Structural Basis of Integrin Regulation and Signaling

Cell Migration: Integrating Signals from Front to Back

2003 • 4,755 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand

2002 • 1,571 citations

Integrin signalling during tumour progression

2004 • 1,430 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3

2001 • 1,256 citations

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

2003 • 1,168 citations

LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins

1987 • 1,147 citations

Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling

2002 • 1,134 citations

Structural Basis of Collagen Recognition by Integrin α2β1

2000 • 945 citations

ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18).

1990 • 898 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

2004 • 802 citations

Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins

2003 • 784 citations

The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation

1999 • 697 citations

Integrin cytoplasmic domains mediate inside-out signal transduction

1994 • 682 citations

Breaking the Integrin Hinge

1996 • 567 citations

Integrins: dynamic scaffolds for adhesion and signaling in platelets

2004 • 567 citations

Ca2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils

1995 • 555 citations

Intracellular signalling controlling integrin activation in lymphocytes

2005 • 547 citations

The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.

1993 • 546 citations

INTEGRIN STRUCTURE, ALLOSTERY, AND BIDIRECTIONAL SIGNALING

2005 • 528 citations

Mechanotransduction at Cell-Matrix and Cell-Cell Contacts

2004 • 520 citations

Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation

2003 • 518 citations

Chemokines Trigger Immediate β2 Integrin Affinity and Mobility Changes

2000 • 517 citations

A Structural Mechanism of Integrin αIIbβ3 “Inside-Out” Activation as Regulated by Its Cytoplasmic Face

2002 • 511 citations

Structural Determinants of Integrin Recognition by Talin

2003 • 505 citations

Integrin avidity regulation: are changes in affinity and conformation underemphasized?

2003 • 491 citations

RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

2003 • 462 citations

Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain

1997 • 414 citations

The Molecular Basis of Filamin Binding to Integrins and Competition with Talin

2006 • 412 citations

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

1995 • 400 citations

Integrin activation and structural rearrangement

2002 • 386 citations

Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow

2003 • 362 citations

Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.

1996 • 343 citations

Avidity regulation of integrins: the driving force in leukocyte adhesion

2000 • 342 citations

Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties

2001 • 338 citations

Structure of integrin 5 1 in complex with fibronectin

2003 • 332 citations

Modulation of the Affinity of Integrin α _IIb β ₃ (GPIIb-IIIa) by the Cytoplasmic Domain of α _IIb

1991 • 322 citations

Activation of Integrin αIIbß3 by Modulation of Transmembrane Helix Associations

2003 • 285 citations

Integrin structures and conformational signaling

2006 • 278 citations

Electron microscopy and structural model of human fibronectin receptor.

1988 • 265 citations

Are changes in integrin affinity and conformation overemphasized?

1998 • 257 citations

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain 1 1Edited by F. E. Cohen

1999 • 255 citations

C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1.

2001 • 255 citations

Activation of Leukocyte β2 Integrins by Conversion from Bent to Extended Conformations

2006 • 246 citations

Platelet/polymorphonuclear leukocyte interaction in dynamic conditions: evidence of adhesion cascade and cross talk between P-selectin and the beta 2 integrin CD11b/CD18

1996 • 244 citations

Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migration

2001 • 237 citations

Integrins and T Cell–Mediated Immunity

2004 • 232 citations

The primacy of affinity over clustering in regulation of adhesiveness of the integrin αLβ2

2004 • 227 citations

Antibody against the Leu-CAM beta-chain (CD18) promotes both LFA-1- and CR3-dependent adhesion events.

1992 • 223 citations

Ligand binding regulates the directed movement of β1 integrins on fibroblasts

1996 • 223 citations

Leukocyte Adhesion

1997 • 219 citations

Adhesive receptor Mac-1 coordinates the activation of factor X on stimulated cells of monocytic and myeloid differentiation: an alternative initiation of the coagulation protease cascade.

1988 • 215 citations

Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activityin vivo

2001 • 214 citations

Intercellular adhesion molecule-1 dimerization and its consequences for adhesion mediated by lymphocyte function associated-1.

1995 • 210 citations

A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes

2005 • 199 citations

Rolling Adhesion through an Extended Conformation of Integrin αLβ2 and Relation to α I and β I-like Domain Interaction

2004 • 196 citations

Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells.

1993 • 195 citations

A Specific Interface between Integrin Transmembrane Helices and Affinity for Ligand

2004 • 193 citations

Locking in alternate conformations of the integrin αLβ2 I domain with disulfide bonds reveals functional relationships among integrin domains

2001 • 184 citations

Three-dimensional EM structure of the ectodomain of integrin αVβ3 in a complex with fibronectin

2005 • 183 citations

The native structure of intercellular adhesion molecule-1 (ICAM-1) is a dimer. Correlation with binding to LFA-1.

1995 • 177 citations

Topography of Ligand-induced Binding Sites, Including a Novel Cation-sensitive Epitope (AP5) at the Amino Terminus, of the Human Integrin β3 Subunit

1995 • 169 citations

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

2000 • 165 citations

Association of the Membrane Proximal Regions of the α and β Subunit Cytoplasmic Domains Constrains an Integrin in the Inactive State

2001 • 163 citations

Chemoattractants Induce a Rapid and Transient Upregulation of Monocyte α4 Integrin Affinity for Vascular Cell Adhesion Molecule 1 Which Mediates Arrest

2001 • 162 citations

Epitope Mapping of Antibodies to the C-Terminal Region of the Integrin β2 Subunit Reveals Regions that Become Exposed Upon Receptor Activation

2001 • 161 citations

Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster

2003 • 154 citations

The alpha subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1.

1997 • 150 citations

Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering

2005 • 149 citations

Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand

2003 • 146 citations

Transmembrane Domain Helix Packing Stabilizes Integrin αIIbβ3 in the Low Affinity State

2005 • 146 citations

Membrane-mediated structural transitions at the cytoplasmic face during integrin activation

2004 • 137 citations

Cytoskeletal Regulation Couples LFA-1 Conformational Changes to Receptor Lateral Mobility and Clustering

2006 • 136 citations

Importance of Force Linkage in Mechanochemistry of Adhesion Receptors

2006 • 136 citations

Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface

1997 • 132 citations

Computational design of an integrin I domain stabilized in the open high affinity conformation.

2000 • 131 citations

Small Molecule Integrin Antagonists that Bind to the β2 Subunit I-like Domain and Activate Signals in One Direction and Block Them in the Other

2003 • 131 citations

An isolated, surface-expressed I domain of the integrin αLβ2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond

2001 • 129 citations

Binding Site Elucidation of Hydantoin-Based Antagonists of LFA-1 Using Multidisciplinary Technologies: Evidence for the Allosteric Inhibition of a Protein−Protein Interaction

2001 • 128 citations

KIM185, a monoclonal antibody to CD18 which induces a change in the conformation of CD18 and promotes both LFA‐1‐ and CR3‐dependent adhesion

1993 • 127 citations

Conformational Changes in the Integrin औA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

2003 • 120 citations

A push-pull mechanism for regulating integrin function

2005 • 120 citations

The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.

1994 • 118 citations

NMR Analysis of Structure and Dynamics of the Cytosolic Tails of Integrin αIIbβ3 in Aqueous Solution

2001 • 117 citations

Structural Basis for Dimerization of ICAM-1 on the Cell Surface

2004 • 104 citations

Conversion between Three Conformational States of Integrin I Domains with a C-Terminal Pull Spring Studied with Molecular Dynamics

2004 • 104 citations

The Critical Cytoplasmic Regions of the αL/β2 Integrin in Rap1-induced Adhesion and Migration

2003 • 104 citations

A Novel Adaptation of the Integrin PSI Domain Revealed from Its Crystal Structure

2004 • 103 citations

Structure of an Integrin-Ligand Complex Deduced from Solution X-ray Scattering and Site-directed Mutagenesis

2003 • 102 citations

Transition From Rolling to Firm Adhesion Is Regulated by the Conformation of the I Domain of the Integrin Lymphocyte Function-associated Antigen-1

2002 • 101 citations

Solution structures of the cytoplasmic tail complex from platelet integrin αIIb- and β3-subunits

2002 • 99 citations

The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1.

1999 • 97 citations

Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring

2004 • 96 citations

Structural and Functional Studies with Antibodies to the Integrin β2 Subunit

2000 • 96 citations

Divalent Cations and Ligands Induce Conformational Changes That Are Highly Divergent among β1 Integrins

1998 • 95 citations

Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin α_Xβ₂

2005 • 94 citations

Role of ADMIDAS Cation-binding Site in Ligand Recognition by Integrin α5β1

2003 • 93 citations

Activation of lymphocyte function-associated molecule-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) mimicked by an antibody directed against CD18.

1995 • 83 citations

Small Molecule Inhibitors Induce Conformational Changes in the I Domain and the I-like Domain of Lymphocyte Function-associated Antigen-1

2002 • 81 citations

The Leukocyte Integrin αDβ2 Binds VCAM-1: Evidence for a Binding Interface Between I Domain and VCAM-1

1999 • 79 citations

Detection of Integrin αIIbβ3Clustering in Living Cells

2003 • 79 citations

Domain-Specific Interactions of Talin with the Membrane-Proximal Region of the Integrin β3 Subunit

2003 • 79 citations

An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin α_Lβ₂

2005 • 77 citations

Integrin-linked kinase: integrin’s mysterious partner

2004 • 77 citations

Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity

2006 • 76 citations

Allosteric β1 Integrin Antibodies That Stabilize the Low Affinity State by Preventing the Swing-out of the Hybrid Domain

2004 • 73 citations

The Lymphocyte Function–associated Antigen 1 I Domain Is a Transient Binding Module for Intercellular Adhesion Molecule (ICAM)-1 and ICAM-3 in Hydrodynamic Flow

1997 • 71 citations

Activation of integrin β-subunit I-like domains by one-turn C-terminal α-helix deletions

2004 • 65 citations

Stabilizing the integrin αM inserted domain in alternative conformations with a range of engineered disulfide bonds

2002 • 64 citations

Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin β subunits

2001 • 63 citations

The integrin α-subunit leg extends at a Ca²⁺-dependent epitope in the thigh/genu interface upon activation

2004 • 62 citations

Rational Design of Intercellular Adhesion Molecule-1 (ICAM-1) Variants for Antagonizing Integrin Lymphocyte Function-associated Antigen-1-dependent Adhesion

2005 • 58 citations

Regulation of outside-in signaling and affinity by the β₂I domain of integrin α_Lβ₂

2006 • 53 citations

Evidence That Monoclonal Antibodies Directed against the Integrin β Subunit Plexin/Semaphorin/Integrin Domain Stimulate Function by Inducing Receptor Extension

2004 • 53 citations

Electron tomography reveals diverse conformations of integrin αIIbβ3 in the active state

2005 • 52 citations

Molecular Basis for Interaction between Icap1α PTB Domain and β1 Integrin

2002 • 50 citations

AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes

2006 • 50 citations

Detecting rapid and transient upregulation of leukocyte integrin affinity induced by chemokines and chemoattractants

2003 • 49 citations

Epitope Mapping of Monoclonal Antibody to Integrin αL β2 Hybrid Domain Suggests Different Requirements of Affinity States for Intercellular Adhesion Molecules (ICAM)-1 and ICAM-3 Binding

2005 • 48 citations

The Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin β2 Subunit at 1.8-Å Resolution

2005 • 44 citations

3D single-particle tracking and optical trap measurements on adhesion proteins

1999 • 36 citations

The Integrin αLβ2 Hybrid Domain Serves as a Link for the Propagation of Activation Signal from Its Stalk Regions to the I-like Domain

2004 • 26 citations

A site involving the “hybrid” and PSI homology domains of GPIIIa (β3-integrin subunit) is a common target for antibodies associated with quinine-induced immune thrombocytopenia

2003 • 25 citations

Dynamitin Controls β2 Integrin Avidity by Modulating Cytoskeletal Constraint on Integrin Molecules

2002 • 20 citations

Mac-1-dependent tyrosine phosphorylation during neutrophil adhesion

2001 • 18 citations

Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1

2006 • 16 citations