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Excess Circulating Angiopoietin-2 May Contribute to Pulmonary Vascular Leak in Sepsis in Humans

Data up to Jan 2025

Published2006
Citations490
References62

Total Citations Per Year

Abstract

References (62)

Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome

2000 • 11,795 citations

Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

2001 • 8,356 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

The Epidemiology of Sepsis in the United States from 1979 through 2000

2003 • 5,679 citations

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

2003 • 5,388 citations

The Acute Respiratory Distress Syndrome

1996 • 5,031 citations

The Acute Respiratory Distress Syndrome

2000 • 4,409 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

A gene atlas of the mouse and human protein-encoding transcriptomes

2004 • 3,443 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1

1999 • 1,372 citations

Angiopoietin-1 protects the adult vasculature against plasma leakage

2000 • 1,271 citations

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

2000 • 1,099 citations

Clinical risks for development of the acute respiratory distress syndrome.

1995 • 884 citations

Pathophysiological consequences of VEGF-induced vascular permeability

2005 • 848 citations

Improved Survival of Patients With Acute Respiratory Distress Syndrome (ARDS): 1983-1993

1995 • 700 citations

The Tie-2 ligand Angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies

2004 • 695 citations

Disrupted Pulmonary Vasculature and Decreased Vascular Endothelial Growth Factor, Flt-1, and TIE-2 in Human Infants Dying with Bronchopulmonary Dysplasia

2001 • 577 citations

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 • 550 citations

Report of the American-European Consensus Conference on acute respiratory distress syndrome: Definitions, mechanisms, relevant outcomes, and clinical trial coordination

1994 • 427 citations

Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors.

1999 • 418 citations

Identification of a Putative Target for Rho as the Serine-Threonine Kinase Protein Kinase N

1996 • 417 citations

Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues

1997 • 410 citations

Regulation of Angiopoietin-2 mRNA Levels in Bovine Microvascular Endothelial Cells by Cytokines and Hypoxia

1998 • 379 citations

Angiopoietin-1 Reduces VEGF-Stimulated Leukocyte Adhesion to Endothelial Cells by Reducing ICAM-1, VCAM-1, and E-Selectin Expression

2001 • 354 citations

Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase.

1985 • 340 citations

Bacteremia and severe sepsis in adults: a multicenter prospective survey in ICUs and wards of 24 hospitals. French Bacteremia-Sepsis Study Group.

1996 • 336 citations

Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2

2001 • 289 citations

Involvement of myosin light-chain kinase in endothelial cell retraction.

1990 • 249 citations

Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

2005 • 227 citations

Endothelial gaps and permeability of venules in rat tracheas exposed to inflammatory stimuli

1994 • 223 citations

Endothelial Gaps as Sites for Plasma Leakage in Inflammation

1999 • 222 citations

Angiopoietin-2 Causes Inflammation in Vivo by Promoting Vascular Leakage

2005 • 217 citations

Hypoxic Regulation of Angiopoietin-2 Expression in Endothelial Cells

2004 • 196 citations

Protective Role of Angiopoietin-1 in Endotoxic Shock

2004 • 195 citations

Angiopoietin-1 Promotes Cardiac and Skeletal Myocyte Survival Through Integrins

2005 • 190 citations

PLASMA VASCULAR ENDOTHELIAL GROWTH FACTOR IN SEVERE SEPSIS

2004 • 181 citations

Angiogenic Actions of Angiopoietin-1 Require Endothelium-Derived Nitric Oxide

2003 • 179 citations

Tumor necrosis factor and interleukin 1 alpha increase vascular endothelial permeability

1989 • 168 citations

Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure

2004 • 158 citations

Protein kinase involved in lung injury susceptibility: Evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment

2003 • 135 citations

Intracellular signalling involved in modulating human endothelial barrier function*

2002 • 133 citations

IL-1 and IFN-gamma increase vascular permeability.

1988 • 131 citations

Angiopoietin‐regulated recruitment of vascular smooth muscle cells by endothelial‐derived heparin binding EGF‐like growth factor

2003 • 122 citations

Endothelial Gaps as Sites for Plasma Leakage in Inflammation

1999 • 121 citations

Role of myosin light-chain phosphorylation in endothelial cell retraction

1993 • 117 citations

Transvascular flux and tissue accrual of Evans blue: effects of endotoxin and histamine.

1988 • 116 citations

Regulation of endothelial cell gap formation and barrier function by myosin-associated phosphatase activities

1995 • 100 citations

C1-inhibitor in patients with severe sepsis and septic shock: Beneficial effect on renal dysfunction

2002 • 95 citations

Myosin light chain kinase transference induces myosin light chain activation and endothelial hyperpermeability

2000 • 82 citations

Mutagenesis of the Phosphorylation Site (Serine 19) of Smooth Muscle Myosin Regulatory Light Chain and Its Effects on the Properties of Myosin

1994 • 80 citations

Pulmonary Vascular Permeability during the Adult Respiratory Distress Syndrome: A Positron Emission Tomographic Study

1988 • 78 citations

Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats

2001 • 65 citations

Myosin light chain phosphorylation and pulmonary endothelial cell hyperpermeability in burns

2004 • 57 citations

Opposing effect of angiopoietin‐1 on VEGF‐mediated disruption of endothelial cell–cell interactions requires activation of PKCβ

2003 • 55 citations

Production and antagonism of cutaneous vascular permeability in the guinea pig in response to histamine, leukotrienes and A23187.

1984 • 51 citations

Gamma scintigraphic analysis of albumin flux in patients with acute respiratory distress syndrome.

1984 • 38 citations

Sensitivity of Scintigraphy for Detection of Pulmonary Capillary Albumin Leak in Canine Oleic Acid ARDS

1981 • 37 citations

Vascular Endothelial Growth Factor Blockade Reduces Plasma Cytokines in a Murine Model of Polymicrobial Sepsis

2004 • 34 citations

The sup 67 gallium-transferrin pulmonary leak index in patients at risk for the acute respiratory distress syndrome

1998 • 26 citations

Comparative scintigraphy in oleic acid pulmonary microvascular injury

1982 • 17 citations

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Excess Circulating Angiopoietin-2 May Contribute to Pulmonary Vascular Leak in Sepsis in… (2006) – PLoS Medicine | Metascience Observatory Explorer