RhoGDI-1 Modulation of the Activity of Monomeric RhoGTPase RhoA Regulates Endothelial Barrier Function in Mouse Lungs

Signaling Mechanisms Regulating Endothelial Permeability

2005 • 1,632 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Rho family proteins: coordinating cell responses

2001 • 763 citations

GDIs: central regulatory molecules in Rho GTPase activation

2005 • 649 citations

Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo

1999 • 559 citations

Rho and Rac but not Cdc42 regulate endothelial cell permeability

2001 • 462 citations

Rho GTPases and the regulation of endothelial permeability

2002 • 457 citations

Activation of RhoA by Thrombin in Endothelial Hyperpermeability

2000 • 402 citations

RhoGDI: multiple functions in the regulation of Rho family GTPase activities

2005 • 396 citations

Identification of a Mouse p21Cdc42/Rac Activated Kinase

1995 • 395 citations

Cell–cell adhesion and signalling

2002 • 327 citations

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.

1990 • 314 citations

Serine Phosphorylation Negatively Regulates RhoA in Vivo

2003 • 307 citations

Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein.

1990 • 277 citations

Inhibition of Myosin Phosphatase by Upregulated Rho-Kinase Plays a Key Role for Coronary Artery Spasm in a Porcine Model With Interleukin-1β

2000 • 273 citations

Protein Kinase C-α Signals Rho-Guanine Nucleotide Dissociation Inhibitor Phosphorylation and Rho Activation and Regulates the Endothelial Cell Barrier Function

2001 • 253 citations

Phosphorylation of RhoGDI by Pak1 Mediates Dissociation of Rac GTPase

2004 • 233 citations

Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading

1999 • 214 citations

Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIα

1999 • 205 citations

The Rho Small G Protein Family-Rho GDI System as a Temporal and Spatial Determinant for Cytoskeletal Control

1998 • 200 citations

Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins.

1991 • 195 citations

Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes.

1993 • 192 citations

The small GTP-binding proteins in the cytosol of insulin-secreting cells are complexed to GDP dissociation inhibitor proteins.

1992 • 174 citations

Phosphorylation states of Cdc42 and RhoA regulate their interactions with Rho GDP dissociation inhibitor and their extraction from biological membranes

2002 • 163 citations

Cytoskeletal Effects of Rho-Like Small Guanine Nucleotide–Binding Proteins in the Vascular System

2001 • 155 citations

Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells

2002 • 140 citations

Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice

2000 • 139 citations

Protein kinase involved in lung injury susceptibility: Evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment

2003 • 135 citations

cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI

2003 • 133 citations

Phosphorylation states of Cdc42 and RhoA regulate their interactions with Rho GDP dissociation inhibitor and their extraction from biological membranes

2002 • 131 citations

Characterization of the Interaction between RhoGDI and Cdc42Hs Using Fluorescence Spectroscopy

1996 • 129 citations

Cdc42 Regulates the Restoration of Endothelial Barrier Function

2003 • 125 citations

RhoA inactivation enhances endothelial barrier function

1999 • 120 citations

RhoGDI-3 Is a New GDP Dissociation Inhibitor (GDI)

1996 • 117 citations

Role of myosin light-chain phosphorylation in endothelial cell retraction

1993 • 117 citations

Both stimulatory and inhibitory exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins

1992 • 116 citations

Attenuation of Endotoxin-Induced Acute Lung Injury by the Rho-Associated Kinase Inhibitor, Y-27632

2005 • 115 citations

G Protein βγ Subunits Stimulate p114RhoGEF, a Guanine Nucleotide Exchange Factor for RhoA and Rac1

2003 • 114 citations

Cell adhesion and Rho small GTPases

1999 • 105 citations

Integrated control of lung fluid balance

2004 • 103 citations

Effect of Fluid Shear Stress on the Permeability of the Arterial Endothelium

2002 • 97 citations

Reversibility of increased microvessel permeability in response to VE-cadherin disassembly

2000 • 95 citations

The Nucleotide Exchange Rates of Rho and Rac Small GTP-Binding Proteins Are Enhanced to Different Extents by Their Regulatory Protein Smg GDS

1993 • 14 citations

Cell adhesion and signaling

2008 • 13 citations