Functional Selectivity of G Protein Signaling by Agonist Peptides and Thrombin for the Protease-activated Receptor-1

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

G PROTEIN–COUPLED RECEPTOR KINASES

1998 • 1,335 citations

GTPase-Activating Proteins for Heterotrimeric G Proteins: Regulators of G Protein Signaling (RGS) and RGS-Like Proteins

2000 • 1,143 citations

Molecular cloning of a potential proteinase activated receptor.

1994 • 887 citations

Protease-activated receptor 3 is a second thrombin receptor in humans

1997 • 878 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.

1992 • 725 citations

PAR3 is a cofactor for PAR4 activation by thrombin

2000 • 538 citations

Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A and 2C Receptors: Evidence for Agonist-Directed Trafficking of Receptor Stimulus

1998 • 502 citations

Membrane Receptors and Hormone Action

1976 • 484 citations

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

1996 • 457 citations

Rho GTPases and the regulation of endothelial permeability

2002 • 457 citations

Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function.

1992 • 424 citations

Principles: Receptor theory in pharmacology

2004 • 406 citations

Activation of RhoA by Thrombin in Endothelial Hyperpermeability

2000 • 402 citations

A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho

1999 • 386 citations

Functionally Different Agonists Induce Distinct Conformations in the G Protein Coupling Domain of the β2Adrenergic Receptor

2001 • 361 citations

Molecular Cloning and Functional Expression of the Gene Encoding the Human Proteinase‐Activated Receptor 2

1995 • 334 citations

Sequential Binding of Agonists to the β2 Adrenoceptor

2003 • 333 citations

Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors

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Thrombin-Induced Increase in Endothelial Permeability Is Associated With Changes in Cell-to-Cell Junction Organization

1996 • 309 citations

Thrombin Responses in Human Endothelial Cells

2000 • 296 citations

Role of Ca2+ signaling in the regulation of endothelial permeability

2002 • 292 citations

Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function.

1992 • 291 citations

Abnormal TNF activity in Timp3−/− mice leads to chronic hepatic inflammation and failure of liver regeneration

2004 • 277 citations

Protease-activated receptors: sentries for inflammation?

2000 • 249 citations

Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems.

1994 • 243 citations

Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins

2001 • 241 citations

Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides

1997 • 240 citations

Control and Plasticity of Intercellular Calcium Waves in Astrocytes: A Modeling Approach

2002 • 235 citations

Leukemia‐associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G₁₂ family to Rho

2000 • 224 citations

Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling

1998 • 223 citations

Regulation of Phospholipase C-β1 by Gq and m1 Muscarinic Cholinergic Receptor

1996 • 220 citations

Mechanisms of increased endothelial permeability

1996 • 218 citations

RhoA Interaction with Inositol 1,4,5-Trisphosphate Receptor and Transient Receptor Potential Channel-1 Regulates Ca2+ Entry

2003 • 218 citations

Ligand Cross-reactivity within the Protease-activated Receptor Family

1996 • 210 citations

Differential Involvement of Gα12 and Gα13 in Receptor-mediated Stress Fiber Formation

1999 • 209 citations

Structure-Function Analysis of Protease-activated Receptor 4 Tethered Ligand Peptides

2000 • 205 citations

Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling

1993 • 205 citations

Protease-activated Receptor-1 Signaling by Activated Protein C in Cytokine-perturbed Endothelial Cells Is Distinct from Thrombin Signaling

2005 • 189 citations

Activation of cytosolic phosphoinositide phospholipase C by G-protein beta gamma subunits

1992 • 188 citations

Molecular mechanisms of thrombin-induced endothelial cell permeability.

2002 • 178 citations

Synthetic alpha-thrombin receptor peptides activate G protein-coupled signaling pathways but are unable to induce mitogenesis.

1992 • 178 citations

Rapid GTP binding and hydrolysis by G _q promoted by receptor and GTPase-activating proteins

1999 • 175 citations

TGF-beta increases retinal endothelial cell permeability by increasing MMP-9: possible role of glial cells in endothelial barrier function.

2001 • 173 citations

Reconstitution of Receptors and GTP-binding Regulatory Proteins (G Proteins) in Sf9 Cells

1997 • 166 citations

Differential activation of p44mapk (ERK1) by α-thrombin and thrombin-receptor peptide agonist

1993 • 163 citations

Dichotomous Regulation of Myosin Phosphorylation and Shape Change by Rho-Kinase and Calcium in Intact Human Platelets

1999 • 158 citations

Serotonin 5-Hydroxytryptamine_2AReceptor-Coupled Phospholipase C and Phospholipase A₂Signaling Pathways Have Different Receptor Reserves

2003 • 155 citations

A Spatial Focusing Model for G Protein Signals

2003 • 129 citations

The Human Proteinase-activated Receptor-3 (PAR-3) Gene

1998 • 122 citations

Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species

2001 • 122 citations

Functional Selectivity of Dopamine Receptor Agonists. I. Selective Activation of Postsynaptic Dopamine D₂Receptors Linked to Adenylate Cyclase

2002 • 121 citations

Coordinated Signaling through Both G12/13 and Gi Pathways Is Sufficient to Activate GPIIb/IIIa in Human Platelets

2002 • 117 citations

Differential Actions of PAR ₂ and PAR ₁ in Stimulating Human Endothelial Cell Exocytosis and Permeability

2003 • 116 citations

Thrombin receptor activating peptides induce Ca²⁺ mobilization, barrier dysfunction, prostaglandin synthesis, and platelet‐derived growth factor mRNA expression in cultured endothelium

1993 • 114 citations

Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats.

2001 • 112 citations

Molecules in focus Thrombin

1998 • 111 citations

The non-stoichiometric floating receptor model for hormone sensitive adenylyl cyclase

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Role of Protease-activated Receptors in the Vascular System

2003 • 103 citations

A Rho Exchange Factor Mediates Thrombin and Gα12-induced Cytoskeletal Responses

1999 • 103 citations

Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations.

2001 • 99 citations

Thrombin induces endothelial cell growth via both a proteolytic and a non-proteolytic pathway

1994 • 98 citations

Thrombin-Mediated Increase in Vascular Endothelial Permeability

1992 • 97 citations

Purification and characterization of a GTP-binding protein with a molecular weight of 20,000 in bovine brain membranes. Identification as the rho gene product.

1988 • 93 citations

Metabotropic receptor activation, desensitization and sequestration—I: modelling calcium and inositol 1,4,5-trisphosphate dynamics following receptor activation

2003 • 91 citations

Single-molecule spectroscopy of the β ₂ adrenergic receptor: Observation of conformational substates in a membrane protein

2001 • 87 citations

Functional Selectivity of D₂Receptor Ligands in a Chinese Hamster Ovary hD_2LCell Line: Evidence for Induction of Ligand-Specific Receptor States

2004 • 86 citations

Requirement for Rho-mediated Myosin Light Chain Phosphorylation in Thrombin-stimulated Cell Rounding and Its Dissociation from Mitogenesis

1998 • 84 citations

Functional Selectivity of Dopamine Receptor Agonists. II. Actions of Dihydrexidine in D_2LReceptor-Transfected MN9D Cells and Pituitary Lactotrophs

2002 • 82 citations

Physiology and pathophysiology of the vascular wall / [Physiologie et pathophysiologie de la paroi vasculaire] Mechanisms of increased endothelial permeability

1996 • 82 citations

A peptide ligand of the human thrombin receptor antagonizes alpha-thrombin and partially activates platelets

1993 • 80 citations

Myosin light chain kinase: functional domains and structural motifs

1998 • 76 citations

Purification and characterization of the alpha subunit of G13.

1994 • 75 citations

Regulators of G Protein Signaling and Transient Activation of Signaling

2003 • 74 citations

Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species

2001 • 74 citations

Molecular Basis of Partial Agonism: Orientation of Indoleamine Ligands in the Binding Pocket of the Human Serotonin 5-HT2A Receptor Determines Relative Efficacy

2003 • 73 citations

Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides

2001 • 71 citations

Extracellular Mutations of Protease-Activated Receptor-1 Result in Differential Activation by Thrombin and Thrombin Receptor Agonist Peptide

2000 • 68 citations

Platelet Shape Change Induced by Thrombin Receptor Activation

1995 • 64 citations

The two-step model of ligand-receptor interaction

1977 • 63 citations

Tethered ligand‐derived peptides of proteinase‐activated receptor 3 (PAR₃) activate PAR₁ and PAR₂ in Jurkat T cells

2004 • 63 citations

REGULATION OF MYOSIN LIGHT CHAIN KINASE BY REVERSIBLE PHOSPHORYLATION AND CALCIUM‐CALMODULIN

1980 • 60 citations

Cleavage of the thrombin receptor: identification of potential activators and inactivators

1996 • 57 citations

Binding of a Thrombin Receptor Tethered Ligand Analogue to Human Platelet Thrombin Receptor

1997 • 57 citations

Different G protein‐coupled signaling pathways are involved in α granule release from human platelets

2004 • 57 citations

Thrombin Receptors Activate Go Proteins in Endothelial Cells to Regulate Intracellular Calcium and Cell Shape Changes

2002 • 56 citations

Protein phosphatases that regulate multifunctional Ca2+/calmodulin-dependent protein kinases: from biochemistry to pharmacology

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Thrombin-induced endothelial cell dysfunction

1994 • 49 citations

Proteinase-Activated Receptor 2: Differential Activation of the Receptor by Tethered Ligand and Soluble Peptide Analogs

2002 • 48 citations

Vascular protease receptors: integrating haemostasis and endothelial cell functions

2000 • 41 citations

Proteolytically Activated Receptor-3 A Member of an Emerging Gene Family of Protease Receptors Expressed on Vascular Endothelial Cells and Platelets

1999 • 38 citations

Proteinase-Activated Receptor-2: Key Role of Amino-Terminal Dipeptide Residues of the Tethered Ligand for Receptor Activation

2004 • 38 citations

Thrombin Peptide, TP508, Induces Differential Gene Expression in Fibroblasts through a Nonproteolytic Activation Pathway

1999 • 37 citations

Application of RGS Box Proteins to Evaluate G-Protein Selectivity in Receptor-Promoted Signaling

2004 • 35 citations

Luteinizing Hormone/Choriogonadotropin-Dependent, Cholera Toxin-Catalyzed Adenosine 5′-Diphosphate (ADP)-Ribosylation of the Long and Short Forms of G_sα and Pertussis Toxin-Catalyzed ADP-Ribosylation of Giα

1997 • 34 citations

Genetic and Pharmacological Analyses of Involvement of Src-family, Syk and Btk Tyrosine Kinases in Platelet Shape Change

2001 • 33 citations

Proliferative effects of apical, but not basal, matrix metalloproteinase-7 activity in polarized MDCK cells

2004 • 31 citations

PAR₁-dependent and independent increases in COX-2 and PGE₂in human colonic myofibroblasts stimulated by thrombin

2003 • 31 citations

Functional Modules in Biological Signalling Networks

2001 • 29 citations

Regulation of the Rate and Extent of Phospholipase C β₂ Effector Activation by the βγ Subunits of Heterotrimeric G Proteins

1998 • 26 citations

Thrombomodulin Modulates the Mitogenic Response to Thrombin of Human Umbilical Vein Endothelial Cells

1998 • 26 citations

Responses of pertussis toxin-treated microvascular endothelial cells to transforming growth factor beta 1. No evidence for pertussis-sensitive G-protein involvement in TGF-beta signal transduction.

1992 • 23 citations

Nonproteolytic activation of the thrombin receptor promotes human umbilical vein endothelial cell growth but not intracellular Ca2+, prostacyclin, or permeability

1997 • 18 citations

Role of pertussis toxin-sensitive G-proteins in intracellular Ca2+ release and apoptosis induced by inhibiting cystic fibrosis transmembrane conductance regulator (CFTR) Cl? channels in HepG2 human hepatoblastoma cells

2001 • 12 citations

Platelet Shape Change Induced by the Peptide YFLLRNP

2001 • 11 citations

Thrombin downregulates muscle acetylcholine receptors via an IP3 signaling pathway by activating its G‐protein‐coupled protease‐activated receptor‐1

2003 • 11 citations

Thrombin receptor-activating peptide sensitizes the human endothelial thrombin receptor

1995 • 10 citations

Receptor Binding and Agonist Efficacy: New Insights from Mutants of the Thrombin Protease-Activated Receptor-1 (PAR-1)

2000 • 7 citations