Advances in pathogenesis and management of sepsis

Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock

2001 • 9,683 citations

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

2001 • 5,900 citations

Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*

2006 • 5,467 citations

An Intervention to Decrease Catheter-Related Bloodstream Infections in the ICU

2006 • 4,116 citations

Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock

2004 • 3,189 citations

Effect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock

2002 • 3,043 citations

Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock

2004 • 2,919 citations

A Comparison of Albumin and Saline for Fluid Resuscitation in the Intensive Care Unit

2004 • 2,683 citations

Sepsis in European intensive care units: Results of the SOAP study*

2006 • 2,578 citations

Variable Selection for Propensity Score Models

2006 • 1,995 citations

A Predominantly Clonal Multi-Institutional Outbreak ofClostridium difficile–Associated Diarrhea with High Morbidity and Mortality

2005 • 1,938 citations

Surviving Sepsis Campaign Management Guidelines Committee. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock

2004 • 1,857 citations

Methicillin-ResistantStaphylococcus aureusDisease in Three Communities

2005 • 1,521 citations

Negative regulation of Toll-like receptor-mediated immune responses

2005 • 1,487 citations

The Risk of Bloodstream Infection in Adults With Different Intravascular Devices: A Systematic Review of 200 Published Prospective Studies

2006 • 1,462 citations

Association between mitochondrial dysfunction and severity and outcome of septic shock

2002 • 1,401 citations

Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction

1999 • 1,307 citations

Severe Herpesvirus Infections in an Adolescent without Natural Killer Cells

1989 • 1,251 citations

Lactate metabolism: a new paradigm for the third millennium

2004 • 1,166 citations

Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial

2004 • 1,073 citations

Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial

2005 • 1,043 citations

Necrotizing Fasciitis Caused by Community-Associated Methicillin-ResistantStaphylococcus aureusin Los Angeles

2005 • 1,037 citations

Emergence of Fluoroquinolones as the Predominant Risk Factor for Clostridium difficile-Associated Diarrhea: A Cohort Study during an Epidemic in Quebec

2005 • 997 citations

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

2006 • 971 citations

Use of Gastric Acid–Suppressive Agents and the Risk of Community-Acquired <EMPH TYPE="ITAL">Clostridium difficile</EMPH>–Associated Disease

2005 • 966 citations

Seroprevalence of Cytomegalovirus Infection in the United States, 1988-1994

2006 • 963 citations

Sirolimus for Kaposi's Sarcoma in Renal-Transplant Recipients

2005 • 951 citations

Pulmonary-Artery versus Central Venous Catheter to Guide Treatment of Acute Lung Injury

2006 • 948 citations

Cytomegalovirus Infection Is Associated With Cardiac Allograft Rejection and Atherosclerosis

1989 • 934 citations

Drotrecogin Alfa (Activated) for Adults with Severe Sepsis and a Low Risk of Death

2005 • 891 citations

Efficacy and Safety of Valganciclovir vs. Oral Ganciclovir for Prevention of Cytomegalovirus Disease in Solid Organ Transplant Recipients

2004 • 854 citations

Meta-Analysis of Probiotics for the Prevention of Antibiotic Associated Diarrhea and the Treatment of Clostridium difficile Disease

2006 • 848 citations

Emergence of Clostridium difficile-associated disease in North America and Europe

2006 • 828 citations

Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis

2007 • 814 citations

Evidence-based model for hand transmission during patient care and the role of improved practices

2006 • 763 citations

Apoptosis and caspases regulate death and inflammation in sepsis

2006 • 753 citations

TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity

2006 • 749 citations

Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: A systematic review and meta-analysis

2006 • 724 citations

Valacyclovir for the Prevention of Cytomegalovirus Disease after Renal Transplantation

1999 • 699 citations

Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: pattern of recovery and correlation with cytomegalovirus infection and disease

1991 • 686 citations

Multicenter Clinical Evaluation of the (1->3) -D-Glucan Assay as an Aid to Diagnosis of Fungal Infections in Humans

2005 • 651 citations

Novel Mechanism for Endothelial Dysfunction

1999 • 649 citations

Neutrophils in development of multiple organ failure in sepsis

2006 • 632 citations

Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis

2006 • 624 citations

A Large Outbreak ofClostridium difficile–Associated Disease with an Unexpected Proportion of Deaths and Colectomies at a Teaching Hospital Following Increased Fluoroquinolone Use

2005 • 621 citations

Cytotoxic T Cells in Cytomegalovirus Infection

1982 • 610 citations

Narrative Review: The New Epidemic of Clostridium difficile–Associated Enteric Disease

2006 • 596 citations

Galactomannan and Computed Tomography-Based Preemptive Antifungal Therapy in Neutropenic Patients at High Risk for Invasive Fungal Infection: A Prospective Feasibility Study

2005 • 592 citations

Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: Relationship to hemodynamics, oxygen transport, and survival

2006 • 582 citations

Murine Norovirus: a Model System To Study Norovirus Biology and Pathogenesis

2006 • 576 citations

A Randomized, Placebo-Controlled Trial of Oral Acyclovir for the Prevention of Cytomegalovirus Disease in Recipients of Renal Allografts

1989 • 548 citations

Guidelines for the control and prevention of meticillin-resistant Staphylococcus aureus (MRSA) in healthcare facilities

2006 • 542 citations

Hemodynamic variables related to outcome in septic shock

2005 • 528 citations

Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantation

2000 • 528 citations

Circulating Cytokine/Inhibitor Profiles Reshape the Understanding of the SIRS/CARS Continuum in Sepsis and Predict Mortality

2006 • 497 citations

Randomised trial of efficacy and safety of oral ganciclovir in the prevention of cytomegalovirus disease in liver-transplant recipients

1997 • 494 citations

Invasive fungal infections: a review of epidemiology and management options

2006 • 487 citations

Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial

2007 • 482 citations

Relation between muscle Na+K+ ATPase activity and raised lactate concentrations in septic shock: a prospective study

2005 • 465 citations

Recognition ofStaphylococcus aureusby the Innate Immune System

2005 • 451 citations

Staphyloxanthin Plays a Role in the Fitness of Staphylococcus aureus and Its Ability To Cope with Oxidative Stress

2006 • 450 citations

Antiviral drugs for cytomegalovirus diseases

2006 • 441 citations

The Epidemiology of Sepsis in Patients With Malignancy

2006 • 435 citations

Genetic Changes That Correlate with Reduced Susceptibility to Daptomycin in Staphylococcus aureus

2006 • 430 citations

Continuous central venous and pulmonary artery oxygen saturation monitoring in the critically ill

2004 • 429 citations

Toll-like receptors and innate immunity

2006 • 428 citations

ADMA and oxidative stress

2003 • 420 citations

Latency and reactivation of human cytomegalovirus

2006 • 416 citations

The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy

2006 • 410 citations

Clinical and Economic Impact of Bacteremia with Extended- Spectrum-β-Lactamase-Producing Enterobacteriaceae

2006 • 409 citations

Endocarditis and biofilm-associated pili of Enterococcus faecalis

2006 • 403 citations

Cytomegalovirus Disease in Renal Allograft Recipients

1980 • 398 citations

Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils

2005 • 397 citations

The diversity of definitions of multidrug-resistant (MDR) and pandrug-resistant (PDR) Acinetobacter baumannii and Pseudomonas aeruginosa

2006 • 396 citations

Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir

1992 • 394 citations

A Controlled Trial of Ganciclovir to Prevent Cytomegalovirus Disease after Heart Transplantation

1992 • 384 citations

Delayed Cord Clamping in Very Preterm Infants Reduces the Incidence of Intraventricular Hemorrhage and Late-Onset Sepsis: A Randomized, Controlled Trial

2006 • 382 citations

Impact of Immediate Primary Lung Allograft Dysfunction on Bronchiolitis Obliterans Syndrome

2006 • 382 citations

Meta-Analysis: The Efficacy of Strategies To Prevent Organ Disease by Cytomegalovirus in Solid Organ Transplant Recipients

2005 • 380 citations

Role of HMGB1 in apoptosis-mediated sepsis lethality

2006 • 378 citations

Early Circulating Lymphocyte Apoptosis in Human Septic Shock Is Associated with Poor Outcome

2002 • 374 citations

The role of infection and comorbidity: Factors that influence disparities in sepsis

2006 • 373 citations

Procalcitonin increase in early identification of critically ill patients at high risk of mortality*

2006 • 372 citations

Early changes in organ function predict eventual survival in severe sepsis*

2005 • 364 citations

Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol*

2006 • 363 citations

Potential use of copper surfaces to reduce survival of epidemic meticillin-resistant Staphylococcus aureus in the healthcare environment

2006 • 362 citations

Zygomycosis: the re-emerging fungal infection

2006 • 361 citations

Impact of Emergency Colectomy on Survival of Patients With Fulminant Clostridium difficile Colitis During an Epidemic Caused by a Hypervirulent Strain

2007 • 359 citations

Protection from cytomegalovirus after transplantation is correlated with immediate early 1–specific CD8 T cells

2005 • 359 citations

Antimicrobial resistance in gram-positive bacteria

2006 • 359 citations

Increased Vancomycin MICs for Staphylococcus aureus Clinical Isolates from a University Hospital during a 5-Year Period

2006 • 357 citations

Attributable cost of catheter-associated bloodstream infections among intensive care patients in a nonteaching hospital*

2006 • 351 citations

Multilocus Sequence Typing Scheme for Enterococcus faecalis Reveals Hospital-Adapted Genetic Complexes in a Background of High Rates of Recombination

2006 • 349 citations

Antiviral medications to prevent cytomegalovirus disease and early death in recipients of solid-organ transplants: a systematic review of randomised controlled trials

2005 • 347 citations

Combination of Voriconazole and Caspofungin as Primary Therapy for Invasive Aspergillosis in Solid Organ Transplant Recipients: A Prospective, Multicenter, Observational Study

2006 • 336 citations

Impact of early cytomegalovirus infection and disease on long-term recipient and kidney graft survival

2004 • 330 citations

Cytomegalovirus Colitis Complicating Inflammatory Bowel Disease

2006 • 328 citations

Accelerated Lymphocyte Death in Sepsis Occurs by both the Death Receptor and Mitochondrial Pathways

2005 • 328 citations

β-Lactam Antibiotics Induce the SOS Response and Horizontal Transfer of Virulence Factors inStaphylococcus aureus

2006 • 327 citations

Prophylactic Versus Preemptive Oral Valganciclovir for the Management of Cytomegalovirus Infection in Adult Renal Transplant Recipients

2006 • 327 citations

Association of coronary artery disease in cardiac transplant recipients with cytomegalovirus infection

1989 • 324 citations

Effect of Farnesol on Staphylococcus aureus Biofilm Formation and Antimicrobial Susceptibility

2006 • 323 citations

Human Cytomegalovirus Envelope Glycoproteins B and H Are Necessary for TLR2 Activation in Permissive Cells

2006 • 322 citations

Vaccine Development to Prevent Cytomegalovirus Disease: Report from the National Vaccine Advisory Committee

2004 • 320 citations

Microarrays Reveal that Each of the Ten Dominant Lineages ofStaphylococcus aureusHas a Unique Combination of Surface-Associated and Regulatory Genes

2005 • 319 citations

Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

2006 • 317 citations

SYMPTOMATIC CYTOMEGALOVIRUS INFECTION IN SEROPOSITIVE KIDNEY RECIPIENTS: REINFECTION WITH DONOR VIRUS RATHER THAN REACTIVATION OF RECIPIENT VIRUS

1988 • 315 citations

Combination Treatment of Invasive Fungal Infections

2005 • 304 citations

Acquisition of Donor Strains of Cytomegalovirus by Renal-Transplant Recipients

1986 • 302 citations

Endothelial microparticles as markers of endothelial dysfunction

2004 • 301 citations

Roles of 34 Virulence Genes in the Evolution of Hospital‐ and Community‐Associated Strains of Methicillin‐ResistantStaphylococcus aureus

2006 • 300 citations

Risk Factors for Invasive Aspergillosis in Solid-Organ Transplant Recipients: A Case-Control Study

2005 • 296 citations

Canadian Society of Transplantation Consensus Workshop on Cytomegalovirus Management in Solid Organ Transplantation Final Report

2005 • 294 citations

Procalcitonin Kinetics as a Prognostic Marker of Ventilator-associated Pneumonia

2004 • 292 citations

Rapid Detection and Identification of Metallo-β-Lactamase-Encoding Genes by Multiplex Real-Time PCR Assay and Melt Curve Analysis

2006 • 291 citations

Infectious Complications among 620 Consecutive Heart Transplant Patients at Stanford University Medical Center

2001 • 290 citations

Impact of Prophylactic Immediate Posttransplant Ganciclovir on Development of Transplant Atherosclerosis

1999 • 290 citations

The Impact of Cytomegalovirus Infection and Disease on Rejection Episodes in Renal Allograft Recipients

2002 • 286 citations

Activity of the major staphylococcal autolysin Atl

2006 • 286 citations

Inactivating a Cellular Intrinsic Immune Defense Mediated by Daxx Is the Mechanism through Which the Human Cytomegalovirus pp71 Protein Stimulates Viral Immediate-Early Gene Expression

2006 • 284 citations

Human cytomegalovirus encodes three G protein-coupled receptor homologues

1990 • 281 citations

Controlling methicillin-resistant Staphylococcus aureus : Quantifying the effects of interventions and rapid diagnostic testing

2006 • 278 citations

Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality

2006 • 277 citations

Adrenal insufficiency in patients with cirrhosis, severe sepsis and septic shock

2006 • 276 citations

Methicillin-resistantStaphylococcus aureusin Community-acquired Skin Infections

2005 • 275 citations

Neonatal Cytomegalovirus Blood Load and Risk of Sequelae in Symptomatic and Asymptomatic Congenitally Infected Newborns

2005 • 274 citations

Randomized Controlled Trial of a Monoclonal Antibody against the Interleukin-2 Receptor (33B3.1) as Compared with Rabbit Antithymocyte Globulin for Prophylaxis against Rejection of Renal Allografts

1990 • 274 citations

The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection.

1997 • 273 citations

Increased carotid intima-media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responses

2006 • 270 citations

Cytomegalovirus reactivation and tumour necrosis factor

1994 • 266 citations

Induction of Daptomycin Heterogeneous Susceptibility in Staphylococcus aureus by Exposure to Vancomycin

2006 • 263 citations

Hematopoietic Stem Cell Transplantation in Hemophagocytic Lymphohistiocytosis: A Single-Center Report of 48 Patients

2006 • 262 citations

Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea

2005 • 260 citations

Using Bacteriophages To Reduce Formation of Catheter-Associated Biofilms byStaphylococcus epidermidis

2006 • 259 citations

Optimization of Quantitative Detection of Cytomegalovirus DNA in Plasma by Real-Time PCR

2004 • 259 citations

Efficacy of an alcohol/chlorhexidine hand hygiene program in a hospital with high rates of nosocomial methicillin‐resistant Staphylococcus aureus (MRSA) infection

2005 • 257 citations

Human Monoclonal Antibodies Directed against Toxins A and B Prevent Clostridium difficile -Induced Mortality in Hamsters

2006 • 256 citations

Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock

1993 • 255 citations

Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters

1995 • 253 citations

A Novel Staphylococcus aureus Vaccine: Iron Surface Determinant B Induces Rapid Antibody Responses in Rhesus Macaques and Specific Increased Survival in a Murine S. aureus Sepsis Model

2006 • 253 citations

Sepsis change bundles: Converting guidelines into meaningful change in behavior and clinical outcome

2004 • 252 citations

Prolonged Lymphopenia, Lymphoid Depletion, and Hypoprolactinemia in Children with Nosocomial Sepsis and Multiple Organ Failure

2005 • 250 citations

OXA-24, a Novel Class D β-Lactamase with Carbapenemase Activity in an Acinetobacter baumannii Clinical Strain

2000 • 247 citations

Cryptococcus neoformansin Organ Transplant Recipients: Impact of Calcineurin‐Inhibitor Agents on Mortality

2007 • 245 citations

Human Cytomegalovirus Infection Is Associated with Increased Proportions of NK Cells That Express the CD94/NKG2C Receptor in Aviremic HIV‐1–Positive Patients

2006 • 242 citations

Several herpesviruses can reactivate in a severe drug-induced multiorgan reaction in the same sequential order as in graft-versus-host disease

2006 • 242 citations

Four Distinct Patterns of Memory CD8 T Cell Responses to Chronic Murine Cytomegalovirus Infection

2006 • 240 citations

Lactate and glucose metabolism in severe sepsis and cardiogenic shock*

2005 • 240 citations

Quorum-sensing regulation governs bacterial adhesion, biofilm development, and host colonization in Pantoea stewartii subspecies stewartii

2006 • 240 citations

Intravenous immune globulin treatment inhibits crossmatch positivity and allows for successful transplantation of incompatible organs in living-donor and cadaver recipients1

2003 • 240 citations

Autocatalytic cleavage of Clostridium difficile toxin B

2007 • 239 citations

Alanine Esters of Enterococcal Lipoteichoic Acid Play a Role in Biofilm Formation and Resistance to Antimicrobial Peptides

2006 • 237 citations

Impact of Cytomegalovirus in Organ Transplant Recipients in the Era of Antiviral Prophylaxis

2006 • 236 citations

Presymptomatic Detection of Prions in Blood

2006 • 235 citations

Patient and Hospital Correlates of Clinical Outcomes and Resource Utilization in Severe Pediatric Sepsis

2007 • 232 citations

SYMPTOMATIC CYTOMEGALOVIRUS DISEASE IN THE CYTOMEGALOVIRUS ANTIBODY SEROPOSITIVE RENAL TRANSPLANT RECIPIENT TREATED WITH OKT31,2

1992 • 232 citations

The Indirect Effects of Cytomegalovirus Infection on the Outcome of Organ Transplantation

1989 • 232 citations

Extended-spectrum -lactamase-producing Enterobacteriaceae in different environments (humans, food, animal farms and sewage)

2006 • 227 citations

In Vivo Transfer of the vanA Resistance Gene from an Enterococcus faecium Isolate of Animal Origin to an E. faecium Isolate of Human Origin in the Intestines of Human Volunteers

2006 • 226 citations

Phenotypic Detection of Carbapenem-Susceptible Metallo-β-Lactamase-Producing Gram-Negative Bacilli in the Clinical Laboratory

2006 • 226 citations

Epidemiology, Outcomes, and Costs of Invasive Aspergillosis in Immunocompromised Children in the United States, 2000

2006 • 223 citations

Infection in the Organ Transplant Recipient

1994 • 221 citations

Cytomegalovirus (CMV) DNA Load Predicts Relapsing CMV Infection after Solid Organ Transplantation

2000 • 220 citations

Hyperchloremic Acidosis Increases Circulating Inflammatory Molecules in Experimental Sepsis

2006 • 218 citations

Clostridium difficile PCR Ribotypes in Calves, Canada

2006 • 217 citations

Identification of Staphylococcus aureus Proteins Recognized by the Antibody-Mediated Immune Response to a Biofilm Infection

2006 • 216 citations

Tolevamer, a Novel Nonantibiotic Polymer, Compared with Vancomycin in the Treatment of Mild to Moderately Severe Clostridium difficile-Associated Diarrhea

2006 • 212 citations

Insertion Sequence–Driven Diversification Creates a Globally Dispersed Emerging Multiresistant Subspecies of E. faecium

2007 • 212 citations

Clinical features of Clostridium difficile-associated diarrhoea due to binary toxin (actin-specific ADP-ribosyltransferase)-producing strains

2005 • 209 citations

Angiopoietin-2 is increased in severe sepsis: Correlation with inflammatory mediators

2006 • 207 citations

Innate Immunity of the Human Newborn Is Polarized Toward a High Ratio of IL-6/TNF-α Production In Vitro and In Vivo

2006 • 206 citations

Caveolin-1 Regulates NF-κB Activation and Lung Inflammatory Response to Sepsis Induced by Lipopolysaccharide

2006 • 206 citations

Comparable increase of B-type natriuretic peptide and amino-terminal pro-B-type natriuretic peptide levels in patients with severe sepsis, septic shock, and acute heart failure*

2006 • 205 citations

C/EBP Homologous Protein (CHOP) Is Crucial for the Induction of Caspase-11 and the Pathogenesis of Lipopolysaccharide-Induced Inflammatio

2006 • 204 citations

CYTOMEGALOVIRUS INFECTION IN TRANSPLANT RECIPIENTS THE ROLE OF TUMOR NECROSIS FACTOR

1994 • 204 citations

Terlipressin or norepinephrine in hyperdynamic septic shock: A prospective, randomized study*

2005 • 202 citations

Effect of Towne Live Virus Vaccine on Cytomegalovirus Disease after Renal Transplant

1991 • 201 citations

Staphylococcus aureus CcpA Affects Virulence Determinant Production and Antibiotic Resistance

2006 • 200 citations

Clinical manifestations, treatment and outcome of Paecilomyces lilacinus infections

2006 • 200 citations

INFECTIOUS DISEASE SYNDROMES ATTRIBUTABLE TO CYTOMEGALOVIRUS AND THEIR SIGNIFICANCE AMONG RENAL TRANSPLANT RECIPIENTS

1977 • 199 citations

Coronary Endothelial Dysfunction After Heart Transplantation Predicts Allograft Vasculopathy and Cardiac Death

2001 • 197 citations

Benefit of Appropriate Empirical Antibiotic Treatment: Thirty-day Mortality and Duration of Hospital Stay

2006 • 196 citations

Excess Risk of Death from Intensive Care Unit--Acquired Nosocomial Bloodstream Infections: A Reappraisal

2006 • 196 citations

Binary Toxin–Producing, Large Clostridial Toxin–NegativeClostridium difficileStrains Are Enterotoxic but Do Not Cause Disease in Hamsters

2006 • 196 citations

Pilot study on the effects of high cutoff hemofiltration on the need for norepinephrine in septic patients with acute renal failure*

2006 • 194 citations

A Portrait of the Geographic Dissemination of the Clostridium difficile North American Pulsed-Field Type 1 Strain and the Epidemiology of C. difficile-Associated Disease in Quebec

2006 • 194 citations

Viral DNA Polymerase Mutations Associated with Drug Resistance in Human Cytomegalovirus

2003 • 194 citations

Comparative Analysis of Prevalence, Risk Factors, and Molecular Epidemiology of Antibiotic-Associated Diarrhea Due to Clostridium difficile , Clostridium perfringens , and Staphylococcus aureus

2006 • 191 citations

Major Human Cytomegalovirus Structural Protein pp65 (ppUL83) Prevents Interferon Response Factor 3 Activation in the Interferon Response

2004 • 191 citations

In vitro susceptibilities of aerobic and facultatively anaerobic Gram-negative bacilli isolated from patients with intra-abdominal infections worldwide: 2004 results from SMART (Study for Monitoring Antimicrobial Resistance Trends)

2006 • 190 citations

High-Dose Acyclovir Compared with Short-Course Preemptive Ganciclovir Therapy To Prevent Cytomegalovirus Disease in Liver Transplant Recipients

1994 • 189 citations

Comparative Antibody-Mediated Phagocytosis ofStaphylococcus epidermidisCells Grown in a Biofilm or in the Planktonic State

2006 • 189 citations

Ganciclovir‐Resistant Cytomegalovirus in Organ Transplant Recipients

2002 • 188 citations

Mechanisms of Mortality in Early and Late Sepsis

2006 • 188 citations

Elevated serum levels of S-100β protein and neuron-specific enolase are associated with brain injury in patients with severe sepsis and septic shock*

2006 • 187 citations

High Incidence of Active Cytomegalovirus Infection Among Septic Patients

1998 • 186 citations

Stimulation of the Human Cytomegalovirus IE Enhancer/Promoter in HL-60 Cells by TNFα Is Mediated via Induction of NF-κB

1995 • 186 citations

NATIONAL NOSOCOMIAL INFECTIONS SURVEILLANCE S. OVERVIEW OF NOSOCOMIAL INFECTIONS CAUSED BY GRAM-NEGATIVE BACILLI

2005 • 185 citations

Severe strongyloidiasis in corticosteroid-treated patients: Case series and literature review

2006 • 183 citations

Effects of epinephrine, norepinephrine, and phenylephrine on microcirculatory blood flow in the gastrointestinal tract in sepsis*

2006 • 182 citations

Glutamine attenuates lung injury and improves survival after sepsis: Role of enhanced heat shock protein expression*

2005 • 182 citations

Reactivation of human herpesvirus (HHV) family members other than HHV-6 in drug-induced hypersensitivity syndrome

2006 • 180 citations

Monitoring of Human Cytomegalovirus-Specific CD4+ and CD8+ T-Cell Immunity in Patients Receiving Solid Organ Transplantation

2006 • 179 citations

Comparisons of Community-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) and Hospital-Associated MSRA Infections in Sacramento, California

2006 • 179 citations

A Randomized and Prospective Study of 3 Procedures for the Diagnosis of Catheter-Related Bloodstream Infection without Catheter Withdrawal

2007 • 178 citations

Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27

2006 • 176 citations

Treatment of Community-Associated Methicillin-Resistant Staphylococcus aureus Infections

2005 • 175 citations

The role of lipopolysaccharide-binding protein in modulating the innate immune response

2006 • 174 citations

The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-γ*

2006 • 174 citations

The Protective Effect of N-Acetylcysteine on Apoptotic Lung Injury in Cecal Ligation and Puncture-Induced Sepsis Model

2003 • 172 citations

Matrix Metalloproteinase-9 Deficiency Impairs Host Defense against Abdominal Sepsis

2006 • 172 citations

Inhibition of Mitochondrial Permeability Transition Prevents Sepsis-Induced Myocardial Dysfunction and Mortality

2006 • 172 citations

Levels of endothelial and platelet microparticles and their interactions with leukocytes negatively correlate with organ dysfunction and predict mortality in severe sepsis

2005 • 171 citations

Potential role of poly(adenosine 5′-diphosphate-ribose) polymerase activation in the pathogenesis of myocardial contractile dysfunction associated with human septic shock

2006 • 171 citations

Molecular Analysis of Clostridium difficile PCR Ribotype 027 Isolates from Eastern and Western Canada

2006 • 170 citations

Tumour necrosis factor stimulates the activity of the human cytomegalovirus major immediate early enhancer/promoter in immature monocytic cells

1993 • 169 citations

Mitochondrial DNA and survival after sepsis: a prospective study

2005 • 169 citations

Treatment of Non-Aspergillus Moulds in Immunocompromised Patients, with Amphotericin B Lipid Complex

2005 • 166 citations

Extravascular lung water determined with single transpulmonary thermodilution correlates with the severity of sepsis-induced acute lung injury

2006 • 166 citations

Absence of Cytomegalovirus‐Resistance Mutations after Valganciclovir Prophylaxis, in a Prospective Multicenter Study of Solid‐Organ Transplant Recipients

2004 • 166 citations

Heart Rate Characteristics and Clinical Signs in Neonatal Sepsis

2007 • 165 citations

In Vitro Analysis of IS Ecp1B -Mediated Mobilization of Naturally Occurring β-Lactamase Gene bla _CTX-M of Kluyvera ascorbata

2006 • 163 citations

Immunization with Staphylococcus aureus Clumping Factor B, a Major Determinant in Nasal Carriage, Reduces Nasal Colonization in a Murine Model

2006 • 163 citations

Pre‐ and post‐engraftment bloodstream infection rates and associated mortality in allogeneic hematopoietic stem cell transplant recipients

2005 • 163 citations

Cardiac allograft vasculopathy: central role of endothelial injury leading to transplant ???atheroma???

2003 • 163 citations

Recurrent Clostridium Difficile

2006 • 160 citations

Spx Is a Global Effector Impacting Stress Tolerance and Biofilm Formation inStaphylococcus aureus

2006 • 160 citations

Identification and Characterization of Bacterial Pathogens Causing Bloodstream Infections by DNA Microarray

2006 • 160 citations

Morbidity and cost burden of methicillin-resistant Staphylococcus aureus in early onset ventilator-associated pneumonia

2006 • 157 citations

Staphylococcus aureus bacteremia in patients with prosthetic devices: Costs and outcomes

2005 • 157 citations

Molecular and functional analysis of occult hepatitis B virus isolates from patients with hepatocellular carcinoma

2007 • 155 citations

Late-Onset Cytomegalovirus Disease in Liver Transplant Recipients Despite Antiviral Prophylaxis1

2004 • 154 citations

Typing and Subtyping of Clostridium difficile Isolates by Using Multiple-Locus Variable-Number Tandem-Repeat Analysis

2006 • 154 citations

One week of ciprofloxacin before percutaneous nephrolithotomy significantly reduces upper tract infection and urosepsis: a prospective controlled study

2006 • 153 citations

A Randomized Trial Comparing Long-term and Short-term Use of Umbilical Venous Catheters in Premature Infants With Birth Weights of Less Than 1251 Grams

2006 • 153 citations

Following Universal Prophylaxis with Intravenous Ganciclovir and Cytomegalovirus Immune Globulin, Valganciclovir is Safe and Effective for Prevention of CMV Infection Following Lung Transplantation

2004 • 151 citations

Multiple mechanisms are implicated in the regulation of NF-kappa B activity during human cytomegalovirus infection.

1993 • 151 citations

Preventing Post–Organ Transplantation Cytomegalovirus Disease with Ganciclovir: A Meta‐Analysis Comparing Prophylactic and Preemptive Therapies

2006 • 150 citations

ASSOCIATION BETWEEN CYTOMEGALOVIRUS DISEASE AND CHRONIC REJECTION IN KIDNEY TRANSPLANT RECIPIENTS1

1999 • 149 citations

Use of Vancomycin-Containing Lock or Flush Solutions for Prevention of Bloodstream Infection Associated with Central Venous Access Devices: A Meta-Analysis of Prospective, Randomized Trials

2006 • 149 citations

Pharmacokinetics and Safety of Oral Posaconazole in Neutropenic Stem Cell Transplant Recipients

2006 • 148 citations

Mechanisms of critical illness--classifying microcirculatory flow abnormalities in distributive shock.

2006 • 148 citations

Cytomegalovirus induction of tumor necrosis factor-alpha by human monocytes and mucosal macrophages.

1992 • 148 citations

Incidence and risk factors of device-associated infections and associated mortality at the intensive care in the Dutch surveillance system

2006 • 147 citations

Interplay of Cellular and Humoral Immune Responses against BK Virus in Kidney Transplant Recipients with Polyomavirus Nephropathy

2006 • 147 citations

Reduced burden of bacterial airway colonization with a novel silver-coated endotracheal tube in a randomized multiple-center feasibility study*

2006 • 147 citations

What is the current and future status of conventional amphotericin B?

2006 • 147 citations

Effects of Phenotype and Genotype on Methods for Detection of Extended-Spectrum-β-Lactamase-Producing Clinical Isolates ofEscherichia coliandKlebsiella pneumoniaein Norway

2006 • 147 citations

Cytomegalovirus Infection Impairs the Nitric Oxide Synthase Pathway

2004 • 146 citations

Methicillin-resistant Staphylococcus aureus sterile-site infection: The importance of appropriate initial antimicrobial treatment*

2006 • 146 citations

Immune escape and exploitation strategies of cytomegaloviruses: impact on and imitation of the major histocompatibility system

2004 • 146 citations

Histoplasmosis in solid organ transplant recipients at a large Midwestern university transplant center

2005 • 145 citations

The emergence of infections with community-associated methicillin resistant Staphylococcus aureus

2005 • 145 citations

Multiple triggers of cell death in sepsis: death receptor and mitochondrial‐mediated apoptosis

2007 • 145 citations

Acute Rejection and Cardiac Allograft Vascular Disease Is Reduced by Suppression of Subclinical Cytomegalovirus Infection

2006 • 144 citations

Human CD4+CD25+ Regulatory T Lymphocytes Inhibit Lipopolysaccharide-Induced Monocyte Survival through a Fas/Fas Ligand-Dependent Mechanism

2006 • 144 citations

Antibiotic-lock therapy for long-term intravascular catheter-related bacteraemia: results of an open, non-comparative study

2006 • 143 citations

Toxin–antitoxin systems are ubiquitous and plasmid-encoded in vancomycin-resistant enterococci

2006 • 143 citations

A Multicenter Intervention to Prevent Catheter-Associated Bloodstream Infections

2006 • 141 citations

Therapeutic Failures of Antibiotics Used To Treat Macrolide-Susceptible Streptococcus pyogenes Infections May Be Due to Biofilm Formation

2006 • 141 citations

IMPACT OF CYTOMEGALOVIRUS HYPERIMMUNE GLOBULIN ON OUTCOME AFTER CARDIOTHORACIC TRANSPLANTATION

2001 • 140 citations

Cytomegalovirus Disease in High-Risk Transplant Recipients Despite Ganciclovir or Valganciclovir Prophylaxis

2003 • 140 citations

Human Cytomegalovirus (HCMV) UL82 Gene Product (pp71) Relieves hDaxx-Mediated Repression of HCMV Replication

2006 • 137 citations

Diagnosis and treatment of cytomegalovirus iridocyclitis without retinal necrosis

2006 • 135 citations

Comparison of OG1RF and an IsogenicfsrBDeletion Mutant by Transcriptional Analysis: the Fsr System ofEnterococcus faecalisIs More than the Activator of Gelatinase and Serine Protease

2006 • 135 citations

Cytomegalovirus (CMV)–Specific T Cell Immunity after Renal Transplantation Mediates Protection from CMV Disease by Limiting the Systemic Virus Load

1999 • 134 citations

Multilocus Variable-Number Tandem-Repeat Analysis for Investigation of Clostridium difficile Transmission in Hospitals

2006 • 134 citations

Spread of blaCTX-M-type and blaPER-2 β-lactamase genes in clinical isolates from Bolivian hospitals

2006 • 133 citations

Identification of Methicillin‐ResistantStaphylococcus aureusCarriage in Less than 1 Hour during a Hospital Surveillance Program

2005 • 133 citations

Lack of Association Between the Increased Incidence ofClostridium difficile–Associated Disease and the Increasing Use of Alcohol-Based Hand Rubs

2006 • 133 citations

Mechanisms of human cytomegalovirus (HCMV) (re)activation and its impact on organ transplant patients

1999 • 133 citations

Increased Natural CD4+CD25+ Regulatory T Cells and Their Suppressor Activity Do Not Contribute to Mortality in Murine Polymicrobial Sepsis

2006 • 132 citations

Contemporary Concepts in Prevention and Treatment of Cardiac Allograft Vasculopathy

2006 • 131 citations

Primary Invasive Aspergillosis of the Digestive Tract: Report of Two Cases and Review of the Literature

2006 • 130 citations

Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome.

2006 • 130 citations

Central Venous and Mixed Venous Oxygen Saturation in Critically Ill Patients

2001 • 130 citations

The Association between Staphylococcus aureus Strains Carrying Panton-Valentine Leukocidin Genes and the Development of Deep-Seated Follicular Infection

2005 • 130 citations

Maribavir sensitivity of cytomegalovirus isolates resistant to ganciclovir, cidofovir or foscarnet

2006 • 129 citations

Occurrence and outcomes of sepsis: Influence of race*

2007 • 128 citations

Plasma gelsolin is a marker and therapeutic agent in animal sepsis*

2007 • 128 citations

Pre-emptive Treatment for Cytomegalovirus Viremia to Prevent Cytomegalovirus Disease in Solid Organ Transplant Recipients

2006 • 128 citations

Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163*

2006 • 126 citations

Reliability and accuracy of Sequential Organ Failure Assessment (SOFA) scoring

2005 • 126 citations

Comparison of two quantitative CMV PCR tests, Cobas Amplicor CMV Monitor and TaqMan assay, and pp65-antigenemia assay in the determination of viral loads from peripheral blood of organ transplant patients

2004 • 126 citations

Early predictors for infection recurrence and death in patients with ventilator-associated pneumonia

2006 • 126 citations

IP-10 Is an Early Diagnostic Marker for Identification of Late-Onset Bacterial Infection in Preterm Infants

2007 • 125 citations

Adenosine A2A Receptor Inactivation Increases Survival in Polymicrobial Sepsis

2006 • 125 citations

Prevalence of Inducible Clindamycin Resistance among Community- and Hospital-Associated Staphylococcus aureus Isolates

2006 • 125 citations

Persistent cytomegalovirus in liver allografts with chronic rejection

1997 • 124 citations

A Multicenter Study Evaluating the Current Strategies for Isolating Staphylococcus aureus Strains with Reduced Susceptibility to Glycopeptides

2006 • 124 citations

Prophylactic fenoldopam for renal protection in sepsis: A randomized, double-blind, placebo-controlled pilot trial*

2005 • 124 citations

Ethanol-Lock Technique for Persistent Bacteremia of Long-term Intravascular Devices in Pediatric Patients

2006 • 124 citations

A Hospital Outbreak of Diarrhea Due to an Emerging Epidemic Strain of Clostridium difficile

2006 • 123 citations

Iron overload is a major risk factor for severe infection after autologous stem cell transplantation: a study of 367 myeloma patients

2006 • 123 citations

Cytomegalovirus Infection Persists in the Liver Graft in the Vanishing Bile Duct Syndrome

1992 • 122 citations

Ecological replacement of Enterococcus faecalis by multiresistant clonal complex 17 Enterococcus faecium

2006 • 121 citations

Statins: panacea for sepsis?

2006 • 120 citations

Human Herpesvirus–6 Is Associated with Cytomegalovirus Reactivation in Liver Transplant Recipients

2000 • 120 citations

Inflammation and Coagulation: Implications for the Septic Patient

2003 • 120 citations

Evaluation of real-time PCR and conventional diagnostic methods for the detection of Clostridium difficile-associated diarrhoea in a prospective multicentre study

2006 • 119 citations

Clumping factor A ofStaphylococcus aureusinhibits phagocytosis by human polymorphonuclear leucocytes

2006 • 118 citations

Role for TLR2 in NK Cell-Mediated Control of Murine Cytomegalovirus In Vivo

2006 • 118 citations

Time to Blood Culture Positivity as a Predictor of Clinical Outcome of Staphylococcus aureus Bloodstream Infection

2006 • 118 citations

Role of cytomegalovirus infection in the development of coronary artery disease in the transplanted heart.

1990 • 117 citations

Community-acquired Methicillin-resistantStaphylococcus aureus, Uruguay

2006 • 116 citations

Human Cytomegalovirus Elicits a Coordinated Cellular Antiviral Response via Envelope Glycoprotein B

2004 • 116 citations

Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes

2006 • 116 citations

β-Lactamase Nomenclature

2006 • 116 citations

Efficacy of Valganciclovir Administered as Preemptive Therapy for Cytomegalovirus Disease in Liver Transplant Recipients: Impact on Viral Load and Late-Onset Cytomegalovirus Disease

2004 • 115 citations

Newer Methods for Diagnosis of Cytomegalovirus Infection

1990 • 115 citations

Rifampicin-impregnated central venous catheters: a meta-analysis of randomized controlled trials

2007 • 115 citations

The Natural Course of Cytomegalovirus Infection and Disease in Renal Transplant Recipients

2006 • 114 citations

Decrease in circulating dendritic cells predicts fatal outcome in septic shock

2006 • 114 citations

Risk Factors for Invasive, Early-Onset Escherichia coli Infections in the Era of Widespread Intrapartum Antibiotic Use

2006 • 114 citations

Combination Antiviral Therapy for Ganciclovir‐Resistant Cytomegalovirus Infection in Solid‐Organ Transplant Recipients

2002 • 114 citations

The influence of metallo- -lactamase production on mortality in nosocomial Pseudomonas aeruginosa infections

2006 • 114 citations

Human Cytomegalovirus Infection Elicits a Glycoprotein M (gM)/gN-Specific Virus-Neutralizing Antibody Response

2006 • 114 citations

A systematic review of the evidence for interventions for the prevention and control of meticillin-resistant Staphylococcus aureus (1996–2004): report to the Joint MRSA Working Party (Subgroup A)

2006 • 114 citations

Clinical efficacy of continuous infusion of piperacillin compared with intermittent dosing in septic critically ill patients

2006 • 113 citations

High incidence of allograft dysfunction in liver transplanted patients treated with pegylated-interferon alpha-2b and ribavirin for hepatitis C recurrence: possible de novo autoimmune hepatitis?

2006 • 113 citations

Oral valganciclovir leads to higher exposure to ganciclovir than intravenous ganciclovir in patients following allogeneic stem cell transplantation

2005 • 113 citations

Prospective Study of Amphotericin B Formulations in Immunocompromised Patients in 4 European Countries

2006 • 113 citations

Epidemiology of cytomegalovirus disease in solid organ and hematopoietic stem cell transplant recipients

2005 • 112 citations

TAT-BH4 and TAT-Bcl-xL Peptides Protect against Sepsis-Induced Lymphocyte Apoptosis In Vivo

2006 • 112 citations

The Influence of High‐Efficiency Particulate Air Filtration on Mortality and Fungal Infection among Highly Immunosuppressed Patients: A Systematic Review

2006 • 111 citations

Putative Surface Proteins Encoded within a Novel Transferable Locus Confer a High-Biofilm Phenotype to Enterococcus faecalis

2006 • 110 citations

Carbamoyl phosphate synthase-1: A marker of mitochondrial damage and depletion in the liver during sepsis

2006 • 110 citations

Community-associated Methicillin-resistantStaphylococcus aureusin Pediatric Patients

2005 • 110 citations

A Common Polymorphism in the Interleukin 8 Gene Promoter Is Associated with Clostridium difficile Diarrhea

2006 • 109 citations

A Phase 1 Study of 4 Live, Recombinant Human Cytomegalovirus Towne/Toledo Chimeric Vaccines

2006 • 109 citations

Staphylococcus aureusCarriers Neutralize Superantigens by Antibodies Specific for Their Colonizing Strain: A Potential Explanation for Their Improved Prognosis in Severe Sepsis

2006 • 108 citations

Evaluation of the IDI-MRSA Assay for Detection of Methicillin-Resistant Staphylococcus aureus from Nasal and Rectal Specimens Pooled in a Selective Broth

2006 • 108 citations

Amphotericin B tissue distribution in autopsy material after treatment with liposomal amphotericin B and amphotericin B colloidal dispersion

2006 • 107 citations

CD4⁺T cells and CXC chemokines modulate the pathogenesis ofStaphylococcus aureuswound infections

2006 • 105 citations

The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanisms

2005 • 105 citations

Nosocomial infections due to methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci at a university hospital in Taiwan from 1991 to 2003: resistance trends, antibiotic usage and in vitro activities of newer antimicrobial agents

2005 • 104 citations

Characterizing the Effect of theStaphylococcus aureusVirulence Factor Regulator, SarA, on Log-Phase mRNA Half-Lives

2006 • 104 citations

Late-Onset Cytomegalovirus Disease as a Significant Complication in Solid Organ Transplant Recipients Receiving Antiviral Prophylaxis: A Call to Heed the Mounting Evidence

2005 • 104 citations

Role of the cellular protein hDaxx in human cytomegalovirus immediate-early gene expression

2006 • 104 citations

Combined CMV Prophylaxis Improves Outcome and Reduces the Risk for Bronchiolitis Obliterans Syndrome (BOS) after Lung Transplantation

2006 • 104 citations

Evaluation of Caspofungin and Amphotericin B Deoxycholate againstCandida albicansBiofilms in an Experimental Intravascular Catheter Infection Model

2006 • 103 citations

Interleukin-18: A novel prognostic cytokine in bacteria-induced sepsis

2006 • 103 citations

Prevention and treatment of cytomegalovirus infection in solid organ transplant recipients

2004 • 102 citations

Proteomic Biomarkers of Intra-amniotic Inflammation: Relationship with Funisitis and Early-onset Sepsis in the Premature Neonate

2007 • 102 citations

Influence of Culture Heterogeneity in Cell Surface Charge on Adhesion and Biofilm Formation by Enterococcus faecalis

2006 • 102 citations

DIRECT INDUCTION OF MHC CLASS I, BUT NOT CLASS II, EXPRESSION ON ENDOTHELIAL CELLS BY CYTOMEGALOVIRUS INFECTION

1989 • 102 citations

Acinetobacter baumannii lipopolysaccharides are potent stimulators of human monocyte activation via Toll-like receptor 4 signalling

2007 • 102 citations

High-Molecular-Weight Protein (pUL48) of Human Cytomegalovirus Is a Competent Deubiquitinating Protease: Mutant Viruses Altered in Its Active-Site Cysteine or Histidine Are Viable

2006 • 102 citations

Allograft Loss in Renal Transplant Recipients with Cryptococcus Neoformans Associated Immune Reconstitution Syndrome

2005 • 102 citations

Prophylactic antibiotics for preventing early central venous catheter Gram positive infections in oncology patients

2007 • 101 citations

A Trial of Valganciclovir Prophylaxis for Cytomegalovirus Prevention in Lung Transplant Recipients

2005 • 101 citations

Clonal Composition of Staphylococcus aureus Isolates at a Brazilian University Hospital: Identification of International Circulating Lineages

2006 • 101 citations

Classifying spa Types in Complexes Improves Interpretation of Typing Results for Methicillin-Resistant Staphylococcus aureus

2006 • 100 citations

Comparison of mortality of patients with Acinetobacter baumannii bacteraemia receiving appropriate and inappropriate empirical therapy

2006 • 100 citations

Mortality Risk Factors with Nosocomial Staphylococcus aureus Infections in Intensive Care Units: Results from the German Nosocomial Infection Surveillance System (KISS)

2005 • 99 citations

Engineering a Disulfide Bond to Stabilize the Calcium-binding Loop of Activated Protein C Eliminates Its Anticoagulant but Not Its Protective Signaling Properties

2007 • 99 citations

Cytomegalovirus Infection in Heart Transplant Recipients Is Associated With Impaired Endothelial Function

2004 • 99 citations

The changing epidemiology of invasive fungal infections: new threats

2006 • 98 citations

Epidemiology, Treatment, and Outcomes of Nosocomial Bacteremic Staphylococcus aureus Pneumonia

2005 • 98 citations

Antiviral drugs for cytomegalovirus in transplant recipients: advantages of preemptive therapy

2006 • 96 citations

Is albumin administration in the acutely ill associated with increased mortality? Results of the SOAP study.

2005 • 96 citations

AN ASSOCIATION BETWEEN CYTOMEGALOVIRUS INFECTION AND CHRONIC REJECTION AFTER LIVER TRANSPLANTATION

2000 • 95 citations

Evolution of surveillance methods for detection of bacterial contamination of platelets in a university hospital, 1991 through 2004

2006 • 95 citations

CYTOMEGALOVIRUS ANTIGENEMIA DIRECTED PRE-EMPTIVE PROPHYLAXIS WITH ORAL VERSUS I.V. GANCICLOVIR FOR THE PREVENTION OF CYTOMEGALOVIRUS DISEASE IN LIVER TRANSPLANT RECIPIENTS1

2000 • 95 citations

Human cytomegalovirus alters interleukin-6 production by endothelial cells

1994 • 94 citations

Persistent Symptomless Human Metapneumovirus Infection in Hematopoietic Stem Cell Transplant Recipients

2006 • 94 citations

A Randomized Trial of Ganciclovir versus Ganciclovir Plus Immune Globulin for Prophylaxis Against Epstein-Barr Virus Related Posttransplant Lymphoproliferative Disorder

2006 • 94 citations

Clonal Structure of Enterococcus faecalis Isolated from Polish Hospitals: Characterization of Epidemic Clones

2006 • 94 citations

Longitudinal Assessment of Cytomegalovirus (CMV)–Specific Immune Responses in Liver Transplant Recipients at High Risk for Late CMV Disease

2007 • 93 citations

IL-12, but Not IL-18, Is Critical to Neutrophil Activation and Resistance to Polymicrobial Sepsis Induced by Cecal Ligation and Puncture

2006 • 93 citations

T-Cell Immunity to Subclinical Cytomegalovirus Infection Reduces Cardiac Allograft Disease

2006 • 92 citations

Bloodstream Infections with Metallo-β-Lactamase-Producing Pseudomonas aeruginosa : Epidemiology, Microbiology, and Clinical Outcomes

2005 • 92 citations

Antimicrobial Susceptibility among Pathogens Collected from Hospitalized Patients in the United States and In Vitro Activity of Tigecycline, a New Glycylcycline Antimicrobial

2006 • 92 citations

Competition between methicillin-sensitive and -resistant in the anterior nares

2005 • 91 citations

Subclinical cytomegalovirus and Epstein–Barr virus viremia are associated with adverse outcomes in pediatric renal transplantation

2006 • 91 citations

Betaherpesvirus-Conserved Cytomegalovirus Tegument Protein ppUL32 (pp150) Controls Cytoplasmic Events during Virion Maturation

2006 • 91 citations

CXCR3-Dependent Recruitment of Antigen-Specific T Lymphocytes to the Liver during Murine Cytomegalovirus Infection

2006 • 90 citations

Nitric oxide up-regulates the glucocorticoid receptor and blunts the inflammatory reaction in porcine endotoxin sepsis*

2006 • 89 citations

EFFICACY OF GANCICLOVIR IN LIVER AND KIDNEY TRANSPLANT RECIPIENTS WITH SEVERE CYTOMEGALOVIRUS INFECTION

1988 • 89 citations

Surface layer proteins from Clostridium difficile induce inflammatory and regulatory cytokines in human monocytes and dendritic cells

2006 • 89 citations

Spleen Depletion in Neonatal Sepsis and Chorioamnionitis

2004 • 88 citations

A 62-month retrospective epidemiological survey of anaerobic bacteraemia in a university hospital

2006 • 88 citations

Emergence and Outbreaks of CTX-M β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Strains in a Tunisian Hospital

2006 • 88 citations

The Cumulative Effect of Acute Rejection on Development of Cardiac Allograft Vasculopathy

2006 • 88 citations

Cytomegalovirus infection of the liver transplant: virological, histological, immunological, and clinical observations

2006 • 87 citations

Association Between Mannose-Binding Lectin Deficiency and Cytomegalovirus Infection After Kidney Transplantation

2007 • 87 citations

In Vivo Selection of Fluoroquinolone-Resistant Escherichia coli Isolates Expressing Plasmid-Mediated Quinolone Resistance and Expanded-Spectrum β-Lactamase

2006 • 87 citations

Growth Condition-Dependent Esp Expression by Enterococcus faecium Affects Initial Adherence and Biofilm Formation

2006 • 87 citations

Dendritic Cell Biology

2005 • 86 citations

A study to determine the safety profile and maximum tolerated dose of micafungin (FK463) in patients undergoing haematopoietic stem cell transplantation

2006 • 86 citations

Low-dose hydrocortisone during severe sepsis: Effects on microalbuminuria

2006 • 86 citations

Investigation of the possible association between nosocomial candiduria and candidaemia

2006 • 86 citations

Characteristics of cutaneous cytomegalovirus infection in non-acquired immune deficiency syndrome, immunocompromised patients

2006 • 86 citations

Successful use of oral ganciclovir for the treatment of intrauterine cytomegalovirus infection in a renal allograft recipient

2005 • 86 citations

Tumor necrosis factor receptor p75 mediates cell-specific activation of nuclear factor kappa B and induction of human cytomegalovirus enhancer.

1994 • 85 citations

Prospective randomized control trial of isoniazid chemoprophylaxis during renal replacement therapy

2005 • 85 citations

Establishing Clonal Relationships between VIM-1-Like Metallo-β-Lactamase-Producing Pseudomonas aeruginosa Strains from Four European Countries by Multilocus Sequence Typing

2006 • 85 citations

Outcome in bacteremia associated with nosocomial pneumonia and the impact of pathogen prediction by tracheal surveillance cultures

2006 • 85 citations

Methicillin-resistant Staphylococcus aureus: a new community-acquired pathogen?

2006 • 85 citations

Importance of cytotoxic lymphocytes during cytomegalovirus infection in renal transplant recipients

1984 • 84 citations

Cryptococcosis in liver and kidney transplant recipients receiving anti-thymocyte globulin or alemtuzumab

2007 • 84 citations

Influence of type of cancer and hematopoietic stem cell transplantation on clinical presentation of Pneumocystis jiroveci pneumonia in cancer patients

2006 • 84 citations

Clinical Utility of Cytomegalovirus Viral Load in Bronchoalveolar Lavage in Lung Transplant Recipients

2005 • 83 citations

Management of Cytomegalovirus Infection in Lung Transplant Recipients: Evidence-Based Recommendations

2005 • 82 citations

Clinical impact of ganciclovir‐resistant cytomegalovirus infections in solid organ transplant patients

2005 • 82 citations

Comparison of a single indicator and gravimetric technique for estimation of extravascular lung water in endotoxemic pigs

2006 • 82 citations

Evaluation of the New VITEK 2 Extended-Spectrum Beta-Lactamase (ESBL) Test for Rapid Detection of ESBL Production in Enterobacteriaceae Isolates

2006 • 82 citations

Reconstitution of Herpes Simplex Virus Microtubule-Dependent Trafficking In Vitro

2006 • 82 citations

Valganciclovir is safe and effective as pre-emptive therapy for CMV infection in allogeneic hematopoietic stem cell transplantation

2006 • 82 citations

Hyperbaric oxygen protects from sepsis mortality via an interleukin-10–dependent mechanism*

2006 • 81 citations

IgMA-enriched immunoglobulin in neutropenic patients with sepsis syndrome and septic shock: A randomized, controlled, multiple-center trial*

2006 • 81 citations

The Inflammatory Caspases: Key Players in the Host Response to Pathogenic Invasion and Sepsis

2006 • 81 citations

Polyomavirus‐associated nephropathy: update on antiviral strategies

2006 • 80 citations

Isolation and characterisation of toxin A-negative, toxin B-positive Clostridium difficile in Dublin, Ireland

2006 • 80 citations

Outcome of cephalosporin treatment of bacteremia due to CTX-M–type extended-spectrum β-lactamase–producing Escherichia coli

2006 • 80 citations

Commensal isolates of methicillin-resistant Staphylococcus epidermidis are also well equipped to produce biofilm on polystyrene surfaces

2006 • 80 citations

Molecular Epidemiology of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in the Calgary Health Region: Emergence of VIM-2-Producing Isolates

2006 • 79 citations

Genomic Organization and Molecular Characterization of Clostridium difficile Bacteriophage ΦCD119

2006 • 79 citations

Identification of Clostridium difficile toxin B cardiotoxicity using a zebrafish embryo model of intoxication

2006 • 78 citations

Immune activation following cytomegalovirus infection: More important than direct viral effects in cardiovascular disease?

2006 • 78 citations

blaOXA-51-type β-lactamase genes are ubiquitous and vary within a strain in Acinetobacter baumannii

2006 • 78 citations

Staphylococcus aureus Carriage Patterns and the Risk of Infections Associated with Continuous Peritoneal Dialysis

2006 • 78 citations

First description of CTX-M β-lactamase-producing clinical Escherichia coli isolates from Egypt

2006 • 78 citations

Persistent cytomegalovirus infection in kidney allografts is associated with inferior graft function and survival

2006 • 78 citations

Cytomegalovirus Encodes a Positive Regulator of Antigen Presentation

2006 • 77 citations

Clonal Distribution and Differential Occurrence of the Enterotoxin Gene Cluster, egc , in Carriage- versus Bacteremia-Associated Isolates of Staphylococcus aureus

2006 • 77 citations

Human Cytomegalovirus-Encoded G Protein-Coupled Receptor US28 Mediates Smooth Muscle Cell Migration through Gα12

2004 • 77 citations

Horizontal transfer of virulence genes encoded on the Enterococcus faecalis pathogenicity island

2006 • 76 citations

Effects of vasopressin, norepinephrine, and l-arginine on intestinal microcirculation in endotoxemia*

2006 • 75 citations

Infection Frequency and Profile in Different Age Groups of Kidney Transplant Recipients

2006 • 75 citations

24-Week Oral Ganciclovir Prophylaxis in Kidney Recipients Is Associated with Reduced Symptomatic Cytomegalovirus Disease Compared to a 12-Week Course

2006 • 75 citations

Clinical Correlation of the CLSI Susceptibility Breakpoint for Piperacillin- Tazobactam against Extended-Spectrum-β-Lactamase-Producing Escherichia coli and Klebsiella Species

2006 • 75 citations

Emergence of Linezolid Resistance in the Vancomycin-Resistant Enterococcus faecium Multilocus Sequence Typing C1 Epidemic Lineage

2006 • 75 citations

Leflunomide failure to control recurrent cytomegalovirus infection in the setting of renal failure after allogeneic stem cell transplantation

2007 • 74 citations

Effect of fluconazole consumption on long-term trends in candidal ecology

2006 • 74 citations

Low Serum Levels of Mannose Binding Lectin Are a Risk Factor for Neonatal Sepsis

2007 • 74 citations

Strain Typing and Determination of Population Structure ofCandida kruseiby Multilocus Sequence Typing

2006 • 74 citations

Stenotrophomonas maltophilia pneumonia in cancer patients without traditional risk factors for infection, 1997–2004

2007 • 74 citations

Detection of Aspergillus DNA in Cerebrospinal Fluid from Patients with Cerebral Aspergillosis by a Nested PCR Assay

2006 • 74 citations

Prevention of catheter-related bloodstream infections: analysis of studies published between 2002 and 2005

2006 • 74 citations

Oxidized Phospholipids Inhibit Phagocytosis and Impair Outcome in Gram-Negative Sepsis In Vivo

2007 • 74 citations

Human CD8+ cytotoxic T cell responses to adenovirus capsid proteins

2006 • 74 citations

Late and Atypical Cytomegalovirus Disease in Solid‐Organ Transplant Recipients

2001 • 74 citations

E6/E7 expression of human papillomavirus types in cutaneous squamous cell dysplasia and carcinoma in immunosuppressed organ transplant recipients

2006 • 73 citations

Comparative Efficacies, Toxicities, and Tissue Concentrations of Amphotericin B Lipid Formulations in a Murine Pulmonary Aspergillosis Model

2006 • 72 citations

Risk Factors for Cytomegalovirus Viremia and Disease Developing after Prophylaxis in High-Risk Solid-Organ Transplant Recipients

2004 • 72 citations

Intrapulmonary Penetration of Voriconazole in Patients Receiving an Oral Prophylactic Regimen

2006 • 72 citations

Cardiac Allograft Vasculopathy and Dysregulation of the NO Synthase Pathway

2003 • 72 citations

The Role of the Tumor Necrosis Factor System and Interleukin‐10 during Cytomegalovirus Infection in Renal Transplant Recipients

2000 • 72 citations

Difference in the Cytotoxic Effects of Toxin B fromClostridium difficileStrain VPI 10463 and Toxin B from VariantClostridium difficileStrain 1470

2006 • 71 citations

Amphotericin B Lipid Complex in the Management of Invasive Aspergillosis in Immunocompromised Patients

2005 • 71 citations

The role of high mobility group box-1 protein in severe sepsis

2006 • 71 citations

HHV‐6 and HHV‐7 antigenemia related to CMV infection after liver transplantation

2006 • 71 citations

Relevance of cytomegalovirus infection and coronary-artery remodeling in the first year after heart transplantation: a prospective three-dimensional intravascular ultrasound study

2003 • 70 citations

Recombinant human activated protein C in the treatment of severe sepsis: An evidence-based review

2004 • 70 citations

Transfer of plasmid and chromosomal glycopeptide resistance determinants occurs more readily in the digestive tract of mice than in vitro and exconjugants can persist stably in vivo in the absence of glycopeptide selection

2007 • 70 citations

Epidemiology and clinical outcome of enterococcal bacteraemia in an acute care hospital

2005 • 69 citations

Oral rifampin for eradication of Staphylococcus aureus carriage from healthy and sick populations: A systematic review of the evidence from comparative trials

2007 • 69 citations

Effect of Novel A_2AAdenosine Receptor Agonist ATL 313 onClostridium difficileToxin A-Induced Murine Ileal Enteritis

2006 • 69 citations

Activated Polymorphonuclear Leukocytes Enhance Production of Leukocyte Microparticles with Increased Adhesion Molecules in Patients with Sepsis

2002 • 68 citations

Antifungal Prophylaxis to Prevent Neonatal Candidiasis: A Survey of Perinatal Physician Practices

2006 • 68 citations

The case for cytomegalovirus prophylaxis in solid organ transplantation

2006 • 68 citations

Epidemiology of infections caused by extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella spp.: a nested case–control study from a tertiary hospital in London

2006 • 67 citations

Hypogammaglobulinemia in Liver Transplant Recipients: Incidence, Timing, Risk Factors, and Outcomes

2006 • 67 citations

Beneficial effects of alkaline phosphatase in septic shock

2006 • 67 citations

Treatment of solid organ transplant patients with invasive fungal infections: should a combination of antifungal drugs be used?

2006 • 66 citations

Genotyping and Preemptive Isolation to Control an Outbreak of Vancomycin-Resistant Enterococcus faecium

2006 • 66 citations

Clonality and Antimicrobial Resistance Gene Profiles of Multidrug- Resistant Salmonella enterica Serovar Infantis Isolates from Four Public Hospitals in Rio de Janeiro, Brazil

2006 • 66 citations

Evaluation of a New Selective Chromogenic Agar Medium for Detection of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae

2006 • 66 citations

Molecular epidemiology of extended-spectrum β-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit

2006 • 66 citations

Rapid Emergence of Resistance to Linezolid during Linezolid Therapy of an Enterococcus faecium Infection

2006 • 65 citations

Bronchoalveolar lavage in immunocompromised patients with haematological malignancy – value of new microbiological methods

2005 • 65 citations

Efficacy and safety of low-dose valganciclovir in the prevention of cytomegalovirus disease in adult liver transplant recipients

2005 • 65 citations

Cytomegalovirus Induction of Interleukin‐6 in Lung Fibroblasts Occurs Independently of Active Infection and Involves a G Protein and the Transcription Factor, NF‐𝛋B

1999 • 65 citations

Comparison of buccal microcirculation between septic and hemorrhagic shock

2006 • 65 citations

Human Cytomegalovirus Attenuates Interleukin-1β and Tumor Necrosis Factor Alpha Proinflammatory Signaling by Inhibition of NF-κB Activation

2006 • 65 citations

Polymorphisms in the Genes Encoding Chemokine Receptor 5, Interleukin-10, and Monocyte Chemoattractant Protein 1 Contribute to Cytomegalovirus Reactivation and Disease after Allogeneic Stem Cell Transplantation

2006 • 65 citations

Positive Pretransplantation Cytomegalovirus Serology Is a Risk Factor for Cardiac Allograft Vasculopathy in Children

2007 • 64 citations

Deletion of Open Reading Frame UL26 from the Human Cytomegalovirus Genome Results in Reduced Viral Growth, Which Involves Impaired Stability of Viral Particles

2006 • 64 citations

A prospective randomized trial of itraconazole vs fluconazole for the prevention of fungal infections in patients with acute leukemia and hematopoietic stem cell transplant recipients

2006 • 64 citations

Vaccines for the Prevention of Human Cytomegalovirus Infection

1990 • 64 citations

Increased incidence of methicillin-resistant Staphylococcus aureus ST80, novel ST125 and SCCmecIV in the south-eastern part of Norway during a 12-year period

2006 • 64 citations

Risk factors for recurrence in patients with Staphylococcus aureus infections complicated by bacteremia

2006 • 64 citations

Cytomegalovirus infection-enhanced allograft arteriosclerosis is prevented by DHPG prophylaxis in the rat.

1994 • 63 citations

Analysis of cytomegalovirus DNA polymerase (UL54) mutations in solid organ transplant patients receiving valganciclovir or ganciclovir prophylaxis

2005 • 63 citations

Central venous catheter-related Stenotrophomonas maltophilia bacteraemia and associated relapsing bacteraemia in haematology and oncology patients

2006 • 62 citations

The innate immune system and its relevance to neonatal sepsis

2006 • 62 citations

Cyclin-Dependent Kinase Activity Is Required for Efficient Expression and Posttranslational Modification of Human Cytomegalovirus Proteins and for Production of Extracellular Particles

2006 • 62 citations

Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and sepsis

2006 • 62 citations

Reactivation of Viruses in Solid Organ Transplant Patients Receiving Cytomegalovirus Prophylaxis

2006 • 62 citations

OVERDIAGNOSIS OF ASTHMA AND ITS RELATIONSHIP TO BODY MASS INDEX

2006 • 62 citations

Cytomegalovirus Infection–Enhanced Cardiac Allograft Vasculopathy Is Abolished by DHPG Prophylaxis in the Rat

1997 • 62 citations

Using Evidence and Process Improvement Strategies to Enhance Healthcare Outcomes for the Critically Ill: A Pilot Project

2006 • 62 citations

Protein C −1641 AA is associated with decreased survival and more organ dysfunction in severe sepsis*

2006 • 61 citations

Microarray-based characterisation of a Panton–Valentine leukocidin-positive community-acquired strain of methicillin-resistant Staphylococcus aureus

2006 • 61 citations

Recognition of intestinal epithelial HIF-1α activation by Pseudomonas aeruginosa

2006 • 61 citations

Treatment of multidrug‐resistant cytomegalovirus retinitis with systemically administered leflunomide

2006 • 61 citations

Multidrug resistance to antimicrobials as a predominant factor influencing patient survival

2006 • 61 citations

Triggering receptor expressed on myeloid cells (TREM-1) is regulated post-transcriptionally and its ligand is present in the sera of some septic patients

2006 • 61 citations

Prevalence of AmpC over-expression in bloodstream isolates of Pseudomonas aeruginosa

2007 • 61 citations

Molecular Evolution of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in a Nosocomial Setting of High-Level Endemicity

2006 • 61 citations

Rat Cytomegalovirus-Accelerated Transplant Vascular Sclerosis Is Reduced with Mutation of the Chemokine-Receptor R33

2005 • 61 citations

Diagnostic accuracy of procalcitonin and interleukin-6 values for predicting bacteremia and clinical sepsis in febrile neutropenic children with cancer

2006 • 60 citations

Typing of Human Adenoviruses in Specimens from Immunosuppressed Patients by PCR-Fragment Length Analysis and Real-Time Quantitative PCR

2006 • 60 citations

Inhibition of Cellular DNA Synthesis by the Human Cytomegalovirus IE86 Protein Is Necessary for Efficient Virus Replication

2006 • 60 citations

Immunoglobulin G Levels before and after Lung Transplantation

2006 • 60 citations

Preprotachykinin-A Gene Products Are Key Mediators of Lung Injury in Polymicrobial Sepsis

2006 • 60 citations

Distribution of the exfoliative toxin D gene in clinical Staphylococcus aureus isolates in France

2006 • 60 citations

Incidence of voriconazole hepatotoxicity during intravenous and oral treatment for invasive fungal infections

2006 • 60 citations

Mouse Cytomegalovirus Crosses the Species Barrier with Help from a Few Human Cytomegalovirus Proteins

2006 • 59 citations

Changing Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Bloodstream Isolates from a Teaching Hospital in Northern Taiwan

2006 • 59 citations

Transfusion‐transmitted viral infections: building bridges to transfusion medicine to reduce risks and understand epidemiology and pathogenesis

2006 • 58 citations

Persistent Cytomegalovirus-Specific Memory Responses in the Lung Allograft and Blood following Primary Infection in Lung Transplant Recipients

2006 • 58 citations

Non‐comparative evaluation of the safety of aerosolized amphotericin B lipid complex in patients undergoing allogeneic hematopoietic stem cell transplantation

2006 • 58 citations

UL26-Deficient Human Cytomegalovirus Produces Virions with Hypophosphorylated pp28 Tegument Protein That Is Unstable within Newly Infected Cells

2006 • 58 citations

Staphylococcal colonization and infection: homeostasis versus disbalance of human (innate) immunity and bacterial virulence

2006 • 58 citations

Sequence Requirements for Localization of Human Cytomegalovirus Tegument Protein pp28 to the Virus Assembly Compartment and for Assembly of Infectious Virus

2006 • 57 citations

Interaction of Radiolabeled Antibodies with Fungal Cells and Components of the Immune System In Vitro and during Radioimmunotherapy for Experimental Fungal Infection

2006 • 57 citations

Translating evidence into practice to prevent central venous catheter-associated bloodstream infections: A systems-based intervention

2006 • 57 citations

Associations betweenStaphylococcus aureusGenotype, Infection, and In‐Hospital Mortality: A Nested Case‐Control Study

2005 • 57 citations

Sepsis-induced cholestasis, steatosis, hepatocellular injury, and impaired hepatocellular regeneration are enhanced in interleukin-6 −/− mice*

2006 • 56 citations

In vitro evaluation of the antibiotic lock technique (ALT) for the treatment of catheter-related infections caused by staphylococci

2006 • 56 citations

Evaluation of different methods to detect oxacillin resistance in Staphylococcus aureus and their clinical laboratory utility

2006 • 56 citations

Signaling via Platelet-Activating Factor Receptors Accounts for the Impairment of Neutrophil Migration in Polymicrobial Sepsis

2006 • 55 citations

Emergence and spread of two distinct clonal groups of multidrug-resistant Escherichia coli in a veterinary teaching hospital in Australia

2006 • 55 citations

Discrete steps in sensing of β-lactam antibiotics by the BlaR1 protein of the methicillin-resistant Staphylococcus aureus bacterium

2006 • 55 citations

Murine Cytomegalovirus Interference with Antigen Presentation Contributes to the Inability of CD8 T Cells To Control Virus in the Salivary Gland

2006 • 55 citations

Endogenous Tissue-Type Plasminogen Activator Is Protective during Escherichia coli-Induced Abdominal Sepsis in Mice

2006 • 55 citations

Reduction in MRSA environmental contamination with a portable HEPA-filtration unit

2006 • 55 citations

C-reactive protein concentrations during bacteraemia: a comparison between patients with and without liver dysfunction

2006 • 55 citations

Staphylococcus aureus bacteraemia: incidence, risk factors and predictors for death in a Brazilian teaching hospital

2006 • 55 citations

BK virus nephropathy in a heart transplant recipient: case report and review of the literature

2006 • 54 citations

ENHANCED (CYTOMEGALOVIRUS) VIRAL REPLICATION ASSOCIATED WITH SEPTIC BACTERIAL COMPLICATIONS IN LIVER TRANSPLANT RECIPIENTS

1997 • 54 citations

Description of an adenovirus A31 outbreak in a paediatric haematology unit

2006 • 54 citations

Antimicrobial Susceptibility Pattern of Clostridium difficile and Its Relation to PCR Ribotypes in a Swedish University Hospital

2006 • 54 citations

High-dose weekly liposomal amphotericin B antifungal prophylaxis following reduced-intensity conditioning allogeneic stem cell transplantation

2007 • 54 citations

Safety and immunogenicity of Towne cytomegalovirus vaccine with or without adjuvant recombinant interleukin-12

2006 • 54 citations

Coronary Flow Reserve by Contrast-Enhanced Echocardiography: A New Noninvasive Diagnostic Tool for Cardiac Allograft Vasculopathy

2006 • 54 citations

Bacteraemia caused byAnaerotruncus colihominisand emended description of the species

2006 • 53 citations

A Prospective Evaluation of Leflunomide Therapy for Cytomegalovirus Disease in Renal Transplant Recipients

2005 • 53 citations

Heterogeneity of Methicillin-SusceptibleStaphylococcus aureusStrains at a German University Hospital Implicates the Circulating-Strain Pool as a Potential Source of Emerging Methicillin-ResistantS. aureusClones

2006 • 53 citations

Ligand-Signaled Upregulation of Enterococcus faecalis ace Transcription, a Mechanism for Modulating Host- E. faecalis Interaction

2006 • 53 citations

Preclinical trial of l-arginine monotherapy alone or with N-acetylcysteine in septic shock*

2006 • 53 citations

Cell Wall-Mediated Neuronal Damage in Early Sepsis

2006 • 52 citations

Activation of Pro-Inflammatory and Anti-Inflammatory Cytokines in Host Organs During Chronic Allograft Rejection: Role of Endothelin Receptor Signaling

2005 • 52 citations

Risk of emergence of Pseudomonas aeruginosa resistance to β-lactam antibiotics in intensive care units

2006 • 52 citations

Analysis of a quantitative PCR assay for CMV infection in liver transplant recipients: an intent to find the optimal cut-off value

2004 • 52 citations

Which patient is a candidate for empirical therapy against Stenotrophomonas maltophilia bacteraemia? An analysis of associated risk factors in a tertiary care hospital

2006 • 52 citations

Influence of drotrecogin alpha (activated) infusion on the variation of Bax/Bcl-2 and Bax/Bcl-xl ratios in circulating mononuclear cells: A cohort study in septic shock patients

2006 • 52 citations

Benefits of Cytomegalovirus Prophylaxis in Solid Organ Transplantation

2006 • 52 citations

CYTOMEGALOVIRUS-MEDIATED MODULATION OF ADHESION MOLECULE EXPRESSION BY HUMAN ARTERIAL AND MICROVASCULAR ENDOTHELIAL CELLS1

1999 • 52 citations

Prevalence of metallo-β lactamase (MBL) producing Pseudomonas spp. and Acinetobacter spp. in a tertiary care hospital in India

2005 • 51 citations

Valganciclovir Preemptive Therapy for the Prevention of Cytomegalovirus Disease in High-Risk Seropositive Solid-Organ Transplant Recipients

2006 • 51 citations

2004 Lowbury Lecture: the Western Australian experience with vancomycin-resistant enterococci – from disaster to ongoing control

2006 • 51 citations

An outbreak of Serratia marcescens on the neonatal unit: a tale of two clones

2006 • 51 citations

CTX-M β-Lactamase-Producing Escherichia coli in French Hospitals: Prevalence, Molecular Epidemiology, and Risk Factors

2006 • 51 citations

Molecular epidemiology of vancomycin-resistant Enterococcus faecium in Argentina

2006 • 50 citations

Variability in the Region Downstream of the bla _CMY-2 β-Lactamase Gene in Escherichia coli and Salmonella enterica Plasmids

2006 • 50 citations

Oral Ganciclovir Versus Low-Dose Valganciclovir for Prevention of Cytomegalovirus Disease in Recipients of Kidney and Pancreas Transplants

2007 • 50 citations

PREVALENCE OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS NASAL CARRIAGE IN PATIENTS ADMITTED TO DRISCOLL CHILDREN'S HOSPITAL

2006 • 50 citations

Microbiologic features and outcome of pneumonia in transplanted patients

2006 • 50 citations

Valganciclovir prophylaxis in patients at high risk for the development of cytomegalovirus disease

2004 • 50 citations

Human cytomegalovirus UL131A, UL130 and UL128 genes are highly conserved among field isolates

2005 • 49 citations

Clinical significance of isolated Staphylococcus aureus central venous catheter tip cultures

2006 • 49 citations

Rhinoviruses in the pathogenesis of asthma: The bronchial epithelium as a major disease target

2006 • 49 citations

Comparative study ofvanAgene transfer fromEnterococcus faeciumtoEnterococcus faecalisand toEnterococcus faeciumin the intestine of mice

2005 • 49 citations

Mixed infection with multiple strains of murine cytomegalovirus occurs following simultaneous or sequential infection of immunocompetent mice

2006 • 49 citations

Agonistic Monoclonal Antibody Against CD40 Receptor Decreases Lymphocyte Apoptosis and Improves Survival in Sepsis

2006 • 49 citations

Blood pressure cuffs: friend or foe?

2006 • 49 citations

Risk factors for Clostridium difficile toxin-positive nosocomial diarrhoea

2006 • 49 citations

Epithelial Cell IκB-Kinase β Has an Important Protective Role inClostridium difficileToxin A-Induced Mucosal Injury

2006 • 48 citations

Epidemiology and incidence of Clostridium difficile-associated diarrhoea diagnosed upon admission to a university hospital

2006 • 48 citations

Annexin 2-mediated enhancement of cytomegalovirus infection opposes inhibition by annexin 1 or annexin 5

2006 • 48 citations

Analysis of the role of CovR and CovS in the dissemination of Streptococcus pyogenes in invasive skin disease

2006 • 48 citations

Health care‐associated Staphylococcus aureus bloodstream infections: a clinical quality indicator for all hospitals

2006 • 48 citations

Infrequency of cytomegalovirus genome in coronary arteriopathy of human heart allografts.

1995 • 48 citations

Gastrointestinal cytomegalovirus disease in patients with cancer: A two decade experience in a tertiary care cancer center

2005 • 48 citations

Quantitation of cytomegalovirus DNA by real-time polymerase chain reaction in peripheral blood specimens of patients with solid organ transplants: Comparison with end-point PCR and pp65 antigen test

2006 • 47 citations

Transcriptional Control of Cardiac Allograft Vasculopathy by Early Growth Response Gene-1 (Egr-1)

2002 • 47 citations

Effects of mild induced hypothermia during experimental sepsis*

2006 • 47 citations

VanG-Type Vancomycin-Resistant Enterococcus faecalis Strains Isolated in Canada

2006 • 47 citations

Comparison of N-terminal Pro-B-Type Natriuretic Peptide Levels in Critically Ill Children With Sepsis Versus Acute Left Ventricular Dysfunction

2006 • 47 citations

Cmv4, a New Locus Linked to the NK Cell Gene Complex, Controls Innate Resistance to Cytomegalovirus in Wild-Derived Mice

2006 • 47 citations

Occurrence of plasmidic AmpC type β-lactamase-mediated resistance in Escherichia coli: report from the SENTRY Antimicrobial Surveillance Program (North America, 2004)

2006 • 47 citations

Potential role of aerosolized amphotericin B formulations in the prevention and adjunctive treatment of invasive fungal infections

2006 • 46 citations

An immunogenicity study of a newly fusion protein Cna-FnBP vaccinated against Staphylococcus aureus infections in a mice model

2006 • 46 citations

The challenge of anticipating catheter tip colonization in major heart surgery patients in the intensive care unit: Are surface cultures useful?

2005 • 46 citations

Abdominal lymph flow in an endotoxin sepsis model: Influence of spontaneous breathing and mechanical ventilation*

2006 • 46 citations

Potential role of Clostridium difficile as a cause of duodenitis-proximal jejunitis in horses

2006 • 46 citations

Pathogenesis of staphylococcal device-related infections: from basic science to new diagnostic, therapeutic and prophylactic approaches

2006 • 46 citations

Toll like receptors and acute allograft rejection

2006 • 45 citations

Functional Comparison of T Cells Recognizing Cytomegalovirus pp65 and Intermediate‐Early Antigen Polypeptides in Hematopoietic Stem‐Cell Transplant and Solid Organ Transplant Recipients

2006 • 45 citations

Epidemiology, clinical and laboratory characteristics of Staphylococcus aureus bacteraemia in a university hospital in UK

2006 • 45 citations

Bac 32, a Novel Bacteriocin Widely Disseminated among Clinical Isolates of Enterococcus faecium

2006 • 45 citations

Total Hydroperoxide and Biological Antioxidant Potentials in a Neonatal Sepsis Model

2006 • 45 citations

The Role of TCR Engagement and Activation-Induced Cell Death in Sepsis-Induced T Cell Apoptosis

2006 • 45 citations

Genes homologous to glycopeptide resistancevanA are widespread in soil microbial communities

2006 • 44 citations

A prospective cross‐sectional study of BK virus infection in non‐renal solid organ transplant recipients with chronic renal dysfunction

2006 • 44 citations

First Detection of the Ambler Class C 1 AmpC β-Lactamase in Citrobacter freundii by a New, Simple Double-Disk Synergy Test

2006 • 44 citations

Progress in cytomegalovirus vaccine development.

2005 • 44 citations

A novel ceftazidime-hydrolysing extended-spectrum -lactamase, CTX-M-54, with a single amino acid substitution at position 167 in the omega loop

2006 • 43 citations

Attenuation of capillary leakage by hydroxyethyl starch (130/0.42) in a porcine model of septic shock

2006 • 43 citations

Cytomegalovirus infection in renal transplant recipients

2006 • 43 citations

Hepatic growth hormone resistance during sepsis is associated with increased suppressors of cytokine signaling expression and impaired growth hormone signaling

2006 • 43 citations

Efficacy of environmental measures to decrease the risk of hospital-acquired aspergillosis in patients hospitalised in haematology wards

2006 • 43 citations

Fungal osteoarticular infections in patients treated at a comprehensive cancer centre: a 10-year retrospective review

2006 • 43 citations

Should We Inhibit Type I Interferons in Sepsis?

2006 • 43 citations

The Conjugative Transposon Tn 5397 Has a Strong Preference for Integration into Its Clostridium difficile Target Site

2006 • 42 citations

The effectiveness of a nurse-initiated intervention to reduce catheter-associated bloodstream infections in an urban acute hospital: An intervention study with before and after comparison

2006 • 42 citations

Changing trends in etiology of bacteremia in patients with cancer

2006 • 42 citations

Development and clinical validation of a molecular diagnostic assay to detect CTX-M-type β-lactamases in Enterobacteriaceae

2006 • 42 citations

Lysozyme-Modified Probiotic Components Protect Rats against Polymicrobial Sepsis: Role of Macrophages and Cathelicidin-Related Innate Immunity

2006 • 42 citations

Human Cytomegalovirus Subverts the Functions of Monocytes, Impairing Chemokine-Mediated Migration and Leukocyte Recruitment

2006 • 42 citations

Rapid Staphylococcus aureus agr Type Determination by a Novel Multiplex Real-Time Quantitative PCR Assay

2006 • 42 citations

Neutrallzing Antibody Responses to Reinfecting Strains of Cytomegalovirus in Transplant Recipients

1989 • 41 citations

Five cases of bacterial endocarditis after furunculosis and the ongoing saga of community-acquired methicillin-resistant Staphylococcus aureus infections

2006 • 41 citations

In vitro antimicrobial activity of the novel polymeric guanidine Akacid plus

2006 • 41 citations

Use of BBL CHROMagar MRSA Medium for Identification of Methicillin-Resistant Staphylococcus aureus Directly from Blood Cultures

2006 • 41 citations

A Prospective, Randomized Multicenter Trial of the Empirical Addition of Antifungal Therapy for Febrile Neutropenic Cancer Patients: Results of the Paul Ehrlich Society for Chemotherapy (PEG) Multicenter Trial II

2006 • 41 citations

Acceleratedin vitrodifferentiation of blood monocytes into dendritic cells in human sepsis

2007 • 40 citations

Heterogeneity and prediction of hemodynamic responses to dobutamine in patients with septic shock

2006 • 40 citations

What is healthcare-associated pneumonia, and how should it be treated?

2006 • 40 citations

Divergent Signaling Pathways in Phagocytic Cells during Sepsis

2006 • 40 citations

What’s new in pediatric intensive care

2006 • 39 citations

Using Interrupted Time Series Analysis To Assess Associations of Fluoroquinolone Formulary Changes with Susceptibility of Gram-Negative Pathogens and Isolation Rates of Methicillin-Resistant Staphylococcus aureus

2006 • 39 citations

Cytomegalovirus infection after autologous stem cell transplantation: incidence and outcome in a group of patients undergoing a surveillance program

2005 • 39 citations

Attenuation and Persistence of and Ability To Induce Protective Immunity to a Staphylococcus aureus aroA Mutant in Mice

2006 • 39 citations

Molecular investigation of an outbreak of multidrug-resistant Acinetobacter baumannii, with characterisation of class 1 integrons

2006 • 39 citations

Evaluation of three rapid assays for detection of Clostridium difficile toxin A and toxin B in stool specimens

2007 • 39 citations

AN OUTBREAK OF NEW, NONMULTIDRUG-RESISTANT, METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS STRAIN (SCCMEC TYPE IIIA VARIANT-1) IN THE NEONATAL INTENSIVE CARE UNIT TRANSMITTED BY A STAFF MEMBER

2006 • 38 citations

Infections following major heart surgery in European intensive care units: there is room for improvement (ESGNI 007 Study)

2006 • 38 citations

Redox Mechanisms of Vascular Cell Dysfunction in Sepsis

2006 • 38 citations

Clinical relevance of quantitative varicella-zoster virus (VZV) DNA detection in plasma after stem cell transplantation

2006 • 38 citations

Diminished Macrophage Inflammatory Response to Staphylococcus aureus Isolates Exposed to Daptomycin versus Vancomycin or Oxacillin

2006 • 38 citations

Life-Threatening Sepsis Caused by Burkholderia cepacia From Contaminated Intravenous Flush Solutions Prepared by a Compounding Pharmacy in Another State

2006 • 37 citations

Rejection rates in a randomised trial of tacrolimus monotherapy versus triple therapy in liver transplant recipients with hepatitis C virus cirrhosis

2006 • 37 citations

Hospital-Acquired Bordetella bronchiseptica Infection following Hematopoietic Stem Cell Transplantation

2006 • 37 citations

NOSOCOMIAL OUTBREAK OF EXTENDED-SPECTRUM β-LACTAMASE-PRODUCING SALMONELLA ISANGI IN PEDIATRIC WARDS

2006 • 37 citations

Quantitation of cytomegalovirus infection-associated histologic findings in endomyocardial biopsies of heart allografts.

1993 • 37 citations

Evaluation of MRSA Select, a new chromogenic medium for the detection of nasal carriage of methicillin-resistant Staphylococcus aureus

2006 • 37 citations

Assessment of ica operon carriage and biofilm production in Staphylococcus epidermidis isolates causing bacteraemia in bone marrow transplant recipients

2006 • 36 citations

CYTOMEGALOVIRUS PP65 ANTIGEN-GUIDED PREEMPTIVE THERAPY WITH GANCICLOVIR IN SOLID ORGAN TRANSPLANT RECIPIENTS: A PROSPECTIVE, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY

2001 • 36 citations

Preemptive oral ganciclovir therapy versus prophylaxis to prevent symptomatic cytomegalovirus infection after kidney transplantation

2001 • 36 citations

INCIDENCE AND PREDICTORS OF CYTOMEGALOVIRUS PNEUMONIA IN ORTHOTOPIC LIVER TRANSPLANT RECIPIENTS1

1996 • 36 citations

Risk factors for Staphylococcus aureus nasal carriage in residents of three nursing homes in Germany

2006 • 36 citations

Processing of Human Cytomegalovirus UL37 Mutant Glycoproteins in the Endoplasmic Reticulum Lumen prior to Mitochondrial Importation

2006 • 36 citations

What is the rationale for hydrocortisone treatment in children with infection-related adrenal insufficiency and septic shock?

2006 • 36 citations

New variants of the tet(M) gene in Clostridium difficile clinical isolates harbouring Tn916-like elements

2006 • 36 citations

Application of Mutated Clostridium difficile Toxin A for Determination of Glucosyltransferase-Dependent Effects

2006 • 36 citations

Detection of Ganciclovir Resistance in Patients with AIDS and Cytomegalovirus Retinitis: Correlation of Genotypic Methods with Viral Phenotype and Clinical Outcome

2006 • 36 citations

CMV-Specific CD8+T-Cell Dynamics in the Blood and the Lung Allograft Reflect Viral Reactivation Following Lung Transplantation

2006 • 36 citations

Acute esophageal necrosis (black esophagus) in the renal transplant recipient: manifestation of primary cytomegalovirus infection

2007 • 36 citations

Toxin Gene Content of the Lyon Methicillin-Resistant Staphylococcus aureus Clone Compared with That of Other Pandemic Clones

2006 • 35 citations

Emergence and prevalence of β-lactamase-producing Klebsiella pneumoniae resistant to cephems in Japan☆

2006 • 35 citations

Treatment of Cytomegalovirus Infection or Disease in Solid Organ Transplant Recipients With Valganciclovir

2005 • 35 citations

Epidemiologic surveillance of Clostridium difficile diarrhea in a freestanding pediatric hospital and a pediatric hospital at a university medical center

2006 • 35 citations

Long‐term remission of recurrent parvovirus‐B associated anemia in a renal transplant recipient induced by treatment with immunoglobulin and positive seroconversion

2005 • 35 citations

Knowledge about sepsis among training-grade doctors

2006 • 35 citations

Late cytomegalovirus disease following liver transplantation

2002 • 35 citations

Experimental Confirmation of Global Murine Cytomegalovirus Open Reading Frames by Transcriptional Detection and Partial Characterization of Newly Described Gene Products

2006 • 34 citations

Prevalence of erm genes encoding macrolide-lincosamide-streptogramin (MLS) resistance among clinical isolates of Staphylococcus aureus in a Turkish university hospital

2006 • 34 citations

Characterization and immunological analysis of the rhesus cytomegalovirus homologue (Rh112) of the human cytomegalovirus UL83 lower matrix phosphoprotein (pp65)

2006 • 34 citations

EARLY ONSET MORGANELLA MORGANII SEPSIS IN A NEWBORN INFANT WITH EMERGENCE OF CEPHALOSPORIN RESISTANCE CAUSED BY DEREPRESSION OF AMPC ??-LACTAMASE PRODUCTION

2006 • 34 citations

Antimicrobial activity of cefepime tested against ceftazidime-resistant Gram-negative clinical strains from North American Hospitals: report from the SENTRY Antimicrobial Surveillance Program (1998–2004)

2006 • 34 citations

Hypertonic saline enhances host defense to bacterial challenge by augmenting Toll-like receptors*

2006 • 34 citations

Integrons Containing the VIM-2 Metallo-β-Lactamase Gene among Imipenem-Resistant Pseudomonas aeruginosa Strains from Different Chinese Hospitals

2006 • 34 citations

The role of procalcitonin in a decision tree for prediction of bloodstream infection in febrile patients

2006 • 33 citations

Role of CMV in transplant coronary artery disease and survival after heart transplantation.

1999 • 33 citations

Quantitative PCR in the diagnosis of CMV infection and in the monitoring of viral load during the antiviral treatment in renal transplant patients

2005 • 33 citations

Necrotizing Gastritis due to Bacillus cereus in an Immunocompromised Patient

2006 • 33 citations

The possible significance of Clostridium spp. in blood cultures

2006 • 33 citations

The source of cytomegalovirus infection in seropositive renal allograft recipients is frequently the donor kidney.

1987 • 33 citations

Determinants of protracted cytomegalovirus infection in solid-organ transplant patients1

2002 • 32 citations

Exploring the bidirectional interactions between human cytomegalovirus and hepatitis C virus replication after liver transplantation

2006 • 32 citations

Plasma antithrombin III and protein C levels in early recognition of late-onset sepsis in newborns

2006 • 32 citations

Current antimicrobial resistance profiles among methicillin-resistant Staphylococcus aureus encountered in the outpatient setting

2006 • 32 citations

Empiric guidelines for treatment of Candida infection in high-risk neonates

2006 • 32 citations

Preemptive treatment approach to cytomegalovirus (CMV) infection in solid organ transplant patients: relationship between compliance with the guidelines and prevention of CMV morbidity

2000 • 32 citations

First national surveillance of susceptibility of extended-spectrum β-lactamase–producing Escherichia coli and Klebsiella spp. to antimicrobials in Israel

2007 • 32 citations

Combination therapy with daptomycin, vancomycin, and rifampin for recurrent, severe bone and prosthetic joint infections involving methicillin-resistant Staphylococcus aureus

2006 • 32 citations

Complex Genetic Structures with Repeated Elements, a sul -Type Class 1 Integron, and the bla _VEB Extended-Spectrum β-Lactamase Gene

2006 • 32 citations

Guidelines for severe infections: are they useful?

2006 • 31 citations

Evidence that Clostridium difficile TcdC Is a Membrane-Associated Protein

2006 • 31 citations

Markers of acute inflammation in assessing and managing lower respiratory tract infections: focus on procalcitonin

2006 • 31 citations

Effects of oxacillin and tetracycline on autolysis, autolysin processing and atl transcription in Staphylococcus aureus

2006 • 31 citations

Confounding: Propensity score adjustment

2006 • 31 citations

A Quantitative Trait Loci Analysis to Map Genes Involved in Lipopolysaccharide-Induced Inflammatory Response: Identification of Macrophage Scavenger Receptor 1 as a Candidate Gene

2006 • 31 citations

Prognostic Value of Low Blood Glucose at the Presentation of E. coli Bacteremia

2006 • 31 citations

Molecular epidemiology of urinary tract isolates of vancomycin-resistant Enterococcus faecium from North America

2006 • 31 citations

Propagation of methicillin-resistant Staphylococcus aureus due to the overloading of medical nurses in intensive care units

2006 • 31 citations

In vitro susceptibility of Gram-positive pathogens to linezolid and teicoplanin and effect on outcome in critically ill patients

2006 • 31 citations

Hepatitis C–Associated Granulomas After Liver Transplantation

2007 • 31 citations

Are antiseptic-coated central venous catheters effective in a real-world setting?

2006 • 31 citations

Characterisation and molecular epidemiology of extended-spectrum β-lactamase-producing Enterobacter cloacae isolated from a district teaching hospital in Taiwan

2006 • 31 citations

Occurrence of the Enterotoxin Gene Cluster and the Toxic Shock Syndrome Toxin 1 Gene among Clinical Isolates of Methicillin-Resistant Staphylococcus aureus Is Related to Clonal Type and agr Group

2006 • 31 citations

Successful Organ Transplantation from Donors with Acinetobacter Baumannii Septic Shock

2006 • 31 citations

Down-modulation of granulocyte macrophage-colony stimulating factor receptor on monocytes during human septic shock

2006 • 31 citations

Factors influencing the intracellular activity of fluoroquinolones: a study using levofloxacin in a Staphylococcus aureus THP-1 monocyte model

2006 • 31 citations

An intact sequence-specific DNA-binding domain is required for human cytomegalovirus-mediated sequestration of p53 and may promote in vivo binding to the viral genome during infection

2006 • 30 citations

Central Venous Catheter Infection with Brevibacterium sp. in an Immunocompetent Woman: Case Report and Review of the Literature

2006 • 30 citations

Evidence that the Human Cytomegalovirus IE2-86 Protein Binds mdm2 and Facilitates mdm2 Degradation

2006 • 30 citations

Activity of imipenem against VIM-1 metallo-β-lactamase-producing Klebsiella pneumoniae in the murine thigh infection model

2006 • 30 citations

Necrotizing Fasciitis Due to a Methicillin-Sensitive Staphylococcus aureus Isolate Harboring an Enterotoxin Gene Cluster

2006 • 30 citations

Detection of clonally related vanB2-containing Enterococcus faecium strains in two Spanish hospitals

2006 • 30 citations

In vivo selection of Enterobacter aerogenes with reduced susceptibility to cefepime and carbapenems associated with decreased expression of a 40kDa outer membrane protein and hyperproduction of AmpC β-lactamase

2006 • 30 citations

Frequent Occult Infection with Cytomegalovirus in Cardiac Transplant Recipients despite Antiviral Prophylaxis

2007 • 30 citations

Is there evidence for recommending needleless closed catheter access systems in guidelines? A systematic review of randomized controlled trials

2006 • 30 citations

Molecular characterization of methicillin-resistant Staphylococcus aureus isolated in Tunisia

2006 • 29 citations

Sedimentation characteristics of leucocytes can predict bacteraemia in critical care patients

2006 • 29 citations

Cellulitis as a manifestation of miliary tuberculosis in a renal transplant recipient

2005 • 29 citations

Multidrug-resistant bacteria isolated from patients hospitalised in Intensive Care Units

2006 • 29 citations

EFFECTS OF COMBINING INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITOR AND RADICAL SCAVENGER DURING PORCINE BACTEREMIA

2006 • 29 citations

Identification of Antigenic Components of Staphylococcus epidermidis Expressed during Human Infection

2006 • 29 citations

Overexpression of Suppressor of Cytokine Signaling-5 in T Cells Augments Innate Immunity during Septic Peritonitis

2006 • 29 citations

Rapid quantification of naive alloreactive T cells by TNF-α production and correlation with allograft rejection in mice

2006 • 29 citations

The rationale of combination antifungal therapy in severely immunocompromised patients: empiricism versus evidence-based medicine

2006 • 29 citations

Autolytic Properties of Glycopeptide-Intermediate Staphylococcus aureus Mu50

2006 • 28 citations

Elevated procalcitonin as a diagnostic marker in meningococcal disease

2006 • 28 citations

Evaluation of clonality in enterococci isolated in Brazil carrying Tn1546-like elements associated with vanA plasmids

2006 • 28 citations

Treatment of implant-associated infections with moxifloxacin: an animal study

2006 • 28 citations

Beneficial Effects of Ethyl Pyruvate in Septic Shock From Peritonitis

2007 • 28 citations

In vitro susceptibilities of aerobic and facultative Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia–Pacific region: 2004 results from SMART (Study for Monitoring Antimicrobial Resistance Trends)

2006 • 28 citations

A 24-Hour Screening Protocol for Identification of Vancomycin-Resistant Enterococcus faecium

2006 • 28 citations

Acute portal and mesenteric thrombosis: unusual presentation of cytomegalovirus infection

2006 • 27 citations

Identification of Two New HLA-A*1101-Restricted Tax Epitopes Recognized by Cytotoxic T Lymphocytes in an Adult T-Cell Leukemia Patient after Hematopoietic Stem Cell Transplantation

2005 • 27 citations

Multifocal spinal and extra‐spinal Mycobacterium chelonae osteomyelitis in a renal transplant recipient

2007 • 27 citations

Diagnostic significance and clinical impact of quantitative assays for diagnosis of human cytomegalovirus infection/disease in immunocompromised patients.

1998 • 27 citations

Clinical significance of Staphylococcus saprophyticus identified on blood culture in a tertiary care hospital

2006 • 26 citations

Contributions of sigB and sarA to distinct multiple antimicrobial resistance mechanisms of Staphylococcus aureus

2006 • 26 citations

POLY(ADP-RIBOSE) SYNTHETASE INHIBITION REDUCES BACTERIAL TRANSLOCATION IN RATS AFTER ENDOTOXIN CHALLENGE

2001 • 26 citations

Use of cefepime for the treatment of infections caused by extended spectrum β-lactamase–producing Klebsiella pneumoniae and Escherichia coli

2006 • 26 citations

A Holistic Approach to MRSA Eradication in Critically Ill Patients with MRSA Pneumonia

2006 • 25 citations

Selection of resistance during sequential use of preferential antibiotic classes

2005 • 25 citations

Modulation of endothelial monolayer permeability induced by plasma obtained from lipopolysaccharide-stimulated whole blood

2006 • 25 citations

Pharmacokinetics of ganciclovir in haematopoietic stem cell transplantation recipients with or without renal impairment

2006 • 25 citations

Microscopic, cultural and molecular evidence of disseminated invasive aspergillosis involving the lungs and the gastrointestinal tract

2006 • 25 citations

Activation of peroxisome proliferator-activated receptor-α by fenofibrate prevents myocardial dysfunction during endotoxemia in rats*

2007 • 25 citations

Comparison of quantitative competitive polymerase chain reaction–enzyme-linked immunosorbent assay with LightCycler-based polymerase chain reaction for measuring cytomegalovirus DNA in patients after hematopoietic stem cell transplantation

2006 • 25 citations

Lymphoma Cell Apoptosis in the Liver Induced by Distant Murine Cytomegalovirus Infection

2006 • 25 citations

Expression and function of Toll-like receptor 9 in severely injured patients prone to sepsis

2006 • 25 citations

Is lumbar puncture necessary for evaluation of early neonatal sepsis?

2006 • 25 citations

THE ROLE OF POLY(ADP-RIBOSE) SYNTHETASE INHIBITION IN PREVENTING ENDOTOXEMIA-INDUCED INTESTINAL EPITHELIAL APOPTOSIS

2002 • 24 citations

Localization of the C3-Like ADP-Ribosyltransferase from Staphylococcus aureus during Bacterial Invasion of Mammalian Cells

2006 • 24 citations

Enhanced (cytomegalovirus) viral replication after transplantation for fulminant hepatic failure

1997 • 24 citations

Sepsis-induced lung injury in rats increases alveolar epithelial vulnerability to stretch*

2006 • 24 citations

Up-regulation of functional CXCR4 expression on human lymphocytes in sepsis

2006 • 24 citations

The Role of Early Colonoscopy in CMV Colitis of Transplant Recipients

2005 • 24 citations

Does cytomegalovirus status influence acute and chronic rejection in heart transplantation during the ganciclovir prophylaxis era?

2003 • 24 citations

Epidemic Clostridium difficile

2006 • 24 citations

Dobutamine does not influence inflammatory pathways during human endotoxemia*

2006 • 23 citations

Late cytomegalovirus infection after oral ganciclovir prophylaxis in renal transplant recipients

2004 • 23 citations

Induction of polymorphonuclear leukocyte response by human cytomegalovirus

2006 • 23 citations

Control of a methicillin-resistant Staphylococcus aureus (MRSA) outbreak in a day-care institution

2006 • 23 citations

Guillain–Barré syndrome associated with cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation

2005 • 23 citations

First isolation of vancomycin-resistant enteroccoci and spread of a single clone in a university hospital in northwestern Turkey

2007 • 23 citations

Impact of Double-Filtration Plasmapheresis in Combination with Interferon and Ribavirin in Living Donor Liver Transplant Recipients with Hepatitis C

2006 • 23 citations

Pharmacodynamic profiling of imipenem, meropenem and ertapenem against clinical isolates of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella spp. from Brazil

2006 • 23 citations

The yjeQ Gene Is Required for Virulence of Staphylococcus aureus

2006 • 23 citations

Glucose-Insulin and Potassium Infusions in Septic Shock

2006 • 23 citations

Comparative proteomic analysis between the invasive and commensal strains ofStaphylococcus epidermidis

2006 • 22 citations

Candida dubliniensis bloodstream infection: a fatal case in a lung transplant recipient

2005 • 22 citations

Loss of hepatitis A virus antibodies after bone marrow transplantation

2006 • 22 citations

Multiplex PCR-ELISA for direct detection of MRSA in nasal swabs advantageous for rapid identification of non-MRSA carriers

2006 • 22 citations

Clonal occurrences of multidrug-resistant Gram-negative bacilli: report from the Meropenem Yearly Susceptibility Test Information Collection Surveillance Program in the United States (2004)

2006 • 22 citations

Assessment of converting from intravenous to oral administration of cyclosporin A in pediatric allogeneic hematopoietic stem cell transplant recipients

2006 • 22 citations

A Grading System Based on Severity of Infection to Predict Mortality in Allogeneic Stem Cell Transplant Recipients

2006 • 22 citations

Role of the factor V Leiden mutation in septic peritonitis assessed in factor V Leiden transgenic mice*

2006 • 22 citations

Methicillin-resistant Staphylococcus aureus in community-acquired meningitis

2006 • 22 citations

Multilocus Sequence Typing of Hospital-Associated Enterococcus faecium from Brazil Reveals Their Unique Evolutionary History

2006 • 22 citations

Consideration of age at admission for selective screening to identify methicillin-resistant Staphylococcus aureus carriers to control dissemination in a medical ward

2006 • 21 citations

Diagnosis of Invasive Group A Streptococcal Infections by Using Immunohistochemical and Molecular Assays

2006 • 21 citations

Aspergillus infection limited to renal allograft: case report and review of literature

2006 • 21 citations

Posaconazole vs Standard Azole (FLU/ITRA) Therapy for Prophylaxis of Invasive Fungal Infections (IFIs) among High-Risk Neutropenic Patients: Results of a Randomized, Multicenter Trial.

2005 • 21 citations

Prospective Study of the Value of Quantitative Culture of Organisms from Blood Collected through Central Venous Catheters in Differentiating between Contamination and Bloodstream Infection

2006 • 20 citations

Reduced dose of foscarnet as preemptive therapy for cytomegalovirus infection following reduced‐intensity cord blood transplantation

2007 • 20 citations

Occurrence of a novel SHV-type enzyme (SHV-55) among isolates of Klebsiella pneumoniae from Portuguese origin in a comparison study for extended-spectrum β-lactamase–producing evaluation

2006 • 20 citations

Simian Parvovirus Infection in Cynomolgus Monkey Heart Transplant Recipients Causes Death Related to Severe Anemia

2006 • 20 citations

Immunomodulatory Effects of Combination of Pooled Human Gammaglobulin and Rapamycin on Cell Proliferation and Apoptosis in the Mixed Lymphocyte Reaction

2004 • 20 citations

First Report of Septicemia Caused by an Obligately Anaerobic Staphylococcus aureus Infection in a Human

2006 • 20 citations

Immunotherapy with Tacrolimus (FK506) Does Not Select for Resistance to Calcineurin Inhibitors inCandida albicansIsolates from Liver Transplant Patients

2006 • 20 citations

Current treatment of severe sepsis

2006 • 20 citations

An open study of the comparative efficacy and safety of caspofungin and liposomal amphotericin B in treating invasive fungal infections or febrile neutropenia in patients with haematological malignancy

2006 • 20 citations

Phenotypic and genetic characterization of vancomycin-resistant enterococci from hospitalized humans and from poultry in Korea

2006 • 20 citations

First Case Report of Neisseria lactamica Causing Cavitary Lung Disease in an Adult Organ Transplant Recipient

2006 • 19 citations

Activity of tigecycline against clinical isolates of Staphylococcus aureus and extended-spectrum β-lactamase-producing Escherichia coli in Granada, Spain

2006 • 19 citations

Cutaneous mucormycosis in an immunocompromised patient

2006 • 19 citations

Cellular and Molecular Requirements for Association of the Murine Cytomegalovirus Protein m4/gp34 with Major Histocompatibility Complex Class I Molecules

2006 • 19 citations

Staphylococcus aureus Decolonization

2005 • 19 citations

Evaluation of the COBAS Amplicor HCMV Monitor for early detection and monitoring of human cytomegalovirus infection after allogeneic stem cell transplantation

2006 • 19 citations

The expression of p16INK4a tumor suppressor is upregulated by human cytomegalovirus infection and required for optimal viral replication

2006 • 19 citations

Comparative in vitro activity of ertapenem against extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolated in Spain

2006 • 19 citations

Treatment of infections caused by metallo-β-lactamase-producing Pseudomonas aeruginosa in the Calgary Health Region

2006 • 19 citations

Comparing cytomegalovirus prophylaxis in renal transplantation: single center experience

2005 • 19 citations

Active Epstein–Barr virus infection after allogeneic stem cell transplantation: re‐infection or reactivation?

2005 • 19 citations

Staphylococcus aureus epidemic in a neonatal nursery: a strategy of infection control

2006 • 19 citations

Streptococcus agalactiae sepsis after transfusion of a plateletpheresis concentrate: benefit of donor evaluation

2006 • 18 citations

Peritonitis due to Lactococcus lactis in a CAPD patient

2006 • 18 citations

Systemic inflammatory response syndrome in adult patients with nosocomial bloodstream infection due to Pseudomonas aeruginosa

2005 • 18 citations

Caspofungin: an advanced treatment approach for suspected or confirmed invasive aspergillosis

2006 • 18 citations

Treatment of verruca vulgaris with topical cidofovir in an immunocompromised patient: a case report and review of the literature

2005 • 18 citations

Frequency and predictors of colonization of the respiratory tract by VIM-2-producing Pseudomonas aeruginosa in patients of a newly established intensive care unit

2006 • 18 citations

Reliability of semiquantitative determination of procalcitonin serum concentrations in neonates

2006 • 18 citations

Multidimensional Volumetric Imaging of Pulmonary Infiltrates for Measuring Therapeutic Response to Antifungal Therapy in Experimental Invasive Pulmonary Aspergillosis

2006 • 18 citations

Comparison of four methods for detection of teicoplanin resistance in methicillin-resistant Staphylococcus aureus

2006 • 17 citations

Antimicrobial susceptibility of non-enterococcal intrinsic glycopeptide-resistant Gram-positive organisms

2006 • 17 citations

Restricted use of glycopeptides in paediatric cancer patients with fever and neutropenia

2006 • 17 citations

Prevalence of extended-spectrum β-lactamase-positive Klebsiella pneumoniae isolates in the Czech Republic

2006 • 17 citations

Leptotrichia buccalis: A rare cause of bacteraemia in non-neutropenic patients

2006 • 17 citations

Granulomatous amebic encephalitis in a multivisceral transplant recipient

2006 • 17 citations

Community associated MRSA: an alert to paediatricians

2006 • 17 citations

Oxidation of Intravenous Lipid in Infants and Children With Systemic Inflammatory Response Syndrome and Sepsis

2007 • 17 citations

Kinetics of US28 Gene Expression during Active Human Cytomegalovirus Infection in Lung‐Transplant Recipients

2006 • 17 citations

The emergence of cytomegalovirus resistance to ganciclovir therapy in kidney transplant recipients

2006 • 17 citations

A Short Isoform of Human Cytomegalovirus US3 Functions as a Dominant Negative Inhibitor of the Full-Length Form

2006 • 17 citations

Blood interleukin 12 as preoperative predictor of fatal postoperative sepsis after neoadjuvant radiochemotherapy

2006 • 16 citations

Comparative analysis of a double primer PCR assay with plasma, leukocytes and antigenemia for diagnosis of active human cytomegalovirus infection in bone marrow transplant patients

2005 • 16 citations

The use of antibiotic-containing agars for the isolation of extended-spectrum β-lactamase-producing organisms in intensive care units

2007 • 16 citations

DISSEMINATED BLASTOMYCOSIS IN AN INFANT

2006 • 16 citations

Human cytomegalovirus infection modulates DNA base excision repair in fibroblast cells

2006 • 16 citations

Inhaled nitric oxide therapy for sepsis: More than just lung*

2006 • 15 citations

Clonal spread of both oxyimino-cephalosporin- and cefoxitin-resistant Klebsiella pneumoniae isolates co-producing SHV-2a and DHA-1 β-lactamase at a burns intensive care unit

2006 • 15 citations

Genetic variation within the glycoprotein B and H genes of human cytomegalovirus in solid organ transplant recipients

2007 • 14 citations

Value of circulating adhesion molecules in assessing cardiac allograft vasculopathy

2003 • 14 citations

Enteral tube hub as a reservoir for transmissible enteric bacteria

2006 • 14 citations

Pyrosequencing for rapid identification of carbapenem-hydrolysing OXA-type β-lactamases in Acinetobacter baumannii

2006 • 14 citations

Is industry guiding the sepsis guidelines? A perspective

2007 • 14 citations

Cytomegalovirus infection in lung transplant patients: The role of prophylaxis and recipient-donor serotype matching

2006 • 14 citations

Risk-factors for gastrointestinal colonisation with resistant Enterobacteriaceae among hospitalised patients: a prospective study

2006 • 14 citations

Osborn Waves in Sepsis

2006 • 14 citations

Multihospital surveillance of nosocomial methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococcus, and Clostridium difficile: Analysis of a 4-year data-sharing project, 1999-2002

2006 • 14 citations

Evaluation of a new chromogenic medium for isolation and presumptive identification of methicillin-resistant Staphylococcus aureus from human clinical specimens

2006 • 14 citations

First report of a linezolid- and vancomycin-resistant Enterococcus faecium strain in Korea

2005 • 13 citations

Laboratory-acquired meticillin-resistant Staphylococcus aureus (MRSA) in two microbiology laboratory technicians

2006 • 12 citations

Application of Minimal Sequence Quality Values Prevents Misidentification of the bla _SHV Type in Single Bacterial Isolates Carrying Different SHV Extended-Spectrum β-Lactamase Genes

2006 • 12 citations

Coeliac crisis presenting with cytomegalovirus hepatitis

2006 • 12 citations

Modulation of inflammatory activation pathways in the Lewis-to-F-344 rat chronic cardiac rejection model.

1995 • 12 citations

Identification of biochemically atypical Staphylococcus aureus clinical isolates with three automated identification systems

2006 • 12 citations

Two cases of parotid gland infection with bacteraemia due to meticillin-resistant Staphylococcus aureus

2006 • 11 citations

Blinded Comparison of Repetitive-Sequence PCR and Multilocus Sequence Typing for Genotyping Methicillin-Resistant Staphylococcus aureus Isolates from a Children's Hospital in St. Louis, Missouri

2006 • 11 citations

The Effect of Preventive Use of Alanyl-Glutamine on Diaphragm Muscle Function in Cecal Ligation and Puncture-Induced Sepsis Model

2005 • 11 citations

Relevance of Cytomegalovirus Infection and Coronary-Artery Remodeling in the First Year after Heart Transplantation: A Prospective Three-Dimensional Intravascular Ultrasound Study.

2003 • 11 citations

Human Papillomavirus Associated with Papillary Squamous Cell Carcinoma of the Oropharynx in a Renal Transplant Recipient

2006 • 11 citations

Late-onset cytomegalovirus reactivation in critically ill renal transplant patients

2003 • 11 citations

Risk factors for specific methicillin-resistant Staphylococcus aureus clones in a Korean hospital

2006 • 10 citations

Emergence of VanD-type vancomycin-resistant Enterococcus faecium in Stockholm, Sweden

2006 • 10 citations

MYCOBACTERIUM BOVIS DISEASE IN A PEDIATRIC RENAL TRANSPLANT PATIENT

2006 • 10 citations

Is combination antifungal therapy for invasive aspergillosis a necessity in hematopoietic stem-cell transplant recipients?

2006 • 10 citations

Disseminated cytomegalovirus infection associated with Pneumocystis carinii pneumonia in a previously normal infant

2006 • 10 citations

Community‐acquired methicillin‐resistant Staphylococcus aureus in bone and joint infections: development of rifampicin resistance

2006 • 10 citations

A simplified strategy for clinical management of late cytomegalovirus infection after oral ganciclovir prophylaxis in renal recipients

2005 • 9 citations

Clinico-epidemiological features of infections caused by CTX-M type extended spectrum beta lactamase-producing Escherichia coli in hospitalised patients

2006 • 9 citations

Successful treatment with allogeneic peripheral blood stem cell transplantation and granulocyte transfusion for severe aplastic anemia with sinusitis

2006 • 9 citations

Blood volume measurements using an integrated fiberoptic monitoring system in a porcine septic shock model

2006 • 8 citations

Impact of targeted oral ganciclovir prophylaxis for transplant recipients of livers from cytomegalovirus‐seropositive donors

2005 • 8 citations

A cluster of deep bacterial infections following eye surgery associated with construction dust

2006 • 7 citations

Emergence of Escherichia coli isolates producing conjugative plasmid-mediated DHA-1 β-lactamase in a Korean university hospital

2006 • 7 citations

Development of extended-spectrum activity in TEM β-lactamases in hyper-mutable, mutS Escherichia coli

2006 • 7 citations

Audit of laboratory mycology services for the management of patients with fungal infections in the northwest of England

2006 • 7 citations

Enhanced Activity of Rifalazil in Combination with Levofloxacin, Linezolid, or Mupirocin against Staphylococcus aureus In Vitro

2006 • 6 citations

Successful treatment of patients with respiratory failure due to fungal infection after allogeneic hematopoietic stem cell transplantation

2005 • 6 citations

A renal transplant recipient with pulmonary nodules

2005 • 6 citations

Clinical‐scale expansion of human cytomegalovirus–specific cytotoxic T lymphocytes from peripheral blood mononuclear cells requiring single‐peptide stimulation and feeder cells but not additional antigen‐presenting cells

2006 • 6 citations