Fibrin structure and wound healing

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Angiogenesis in health and disease

2003 • 4,127 citations

RGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS

1996 • 3,074 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

HOW NEUTROPHILS KILL MICROBES

2005 • 1,707 citations

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.

1987 • 1,287 citations

Fibrinogen and Fibrin

2005 • 758 citations

Fundamental Concepts of the Angiogenic Process

2003 • 657 citations

The Structure and Biological Features of Fibrinogen and Fibrin

2001 • 605 citations

Normal Cutaneous Wound Healing: Clinical Correlation with Cellular and Molecular Events

2006 • 591 citations

Impaired wound healing in mice with a disrupted plasminogen gene

1996 • 568 citations

Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells

2000 • 555 citations

Chemotactic activity of elastin-derived peptides.

1980 • 519 citations

Influence of Fibrin Network Conformation and Fibrin Fiber Diameter on Fibrinolysis Speed

2000 • 474 citations

Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro.

1990 • 466 citations

Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing.

1987 • 450 citations

Normal Cutaneous Wound Healing

2005 • 366 citations

Role of factor XIII in fibrin clot formation and effects of genetic polymorphisms

2002 • 347 citations

Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells

1989 • 343 citations

Smart materials as scaffolds for tissue engineering

2005 • 342 citations

Size and Density of Fibrin Fibers from Turbidity

1978 • 322 citations

Collagen-and collagen peptide-induced chemotaxis of human blood monocytes.

1976 • 312 citations

Cooperative effect of TNFalpha, bFGF, and VEGF on the formation of tubular structures of human microvascular endothelial cells in a fibrin matrix. Role of urokinase activity.

1996 • 298 citations

Regulation of Fibroplasia in Cutaneous Wound Repair

1993 • 295 citations

Central Roles of α ₅ β ₁ Integrin and Fibronectin in Vascular Development in Mouse Embryos and Embryoid Bodies

2002 • 275 citations

Stimulation of in vitro human skin collagenase expression by platelet-derived growth factor.

1985 • 236 citations

The binding of thrombin by fibrin.

1979 • 223 citations

VE-Cadherin Mediates Endothelial Cell Capillary Tube Formation in Fibrin and Collagen Gels1

1998 • 216 citations

v 3 and αvβ5 integrin antagonists inhibit angiogenesis in vitro

2003 • 201 citations

Genetic regulation of fibrin structure and function: complex gene-environment interactions may modulate vascular risk

2003 • 192 citations

Fibrinogen Is a Ligand for Integrin α5β1 on Endothelial Cells

1997 • 172 citations

Thrombin immobilized to extracellular matrix is a potent mitogen for vascular smooth muscle cells: nonenzymatic mode of action.

1990 • 167 citations

Behavior of Human Dermal Fibroblasts in Three-Dimensional Fibrin Clots: Dependence on Fibrinogen and Thrombin Concentration

2004 • 165 citations

Platelet‐Fibrinogen Interactions

2001 • 164 citations

Binding of recombinant fibrinogen mutants to platelets.

1994 • 154 citations

Cryptic chemotactic activity of fibronectin for human monocytes resides in the 120-kDa fibroblastic cell-binding fragment.

1988 • 153 citations

Genetic and Environmental Determinants of Fibrin Structure and Function

2004 • 151 citations

The molecular physiology and pathology of fibrin structure/function

2005 • 148 citations

Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix

2003 • 143 citations

Human Fibroblasts Bind Directly to Fibrinogen at RGD Sites through Integrin αvβ3

1997 • 143 citations

Unfractionated and low molecular weight heparin affect fibrin structure and angiogenesis in vitro.

2000 • 141 citations

Chemotaxis for Human Monocytes by Fibrinogen‐derived Peptides

1976 • 138 citations

Fibrin II induces endothelial cell capillary tube formation.

1995 • 137 citations

Recognition of Fibrinogen by Leukocyte Integrins

2001 • 135 citations

Human monocyte adherence: a primary effect of chemotactic factors on the monocyte to stimulate adherence to human endothelium.

1987 • 128 citations

Interaction of Fibrin(ogen) with Fibronectin: Further Characterization and Localization of the Fibronectin-Binding Site

2002 • 128 citations

Functional Analysis of the Fibrinogen Aα Thr312Ala Polymorphism

2003 • 124 citations

Covalent Cross-linking of Fibronectin to Fibrin Is Required for Maximal Cell Adhesion to a Fibronectin-Fibrin Matrix

1997 • 124 citations

Fibrinogen gamma-chain splice variant γ′ alters fibrin formation and structure

2003 • 122 citations

Tumor metastasis but not tumor growth is dependent on Src-mediated vascular permeability

2004 • 121 citations

Crystal structure of the complex between thrombin and the central “E” region of fibrin

2004 • 113 citations

The role of fibrinogen and related fragments in tumour angiogenesis and metastasis

2003 • 109 citations

Structural Recognition of a Novel Fibrinogen γ Chain Sequence (117 – 133) by Intercellular Adhesion Molecule-1 Mediates Leukocyte-Endothelium Interaction

1995 • 108 citations

Fibrin(ogen)-α_Mβ₂Interactions Regulate Leukocyte Function and Innate Immunity In Vivo

2004 • 105 citations

Matrix-fibrinogen enhances wound closure by increasing both cell proliferation and migration

2003 • 102 citations

Fibrin and Collagen Differentially Regulate Human Dermal Microvascular Endothelial Cell Integrins: Stabilization of αv/β3 mRNA by Fibrin1

1999 • 101 citations

The coordinated regulation of fibrinogen gene transcription by hepatocyte-stimulating factor and dexamethasone.

1987 • 100 citations

Fibrinogen and Fibrin are Anti-Adhesive for Keratinocytes: A Mechanism for Fibrin Eschar Slough During Wound Repair

2001 • 99 citations

Fibrin Microbeads (FMB) as Biodegradable Carriers for Culturing Cells and for Accelerating Wound Healing11The authors declared conflict of interest. A patent on the method of preparation and commercial uses of FMB is pending.

1999 • 98 citations

Purification and characterization of 3 fibrinogens with different molecular weights obtained from normal human plasma

1985 • 96 citations

Influence of fibrin structure on the formation and maintenance of capillary-like tubules by human microvascular endothelial cells.

1998 • 93 citations

Human fibrinogen polymorphic site analysis by restriction endonuclease digestion and allele-specific polymerase chain reaction amplification: identification of polymorphisms at positions A alpha 312 and B beta 448

1993 • 92 citations

Transplantation of cultured autologous keratinocytes in fibrin sealant biomatrix to resurface chronic wounds

2001 • 91 citations

Therapeutic expression of the platelet-specific integrin, IIb 3, in a murine model for Glanzmann thrombasthenia

2005 • 90 citations

Fibrinogen γ chain functions

2003 • 89 citations

Cl− Regulates the Structure of the Fibrin Clot

1998 • 87 citations

Specific Binding of Integrin αvβ3 to the Fibrinogen γ and α_E Chain C-Terminal Domains

1999 • 85 citations

Transglutaminase-mediated oligomerization of the fibrin(ogen) αC domains promotes integrin-dependent cell adhesion and signaling

2005 • 83 citations

Studies in Vitro on the Role of αv and β1 Integrins in the Adhesion of Human Dermal Fibroblasts to Provisional Matrix Proteins Fibronectin, Vitronectin, and Fibrinogen

1996 • 82 citations

Coordinate accumulation of the mRNAs for the alpha, beta, and gamma chains of rat fibrinogen following defibrination.

1982 • 81 citations

.alpha.-Chain domain of fibrinogen controls generation of fibrinoligase (coagulation factor XIIIa). Calcium ion regulatory aspects

1981 • 80 citations

Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires αvβ3

2004 • 77 citations

Extracellular matrix-enriched polymeric scaffolds as a substrate for hepatocyte cultures: in vitro and in vivo studies

2005 • 75 citations

Interaction of Fibrin with VE‐Cadherin

2001 • 70 citations

Thrombin Cleavage-Independent Deposition of Fibrinogen in Extracellular Matrices

1997 • 70 citations

Type 1 Plasminogen Activator Inhibitor Binds to Fibrin via Vitronectin

2000 • 69 citations

Fibrinogen Binds to Integrin 5 1via the Carboxyl-Terminal RGD Site of the A -Chain

2000 • 68 citations

Fib420: a normal human variant of fibrinogen with two extended alpha chains.

1994 • 68 citations

Pathophysiologic roles of the fibrinogen gamma chain

2004 • 68 citations

Fibrinogen synthesis in serum-free hepatocyte cultures: Stimulation by glucocorticoids

1978 • 67 citations

Influence of γ′ Fibrinogen Splice Variant on Fibrin Physical Properties and Fibrinolysis Rate

2003 • 63 citations

Identification of a Novel Binding Site for Platelet Integrins αIIbβ3 (GPIIbIIIa) and α5β1 in the γC-domain of Fibrinogen

2003 • 62 citations

CD11b/CD18 mediates the neutrophil chemotactic activity of fibrin degradation product D domain.

1997 • 62 citations

Alphastatin, a 24–amino acid fragment of human fibrinogen, is a potent new inhibitor of activated endothelial cells in vitro and in vivo

2003 • 59 citations

Alternative Adhesion Sites in Human Fibrinogen for Vascular Endothelial Cells

1996 • 58 citations

The Role of αvβ3 Integrins in Vascular Healing

2002 • 57 citations

Fibrinogen heterogeneity: inherited and noninherited

2005 • 57 citations

CD1lb/CD 18 Mediates the Neutrophil Chemotactic Activity of Fibrin Degradation Product D Domain

1997 • 53 citations

Conformational Changes upon Conversion of Fibrinogen into Fibrin

2001 • 53 citations

Interaction of Fibrin(ogen) with Leukocyte Receptor α_Mβ₂ (Mac-1): Further Characterization and Identification of a Novel Binding Region within the Central Domain of the Fibrinogen γ-Module

2004 • 52 citations

Fibrin glue for wound repair: facts and fancy

2003 • 50 citations

Fibronectin–Fibrin Cross-Linking

1998 • 48 citations

Biological in vitro effects of fibrin glue: fibroblast proliferation, expression and binding of growth factors

2004 • 47 citations

Determination of the topology of factor XIIIa-induced fibrin gamma-chain cross-links by electron microscopy of ligated fragments.

1993 • 46 citations

Disorders of platelet function

1992 • 46 citations

Overexpression of any fibrinogen chain by Hep G2 cells specifically elevates the expression of the other two chains.

1994 • 45 citations

Human Fibroblast Adhesion to Fibrinogen

1997 • 44 citations

Involvement of the .alpha. chain in fibrin clot formation. Effect of monoclonal antibodies

1992 • 41 citations

Requirements for α5β1Integrin-mediated Retraction of Fibronectin-Fibrin Matrices

1999 • 40 citations

The effects of tissue sealants, platelet gels, and growth factors on wound healing

2003 • 40 citations

Aberrant fibrin formation and cross-linking of fibrinogen Nieuwegein, a variant with a shortened Aα-chain, alters endothelial capillary tube formation

2001 • 38 citations

Role of α5β1 and αvβ3 Integrins on Smooth Muscle Cell Spreading and Migration in Fibrin Gels

2000 • 34 citations

Factor XIIIa supports microvascular endothelial cell adhesion and inhibits capillary tube formation in fibrin

2000 • 31 citations

Polymerization properties of two normally circulating fibrinogens, HMW and LMW. Evidence that the COOH-terminal end of the a-chain is of importance for fibrin polymerization

1985 • 31 citations

Fibrinogen Bβ polymorphisms do not directly contribute to an altered in vitro clot structure in humans

2003 • 28 citations

Interactions between Fibrin, Collagen and Endothelial Cells in Angiogensis

1990 • 27 citations

An ex vivo model for functional studies of myofibroblasts

2005 • 25 citations

Fibrinogen αC Domains Contain Cryptic Plasminogen and tPA Binding Sites

2001 • 24 citations

Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model

2002 • 23 citations

Cell Type–Specific Regulation of Fibrinogen Expression in Lung Epithelial Cells by Dexamethasone and Interleukin-1 β

2000 • 23 citations

Evidence that low molecular fibrinogen (LMW) is formed in man by degradation of high molecular weight fibrinogen (HMW)

1986 • 21 citations

The Role of Putative Fibrinogen Aα-, Bβ-, and γA-chain Integrin Binding Sites in Endothelial Cell-mediated Clot Retraction

1997 • 21 citations

Effects of low molecular weight heparins on fibrin polymerization and clot sensitivity to t-PA-induced lysis.

1993 • 17 citations

Contribution of the α_EC Domain to the Structure and Function of Fibrinogen‐420

2001 • 17 citations

Effects of low molecular weight heparins on fibrin polymerization and clot sensitivity to t-PA-induced lysis

1993 • 16 citations

Differences Between Bacterial Species Shown by Simultaneous Assessment of Neutrophil Phagocytosis and Generation of Reactive Oxygen Intermediates in Trauma Patients

1999 • 9 citations

Immunological Monitoring of Fenton Fragmentation of Fibrinogen

1991 • 6 citations