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Tumor necrosis factor-alpha blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation.

Data up to Jan 2025

Published1993
Citations114
References74

Total Citations Per Year

Abstract

References (74)

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

The Pathogenesis of Sepsis

1991 • 1,376 citations

Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.

1989 • 1,115 citations

Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo.

1991 • 977 citations

Human tumor necrosis factor. Production, purification, and characterization.

1985 • 922 citations

Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.

1987 • 823 citations

Chlorination of Taurine by Human Neutrophils

1982 • 794 citations

Comparison of in vitro cell cytotoxic assays for tumor necrosis factor

1984 • 752 citations

Septic shock: pathogenesis

1991 • 743 citations

Endotoxin and lung injury.

1986 • 679 citations

Protein measurement using bicinchoninic acid: elimination of interfering substances

1989 • 667 citations

Monoclonal Antibodies: Principles and Practice

1985 • 648 citations

Structure and Function of Leukocyte Integrins

1990 • 620 citations

The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140

1991 • 592 citations

Alterations of the Gas Exchange Apparatus in Adult Respiratory Insufficiency Associated with Septicemia1,2

1977 • 551 citations

Elastolytic Activity in Pulmonary Lavage Fluid from Patients with Adult Respiratory-Distress Syndrome

1981 • 528 citations

Cytokine appearance in human endotoxemia and primate bacteremia.

1988 • 528 citations

Tumor necrosis factor-α

1991 • 508 citations

Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans

1989 • 485 citations

Sticky sugars for selectins

1991 • 456 citations

Lung neutrophils in the adult respiratory distress syndrome. Clinical and pathophysiologic significance

1987 • 452 citations

Increased Sheep Lung Vascular Permeability Caused by Pseudomonas Bacteremia

1974 • 434 citations

Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia.

1981 • 426 citations

Tissue Destruction by Neutrophils

1989 • 389 citations

Studies on the Pathogenesis of the Adult Respiratory Distress Syndrome

1982 • 359 citations

Studies of endotoxin-induced decrease in lipoprotein lipase activity.

1981 • 333 citations

Enhancement of neutrophil superoxide production by preincubation with recombinant human tumor necrosis factor.

1987 • 292 citations

Leukocytes are required for increased lung microvascular permeability after microembolization in sheep.

1981 • 271 citations

Acute effects of Escherichia coli endotoxin on the pulmonary microcirculation of anesthetized sheep structure:function relationships.

1983 • 245 citations

Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophils.

1987 • 229 citations

Receptor Binding and Activation of Polymorphonuclear Neutrophils by Tumor Necrosis Factor-Alpha

1987 • 219 citations

Changes in membrane potential of human granulocytes antecede the metabolic responses to surface stimulation

1978 • 218 citations

Neutrophil‐mediated Vascular Injury

1987 • 217 citations

Serum cachectin/tumor necrosis factor in critically ill patients with burns correlates with infection and mortality.

1990 • 217 citations

Pretreatment with recombinant murine tumor necrosis factor alpha/cachectin and murine interleukin 1 alpha protects mice from lethal bacterial infection.

1989 • 196 citations

Antibodies against human neutrophil LECAM-1 (LAM-1/Leu-8/DREG-56 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro

1991 • 178 citations

Recombinant tumor necrosis factor causes activation of human granulocytes

1987 • 164 citations

Mechanisms of neutrophil-mediated tissue injury

1991 • 151 citations

Granulocyte Depletion Prevents Tumor Necrosis Factor-mediated Acute Lung Injury in Guinea Pigs

1988 • 141 citations

Anti-CD18 antibody attenuates neutropenia and alveolar capillary-membrane injury during gram-negative sepsis.

1991 • 116 citations

Mechanisms and Mediators of the Adult Respiratory Distress Syndrome

1990 • 106 citations

The adult respiratory distress syndrome: Cell populations and soluble mediators in the air spaces of patients at high risk

1988 • 102 citations

Prevention of pulmonary injury in isolated perfused rat lungs by activated human neutrophils preincubated with anti-Mo1 monoclonal antibody.

1987 • 93 citations

Endotoxin-induced cytokine gene expression in vivo. I. Expression of tumor necrosis factor mRNA in visceral organs under physiologic conditions and during endotoxemia.

1989 • 79 citations

Effect of granulocytopenia on extravascular lung water content after microembolization.

1980 • 74 citations

Effect of granulocyte depletion on altered lung mechanics after endotoxemia in sheep

1983 • 72 citations

Monoclonal Antibody to Tumor Necrosis Factor α Attenuates Cardiopulmonary Dysfunction in Porcine Gram-negative Sepsis

1992 • 70 citations

Lung Neutrophils in the Adult Respiratory Distress Syndrome

2015 • 65 citations

Independent stimulation of membrane potential changes and the oxidative metabolic burst in polymorphonuclear leukocytes

1985 • 63 citations

Tumour necrosis factor and bacterial sepsis

1989 • 56 citations

The Pulmonary Air-Blood Barrier of Human Shock Lungs (A Clinical, Ultrastructural and Morphometric Study)

1978 • 52 citations

Cytokines, sepsis and the surgeon.

1989 • 42 citations

Sepsis-induced Lung Injury and the Effects of Ibuprofen Pretreatment: Analysis of Early Alveolar Events via Repetitive Bronchoalveolar Lavage

1991 • 42 citations

The effect of tumor necrosis factor-α and interferon-γ on neutrophil function

1989 • 41 citations

Oxidative Metabolism of Polymorphonuclear Leukocytes: Modulation by Adhesive Stimuli

1991 • 41 citations

LUNG PATHOLOGY IN RESPIRATORY DISTRESS FOLLOWING SHOCK IN THE ADULT

1971 • 40 citations

CD18 adhesion receptors, tumor necrosis factor, and neutropenia during septic lung injury

1991 • 37 citations

Experimental and clinical assessment of lung injury by measurement of extravascular lung water and transcapillary protein flux in ARDS: A review of current techniques

1988 • 34 citations

Tumor necrosis factor primes neutrophils for hypochlorous acid production

1989 • 32 citations

Ibuprofen attenuates hypochlorous acid production from neutrophils in porcine acute lung injury

1990 • 32 citations

Delayed Cyclo-oxygenase Blockade Reduces the Neutrophil Respiratory Burst and Plasma Tumor Necrosis Factor Levels in Sepsis-Induced Acute Lung Injury

1991 • 30 citations

Cytokine Receptors of the Lung

1991 • 27 citations

Dissociation between aggregation and superoxide production in human granulocytes.

1985 • 18 citations

Role of granulocytes and C5a in myocardial response to zymosan-activated serum

1991 • 18 citations

Increased survival time after delayed histamine and prostaglandin blockade in a porcine model of severe sepsis-induced lung injury

1990 • 17 citations

Tumour necrosis factor-alpha induces translocation of protein kinase C in tumour necrosis factor-sensitive cell lines.

1991 • 17 citations

The Adult Respiratory Distress Syndrome: Cell Populations and Soluble Mediators in the Air Spaces of Patients at High Risk

1987 • 7 citations

Independent stimulation of membrane potential changes and the oxidative metabolic burst in polymorphonuclear leukocytes

1985 • 5 citations

Multisystem Organ Failure

2012 • 1 citations

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Tumor necrosis factor-alpha blockade prevents neutrophil CD18 receptor upregulation and… (1993) – Journal of Clinical Investigation | Metascience Observatory Explorer