Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes

1998 • 765 citations

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

1992 • 743 citations

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.

1997 • 532 citations

Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia

1994 • 444 citations

Protein Kinase C-ζ as a Downstream Effector of Phosphatidylinositol 3-Kinase during Insulin Stimulation in Rat Adipocytes

1997 • 434 citations

Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

1989 • 324 citations

Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation

1993 • 306 citations

Purification and characterization of the zeta isoform of protein kinase C from bovine kidney.

1992 • 283 citations

Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus

1997 • 282 citations

Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy

1994 • 273 citations

High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures

1991 • 251 citations

Protein Kinase C-ζ Mediates Angiotensin II Activation of ERK1/2 in Vascular Smooth Muscle Cells

1997 • 220 citations

Increase in Diacylglycerol Mass in Isolated Glomeruli by Glucose From De Novo Synthesis of Glycerolipids

1990 • 219 citations

Evidence for Involvement of Protein Kinase C (PKC)-ζ and Noninvolvement of Diacylglycerol-Sensitive PKCs in Insulin-Stimulated Glucose Transport in L6 Myotubes*

1997 • 218 citations

High Glucose Concentrations Increase Endothelial Cell Permeability via Activation of Protein Kinase Cα

1997 • 206 citations

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1998 • 194 citations

Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels.

1991 • 191 citations

Role for Protein Kinase C in the Mediation of Increased Fibronectin Accumulation by Mesangial Cells Grown in High-Glucose Medium

1993 • 178 citations

Normalization of Diacylglycerol-Protein Kinase C Activation by Vitamin E in Aorta of Diabetic Rats and Cultured Rat Smooth Muscle Cells Exposed to Elevated Glucose Levels

1994 • 170 citations

Direct evidence that protein kinase C plays an essential role in the development of late preconditioning against myocardial stunning in conscious rabbits and that epsilon is the isoform involved.

1998 • 163 citations

Antisense oligonucleotides for ICAM-1 attenuate reperfusion injury and renal failure in the rat

1996 • 155 citations

Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells.

1993 • 141 citations

Experimental Diabetes Is Associated With Functional Activation of Protein Kinase Cε and Phosphorylation of Troponin I in the Heart, Which Are Prevented by Angiotensin II Receptor Blockade

1997 • 135 citations

PKC-ε Is Required for Mechano-sensitive Activation of ERK1/2 in Endothelial Cells

1997 • 122 citations

Characterization of Glucose-Induced In Situ Protein Kinase C Activity in Cultured Vascular Smooth Muscle Cells

1992 • 118 citations

Differentiation of Vascular Smooth Muscle Cells and the Regulation of Protein Kinase C-α

1995 • 112 citations

Protein kinase C translocation in intact vascular smooth muscle strips

1990 • 112 citations

Translocation of protein kinase C ? and ? in rat glomerular mesangial cells cultured under high glucose conditions

1994 • 107 citations

Protein kinase C isoforms in rat kidney proximal tubule: acute effect of angiotensin II

1995 • 99 citations

Diabetic microvascular complications and growth factors

2009 • 91 citations

Left Ventricular Stretch Stimulates Angiotensin II– Mediated Phosphatidylinositol Hydrolysis and Protein Kinase C ε Isoform Translocation in Adult Guinea Pig Hearts

1997 • 90 citations

Cross-talk between secretory phospholipase A2 and cytosolic phospholipase A2 in rat renal mesangial cells

1997 • 88 citations

Glucose-induced changes in Na+/H+ antiport activity and gene expression in cultured vascular smooth muscle cells. Role of protein kinase C.

1994 • 86 citations

Expression of the major isoenzyme of protein kinase-C in skeletal muscle, nPKC theta, varies with muscle type and in response to fructose-induced insulin resistance.

1994 • 80 citations

Activation of novel protein kinases C delta and C epsilon upon mitogenic stimulation of quiescent rat 3Y1 fibroblasts

1994 • 80 citations

High glucose concentrations and protein kinase C isoforms in vascular smooth muscle cells

1995 • 75 citations

Glucose-induced downregulation of angiotensin II and arginine vasopressin receptors in cultured rat aortic vascular smooth muscle cells. Role of protein kinase C.

1992 • 70 citations

Protein Kinase C-Mediated Inhibition of Vascular Smooth Muscle Cell Proliferation: The Isoforms That May Mediate G1/S Inhibition

1993 • 69 citations

Alteration of 1,2-Diacylglycerol Content in Myocardium From Diabetic Rats

1988 • 65 citations

Endothelial Cell Tyrosine Kinase Receptor and G Protein–Coupled Receptor Activation Involves Distinct Protein Kinase C Isoforms

1996 • 58 citations

Protein kinase C-mediated phospholipase A2 activation, platelet-activating factor generation and prostacyclin release in spontaneously beating rat cardiomyocytes

1993 • 58 citations

Glucose-induced vascular smooth muscle dysfunction: the role of protein kinase C

1995 • 57 citations

Overexpression of protein kinase C-zeta isoform increases cyclooxygenase-2 and inducible nitric oxide synthase

1997 • 55 citations

Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat

1998 • 53 citations

Glucose‐induced synthesis of diacylglycerol de novo is associated with translocation (activation) of protein kinase C in rat adipocytes

1989 • 47 citations

Protein kinase C in diabetic nephropathy

1995 • 45 citations

Vitamin E Normalizes Diacylglycerol—Protein Kinase C Activation Induced by Hyperglycemia in Rat Vascular Tissues

1996 • 44 citations

Insulin increases mRNA levels of protein kinase C-α and -β in rat adipocytes and protein kinase C-α, -β and -θ in rat skeletal muscle

1995 • 43 citations

Leukocyte infiltration and ICAM-1 expression in two-kidney one-clip hypertension

1997 • 41 citations

The role of hyperglycemia and hyperinsulinemia in the pathogenesis of diabetic angiopathy.

1996 • 41 citations

Synthesis of diacylglycerol de novo is responsible for permanent activation and down-regulation of protein kinase C in transformed cells

1989 • 39 citations

Hyperglycemia and microangiopathy. Direct regulation by glucose of microvascular cells.

1992 • 39 citations

Effect of verapamil on cardiac protein kinase C activity in diabetic rats

1991 • 38 citations

Anti sense DNA down-regulates proteins kinase C-epsilon and enhances vasopressin-stimulated Na+ absorption in rabbit cortical collecting duct.

1995 • 38 citations

Role of protein kinase C and cyclic AMP/protein kinase A in high glucose-stimulated transcriptional activation of collagen α1 (IV) in glomerular mesangial cells

1995 • 36 citations

Protein kinase C (PKC) ϵ enhances the inhibitory effect of TNFα on insulin signaling in HEK293 cells

1997 • 36 citations

Role of Protein Kinase C in Intracellular Signaling

1994 • 33 citations

Prevention of diabetes‐induced abnormal retinal blood flow by treatment with d‐α‐tocopherol

1998 • 32 citations

Involvement of Raf-1 kinase and protein kinase C zeta in insulin-like growth factor I-induced brown adipocyte mitogenic signaling cascades: inhibition by cyclic adenosine 3',5'-monophosphate.

1996 • 30 citations

Mediators of hyperglycemia and the pathogenesis of matrix accumulation in diabetic renal disease.

1995 • 27 citations

Characterization and Localization of Calcium/Phospholipid-Dependent Protein Kinase-C during Diabetic Renal Growth

1988 • 20 citations

Effects of insulin on protein kinase-C (PKC) in HIRC-B cells: specific activation of PKC epsilon and its resistance to phorbol ester-induced down-regulation.

1994 • 18 citations

Glucose-induced fibronectin expression in endothelial cells is mediated by Protein Kinase C

2009 • 12 citations

Biochemical alterations and complications in diabetes.

1986 • 12 citations

Further Evidence Implicating Diacylglycerol Generation and Protein Kinase C Activation in Agonist-Induced Increases in Glucose Uptake: Insulin-Like Effects of Phenylephrine in BC3H-1 Myocytes

1986 • 12 citations

Alteration of Protein Kinase C Activity in Diabetic Rat Prostate

1993 • 10 citations

Biochemical alterations and complications in diabetes.

1986 • 9 citations

Protein kinase C activity and its relationship to myo-inositol uptake during hyperglycemic conditions in cultured bovine lens epithelial cells

1993 • 7 citations