Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

2016 • 8,701 citations

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Vascular-specific growth factors and blood vessel formation

2000 • 3,667 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

1999 • 2,176 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Genes Expressed in Human Tumor Endothelium

2000 • 1,838 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

2002 • 1,526 citations

Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1

1999 • 1,372 citations

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1999 • 1,102 citations

Angiopoietin-2 Is Required for Postnatal Angiogenesis and Lymphatic Patterning, and Only the Latter Role Is Rescued by Angiopoietin-1

2002 • 993 citations

Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts

1999 • 919 citations

Negative Regulation of the Forkhead Transcription Factor FKHR by Akt

1999 • 763 citations

New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF

1999 • 751 citations

Reelin and brain development

2003 • 713 citations

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

2004 • 660 citations

Angiopoietin-1 Inhibits Endothelial Cell Apoptosis via the Akt/Survivin Pathway

2000 • 633 citations

Angiopoietin-1 Regulates Endothelial Cell Survival Through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

2000 • 623 citations

Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function

2003 • 559 citations

14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

2002 • 555 citations

Cell Type-Specific Expression of Angiopoietin-1 and Angiopoietin-2 Suggests a Role in Glioblastoma Angiogenesis

1998 • 491 citations

Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation

1996 • 469 citations

Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty

2003 • 443 citations

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR

2002 • 428 citations

The Many Forks in FOXO's Road

2003 • 425 citations

Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues

1997 • 410 citations

Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity

2003 • 391 citations

Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling

2002 • 386 citations

FOXO Proteins Regulate Tumor Necrosis Factor-related Apoptosis Inducing Ligand Expression

2002 • 368 citations

Control of Apoptosis during Angiogenesis by Survivin Expression in Endothelial Cells

2000 • 347 citations

Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF)

2002 • 335 citations

Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis.

1998 • 311 citations

Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61).

2002 • 296 citations

Phosphorylation of Serine 256 Suppresses Transactivation by FKHR (FOXO1) by Multiple Mechanisms

2002 • 291 citations

The Akt-regulated Forkhead Transcription Factor FOXO3a Controls Endothelial Cell Viability through Modulation of the Caspase-8 Inhibitor FLIP

2004 • 273 citations

Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer.

2003 • 261 citations

Vascular Endothelial Growth Factor Activates PI3K/Akt/Forkhead Signaling in Endothelial Cells

2003 • 225 citations

Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering

2002 • 222 citations

The Forkhead Transcription Factor AFX Activates Apoptosis by Induction of the BCL-6 Transcriptional Repressor

2002 • 222 citations

In Situ Expression of Angiopoietins in Astrocytomas Identifies Angiopoietin-2 as an Early Marker of Tumor Angiogenesis

1999 • 222 citations

Placental Growth Factor (PlGF) and Its Receptor Flt‐1 (VEGFR‐1)

2002 • 200 citations

Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors.

2003 • 187 citations

DANCE, a Novel Secreted RGD Protein Expressed in Developing, Atherosclerotic, and Balloon-injured Arteries

1999 • 180 citations

TRAIL Induces Apoptosis and Inflammatory Gene Expression in Human Endothelial Cells

2003 • 168 citations

11,12-Epoxyeicosatrienoic Acid-induced Inhibition of FOXO Factors Promotes Endothelial Proliferation by Down-Regulating p27

2003 • 157 citations

Activation of the Tie2 Receptor by Angiopoietin-1 Enhances Tumor Vessel Maturation and Impairs Squamous Cell Carcinoma Growth

2002 • 151 citations

Identification of Endothelial Cell Genes Expressed in an in Vitro Model of Angiogenesis: Induction of ESM-1, βig-h3, and NrCAM

2002 • 147 citations

Control of semaphorin signaling

2002 • 101 citations

Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function

2001 • 93 citations

Decorin Is Produced by Capillary Endothelial Cells in Inflammation-Associated Angiogenesis

2001 • 82 citations

Sphingosine-1-phosphate Signaling in Endothelial Activation

2003 • 57 citations

Kallmann’s syndrome: molecular pathogenesis

2003 • 52 citations

Global gene expression patterns during neural differentiation of P19 embryonic carcinoma cells

2002 • 45 citations

Deleted Work

1955 • 0 citations