Positive and Negative Selection of T Cells

Apoptosis by Death Factor

1997 • 5,038 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

Life-or-death decisions by the Bcl-2 protein family

2001 • 887 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator

1998 • 760 citations

Generic Signals and Specific Outcomes

1999 • 732 citations

Requirement for RORγ in Thymocyte Survival and Lymphoid Organ Development

2000 • 714 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

1999 • 641 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

The enemy within: keeping self-reactive T cells at bay in the periphery

2002 • 586 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

Essential Role of LAT in T Cell Development

1999 • 537 citations

A Thymic Precursor to the NK T Cell Lineage

2002 • 517 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

SELECTION OF THE T CELL REPERTOIRE

1999 • 507 citations

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

1998 • 504 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Intraepithelial lymphocytes: exploring the Third Way in immunology

2001 • 481 citations

Lymphostromal interactions in thymic development and function

2001 • 461 citations

Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation

2002 • 442 citations

THE DYNAMICS OF T CELL RECEPTOR SIGNALING: Complex Orchestration and the Key Roles of Tempo and Cooperation

1999 • 439 citations

Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen

2001 • 429 citations

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

2000 • 420 citations

Autoreactivity by design: innate B and T lymphocytes

2001 • 409 citations

Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells

2001 • 406 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

Mapping Precursor Movement through the Postnatal Thymus Reveals Specific Microenvironments Supporting Defined Stages of Early Lymphoid Development

2001 • 394 citations

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.

1995 • 393 citations

Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3(Mkk3)-deficient mice

1999 • 390 citations

Impact of Negative Selection on the T Cell Repertoire Reactive to a Self-Peptide

2000 • 377 citations

Mammalian Grb2 Regulates Multiple Steps in Embryonic Development and Malignant Transformation

1998 • 377 citations

Effects of Cyclosporine A on T Cell Development and Clonal Deletion

1988 • 354 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

Altered thymic positive selection and intracellular signals in Cbl-deficient mice

1998 • 343 citations

EVOLUTION OF ANTIGEN BINDING RECEPTORS

1999 • 322 citations

JNK is required for effector T-cell function but not for T-cell activation

2000 • 322 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis

2002 • 321 citations

RasGRP links T-cell receptor signaling to Ras

2000 • 315 citations

Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

1997 • 315 citations

Contribution of Receptor Editing to the Antibody Repertoire

2001 • 312 citations

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1995 • 305 citations

The ST3Gal-I Sialyltransferase Controls CD8+ T Lymphocyte Homeostasis by Modulating O-Glycan Biosynthesis

2000 • 301 citations

Role of self-peptides in positively selecting the T-cell repertoire

1990 • 300 citations

TRANSCRIPTIONAL REGULATION OF T LYMPHOCYTE DEVELOPMENT AND FUNCTION

1999 • 293 citations

Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells

2002 • 290 citations

NF-κB Activation by the Pre-T Cell Receptor Serves as a Selective Survival Signal in T Lymphocyte Development

2000 • 280 citations

A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferation

2002 • 278 citations

Dynamics of Thymocyte-Stromal Cell Interactions Visualized by Two-Photon Microscopy

2002 • 278 citations

Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

2001 • 276 citations

Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)

1995 • 273 citations

A defect in central tolerance in NOD mice

2001 • 272 citations

The Transcription Factor NFAT4 Is Involved in the Generation and Survival of T Cells

1998 • 271 citations

Identification and Characterization of Thymic Epithelial Progenitor Cells

2002 • 269 citations

Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells.

1996 • 268 citations

Induction of T Helper Type 2 Immunity by a Point Mutation in the LAT Adaptor

2002 • 265 citations

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

1994 • 257 citations

Targeted Disruption of LIGHT Causes Defects in Costimulatory T Cell Activation and Reveals Cooperation with Lymphotoxin β in Mesenteric Lymph Node Genesis

2002 • 255 citations

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

1993 • 247 citations

The β-catenin–TCF-1 pathway ensures CD4+CD8+ thymocyte survival

2001 • 241 citations

CD4+ regulatory T cells

2001 • 241 citations

T cell development in mice lacking the CD3-zeta/eta gene.

1993 • 235 citations

Positive and negative selection invoke distinct signaling pathways.

1996 • 234 citations

Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes

2002 • 227 citations

Receptor Selection in B and T Lymphocytes

2000 • 226 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes

1998 • 221 citations

Thymocyte Selection Is Regulated by the Helix-Loop-Helix Inhibitor Protein, Id3

2000 • 220 citations

C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation

2001 • 219 citations

Differential Roles of ERK and p38 MAP Kinase Pathways in Positive and Negative Selection of T Lymphocytes

1998 • 217 citations

Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides

1997 • 214 citations

CD3delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

1997 • 209 citations

Preselection Thymocytes Are More Sensitive to T Cell Receptor Stimulation Than Mature T Cells

1998 • 208 citations

The function of E- and id proteins in lymphocyte development

2001 • 203 citations

A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity

2000 • 203 citations

Precursors of Functional MHC Class I- or Class II-Restricted CD8αα+ T Cells Are Positively Selected in the Thymus by Agonist Self-Peptides

2002 • 201 citations

Developmentally Regulated Glycosylation of the CD8αβ Coreceptor Stalk Modulates Ligand Binding

2001 • 200 citations

E Protein Function in Lymphocyte Development

2002 • 199 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

Thymocyte Development in the Absence of Pre-T Cell Receptor Extracellular Immunoglobulin Domains

1998 • 194 citations

Identification of a Naturally Occurring Ligand for Thymic Positive Selection

1997 • 193 citations

Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-κB and NFAT

2001 • 189 citations

CD8 Binding to MHC Class I Molecules Is Influenced by T Cell Maturation and Glycosylation

2001 • 187 citations

Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.

1993 • 186 citations

Defective T cell development and function incalcineurinAβ-deficient mice

2002 • 182 citations

Divergent Changes in the Sensitivity of Maturing T Cells to Structurally Related Ligands Underlies Formation of a Useful T Cell Repertoire

1999 • 176 citations

Somatic activation of β-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development

2001 • 175 citations

A Role for Fas in Negative Selection of Thymocytes In Vivo

1998 • 167 citations

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency

2001 • 165 citations

Selection of intraepithelial lymphocytes with CD8 alpha/alpha co-receptors by self-antigen in the murine gut.

1992 • 163 citations

Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

1995 • 161 citations

The JNK and P38 MAP kinase signaling pathways in T cell–mediated immune responses44This team of investigators has contributed extensively to the field of MAP kinase signal transduction in thymocyte and T cell differentiation.

2000 • 161 citations

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.

1996 • 161 citations

The CD3γ chain is essential for development of both the TCRαβ and TCRγδ lineages

1998 • 158 citations

T Lymphocyte Tolerance: From Thymic Deletion to Peripheral Control Mechanisms

1998 • 158 citations

Receptor editing in developing T cells

2000 • 157 citations

Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression.

1992 • 152 citations

Requirement for Diverse, Low-Abundance Peptides in Positive Selection of T Cells

1999 • 151 citations

Positive selection of MHC class Ib–restricted CD8+ T cells on hematopoietic cells

2002 • 151 citations

T cell responses in calcineurin A alpha-deficient mice.

1996 • 149 citations

Mature T cell reactivity altered by peptide agonist that induces positive selection.

1996 • 148 citations

An essential role for gp39, the ligand for CD40, in thymic selection.

1995 • 148 citations

Positive and negative selection of T cells in T-cellreceptor transgenic mice expressing a bcl-2 transgene.

1994 • 147 citations

Requirement for the SLP-76 Adaptor GADS in T Cell Development

2001 • 145 citations

Two signals are required for negative selection of CD4+CD8+ thymocytes.

1993 • 143 citations

Imaging Synapse Formation during Thymocyte Selection

2002 • 142 citations

Induction of the Early Growth Response (Egr) Family of Transcription Factors during Thymic Selection

1997 • 141 citations

Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes

2002 • 140 citations

Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains

1999 • 138 citations

CD3δ couples T-cell receptor signalling to ERK activation and thymocyte positive selection

2000 • 137 citations

Self-antigen presentation by thymic stromal cells: a subtle division of labor

2000 • 135 citations

Thymic Selection by a Single MHC/Peptide Ligand Produces a Semidiverse Repertoire of CD4+ T Cells

1997 • 134 citations

Tec Family Kinases Modulate Thresholds for Thymocyte Development and Selection

2000 • 131 citations

Autoreactivity, dynamic tuning and selectivity

2001 • 130 citations

Several Different Cell Surface Molecules Control Negative Selection of Medullary Thymocytes

1999 • 127 citations

Distinct Structure and Signaling Potential of the γδTCR Complex

2002 • 125 citations

Thymocyte Maturation Is Regulated by the Activity of the Helix-Loop-Helix Protein, E47

1999 • 125 citations

Selection of a Broad Repertoire of CD4+ T Cells in H-2Ma0/0 Mice

1997 • 122 citations

A Kinetic Threshold between Negative and Positive Selection Based on the Longevity of the T Cell Receptor–Ligand Complex

1999 • 122 citations

Dual receptor T cells extend the immune repertoire for foreign antigens

2002 • 121 citations

CD11c+ Eosinophils in the Murine Thymus: Developmental Regulation and Recruitment upon MHC Class I-Restricted Thymocyte Deletion

2000 • 120 citations

Peptide-Induced Negative Selection of Thymocytes Activates Transcription of an NF-ΚB Inhibitor

2002 • 117 citations

Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals.

1993 • 117 citations

T Cells Can Be Activated by Peptides That Are Unrelated in Sequence to Their Selecting Peptide

1997 • 116 citations

A Model for Developmentally Acquired Thymus‐Dependent Tolerance to Central and Peripheral Antigens

1996 • 116 citations

Anergy and suppression regulate CD4+ T cell responses to a self peptide

2000 • 115 citations

Dynamic Tuning of T Cell Reactivity by Self-Peptide–Major Histocompatibility Complex Ligands

2001 • 114 citations

Positive Selection Through a Motif in the αβ T Cell Receptor

1998 • 111 citations

LAT, the Linker for Activation of T Cells: A Bridge Between T Cell-Specific and General Signaling Pathways

2000 • 111 citations

Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte Selection

2001 • 110 citations

Negative Selection of Precursor Thymocytes Before their Differentiation into CD4 ⁺ CD8 ⁺ Cells

1992 • 109 citations

Positive Selection of T Cells Induced by Viral Delivery of Neopeptides to the Thymus

1997 • 108 citations

CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance.

1996 • 105 citations

Rapid deletion of rearranged T cell antigen receptor (TCR) Vα-Jα segment by secondary rearrangement in the thymus: Role of continuous rearrangement of TCR α chain gene and positive selection in the T cell repertoire formation

1998 • 104 citations

A Motif within the T Cell Receptor α Chain Constant Region Connecting Peptide Domain Controls Antigen Responsiveness

1996 • 102 citations

Divinations and Surprises: Genetic Analysis of Caspase Function in Mice

2000 • 101 citations

The Src-like Adaptor Protein Downregulates the T Cell Receptor on CD4+CD8+ Thymocytes and Regulates Positive Selection

2001 • 98 citations

T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection.

1995 • 97 citations

Rare, Structurally Homologous Self-Peptides Promote Thymocyte Positive Selection

2002 • 95 citations

Specific Recognition of Thymic Self-Peptides Induces the Positive Selection of Cytotoxic T Lymphocytes

1997 • 95 citations

Thymocyte Development in Early Growth Response Gene 1-Deficient Mice

2002 • 95 citations

Antigen‐specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection

1997 • 95 citations

Cutting Edge: Selective Impairment of CD8+ T Cell Function in Mice Lacking the TNF Superfamily Member LIGHT

2002 • 94 citations

T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection

1997 • 88 citations

Thymocyte selection: not by TCR alone

1998 • 88 citations

A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes.

1994 • 86 citations

TNF Receptor-Deficient Mice Reveal Striking Differences Between Several Models of Thymocyte Negative Selection

1998 • 84 citations

A Developmental Switch from TCRδ Enhancer to TCRα Enhancer Function during Thymocyte Maturation

1999 • 82 citations

ITAM Multiplicity and Thymocyte Selection

2000 • 81 citations

Caspase Enzyme Activity Is Not Essential for Apoptosis During Thymocyte Development

2000 • 79 citations

The Critical Role of LIGHT, a TNF Family Member, in T Cell Development

2001 • 77 citations

Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection.

1996 • 74 citations

The Developmentally Regulated Expression of Twisted Gastrulation Reveals a Role for Bone Morphogenetic Proteins in the Control of T Cell Development

2002 • 74 citations

Murine Schnurri-2 is required for positive selection of thymocytes

2001 • 72 citations

Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes

1998 • 71 citations

Identification of Genes Induced during Apoptosis in T Lymphocytes

1994 • 71 citations

Positive Selection of a Qa-1-Restricted T Cell Receptor with Specificity for Insulin

2002 • 71 citations

Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing

2002 • 71 citations

Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor

1999 • 70 citations

Positive selection of thymocytes involves sustained interactions with the thymic microenvironment.

1995 • 70 citations

Negative Selection of T Cells Occurs Throughout Thymic Development

1999 • 70 citations

Perinatal Blockade of B7-1 and B7-2 Inhibits Clonal Deletion of Highly Pathogenic Autoreactive T Cells

2002 • 70 citations

T cell positive selection by a high density, low affinity ligand

1998 • 69 citations

Antigen compartmentation and T helper cell tolerance induction.

1996 • 68 citations

SEK1/MKK4 Is Required for Maintenance of a Normal Peripheral Lymphoid Compartment but Not for Lymphocyte Development

1998 • 67 citations

An Opposite Pattern of Selection of a Single T Cell Antigen Receptor in the Thymus and among Intraepithelial Lymphocytes

1998 • 67 citations

The Absence of Itk Inhibits Positive Selection Without Changing Lineage Commitment

2002 • 63 citations

NF-κB Is Required for the Positive Selection of CD8+ Thymocytes

2000 • 60 citations

Degree of ERK activation influences both positive and negative thymocyte selection

2000 • 59 citations

Cutting Edge: Thymic Selection and Autoreactivity Are Regulated by Multiple Coreceptors Involved in T Cell Activation

1999 • 55 citations

Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity

2002 • 54 citations

Cross-linking of T-cell receptors on double-positive thymocytes induces a cytokine-mediated stromal activation process linked to cell death.

1996 • 53 citations

Intracellular signaling events during positive and negative selection of CD4+CD8+ thymocytes in vitro.

1995 • 53 citations

Quantitation of the Cell Surface Level of Ld Resulting in Positive Versus Negative Selection of the 2C Transgenic T Cell Receptor In Vivo

1997 • 53 citations

Impaired Negative Selection in CD28-Deficient Mice

1998 • 53 citations

Permissive recognition during positive selection

1996 • 52 citations

T cell fate specification and αβ/γδ lineage commitment

2001 • 51 citations

Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide.

1992 • 50 citations

Modulation of Thymic Selection by Expression of an Immediate-early Gene, Early Growth Response 1 (Egr-1)

1998 • 50 citations

Positive Selection of an H2-M3 Restricted T Cell Receptor

1999 • 49 citations

Limits to the differential avidity model of T cell selection in the thymus.

1997 • 48 citations

High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8αα and CD8αβ T lymphocytes

1999 • 48 citations

The Apoptotic Protease-Activating Factor 1-Mediated Pathway of Apoptosis Is Dispensable for Negative Selection of Thymocytes

2002 • 48 citations

The tight interallelic positional coincidence that distinguishes T-cell receptor Jalpha usage does not result from homologous chromosomal pairing during ValphaJalpha rearrangement

2001 • 48 citations

Requirement for a Complex Array of Costimulators in the Negative Selection of Autoreactive Thymocytes In Vivo

2001 • 46 citations

Autonomous Maturation of α/β T Lineage Cells in the Absence of Cooh-Terminal Src Kinase (Csk)

2001 • 45 citations

The Selection of M3-Restricted T Cells Is Dependent on M3 Expression and Presentation of N-Formylated Peptides in the Thymus

1999 • 44 citations

Deficiency of phospholipase C-γ1 impairs renal development and hematopoiesis

2001 • 43 citations

A Low Affinity TCR Ligand Restores Positive Selection of CD8+ T Cells In Vivo

2001 • 42 citations

In vivoantagonism of a T cell response by an endogenously expressed ligand

1998 • 42 citations

Identification of a cross-reactive self ligand in virus-mediated autoimmunity

1999 • 41 citations

Contributions of the T Cell Receptor–associated CD3γ–ITAM to Thymocyte Selection

2002 • 40 citations

TCR-Associated ζ-FcϵRlγ heterodimers on CD4−CD8− NK1.1+ t cells selected by specific class I MHC antigen

1995 • 38 citations

Inefficient ZAP-70 Phosphorylation and Decreased Thymic Selection In Vivo Result from Inhibition of NF-κB/Rel

2001 • 37 citations

Inhibition of thymocyte negative selection by T cell receptor antagonist peptides

1996 • 36 citations

Inhibition of I‐A^d‐, but not D^b‐restricted peptide‐induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice

1996 • 36 citations

Discrimination between maintenance‐ and differentiation‐inducing signals during initial and intermediate stages of positive selection

1997 • 35 citations

A T Cell Receptor–specific Blockade of Positive Selection

1999 • 34 citations

Identification and Characterization of Thymus LIM Protein: Targeted Disruption Reduces Thymus Cellularity

2001 • 32 citations

Activated p56lck Directs Maturation of Both CD4 and CD8 Single-Positive Thymocytes

2001 • 32 citations

A Naturally Processed Mitochondrial Self-Peptide in Complex with Thymic Mhc Molecules Functions as a Selecting Ligand for a Viral-Specific T Cell Receptor

2001 • 32 citations

Positive Selection of Cd4+ T Cells Is Induced in Vivo by Agonist and Inhibited by Antagonist Peptides

2001 • 31 citations

Negative selection of thymocytes expressing the D10 TCR

2002 • 28 citations

A Putative 12 Transmembrane Domain Cotransporter Expressed in Thymic Cortical Epithelial Cells

2000 • 28 citations

Thymic stromal organization is regulated by the specificity of T cell receptor/major histocompatibility complex interactions

1997 • 26 citations

Calcineurin Aα plays an exclusive role in TCR signaling in mature but not in immature T cells

2002 • 25 citations

Requirement of a second signal from antigen presenting cells in the clonal deletion of immature T cells

1994 • 23 citations

On the Self-Referential Nature of Naive MHC Class II-Restricted T Cells

2000 • 21 citations

Affinity of thymic self-peptides for the TCR determines the selection of CD8+ T lymphocytes in the thymus

2000 • 21 citations

αβTCRs Differ in the Degree of Their Specificity for the Positively Selecting MHC/Peptide Ligand

2001 • 19 citations

Susceptibility and Resistance to Antigen-Induced Apoptosis in the Thymus of Transgenic Mice

1998 • 19 citations

A critical role for the T cell receptor α-chain connecting peptide domain in positive selection of CD1-independent NKT cells

2001 • 18 citations

Evaluating peptide repertoires within the context of thymocyte development

1999 • 17 citations

Positive Selection Is Limited by Available Peptide-Dependent MHC Conformations

2000 • 16 citations

Cutting Edge: Positive Selection Induced by a Self-Peptide with TCR Antagonist Activity

2001 • 15 citations

Inhibition of intrathymic T cell development by expression of a transgenic antagonist peptide

1998 • 15 citations

Specialisation of thymic epithelial cells for positive selection of CD4+8+ thymocytes.

2001 • 14 citations

Surface Molecules Essential for Positive Selection Are Retained but Interfered in Thymic Epithelial Cells after Monolayer Culture

2001 • 14 citations

The lack of NF-κB transactivation and PKCε expression in CD4+CD8+ thymocytes correlates with negative selection

2000 • 13 citations

A Physiological Ligand of Positive Selection Is Recognized as a Weak Agonist

2000 • 11 citations

An Incremental Increase in the Complexity of Peptides Bound to Class II MHC Changes the Diversity of Positively Selected αβ TCRs

2001 • 11 citations

Developmental regulation of TCR efficiency

2000 • 7 citations

Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes (vol 95, pg 8193, 1998)

1998 • 6 citations

T cell receptor editing

2000 • 5 citations