High Glucose Concentrations Increase Endothelial Cell Permeability via Activation of Protein Kinase Cα

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

Diabetes and Glucose Tolerance as Risk Factors for Cardiovascular Disease: The Framingham Study

1979 • 1,212 citations

Protein kinase C - a question of specificity

1994 • 958 citations

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

1992 • 743 citations

Regulation of vascular endothelial barrier function

1994 • 481 citations

The Family of Protein Kinase C for Signal Transduction

1989 • 383 citations

Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications.

1989 • 374 citations

Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.

1995 • 337 citations

Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts.

1989 • 310 citations

Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation

1993 • 306 citations

Inhibition of protein kinase C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters.

1994 • 289 citations

Microvascular Function in Human Diabetes: A Physiological Perspective

1995 • 287 citations

Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy

1994 • 273 citations

Increased endothelial albumin permeability mediated by protein kinase C activation.

1990 • 271 citations

Inhibition of protein kinase C-alpha expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides.

1994 • 242 citations

Regulation of Protein Kinase C by Nerve Growth Factor, Epidermal Growth Factor, and Phorbol Esters in PC12 Pheochromocytoma Cells

1989 • 219 citations

Role for Protein Kinase C in the Mediation of Increased Fibronectin Accumulation by Mesangial Cells Grown in High-Glucose Medium

1993 • 178 citations

Protein kinase C phosphorylates caldesmon₇₇ and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers

1992 • 163 citations

Characterization of Glucose-Induced In Situ Protein Kinase C Activity in Cultured Vascular Smooth Muscle Cells

1992 • 118 citations

Differentiation of Vascular Smooth Muscle Cells and the Regulation of Protein Kinase C-α

1995 • 112 citations

Role of protein kinase C in bradykinin-induced increases in microvascular permeability.

1991 • 99 citations

Prevention by Protein Kinase C Inhibitors of Glucose-Induced Insulin-Receptor Tyrosine Kinase Resistance in Rat Fat Cells

1991 • 94 citations

Increased Transcapillary Escape Rate of Albumin in Microalbuminuric Type II Diabetic Patients

1995 • 92 citations

Human endothelial cells are targets for platelet-activating factor (PAF). Activation of alpha and beta protein kinase C isozymes in endothelial cells stimulated by PAF.

1994 • 81 citations

Mechanisms of Cholera Toxin Prevention of Thrombin- and PMA-Induced Endothelial Cell Barrier Dysfunction

1994 • 78 citations

High glucose concentrations and protein kinase C isoforms in vascular smooth muscle cells

1995 • 75 citations

Current Hypotheses for the Biochemical Basis of Diabetic Retinopathy

1992 • 72 citations

Platelet-derived growth factor and angiotensin II induce different spatial distribution of protein kinase C-alpha and -beta in vascular smooth muscle cells.

1994 • 71 citations

Glucose-induced downregulation of angiotensin II and arginine vasopressin receptors in cultured rat aortic vascular smooth muscle cells. Role of protein kinase C.

1992 • 70 citations

Human endothelial cells are targets for platelet-activating factor (PAF). Activation of alpha and beta protein kinase C isozymes in endothelial cells stimulated by PAF.

1994 • 69 citations

High glucose inhibits cytosolic calcium signaling in cultured rat mesangial cells

1993 • 68 citations

Early changes in diabetic retinopathy: Capillary loss and blood‐retina barrier permeability in relation to metabolic control

1994 • 60 citations

Endothelial Cell Tyrosine Kinase Receptor and G Protein–Coupled Receptor Activation Involves Distinct Protein Kinase C Isoforms

1996 • 58 citations

Glucose-induced vascular smooth muscle dysfunction: the role of protein kinase C

1995 • 57 citations

Initiation of hyperpermeability in energy-depleted coronary endothelial monolayers

1995 • 45 citations

Arachidonic Acid Release and Permeability Changes Induced by Endothelins in Human Cerebromicrovascular Endothelium

1994 • 42 citations

Functional antagonism between cAMP and cGMP on permeability of coronary endothelial monolayers

1996 • 41 citations

Role of Protein Kinase C in Intracellular Signaling

1994 • 33 citations

Vascular permeability in diabetics and implications for therapy

1994 • 30 citations

Regulation of inositol transport by glucose and protein kinase C in mesangial cells

1992 • 29 citations

Increased transendothelial permeation of albumin by high glucose concentration

1995 • 28 citations

Transformation-sensitive localization of alpha-protein kinase C at cell-cell contacts in rat renal proximal tubule epithelial cells.

1993 • 24 citations

Antisense DNA Downregulates Protein Kinase C Isozymes (β and α) and Insulin-Stimulated 2-Deoxyglucose Uptake in Rat Adipocytes

1991 • 21 citations

Effect of elevated extracellular glucose concentrations on transmembrane calcium ion fluxes in cultured rat VSMC

1993 • 20 citations

Stimulation of protein kinase C activity may increase microvascular permeability to colloidal carbon viaα-isoenzyme

1994 • 13 citations

Fibronectin-Induced Increase in Mesangial Cell Prostaglandin Release: Effect of Hyperglycemia and PKC Inhibition

1993 • 11 citations

The roles of specific isoforms of protein kinase C in growth control and human colon cancer.

1991 • 9 citations