Thymocyte Development in the Absence of Pre-T Cell Receptor Extracellular Immunoglobulin Domains

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

1991 • 782 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

STRUCTURE AND FUNCTION OF THE PRE-T CELL RECEPTOR

1997 • 362 citations

Vav and SLP-76 Interact and Functionally Cooperate in IL-2 Gene Activation

1996 • 335 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer

1985 • 299 citations

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

1990 • 235 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

Fyn Can Partially Substitute for Lck in T Lymphocyte Development

1996 • 213 citations

CD3ε-mediated signals rescue the development of CD4⁺CD8⁺ thymocytes in RAG-2^−/− mice in the absence of TCR β chain expression

1994 • 205 citations

Evidence for a preformed transducer complex organized by the B cell antigen receptor.

1996 • 186 citations

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

1997 • 159 citations

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

1994 • 157 citations

CD3 components at the surface of pro‐T cells can mediate pre‐T cell development in vivo

1994 • 156 citations

p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells.

1993 • 139 citations

A truncated heavy chain protein relieves the requirement for surrogate light chains in early B cell development.

1997 • 115 citations

Functional interactions of recombinant .alpha.2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles

1991 • 89 citations

The T cell antigen receptor α and β chains interact via distinct regions with CD3 chains

1994 • 77 citations

Pre-B-cell development in the absence of λ5 in transgenic mice expressing a heavy-chain disease protein

1995 • 65 citations

Double-negative thymocyte subsets in CD3′ chain-deficient mice: Absence of HSA+CD44−CD25− cells

1994 • 53 citations

Exit of the Pre-TCR from the ER/cis-Golgi Is Necessary for Signaling Differentiation, Proliferation, and Allelic Exclusion in Immature Thymocytes

1997 • 51 citations

Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice.

1995 • 48 citations

Control of immunoglobulin gene rearrangements in developing B cells

1997 • 43 citations

Allelic Exclusion in pTα-deficient Mice: No Evidence for Cell Surface Expression of Two T Cell Receptor (TCR)-β Chains, but Less Efficient Inhibition of Endogeneous Vβ→ (D)Jβ Rearrangements in the Presence of a Functional TCR-β Transgene

1997 • 43 citations

Efficient maturation of alpha beta lineage thymocytes to the CD4+CD8+ stage in the absence of TCR-beta rearrangement.

1995 • 36 citations