Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors

1998 • 1,475 citations

Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor

1986 • 1,211 citations

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

1996 • 884 citations

Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension

1997 • 831 citations

Generation of superoxide by purified brain nitric oxide synthase.

1992 • 765 citations

Does superoxide underlie the pathogenesis of hypertension?

1991 • 760 citations

Endothelial Regulation of Vasomotion in ApoE-Deficient Mice

2001 • 719 citations

Oscillatory and Steady Laminar Shear Stress Differentially Affect Human Endothelial Redox State

1998 • 607 citations

Ascorbic Acid Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

1996 • 593 citations

Vascular Superoxide Production by NAD(P)H Oxidase

2000 • 565 citations

p22phox mRNA Expression and NADPH Oxidase Activity Are Increased in Aortas From Hypertensive Rats

1997 • 555 citations

Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase

1992 • 534 citations

Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta.

1990 • 527 citations

Expression of Multiple Isoforms of Nitric Oxide Synthase in Normal and Atherosclerotic Vessels

1997 • 468 citations

Tetrahydrobiopterin Improves Endothelium-Dependent Vasodilation in Chronic Smokers

2000 • 448 citations

Superoxide Anion Production Is Increased in a Model of Genetic Hypertension

1999 • 413 citations

Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits.

1991 • 403 citations

The loss of endothelium-dependent vascular relaxation in hypertension.

1986 • 372 citations

Vascular NADH/NADPH Oxidase Is Involved in Enhanced Superoxide Production in Spontaneously Hypertensive Rats

2000 • 371 citations

Endothelial Dysfunction in Chronic Myocardial Infarction Despite Increased Vascular Endothelial Nitric Oxide Synthase and Soluble Guanylate Cyclase Expression

1999 • 361 citations

Attenuation of endothelium-dependent relaxation in aorta from diabetic rats

1986 • 350 citations

In Vivo Evidence for Microvascular Oxidative Stress in Spontaneously Hypertensive Rats

1995 • 341 citations

Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide.

1991 • 331 citations

Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta.

1999 • 327 citations

Tumour necrosis factor α activates a p22phox-based NADH oxidase in vascular smooth muscle

1998 • 313 citations

Endothelial Function and Oxidant Stress

1997 • 309 citations

Vitamin C Improves Endothelial Dysfunction of Epicardial Coronary Arteries in Hypertensive Patients

1997 • 288 citations

Platelet-Derived Growth Factor–Stimulated Superoxide Anion Production Modulates Activation of Transcription Factor NF-κB and Expression of Monocyte Chemoattractant Protein 1 in Human Aortic Smooth Muscle Cells

1997 • 257 citations

Impairment of endothelium‐dependent relaxation in aortae from spontaneously diabetic rats

1988 • 255 citations

Nitric Oxide Inhibition of Lipid Peroxidation: Kinetics of Reaction with Lipid Peroxyl Radicals and Comparison with α-Tocopherol

1997 • 252 citations

Xanthine Oxidase Inhibition With Oxypurinol Improves Endothelial Vasodilator Function in Hypercholesterolemic but Not in Hypertensive Patients

1997 • 247 citations

Effects of Long-Term Nitroglycerin Treatment on Endothelial Nitric Oxide Synthase (NOS III) Gene Expression, NOS III–Mediated Superoxide Production, and Vascular NO Bioavailability

2000 • 237 citations

Vascular endothelium: An integrator of pathophysiologic stimuli in atherosclerosis

1995 • 230 citations

Redox-regulated Signaling by Lactosylceramide in the Proliferation of Human Aortic Smooth Muscle Cells

1997 • 202 citations

Loss of endothelial pertussis toxin-sensitive G protein function in atherosclerotic porcine coronary arteries.

1991 • 195 citations

Decreased Endothelium-dependent Relaxation in New Zealand Genetic Hypertensive Rats

1984 • 189 citations

Kinetics of Cytochrome C2+ Oxidation by Peroxynitrite: Implications for Superoxide Measurements in Nitric Oxide-Producing Biological-Systems

1995 • 188 citations

Diabetic-induced endothelial dysfunction in rat aorta: role of hydroxyl radicals

1997 • 180 citations

NADH Oxidase Activity of Human Xanthine Oxidoreductase

1997 • 172 citations

Regulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells.

1992 • 142 citations

4-Hydroxynonenal induces dysfunction and apoptosis of cultured endothelial cells

1999 • 110 citations

Thrombin Stimulated Reactive Oxygen Species Production in Cultured Human Endothelial Cells

1998 • 98 citations

Stimulation of the Brain NO/Cyclic GMP Pathway by Peripheral Administration of Tetrahydrobiopterin in the hph‐1 Mouse

1999 • 21 citations

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