Diabetic vascular dysfunction: Links to glucose‐induced reductive stress and VEGF

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

2001 • 3,295 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

1988 • 2,527 citations

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.

1999 • 2,452 citations

Advanced glycation end-products: a review

2001 • 2,449 citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

1996 • 1,955 citations

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.

1992 • 1,488 citations

Protein kinase C activation and the development of diabetic complications.

1998 • 1,328 citations

Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins

1994 • 1,311 citations

ADVANCED PROTEIN GLYCOSYLATION IN DIABETES AND AGING

1995 • 1,277 citations

Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts

1998 • 1,102 citations

Hyperglycemic Pseudohypoxia and Diabetic Complications

1993 • 1,025 citations

Regulation of protein kinase C

1997 • 919 citations

Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

1995 • 886 citations

MAP kinase pathways

1999 • 875 citations

N ε-(Carboxymethyl)Lysine Adducts of Proteins Are Ligands for Receptor for Advanced Glycation End Products That Activate Cell Signaling Pathways and Modulate Gene Expression

1999 • 848 citations

p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells

1997 • 847 citations

Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface.

1992 • 808 citations

Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

1997 • 803 citations

Advanced glycation end products contribute to amyloidosis in Alzheimer disease.

1994 • 791 citations

Activation of Receptor for Advanced Glycation End Products

1999 • 775 citations

Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues.

1993 • 764 citations

Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition

1999 • 753 citations

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

1992 • 743 citations

The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival

1998 • 742 citations

Diabetes mellitus

2001 • 735 citations

Vascular Endothelial Growth Factor Expression of Intercellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule 1 (VCAM-1), and E-selectin through Nuclear Factor-κB Activation in Endothelial Cells

2001 • 722 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

1994 • 712 citations

VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells

1998 • 694 citations

Vascular Endothelial Growth Factor–Induced Retinal Permeability Is Mediated by Protein Kinase C In Vivo and Suppressed by an Orally Effective β-Isoform–Selective Inhibitor

1997 • 665 citations

Vascular Endothelial Growth Factor Induces Rapid Phosphorylation of Tight Junction Proteins Occludin and Zonula Occluden 1

1999 • 653 citations

Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions.

1994 • 632 citations

Occludin as a possible determinant of tight junction permeability in endothelial cells

1997 • 626 citations

Endothelins and Endothelin Receptor Antagonists

2000 • 596 citations

Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.

1994 • 584 citations

Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group.

1998 • 571 citations

Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.

1996 • 567 citations

Hyperglycemia and Diabetic Kidney Disease: The Case for Transforming Growth Factor–β as a Key Mediator

1995 • 560 citations

Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats.

1996 • 551 citations

Hypoxic Regulation of Vascular Endothelial Growth Factor in Retinal Cells

1995 • 549 citations

From receptors to stress-activated MAP kinases

1999 • 525 citations

Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy.

1991 • 522 citations

The missing link: A single unifying mechanism for diabetic complications

2000 • 517 citations

Contributions of polyol pathway to oxidative stress in diabetic cataract

1999 • 517 citations

Alterations in nonenzymatic biochemistry in uremia: Origin and significance of “carbonyl stress” in long-term uremic complications

1999 • 515 citations

Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies.

1999 • 505 citations

Glycation Products and the Pathogenesis of Diabetic Complications

1992 • 493 citations

Hypoxia Induces Vascular Endothelial Growth Factor in Cultured Human Endothelial Cells

1995 • 487 citations

Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries

1993 • 448 citations

Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia

1994 • 444 citations

The Roles of Oxidative Stress and Antioxidant Treatment in Experimental Diabetic Neuropathy

1997 • 436 citations

Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo.

1996 • 420 citations

Advanced glycation end products increase retinal vascular endothelial growth factor expression.

1998 • 413 citations

Identification of Galectin-3 As a High-Affinity Binding Protein for Advanced Glycation End Products (AGE): A New Member of the AGE-Receptor Complex

1995 • 410 citations

Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways

1999 • 386 citations

Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEs.

1998 • 382 citations

Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals: a model for diabetic and aging complications.

1992 • 378 citations

Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications.

1989 • 374 citations

Molecular identity and cellular distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins.

1996 • 340 citations

Vascular Endothelial Growth Factor (VEGF)-Induced Retinal Vascular Permeability Is Mediated by Intercellular Adhesion Molecule-1 (ICAM-1)

2000 • 330 citations

Requirement for p38 and p44/p42 Mitogen-Activated Protein Kinases in RAGE-Mediated Nuclear Factor-κB Transcriptional Activation and Cytokine Secretion

2001 • 327 citations

Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

1989 • 324 citations

Recent Progress in Advanced Glycation End Products and Diabetic Complications

1997 • 317 citations

Hypoxia Is a Strong Inducer of Vascular Endothelial Growth Factor mRNA Expression in the Heart

1993 • 308 citations

Advanced glycation end products up-regulate gene expression found in diabetic glomerular disease.

1994 • 298 citations

The involvement of aldose reductase in diabetic complications

1988 • 296 citations

The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis.

1996 • 286 citations

Glucose-Induced Protein Kinase C Activation Regulates Vascular Permeability Factor mRNA Expression and Peptide Production by Human Vascular Smooth Muscle Cells In Vitro

1997 • 276 citations

Endothelin 1 transcription is controlled by nuclear factor-kappaB in AGE-stimulated cultured endothelial cells.

2000 • 275 citations

The relation between expression of vascular endothelial growth factor and breakdown of the blood-retinal barrier in diabetic rat retinas.

1996 • 274 citations

VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly

2001 • 274 citations

Advanced Glycation End Products-driven Angiogenesis in Vitro

1997 • 272 citations

Antioxidants, diabetes and endothelial dysfunction

2000 • 270 citations

Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.

2000 • 268 citations

Vascular endothelial growth factor activates nuclear factor-kappaB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells.

1999 • 248 citations

Effects of Vascular Endothelial Growth Factor on Hemodynamics and Cardiac Performance

1996 • 245 citations

Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver

1996 • 234 citations

Molecular Mechanisms of Vascular Permeability in Diabetic Retinopathy

1999 • 227 citations

Pyruvate‐enhanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart

1989 • 223 citations

Increase in Diacylglycerol Mass in Isolated Glomeruli by Glucose From De Novo Synthesis of Glycerolipids

1990 • 219 citations

Advanced glycation end products, oxidant stress and vascular lesions

1997 • 215 citations

Reversible oxidant-induced increases in albumin transfer across cultured endothelium: alterations in cell shape and calcium homeostasis

1985 • 210 citations

Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition

1999 • 208 citations

Vasoactive Peptides Modulate Vascular Endothelial Cell Growth Factor Production and Endothelial Cell Proliferation and Invasion

1997 • 205 citations

Advanced glycosylation end products in diabetic renal and vascular disease

1995 • 205 citations

The relationship between accumulation of advanced glycation end products and expression of vascular endothelial growth factor in human diabetic retinas

1997 • 197 citations

Vascular Endothelial Growth Factor Plays a Role in Hyperpermeability of Diabetic Retinal Vessels

1995 • 197 citations

Vascular endothelial growth factor–stimulated endothelial cells promote adhesion and activation of platelets

2000 • 196 citations

Mitogen-activated protein kinases as glucose transducers for diabetic complications

1999 • 195 citations

Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor.

1997 • 194 citations

Vascular endothelial growth factor

1993 • 191 citations

Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels.

1991 • 191 citations

Aldose reductase inhibitors: therapeutic implications for diabetic complications

1999 • 191 citations

Two novel rat liver membrane proteins that bind advanced glycosylation endproducts: relationship to macrophage receptor for glucose-modified proteins.

1991 • 189 citations

Histamine increases venular permeability via a phospholipase C-NO synthase-guanylate cyclase cascade

1993 • 174 citations

Platelet hyperactivity and abnormal Ca²⁺homeostasis in diabetes mellitus

2001 • 169 citations

Role for nitric oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF.

1999 • 159 citations

Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats

1997 • 153 citations

Antibacterial activity of lysozyme and lactoferrin is inhibited by binding of advanced glycation–modified proteins to a conserved motif

1995 • 152 citations

Pathogenetic Potential of Leukocytes in Diabetic Retinopathy

1999 • 147 citations

Glutathione depletion in the lens of galactosemic and diabetic rats

1988 • 144 citations

The effect of high glucose and oxidative stress on lens metabolism, aldose reductase, and senile cataractogenesis

1986 • 143 citations

Inhibition of Sorbitol Dehydrogenase: Effects on Vascular and Neural Dysfunction in Streptozocin-Induced Diabetic Rats

1995 • 141 citations

Modulation of venular microvessel permeability by calcium influx into endothelial cells

1992 • 138 citations

Effect of a Specific Endothelin Receptor A Antagonist on mRNA Levels for Extracellular Matrix Components and Growth Factors in Diabetic Glomeruli

1995 • 137 citations

Reactive Oxygen Species and Vascular Signal Transduction Mechanisms

1996 • 133 citations

Vascular Endothelial Growth Factor and Microvascular Permeability

1999 • 131 citations

Stimulatory Interaction Between Vascular Endothelial Growth Factor and Endothelin-1 on Each Gene Expression

1998 • 131 citations

Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism. Implications for diabetic retinopathy.

1995 • 120 citations

Advanced Glycation End Products Induce Expression of Vascular Endothelial Growth Factor by Retinal Müller Cells

1997 • 117 citations

Increased NADH Oxidase Activity in the Retina of the BBZ/WOR Diabetic Rat

1998 • 112 citations

Aminoguanidine ameliorates albuminuria in diabetic hypertensive rats

1992 • 110 citations

Activation of the tissue factor pathway of blood coagulation during prolonged hyperglycemia in young healthy men.

1999 • 107 citations

Diabetes-induced glomerular dysfunction: Links to a more reduced cytosolic ratio of NADH/NAD+

1992 • 105 citations

Metabolism of Fructose-3-phosphate in the Diabetic Rat Lens

1995 • 102 citations

Endothelin receptor blockade prevents augmented extracellular matrix component mRNA expression and capillary basement membrane thickening in the retina of diabetic and galactose-fed rats.

2000 • 102 citations

The Receptor for Advanced Glycation End Products Mediates the Chemotaxis of Rabbit Smooth Muscle Cells

1997 • 98 citations

Aldose Reductase Inhibition Fails to Prevent Retinopathy in Diabetic and Galactosemic Dogs

1993 • 97 citations

Endothelin and Pulmonary Hypertension

2000 • 92 citations

Protein Kinase C and Myocardial Biology and Function

2000 • 85 citations

Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes.

2000 • 83 citations

Polyol pathway activation and glutathione redox status in non—insulin-dependent diabetic patients

1997 • 82 citations

Involvement of Ca2+ in the H2O2-induced increase in endothelial permeability

1996 • 79 citations

Advanced glycation endproducts stimulate the MAP‐kinase pathway in tubulus cell line LLC‐PK₁

1997 • 77 citations

The Role of Hyperglycaemia and Hyperinsulinaemia in Causing Vascular Dysfunction in Diabetes

1996 • 77 citations

Pericyte degeneration and acellular capillaries are increased in the feet of human diabetic patients

1985 • 75 citations

An Aldose Reductase Inhibitor and Aminoguanidine Prevent Vascular Endothelial Growth Factor Expression in Rats With Long-term Galactosemia

1997 • 72 citations

Evaluation of a sorbitol dehydrogenase inhibitor on diabetic peripheral nerve metabolism: a prevention study

1999 • 70 citations

Diabetes in the New Millennium

1999 • 67 citations

Amyloid β2-microglobulin is modified with Nε-(carboxymethyl)lysine in dialysis-related amyloidosis

1996 • 66 citations

Immunocytochemical detection of advanced glycated end products in rat renal tissue as a function of age and diabetes

1998 • 66 citations

Acute modulation of albumin microvascular leakage by advanced glycation end products in microcirculation of diabetic rats in vivo.

1999 • 63 citations

Augmented retinal endothelin-1, endothelin-3, endothelinA and endothelinB gene expression in chronic diabetes

1998 • 63 citations

Effect of glycated proteins on the matrix of glomerular epithelial cells.

1998 • 62 citations

The Aldose Reductase Controversy

1994 • 59 citations

The role of COX-2 in intestinal cancer

1999 • 59 citations

Deposition of advanced glycation end products (AGE) and expression of the receptor for AGE in cardiovascular tissue of the diabetic rat.

1998 • 58 citations

Glucose-induced vascular smooth muscle dysfunction: the role of protein kinase C

1995 • 57 citations

Diabetes-Induced Changes in Retinal NAD-Redox Status

2001 • 56 citations

The protective action of pyruvate on recovery of ischemic rat heart: Comparison with other oxidizable substrates

1990 • 53 citations

Interaction between osmotic and oxidative stress in diabetic precataractous lens

1999 • 51 citations

Vascular filtration function in galactose-fed versus diabetic rats: The role of polyol pathway activity

1990 • 49 citations

Effect of aldose reductase inhibition on glutathione redox status in erythrocytes of diabetic patients

1994 • 45 citations

The effect of hypertonicity on aldose reductase, alpha B-crystallin, and organic osmolytes in the retinal pigment epithelium.

1993 • 40 citations

INTENSE FOCAL EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR MESSENGER-RNA IN HUMAN INTRACRANIAL NEOPLASMS - ASSOCIATION WITH REGIONS OF NECROSIS

1993 • 40 citations

The receptor for advanced glycation end products mediates the chemotaxis of rabbit smooth muscle cells

1997 • 37 citations

Angiogenic Effects of Advanced Glycation End Products of the Maillard Reaction on Cultured Human Umbilical Cord Vein Endothelial Cells

1993 • 36 citations

Vascular Dysfunction Induced by AGE is Mediated by VEGF via Mechanisms Involving Reactive Oxygen Species, Guanylate Cyclase, and Protein Kinase C

2001 • 30 citations

Active site modification of aldose reductase by nitric oxide donors

1997 • 27 citations

Amelioration of Diabetes-like Retinal Changes in Galactose-Fed Dogs

1994 • 25 citations

Simultaneous measurement of ERK, p38, and JNK MAP kinase cascades in vascular smooth muscle cells

2000 • 22 citations

Reactive Oxygen Species and Acute Modulation of Albumin Microvascular Leakage in the Microcirculation of Diabetic Rats in vivo

2000 • 21 citations

Interactions between the sorbitol pathway, non-enzymatic glycation, and diabetic vascular dysfunction

1996 • 20 citations

Elevation of erythrocyte redox potential linked to galactonate biosynthesis: Elimination by Tolrestat

1998 • 19 citations

Effects on rat renal osmolytes of extended treatment with an aldose reductase inhibitor

1992 • 10 citations