Endogenous protein C activation in patients with severe sepsis

Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

2001 • 8,356 citations

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

2001 • 5,900 citations

The Roles of Protein C and Thrombomodulin in the Regulation of Blood Coagulation

1989 • 1,059 citations

Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.

1987 • 836 citations

Novel strategies for the treatment of sepsis

2003 • 784 citations

Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis

2001 • 665 citations

Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis

2001 • 655 citations

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

2003 • 556 citations

The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.

1996 • 524 citations

Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor

1994 • 508 citations

Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: A randomized, double-blinded, placebo-controlled, dose-finding study

2003 • 434 citations

Tumor Necrosis Factor Suppresses Transcription of the Thrombomodulin Gene in Endothelial Cells

1988 • 367 citations

Plasma thrombomodulin in health and diseases

1990 • 357 citations

Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture

1989 • 337 citations

Plasma thrombomodulin in health and diseases

1990 • 296 citations

Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells.

1988 • 284 citations

Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester.

1994 • 277 citations

Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis

2001 • 273 citations

Treatment of Homozygous Protein C Deficiency and Neonatal Purpura Fulminans with a Purified Protein C Concentrate

1991 • 261 citations

Low Levels of Protein C Are Associated With Poor Outcome in Severe Sepsis

2001 • 260 citations

Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats

1996 • 252 citations

Activated protein C inhibits lipopolysaccharide‐induced nuclear translocation of nuclear factor κB (NF‐κB) and tumour necrosis factor α (TNF‐α) production in the THP‐1 monocytic cell line

2000 • 228 citations

Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor

2003 • 217 citations

The Endothelial Cell Protein C Receptor

2000 • 213 citations

Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications

2000 • 206 citations

Rebound Increase in Thrombin Generation and Activity After Cessation of Intravenous Heparin in Patients With Acute Coronary Syndromes

1995 • 197 citations

Release of thrombomodulin from endothelial cells by concerted action of TNF-alpha and neutrophils: in vivo and in vitro studies.

1996 • 193 citations

Anti-Inflammatory, Antithrombotic, and Neuroprotective Effects of Activated Protein C in a Murine Model of Focal Ischemic Stroke

2001 • 191 citations

Metalloproteolytic Release of Endothelial Cell Protein C Receptor

2000 • 184 citations

Activated Protein C Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-α Production by Inhibiting Activation of both Nuclear Factor-κB and Activator Protein-1 in Human Monocytes

2002 • 183 citations

Direct detection of activated protein C in blood from human subjects

1992 • 179 citations

Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates.

1993 • 178 citations

Direct detection of activated protein C in blood from human subjects

1992 • 151 citations

Heterogeneous regulation of constitutive thrombomodulin or inducible tissue-factor activities on the surface of human saphenous-vein endothelial cells in culture following stimulation by interleukin-1, tumour necrosis factor, thrombin or phorbol ester

1991 • 112 citations

Pharmacokinetic‐pharmacodynamic analysis of drotrecogin alfa (activated) in patients with severe sepsis

2002 • 100 citations

Reconstitution of the Human Endothelial Cell Protein C Receptor with Thrombomodulin in Phosphatidylcholine Vesicles Enhances Protein C Activation

1999 • 84 citations

A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation

2003 • 83 citations

Identification of divalent metal ion-dependent inhibition of activated protein C by alpha 2-macroglobulin and alpha 2-antiplasmin in blood and comparisons to inhibition of factor Xa, thrombin, and plasmin.

1991 • 76 citations

Activation of protein C and its distribution between its inhibitors, protein C inhibitor, alpha 1-antitrypsin and alpha 2-macroglobulin, in patients with disseminated intravascular coagulation.

1993 • 63 citations

The normal role of Activated Protein C in maintaining homeostasis and its relevance to critical illness

2001 • 61 citations

Activation of Protein C and Its Distribution between Its Inhibitors, Protein C Inhibitor, α1-Antitrypsin and α2-Macroglobulin, in Patients with Disseminated intravascular Coagulation

1993 • 54 citations

Contribution of Plasma Proteinase Inhibitors to the Regulation of Activated Protein C in Plasma

1993 • 27 citations

A Sensitive and Facile Assay for the Measurement of Activated Protein C Activity Levels in Vivo

1993 • 22 citations

Homozygous protein C deficiency—management with protein C concentrate

1995 • 18 citations

Association of Plasma Levels of Activated Protein C with Recanalization of the Infarct-Related Coronary Artery after Thrombolytic Therapy in Acute Myocardial Infarction

1999 • 12 citations