The Role of Nuclear Factor- κ B in Cytokine Gene Regulation

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.

1994 • 1,057 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

Local administration of antisense phosphorothiate olignucleotides to the p65 subunit of NF–κB abrogates established experimental colitis in mice

1996 • 839 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

1991 • 805 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

Interleukin (IL)-10 Inhibits Nuclear Factor кB (NFкB) Activation in Human Monocytes

1995 • 698 citations

IL‐6 and NF‐IL6 in Acute‐Phase Response and Viral Infection

1992 • 540 citations

Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation

1992 • 501 citations

In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation.

1996 • 490 citations

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

1995 • 477 citations

Elevated Levels of NAP-1/Interleukin-8 Are Present in the Airspaces of Patients with the Adult Respiratory Distress Syndrome and Are Associated with Increased Mortality

1992 • 472 citations

The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB

1995 • 460 citations

IκBα Deficiency Results in a Sustained NF-κB Response and Severe Widespread Dermatitis in Mice

1996 • 347 citations

Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers.

1994 • 315 citations

Nuclear factor-kappa B is activated in alveolar macrophages from patients with acute respiratory distress syndrome

1996 • 288 citations

Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation.

1992 • 286 citations

REL/NF-κB/IκB Story

1995 • 278 citations

NF-κB activity in transgenic mice: developmental regulation and tissue specificity

1996 • 229 citations

Three NF-χB sites in the IχB-α promoter are required for induction of gene expression by TNFα

1994 • 219 citations

Tumor Necrosis Factor Levels in Serum and Bronchoalveolar Lavage Fluid of Patients with the Adult Respiratory Distress Syndrome

1991 • 193 citations

Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105

1995 • 150 citations

Activation of transcription factor NF-κB in experimental glomerulonephritis in rats

1996 • 124 citations

Cytokine-induced neutrophil chemoattractant mediates neutrophilic alveolitis in rats: association with nuclear factor kappa B activation.

1994 • 107 citations

Promoter of the human NF-kappa B p50/p105 gene. Regulation by NF-kappa B subunits and by c-REL.

1993 • 104 citations

Ozone induction of cytokine‐induced neutrophil chemoattractant (CINC) and nuclear factor‐κb in rat lung: inhibition by corticosteroids

1996 • 102 citations

Differential Transcriptional Activation in Vitro by NF- κB/Rel Proteins

1995 • 101 citations

Regulation of interleukin-8 expression in porcine alveolar macrophages by bacterial lipopolysaccharide.

1994 • 75 citations

High DNA-binding activity of transcription factor NF-kappa B in synovial membranes of patients with rheumatoid arthritis.

1995 • 74 citations

Hemorrhage activates NF-kappa B in murine lung mononuclear cells in vivo

1996 • 69 citations

Effect of overexpression of human Cu,Zn superoxide dismutase in transgenic mice on macrophage functions.

1996 • 61 citations