Mini‐review: Transendothelial migration of leukocytes: through the front door or around the side of the house?

The route of re-circulation of lymphocytes in the rat

1964 • 1,449 citations

PECAM-1 is required for transendothelial migration of leukocytes.

1993 • 1,134 citations

Endothelial cell–cell junctions: happy together

2004 • 1,123 citations

Leukocyte–endothelial-cell interactions in leukocyte transmigration and the inflammatory response

2003 • 798 citations

Lymphocyte Trafficking and Regional Immunity

1999 • 686 citations

Vascular endothelial–cadherin is an important determinant of microvascular integrityinvivo

1999 • 659 citations

JAM-1 is a ligand of the β2 integrin LFA-1 involved in transendothelial migration of leukocytes

2002 • 636 citations

Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes

2002 • 581 citations

The migration of lymphocytes through the endothelium of venules in lymph nodes: an electron microscope study

1964 • 503 citations

CD99 plays a major role in the migration of monocytes through endothelial junctions

2002 • 497 citations

Tight junctions of the blood-brain barrier.

2000 • 490 citations

Junctional adhesion molecules (JAMs): more molecules with dual functions?

2003 • 483 citations

Involvement of Platelet-Endothelial Cell Adhesion Molecule-1 in Neutrophil Recruitment in Vivo

1993 • 468 citations

Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme

2003 • 431 citations

Genetic Evidence for Functional Redundancy of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1): CD31-Deficient Mice Reveal PECAM-1-Dependent and PECAM-1-Independent Functions

1999 • 430 citations

Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages.

1996 • 423 citations

Neutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP

1998 • 415 citations

Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes.

1991 • 388 citations

ELECTRON MICROGRAPHIC OBSERVATIONS ON THE EMIGRATION OF LEUCOCYTES

1960 • 388 citations

α4-integrin-VCAM-1 binding mediates G protein–independent capture of encephalitogenic T cell blasts to CNS white matter microvessels

2001 • 330 citations

Biological Interaction Between Lymphocytes and. Other Cells

1956 • 317 citations

VE-cadherin antibody accelerates neutrophil recruitment in vivo

1997 • 314 citations

Lymphocyte Migration Through Brain Endothelial Cell Monolayers Involves Signaling Through Endothelial ICAM-1 Via a Rho-Dependent Pathway

1999 • 299 citations

Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability

2001 • 293 citations

Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1–deficient mice

2002 • 290 citations

Leukocyte Recruitment in the Cerebrospinal Fluid of Mice with Experimental Meningitis Is Inhibited by an Antibody to Junctional Adhesion Molecule (Jam)

1999 • 288 citations

Real-Time Imaging of Vascular Endothelial-Cadherin During Leukocyte Transmigration Across Endothelium

2001 • 287 citations

Neutrophil transendothelial migration is independent of tight junctions and occurs preferentially at tricellular corners.

1997 • 280 citations

Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1–deficient mice

2002 • 261 citations

Regulation of Cadherin Function by Rho and Rac: Modulation by Junction Maturation and Cellular Context

1999 • 257 citations

ICAM-1 Signaling Pathways Associated with Rho Activation in Microvascular Brain Endothelial Cells

1998 • 252 citations

Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells.

1994 • 241 citations

Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1.

1995 • 240 citations

Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination.

1990 • 229 citations

Observations on changes in blood vascular endothelium in the living animal

1935 • 221 citations

Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact

2004 • 210 citations

Endothelial Cells Proactively Form Microvilli-Like Membrane Projections upon Intercellular Adhesion Molecule 1 Engagement of Leukocyte LFA-1

2003 • 207 citations

An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane.

1996 • 198 citations

THE SITE OF LEUCOCYTE EMIGRATION DURING INFLAMMATION

1961 • 190 citations

Lymphocyte emigration from high endothelial venules in rat lymph nodes.

1976 • 180 citations

Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. off.

1995 • 178 citations

Involvement of ezrin/moesin in de novo actin assembly on phagosomal membranes

2000 • 175 citations

T cell interaction with ICAM-1-deficient endotheliumin vitro: essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells

1998 • 174 citations

In Vitro Adhesion and Migration of T Lymphocytes Across Monolayers of Human Brain Microvessel Endothelial Cells: Regulation by ICAM-1, VCAM-1, E-selectin and PECAM-1

1999 • 160 citations

Electron microscopy of leukocytic margination and emigration in acute inflammation in dog pancreas.

1961 • 147 citations

Intracellular Domain of Brain Endothelial Intercellular Adhesion Molecule-1 Is Essential for T Lymphocyte-Mediated Signaling and Migration

2003 • 144 citations

T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells

2003 • 143 citations

Effects of human neutrophil chemotaxis across human endothelial cell monolayers on the permeability of these monolayers to ions and macromolecules

1988 • 135 citations

Intercellular Adhesion Molecule (ICAM)-1, But Not ICAM-2, Activates RhoA and Stimulates c-fos and rhoA Transcription in Endothelial Cells

2002 • 132 citations

Leukocyte transendothelial migration: A junctional affair

2002 • 126 citations

Mouse CD99 participates in T-cell recruitment into inflamed skin

2004 • 124 citations

Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumor‐associated microvessels in man and animals

2002 • 121 citations

Leucocyte migration from small blood vessels stimulated with ultraviolet light: An electron‐microscope study

1961 • 119 citations

Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1low mice

2004 • 112 citations

Interaction of Very Late Antigen-4 with VCAM-1 Supports Transendothelial Chemotaxis of Monocytes by Facilitating Lateral Migration

1998 • 97 citations

The blood-retinal barrier in experimental autoimmune uveoretinitis. Leukocyte interactions and functional damage.

1994 • 93 citations

Antibodies to the Junctional Adhesion Molecule Cause Disruption of Endothelial Cells and Do Not Prevent Leukocyte Influx into the Meninges after Viral or Bacterial Infection

2000 • 90 citations

Sites of egress of inflammatory cells and horseradish peroxidase transport across the blood-brain barrier in a murine model of chronic relapsing experimental allergic encephalomyelitis

1989 • 84 citations

The mode of lymphocyte migration through postcapillary venule endothelium in lymph node

1975 • 83 citations

Encephalitogenic T?cells use LFA-1 for transendothelial migration but not during capture and initial adhesion strengthening in healthy spinal cord microvesselsin vivo

2002 • 79 citations

Kinetics of the Different Steps during Neutrophil Migration through Cultured Endothelial Monolayers Treated with Tumour Necrosis Factor-α

1999 • 62 citations

Interaction of T Lymphocytes with Cerebral Endothelial Cells in vitro

1991 • 50 citations

Acceleration of the onset of collagen‐induced arthritis by a deficiency of platelet endothelial cell adhesion molecule 1

2003 • 50 citations

Forging the endothelium during inflammation: pushing at a half-open door?

2003 • 45 citations

ELECTRON MICROSCOPIC OBSERVATIONS ON THE EMIGRATION OF LEUCOCYTES

1961 • 44 citations

Ultrastructural pathology of experimental autoimmune uveitis. Quantitative evidence of activation and possible high endothelial venule-like changes in retinal vascular endothelium.

1992 • 41 citations

Migration of lymphocytes through the endothelium of venules in experimental allergic neuritis

1968 • 8 citations