Mechanisms for early microvascular injury in obesity and type II diabetes

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.

2000 • 1,537 citations

Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications

2002 • 1,000 citations

Ion Channels and Their Functional Role in Vascular Endothelium

2001 • 850 citations

High Glucose Causes Upregulation of Cyclooxygenase-2 and Alters Prostanoid Profile in Human Endothelial Cells

2003 • 421 citations

Protein Kinase C–Dependent Increase in Reactive Oxygen Species (ROS) Production in Vascular Tissues of Diabetes

2003 • 419 citations

Ascorbic Acid Enhances Endothelial Nitric-oxide Synthase Activity by Increasing Intracellular Tetrahydrobiopterin

2000 • 357 citations

Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: an effect prevented by vitamins C and E

2000 • 333 citations

Effects of Free Fatty Acids (FFA) on Glucose Metabolism: Significance for Insulin Resistance and Type 2 Diabetes

2003 • 330 citations

Protein kinase C and the development of diabetic vascular complications

2001 • 314 citations

Effect of Reinstitution of Good Glycemic Control on Retinal Oxidative Stress and Nitrative Stress in Diabetic Rats

2003 • 275 citations

Inhibition of Protein Kinase Cβ Prevents Impaired Endothelium-Dependent Vasodilation Caused by Hyperglycemia in Humans

2002 • 274 citations

Prostaglandins mediate arteriolar dilation to increased blood flow velocity in skeletal muscle microcirculation.

1990 • 206 citations

Nitric Oxide Has a Vasodilatory Role in Cat Optic Nerve Head during Flicker Stimuli

1996 • 160 citations

Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway

1995 • 158 citations

Topical hyperglycemia rapidly suppresses EDRF-mediated vasodilation of normal rat arterioles

1993 • 144 citations

Regulation of Endothelial Nitric Oxide Synthase by Protein Kinase C

2003 • 112 citations

Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects

2003 • 109 citations

Stimulation of perivascular nitric oxide synthesis by oxygen

2003 • 98 citations

Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na⁺-K⁺-ATPase activity

2002 • 88 citations

Signaling Pathways of Mechanotransduction in Arteriolar Endothelium and Smooth Muscle Cells in Hypertension

2002 • 86 citations

Endothelial dysfunction: its relationship with acute hyperglycaemia and hyperlipidemia.

2002 • 82 citations

Hyperglycemia affects flicker-induced vasodilation in the retina of healthy subjects

2003 • 74 citations

Arteriolar nitric oxide concentration is decreased during hyperglycemia-induced βII PKC activation

2001 • 71 citations

Dependence of intestinal arteriolar regulation on flow-mediated nitric oxide formation

2000 • 66 citations

Acute effects of glucose on reactivity of cerebral microcirculation: role of activation of protein kinase C

1995 • 61 citations

Acute hyperglycemia depresses arteriolar NO formation in skeletal muscle

1999 • 58 citations

Reduced perivascular P<scp>o</scp>₂ increases nitric oxide release from endothelial cells

2003 • 55 citations

Impaired dilation of skeletal muscle microvessels to reduced oxygen tension in diabetic obese Zucker rats

2001 • 53 citations

Vitamin E Normalizes Diacylglycerol—Protein Kinase C Activation Induced by Hyperglycemia in Rat Vascular Tissues

1996 • 44 citations

Obesity lowers hyperglycemic threshold for impaired in vivo endothelial nitric oxide function

2002 • 38 citations

Non-insulin-dependent diabetes and hyperglycemia impair rat intestinal flow-mediated regulation

1997 • 36 citations

Power dissipation as a measure of peripheral resistance in vascular networks.

1986 • 34 citations

Overall Hemodynamic Studies After the Chronic Inhibition of Endothelial-Derived Nitric Oxide in Rats

1995 • 32 citations

Determinants of resting and passive intestinal vascular pressures in rat and rabbit

1987 • 32 citations

Impaired dilation of coronary arterioles during increases in myocardial O₂ consumption with hyperglycemia

2000 • 23 citations

Multiple Mechanisms Of Early Hyperglycaemic Injury Of The Rat Intestinal Microcirculation

2002 • 16 citations