PAR1 Is a Matrix Metalloprotease-1 Receptor that Promotes Invasion and Tumorigenesis of Breast Cancer Cells

Gene expression profiling predicts clinical outcome of breast cancer

2002 • 9,314 citations

New functions for the matrix metalloproteinases in cancer progression

2002 • 5,937 citations

Involvement of chemokine receptors in breast cancer metastasis

2001 • 5,203 citations

How Matrix Metalloproteinases Regulate Cell Behavior

2001 • 3,860 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

A multigenic program mediating breast cancer metastasis to bone

2003 • 2,539 citations

Thrombin signalling and protease-activated receptors

2000 • 2,383 citations

Systematic variation in gene expression patterns in human cancer cell lines

2000 • 2,119 citations

Matrix Metalloproteinases: Biologic Activity and Clinical Implications

2000 • 1,533 citations

Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway

2002 • 832 citations

Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa

2000 • 663 citations

Stabilization of atherosclerotic plaques: New mechanisms and clinical targets

2002 • 576 citations

Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.

1996 • 515 citations

Thrombin receptor overexpression in malignant and physiological invasion processes

1998 • 408 citations

Thrombin receptor expression in normal and atherosclerotic human arteries.

1992 • 318 citations

Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides

2002 • 305 citations

Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer

1998 • 281 citations

Vascular endothelial groth factor induces tissue factor and matrix metalloproteinase production in endothelial cells: Conversion of prothrombin to thrombin results in progelatininase a activation and cell proliferation

1998 • 274 citations

Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation

2002 • 267 citations

A Role for Thrombin Receptor Signaling in Endothelial Cells During Embryonic Development

2001 • 262 citations

On the Mechanism of Thrombin-induced Angiogenesis

1999 • 222 citations

Chemokines induce migrational responses in human breast carcinoma cell lines

1997 • 222 citations

Plasmin Desensitization of the PAR1 Thrombin Receptor: Kinetics, Sites of Truncation, and Implications for Thrombolytic Therapy

1999 • 218 citations

Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo.

1992 • 201 citations

Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode.

1994 • 188 citations

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

1999 • 187 citations

Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1

2001 • 185 citations

Protease-Activated Receptor 1 (PAR-1) Is Required and Rate-Limiting for Thrombin-Enhanced Experimental Pulmonary Metastasis

1998 • 181 citations

Expression Cloning of Oncogenes by Retroviral Transfer of cDNA Libraries

1995 • 178 citations

Protease-Activated Receptor 1 (PAR-1) Is Required and Rate-Limiting for Thrombin-Enhanced Experimental Pulmonary Metastasis

1998 • 160 citations

Development of Potent Thrombin Receptor Antagonist Peptides

1996 • 142 citations

Tumor Cell Invasion Is Promoted by Activation of Protease Activated Receptor-1 in Cooperation with the αvβ5 Integrin

2001 • 137 citations

Signaling from protease-activated receptor-1 inhibits migration and invasion of breast cancer cells.

2001 • 132 citations

Concentration-dependent dual effect of thrombin on impaired growth/apoptosis or mitogenesis in tumor cells

2000 • 116 citations

Concentration-dependent dual effect of thrombin on impaired growth/apoptosis or mitogenesis in tumor cells

2000 • 114 citations

Oncogenic transformation induces tumor angiogenesis: a role for PAR1 activation

2003 • 113 citations

The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways

2001 • 111 citations

Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant melanoma cells.

1995 • 103 citations

Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage

2003 • 97 citations

Thrombin induces neoangiogenesis in the chick chorioallantoic membrane

2003 • 85 citations

Inhibition of Matrix Metalloproteinases by Peptidyl Hydroxamic Acids

1994 • 71 citations

Structural Basis for Thrombin Activation of a Protease-Activated Receptor

2003 • 66 citations

The pattern of expression of protease‐activated receptors (PARs) during early trophoblast development

2003 • 49 citations

Expression of Thrombin Receptors in Human Atherosclerotic Coronary Arteries Leads to an Exaggerated Vasoconstrictory Response In Vitro

1997 • 48 citations

A third‐generation matrix metalloproteinase (MMP) inhibitor (ONO‐4817) combined with docetaxel suppresses progression of lung micrometastasis of MMP‐expressing tumor cells in nude mice

2002 • 34 citations