Molecular mechanisms of endothelial hyperpermeability: implications in inflammation

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

2003 • 7,170 citations

The Pathobiology of Diabetic Complications

2005 • 4,849 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Pathophysiology of ischaemia-reperfusion injury

2000 • 1,664 citations

Signaling Mechanisms Regulating Endothelial Permeability

2005 • 1,632 citations

Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness

2000 • 1,627 citations

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.

1995 • 1,280 citations

Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities

2001 • 1,144 citations

Endothelial cell–cell junctions: happy together

2004 • 1,123 citations

Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome

2003 • 1,069 citations

Abnormalities in Pericytes on Blood Vessels and Endothelial Sprouts in Tumors

2002 • 955 citations

The Role of Nuclear Factor- κ B in Cytokine Gene Regulation

1997 • 948 citations

VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin

2006 • 943 citations

International Union of Pharmacology. XIII. Classification of histamine receptors.

1997 • 869 citations

Pathophysiological consequences of VEGF-induced vascular permeability

2005 • 848 citations

Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway

2002 • 832 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

Selective Requirement for Src Kinases during VEGF-Induced Angiogenesis and Vascular Permeability

1999 • 802 citations

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

1996 • 718 citations

Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells

1998 • 695 citations

The biology of the receptor for advanced glycation end products and its ligands

2000 • 690 citations

Vascular Endothelial Growth Factor–Induced Retinal Permeability Is Mediated by Protein Kinase C In Vivo and Suppressed by an Orally Effective β-Isoform–Selective Inhibitor

1997 • 665 citations

Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis

2001 • 655 citations

Caveolin-1 Regulates Transforming Growth Factor (TGF)-β/SMAD Signaling through an Interaction with the TGF-β Type I Receptor

2001 • 638 citations

Glucocorticoids and the Th1/Th2 Balance

2004 • 566 citations

Histamine and its receptors

2006 • 526 citations

Contributions of polyol pathway to oxidative stress in diabetic cataract

1999 • 517 citations

Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1–phosphate receptor-1 crossactivation

2004 • 470 citations

INTRAVITREAL BEVACIZUMAB (AVASTIN) THERAPY FOR PERSISTENT DIFFUSE DIABETIC MACULAR EDEMA

2006 • 459 citations

VEGF signalling: integration and multi-tasking in endothelial cell biology

2003 • 419 citations

Activation of RhoA by Thrombin in Endothelial Hyperpermeability

2000 • 402 citations

Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

2008 • 391 citations

Endothelial-Dependent Mechanisms of Leukocyte Recruitment to the Vascular Wall

2007 • 390 citations

Cellular consequences of thrombin-receptor activation

1996 • 341 citations

Applications for ROCK kinase inhibition

2008 • 340 citations

Caveolae and Caveolins in the Cardiovascular System

2004 • 310 citations

Advanced Glycation End Product-induced Apoptosis and Overexpression of Vascular Endothelial Growth Factor and Monocyte Chemoattractant Protein-1 in Human-cultured Mesangial Cells

2002 • 308 citations

The role of integrins in the maintenance of endothelial monolayer integrity.

1991 • 290 citations

The vesiculo-vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation

1996 • 266 citations

p120-Catenin Regulates Clathrin-dependent Endocytosis of VE-Cadherin

2005 • 261 citations

Protein Kinase C-α Signals Rho-Guanine Nucleotide Dissociation Inhibitor Phosphorylation and Rho Activation and Regulates the Endothelial Cell Barrier Function

2001 • 253 citations

Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor.

2000 • 244 citations

Protein kinase signaling in the modulation of microvascular permeability

2002 • 234 citations

Ca²⁺ Signaling, TRP Channels, and Endothelial Permeability

2006 • 229 citations

Mechanisms and Consequences of Neutrophil Interaction with the Endothelium

2007 • 222 citations

Vascular Endothelial Growth Factor and Diabetic Retinopathy: Role of Oxidative Stress

2005 • 222 citations

Upregulation of vascular endothelial growth factor by H2O2 in rat heart endothelial cells

1998 • 218 citations

The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells

2007 • 216 citations

Ca²⁺ signalling and PKCα activate increased endothelial permeability by disassembly of VE—cadherin junctions

2001 • 216 citations

Role of Src-induced Dynamin-2 Phosphorylation in Caveolae-mediated Endocytosis in Endothelial Cells

2004 • 211 citations

Modulating leukocyte recruitment in inflammation

2007 • 210 citations

Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression‐free survival among patients with low‐grade neuroendocrine tumors

2007 • 198 citations

Novel role of microtubules in thrombin‐induced endothelial barrier dysfunction

2004 • 192 citations

Rho Kinase Inhibition by Fasudil Ameliorates Diabetes-Induced Microvascular Damage

2008 • 191 citations

VEGF Increases Permeability of the Endothelial Cell Monolayer by Activation of PKB/akt, Endothelial Nitric-Oxide Synthase, and MAP Kinase Pathways

2001 • 190 citations

Bench-to-bedside review: acute respiratory distress syndrome - how neutrophils migrate into the lung.

2004 • 184 citations

RhoA/Rho-Kinase Contribute to the Pathogenesis of Diabetic Renal Disease

2008 • 179 citations

Molecular mechanisms of thrombin-induced endothelial cell permeability.

2002 • 178 citations

Extracellular matrix, junctional integrity and matrix metalloproteinase interactions in endothelial permeability regulation*

2002 • 171 citations

Pulmonary Edema Fluid from Patients with Acute Lung Injury Augments In Vitro Alveolar Epithelial Repair by an IL-1 β -dependent Mechanism

2001 • 164 citations

Vascular endothelial growth factor and platelet-derived growth factor are potential angiogenic and metastatic factors in human breast cancer

1996 • 163 citations

VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide

2003 • 163 citations

Protein kinase C phosphorylates caldesmon₇₇ and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers

1992 • 163 citations

Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase‐3β

2002 • 159 citations

Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis

2004 • 158 citations

Comparison of systemic cytokine levels in patients with acute respiratory distress syndrome, severe pneumonia, and controls

2000 • 158 citations

Rho and ROCK Signaling in VEGF‐Induced Microvascular Endothelial Hyperpermeability

2006 • 156 citations

Regulation of Leukocyte Transmigration: Cell Surface Interactions and Signaling Events

2004 • 155 citations

Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets

2000 • 152 citations

p21-activated Kinase Regulates Endothelial Permeability through Modulation of Contractility

2004 • 151 citations

Differential Regulation of Alternatively Spliced Endothelial Cell Myosin Light Chain Kinase Isoforms by p60Src

2001 • 150 citations

Signal transduction and regulation of lung endothelial cell permeability. Interaction between calcium and cAMP

1998 • 150 citations

Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway

1997 • 150 citations

Targets for pharmacological intervention of endothelial hyperpermeability and barrier function

2002 • 149 citations

Nonvascular role for vascular endothelial growth factor (VEGF): VEGFR‐1 and VEGFR‐2 activity is critical for neural retinal development

2001 • 147 citations

Caveolin-1–Deficient Mice Have Increased Tumor Microvascular Permeability, Angiogenesis, and Growth

2007 • 147 citations

Endothelial Ca ²⁺ waves preferentially originate at specific loci in caveolin-rich cell edges

1998 • 147 citations

Protein Kinase Cα-Induced p115RhoGEF Phosphorylation Signals Endothelial Cytoskeletal Rearrangement

2003 • 147 citations

Simvastatin Improves Disturbed Endothelial Barrier Function

2000 • 147 citations

Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability

1999 • 147 citations

Complement activation following oxidative stress

1999 • 141 citations

Redox Regulation of Reactive Oxygen Species-Induced p38 MAP Kinase Activation and Barrier Dysfunction in Lung Microvascular Endothelial Cells

2003 • 137 citations

VE-cadherin-p120 interaction is required for maintenance of endothelial barrier function

2004 • 135 citations

The Soluble Endothelial Protein C Receptor Binds to Activated Neutrophils: Involvement of Proteinase-3 and CD11b/CD18

2000 • 128 citations

Intercellular Adhesion Molecule-1–Dependent Neutrophil Adhesion to Endothelial Cells Induces Caveolae-Mediated Pulmonary Vascular Hyperpermeability

2008 • 126 citations

Cdc42 Regulates the Restoration of Endothelial Barrier Function

2003 • 125 citations

VEGF‐induced paracellular permeability in cultured endothelial cells involves urokinase and its receptor

2003 • 120 citations

Endothelial focal adhesions and barrier function

2005 • 117 citations

Vascular pharmacology of acute lung injury and acute respiratory distress syndrome

2002 • 117 citations

Tumor necrosis factor-alpha blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation.

1993 • 114 citations

Mac-1 Signaling via Src-Family and Syk Kinases Results in Elastase-Dependent Thrombohemorrhagic Vasculopathy

2006 • 112 citations

Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits

2008 • 110 citations

A Novel Snake Venom Vascular Endothelial Growth Factor (VEGF) Predominantly Induces Vascular Permeability through Preferential Signaling via VEGF Receptor-1

2004 • 109 citations

Gene Expression Profiling of Inflamed Human Endothelial Cells and Influence of Activated Protein C

2004 • 108 citations

Leukocyte-endothelial cell interactions are linked to vascular permeability via ICAM-1-mediated signaling

2008 • 108 citations

Tumor Necrosis Factor-α and Angiostatin Are Mediators of Endothelial Cytotoxicity in Bronchoalveolar Lavages of Patients with Acute Respiratory Distress Syndrome

2002 • 104 citations

Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: Role of NADPH oxidase-derived ROS

2007 • 102 citations

Protein Kinase C Activation Contributes to Microvascular Barrier Dysfunction in the Heart at Early Stages of Diabetes

2000 • 101 citations

Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin

2002 • 98 citations

Differential regulation of Rho GTPases by β1 and β3 integrins: the role of an extracellular domain of integrin in intracellular signaling

2002 • 97 citations

Myosin Light Chain Phosphorylation in Neutrophil-Stimulated Coronary Microvascular Leakage

2002 • 95 citations

Introduction: The complexities of leukocyte recruitment

2002 • 93 citations

Role of Ras-dependent ERK activation in phorbol ester-induced endothelial cell barrier dysfunction

2000 • 93 citations

Signal Transduction Pathways in Enhanced Microvascular Permeability

2000 • 92 citations

Role of CaM kinase II and ERK activation in thrombin-induced endothelial cell barrier dysfunction

2003 • 89 citations

ZM323881, a Novel Inhibitor of Vascular Endothelial Growth Factor‐Receptor‐2 Tyrosine Kinase Activity

2002 • 86 citations

Diabetes-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1) expression.

2002 • 84 citations

Microvascular Permeability in Diabetes and Insulin Resistance

2007 • 84 citations

Fasudil inhibits vascular endothelial growth factor–induced angiogenesisin vitroandin vivo

2007 • 83 citations

VE-cadherin and β-catenin binding dynamics during histamine-induced endothelial hyperpermeability

2008 • 78 citations

Src-dependent, neutrophil-mediated vascular hyperpermeability and β-catenin modification

2002 • 78 citations

Effects of H₁antagonists on the cutaneous vascular response to histamine and bradykinin: a study using scanning laser Doppler imaging

1998 • 76 citations

Upregulation of PKC genes and isozymes in cardiovascular tissues during early stages of experimental diabetes

2003 • 76 citations

Vascular endothelial growth factor stimulates differential signaling pathways in in vivo microcirculation

2004 • 74 citations

Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability

2004 • 72 citations

Integrin binding to fibronectin and vitronectin maintains the barrier function of isolated porcine coronary venules

2001 • 71 citations

HMG CoA reductase inhibition modulates VEGF‐induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation

2005 • 69 citations

Principles of Molecular Oncology

2004 • 67 citations

Albumin-derived advanced glycation end-products trigger the disruption of the vascular endothelial cadherin complex in cultured human and murine endothelial cells

2001 • 65 citations

Acute modulation of albumin microvascular leakage by advanced glycation end products in microcirculation of diabetic rats in vivo.

1999 • 63 citations

The protein kinase MEK1/2 mediate vascular endothelial growth factor‐ and histamine‐induced hyperpermeability in porcine coronary venules

2004 • 61 citations

Involvement of ROCK-mediated endothelial tension development in neutrophil-stimulated microvascular leakage

2005 • 60 citations

Rho signaling and mechanical control of vascular development

2008 • 60 citations

Focal adhesion kinase mediates porcine venular hyperpermeability elicited by vascular endothelial growth factor

2003 • 59 citations

HISTAMINE RELEASE AND ENDOTOXIN SHOCK IN THE PRIMATE*

1961 • 59 citations

Role of Protein Kinase C Isoforms in Rat Epididymal Microvascular Endothelial Barrier Function

2003 • 57 citations

Aggravation of hemorrhagic transformation by early intraarterial infusion of low-dose vascular endothelial growth factor after transient focal cerebral ischemia in rats

2005 • 56 citations

Involvement of PKCδ and PKD in pulmonary microvascular endothelial cell hyperpermeability

2004 • 55 citations

RhoA- and PKC-α-mediated phosphorylation of MYPT and its association with HSP27 in colonic smooth muscle cells.

2005 • 50 citations

Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia‐reperfusion injury in rats

2006 • 48 citations

Effects of antihistamines on the lung vascular response to histamine in unanesthetized sheep. Diphenhydramine prevention of pulmonary edema and increased permeability.

1976 • 47 citations

Macromolecule permeability of in situ and excised rodent skeletal muscle arterioles and venules

2005 • 45 citations

Synergistic Antitumor Activity of Ixabepilone (BMS-247550) Plus Bevacizumab in Multiple In vivo Tumor Models

2008 • 44 citations

A role for endothelial-derived matrix metalloproteinase-2 in breast cancer cell transmigration across the endothelial-basement membrane barrier

2007 • 43 citations

p42/44MAPK Regulates Baseline Permeability and cGMP-Induced Hyperpermeability in Endothelial Cells

2002 • 40 citations

Albumin-derived advanced glycation end-products trigger the disruption of the vascular endothelial cadherin complex in cultured human and murine endothelial cells

2001 • 38 citations

Activation of Rho Is Involved in the Mechanism of Hydrogen-Peroxide-Induced Lung Edema in Isolated Perfused Rabbit Lung

2001 • 37 citations

Role of Ca²⁺in diperoxovanadate-induced cytoskeletal remodeling and endothelial cell barrier function

2003 • 34 citations

Reduced expression of the adherens junction protein cadherin-5 in a diabetic retina

2000 • 34 citations

Effects of Glutathione Depletion on Oxidant-Induced Endothelial Cell Injury

1998 • 31 citations

Protein C/activated protein C pathway: Overview of clinical trial results in severe sepsis

2004 • 31 citations

Rho-kinase (ROCK-1 and ROCK-2) upregulation in oleic acid-induced lung injury and its restoration by Y-27632

2005 • 30 citations

Mast Cell-Derived Mediators of Enhanced Microvascular Permeability, Vascular Permeability Factor/ Vascular Endothelial Growth Factor, Histamine, and Serotonin, Cause Leakage of Macromolecules through a New Endothelial Cell Permeability Organelle, the Vesiculo-Vacuolar Organelle

2005 • 30 citations

Prevention of Ischemia-Reperfusion Injury in a Rat Skin Flap Model: The Role of Mast Cells, Cromolyn Sodium, and Histamine Receptor Blockade

2000 • 28 citations

Molecular Mechanisms of ThrombinInduced Endothelial Cell Permeability

2002 • 27 citations

Effects of bradykinin, histamine and serotonin on pulmonary vascular resistance and permeability

1997 • 26 citations

Emerging Topics in the Regulation of Leukocyte Transendothelial Migration

2005 • 21 citations

Activated protein C attenuates intestinal reperfusion–induced acute lung injury: an experimental study in a rat model

2008 • 20 citations

Leukocyte-Endothelial Cell Interactions – Lessons from Knockout Mice

1999 • 20 citations

Ischemia-Reperfusion Injury, Reactive Oxygen Metabolites, and the Surgeon

1998 • 18 citations

Drotrecogin Alfa (activated) Prevents Smoke-Induced Increases in Pulmonary Microvascular Permeability and Proinflammatory Cytokine IL-1β in Rats

2004 • 16 citations

Fasudil inhibits vascular endothelial growth factor-induced angiogenesis in vitro and in vivo

2009 • 13 citations

Effects of glucocorticoids on the airways.

1982 • 13 citations

Effect of H1 antihistamines in a model of mesenteric ischaemia/reperfusion

2008 • 10 citations

Angiogenesis Switch Pathways

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The role of histamine release in shock.

1990 • 7 citations

Transendothelial Pathways in Venular Microvessels Exposed to Agents Which Increase Permeability: The Gaps in Our Knowledge

1999 • 7 citations

DIPHENHYDRAMINE PREVENTION OF PULMONARY EDEMA AND INCREASED PERMEABILITY

1976 • 2 citations