes

1985 • 28 citations

Prostaglandin E1 prevents increased lung microvascular permeability during intravascular complement activation in sheep.

1987 • 27 citations

Stimulation of mono- and diacylglycerol lipase activities by bradykinin in neural cultures

1990 • 25 citations

Fatty acids inhibit growth-factor-induced diacylglycerol kinase α activation in vascular smooth-muscle cells

2001 • 23 citations

Generation of the catalytic fragment of protein kinase C alpha in spastic canine basilar artery

1997 • 21 citations

Fatty acids modulate protein kinase C activation in porcine vascular smooth muscle cells independently of their effect on de novo diacylglycerol synthesis

2000 • 20 citations

Alternations of Diacylglycerol Kinase in Streptozotocin-Induced Diabetic Rats

1998 • 20 citations

Effects of Low-Dose Beraprost Sodium, a Stable Prostaglandin I₂ Analogue, on Reperfusion Injury to Rabbit Lungs

1998 • 20 citations

Diacylglycerol lipase and kinase activities in rabbit aorta and coronary microvessels

1986 • 20 citations

A thiol proteinase inhibitor, E-64-d, corrects the abnormalities in concanavalin A cap formation and the lysosomal enzyme activity in leucocytes from patients with Chediak–Higashi syndrome by reversing the down-regulated protein kinase C activity

2001 • 20 citations

Diacylglycerol lipase and the contractile action of epidermal growth factor-urogastrone: evidence for distinct signal pathways in a single strip of gastric smooth muscle

1991 • 19 citations

Interaction of glucose and long chain fatty acids (C18) on antioxidant defences and free radical damage in porcine vascular smooth muscle cells in vitro

2003 • 19 citations

Metabolism of a long-chain diacylglycerol by permeabilized A10 smooth muscle cells

1993 • 18 citations

Changes of structural and dynamic properties of model lipid membranes induced by α-tocopherol: implication to the membrane stabilization under external electric field

2001 • 18 citations

Sapintoxin A. A fluorescent phorbol ester that is a potent activator of protein kinase C but is not a tumour promoter

1987 • 16 citations

Pseudosubstrate peptide inhibitors of β-cell protein kinases: altered selectivity after myristoylation

1999 • 15 citations

Partial purification of a diacylglycerol lipase from bovine aorta

1994 • 15 citations

Diacylglycerol metabolism in neonatal rat liver: characterization of cytosolic diacylglycerol lipase activity and its activation by monoalkylglycerols

1992 • 13 citations

Diradylglycerol Formation in Cholecystokinin‐Stimulated Rabbit Pancreatic Acini

1996 • 13 citations

Proteasome Implication in Phorbol Ester- and GnRH-Induced Selective Down-Regulation of PKC ( , , ) in T3-1 and L T2 Gonadotrope Cell Lines

2002 • 12 citations

Inhibition of effects of flow on potassium permeability in single perfused frog mesenteric capillaries

1999 • 11 citations

Diacylglycerol metabolism in SM-3 smooth muscle cells

1997 • 10 citations

Effect of diacylglycerol lipase inhibitor RHC 80267 on pancreatic mouse islet metabolism and insulin secretion

1989 • 10 citations

Lysophosphatidylcholine inhibits the expression of prostacyclin stimulating factor in cultured vascular smooth muscle cells

2002 • 8 citations

Phospholipids inhibit proteolysis of protein kinase C? by mM calcium-requiring calpain

1995 • 8 citations

High glucose modulates albumin permeability across glomerular endothelial cells via a protein kinase C-dependent mechanism.

1995 • 6 citations

Stimulation of mono- and diacylglycerol lipase activities by gangliosides in chicken neuronal cultures

1991 • 5 citations

Differential abilities of phorbol esters in inducing protein kinase C (PKC) down-regulation in noradrenergic neurones

2001 • 5 citations