Activated Protein C Mediates Novel Lung Endothelial Barrier Enhancement

Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

2001 • 8,356 citations

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

2001 • 5,900 citations

High-Dose Antithrombin III in Severe Sepsis

2001 • 1,381 citations

Deficiency of protein C in congenital thrombotic disease.

1981 • 1,260 citations

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

1999 • 1,048 citations

Cytoskeletal regulation of pulmonary vascular permeability

2001 • 954 citations

Efficacy and Safety of Tifacogin (Recombinant Tissue Factor Pathway Inhibitor) in Severe Sepsis

2003 • 931 citations

Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway

2002 • 832 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

2003 • 556 citations

Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock.

1993 • 552 citations

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 • 550 citations

Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor

1994 • 508 citations

Protective Effects of Sphingosine 1-Phosphate in Murine Endotoxin-induced Inflammatory Lung Injury

2004 • 491 citations

Homozygous Protein C Deficiency Manifested by Massive Venous Thrombosis in the Newborn

1984 • 444 citations

INHERITED PROTEIN C DEFICIENCY AND COUMARIN-RESPONSIVE CHRONIC RELAPSING PURPURA FULMINANS IN A NEWBORN INFANT

1983 • 346 citations

The Role of the Microtubules in Tumor Necrosis Factor-α–Induced Endothelial Cell Permeability

2003 • 316 citations

Thrombin‐induced increase in albumin permeability across the endothelium

1986 • 307 citations

Derangements of Coagulation and Fibrinolysis in Critically III Patients with Sepsis and Septic Shock

1998 • 300 citations

Pulmonary Endothelial Cell Barrier Enhancement by Sphingosine 1-Phosphate

2004 • 295 citations

Akt-Mediated Phosphorylation of the G Protein-Coupled Receptor EDG-1 Is Required for Endothelial Cell Chemotaxis

2001 • 284 citations

Endothelial cell protein C receptor plays an important role in protein C activation in vivo

2001 • 266 citations

Transient and Prolonged Increase in Endothelial Permeability Induced by Histamine and Thrombin

1998 • 266 citations

Intravascular coagulation associated with the adult respiratory distress syndrome

1976 • 254 citations

Regulation of the Actin Cytoskeleton by Thrombin in Human Endothelial Cells: Role of Rho Proteins in Endothelial Barrier Function

1998 • 238 citations

Sphingosine 1-Phosphate Reduces Vascular Leak in Murine and Canine Models of Acute Lung Injury

2004 • 217 citations

Differential effect of MLC kinase in TNF-α-induced endothelial cell apoptosis and barrier dysfunction

2001 • 216 citations

Shear Stress-Mediated Cytoskeletal Remodeling and Cortactin Translocation in Pulmonary Endothelial Cells

2002 • 212 citations

SCHIZOPHRENIA-MELANOSIS

1965 • 203 citations

Myosin light chain kinase in endothelium: molecular cloning and regulation.

1997 • 200 citations

Disseminated Intravascular Coagulation Is a Frequent Complication of Systemic Inflammatory Response Syndrome

1996 • 199 citations

The Crystal Structure of the Endothelial Protein C Receptor and a Bound Phospholipid

2002 • 197 citations

VEGF induces S1P ₁ receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors

2003 • 190 citations

Transactivation of Vascular Endothelial Growth Factor (VEGF) Receptor Flk-1/KDR Is Involved in Sphingosine 1-Phosphate-stimulated Phosphorylation of Akt and Endothelial Nitric-oxide Synthase (eNOS)

2002 • 188 citations

Activated Protein C Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-α Production by Inhibiting Activation of both Nuclear Factor-κB and Activator Protein-1 in Human Monocytes

2002 • 183 citations

Expression and function of the endothelial protein C receptor in human neutrophils

2003 • 176 citations

Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products

2003 • 173 citations

EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration

2001 • 167 citations

Regulation of endothelial cell gap formation and paracellular permeability.

1995 • 165 citations

Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase‐3β

2002 • 159 citations

Epoxycyclopentenone-Containing Oxidized Phospholipids Restore Endothelial Barrier Function via Cdc42 and Rac

2004 • 156 citations

Antithrombin Reduces Ischemia/Reperfusion Injury of Rat Liver by Increasing the Hepatic Level of Prostacyclin

1999 • 155 citations

Differential Regulation of Alternatively Spliced Endothelial Cell Myosin Light Chain Kinase Isoforms by p60Src

2001 • 150 citations

Cytoskeletal Activation and Altered Gene Expression in Endothelial Barrier Regulation by Simvastatin

2003 • 149 citations

Phosphocreatine content in single fibers of human muscle after sustained submaximal exercise

1997 • 139 citations

Sphingosine 1-Phosphate and Platelet-derived Growth Factor (PDGF) Act via PDGFβ Receptor-Sphingosine 1-Phosphate Receptor Complexes in Airway Smooth Muscle Cells

2003 • 126 citations

Thrombin receptor activating peptides induce Ca²⁺ mobilization, barrier dysfunction, prostaglandin synthesis, and platelet‐derived growth factor mRNA expression in cultured endothelium

1993 • 114 citations

Sphingosine 1-Phosphate Transactivates the Platelet-Derived Growth Factor β Receptor and Epidermal Growth Factor Receptor in Vascular Smooth Muscle Cells

2004 • 109 citations

Effects of Drotrecogin Alfa (Activated) in Human Endotoxemia

2004 • 85 citations

CD44v10 interaction with Rho‐kinase (ROK) activates inositol 1,4,5‐triphosphate (IP₃) receptor‐mediated Ca²⁺ signaling during hyaluronan (HA)‐induced endothelial cell migration

2002 • 83 citations

Thrombin-mediated Focal Adhesion Plaque Reorganization in Endothelium: Role of Protein Phosphorylation

1997 • 76 citations

Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization.

1993 • 75 citations

Endothelial protein C receptor-dependent inhibition of human eosinophil chemotaxis by protein C

2003 • 65 citations

The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility

2001 • 46 citations

The sphingosine-I -phosphate receptor EDG-I is essential for platelet-derived growth factor-induced cell motility

2001 • 39 citations

Fibrin contact increases endothelial permeability to albumin

1992 • 12 citations