Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels.

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONS

1989 • 739 citations

Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications.

1989 • 374 citations

Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

1989 • 324 citations

Banting Lecture 1986: Does a Common Mechanism Induce the Diverse Complications of Diabetes?

1987 • 275 citations

Increased endothelial albumin permeability mediated by protein kinase C activation.

1990 • 271 citations

Diacylglycerols, lysolecithin, or hydrocarbons markedly alter the bilayer to hexagonal phase transition temperature of phosphatidylethanolamines

1985 • 224 citations

1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells.

1987 • 211 citations

Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets.

1988 • 173 citations

Quantitative measurement of sn-1,2-diacylglycerols

1987 • 166 citations

Increased Vascular Permeability in Spontaneously Diabetic BB/W Rats and in Rats With Mild Versus Severe Streptozocin-Induced Diabetes: Prevention by Aldose Reductase Inhibitors and Castration

1987 • 156 citations

Glutathione depletion in the lens of galactosemic and diabetic rats

1988 • 144 citations

Differential regulation of protein kinase C and (Na,K)-adenosine triphosphatase activities by elevated glucose levels in retinal capillary endothelial cells.

1989 • 140 citations

Na+-K+-ATPase is an effector protein for protein kinase C in renal proximal tubule cells

1989 • 134 citations

Metabolic alterations in the human erythrocyte produced by increases in glucose concentration

1971 • 122 citations

Basement membrane abnormalities in diabetes mellitus: Relationship to clinical microangiopathy

1988 • 114 citations

Attenuation of sn-1,2-diacylglycerol second messengers. Metabolism of exogenous diacylglycerols by human platelets.

1986 • 106 citations

Pathogenesis and prevention of diabetic neuropathy

1988 • 91 citations

Secretagogue-induced diacylglycerol accumulation in isolated pancreatic islets. Mass spectrometric characterization of the fatty acyl content indicates multiple mechanisms of generation

1989 • 83 citations

Pancreatic islets synthesize phospholipids de novo from glucose via acyl-dihydroxyacetone phosphate

1985 • 76 citations

Diacylglycerol synthesis de novo from glucose by pancreatic islets isolated from rats and humans.

1990 • 74 citations

Mechanisms whereby insulin increases diacylglycerol in BC3H-1 myocytes

1988 • 69 citations

Effects of diacylglycerols on the structure of phosphatidylcholine bilayers: a deuterium and phosphorus-31 NMR study

1989 • 69 citations

Alteration of 1,2-Diacylglycerol Content in Myocardium From Diabetic Rats

1988 • 65 citations

Comparison of effects of phorbol esters and glucose on protein kinase C activation and insulin secretion in pancreatic islets

1989 • 63 citations

Glucose-induced microvascular functional changes in nondiabetic rats are stereospecific and are prevented by an aldose reductase inhibitor.

1990 • 63 citations

Phorbol esters and diacylglycerols amplify bradykinin-stimulated prostaglandin synthesis in Swiss 3T3 fibroblasts. Possible independence from protein kinase C.

1988 • 57 citations

In vitro correction of impaired Na+-K+-ATPase in diabetic nerve by protein kinase C agonists

1989 • 57 citations

The antiproliferative effects of staurosporine are not exclusively mediated by inhibition of protein kinase C

1988 • 54 citations

Biochemical manifestations of diabetes mellitus in microscopic layers of the cornea and retina

1989 • 47 citations

Albumin Permeation of New Vessels Is Increased in Diabetic Rats

1985 • 43 citations

Mechanisms underlying atriopeptin-induced increases in hematocrit and vascular permeation in rats.

1989 • 40 citations

Differential regulation of phosphatidylcholine biosynthesis by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol in NG108-15 neuroblastoma x glioma hybrid cells.

1987 • 39 citations

The Protein Kinase C Family: Heterogeneity And Its Implications

1989 • 28 citations

Reduced Na++K+-ATPase activity in peripheral nerve of streptozotocin-diabetic rats: a role for protein kinase C?

1988 • 28 citations

Alteration of 1,2-diacylglycerol content in myocardium from diabetic rats

1988 • 24 citations

Effects of hypothyroidism on vascular 125I-albumin permeation and blood flow in rats

1989 • 24 citations

The inflammatory reaction in an experimental model of open wounds in the rat. The effect of arachidonic acid metabolites

1984 • 23 citations

Rapid analysis of sorbitol, galactitol, mannitol and myoinositol mixtures from biological sources

1989 • 22 citations

The diacylglycerol analogue, 1,2-sn-dioctanoylglycerol, induces an increase in cytosolic free Ca2+ and cytosolic acidification of T lymphocytes through a protein kinase C-independent process

1989 • 21 citations

Albumin catabolism in diabetic rats

1983 • 19 citations

Prevention of Hemodynamic and Vascular Albumin Filtration Changes in Diabetic Rats by Aldose Reductase Inhibitors

1989 • 17 citations

Albumin permeation of new vessels is increased in diabetic rats

1985 • 16 citations

Influence of α<sub>1</sub>-Adrenergic Receptor Stimulation and Phorbol Esters on Hepatic Na<sup>+</sup>/K<sup>+</sup>-ATPase Activity

1988 • 14 citations

Comparison of the HPLC-separated species patterns of phosphatidic acid, CDP-diacylglycerol and diacylglycerol synthesized de novo in rat liver microsomes (a new method)

1988 • 13 citations

Deleted Work

1955 • 0 citations