A Model for Developmentally Acquired Thymus‐Dependent Tolerance to Central and Peripheral Antigens

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

‘Actively Acquired Tolerance’ of Foreign Cells

1953 • 3,103 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Positive Selection of Thymocytes

1995 • 604 citations

The T Cell Receptor

1987 • 554 citations

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1994 • 544 citations

In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells

1977 • 534 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

T Cell Selection in the Thymus

1988 • 405 citations

OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

1990 • 399 citations

Self-Nonself Discrimination by T Cells

1990 • 331 citations

Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis.

1982 • 321 citations

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

1987 • 269 citations

Beyond Clonal Selection and Network

1989 • 215 citations

Antigen Analogs/MHC Complexes as Specific T Cell Receptor Antagonists

1994 • 195 citations

Regulation of Autoimmune Disease Physiological and Therapeutic

1986 • 190 citations

Thymic Epithelium Tolerizes for Histocompatibility Antigens

1990 • 179 citations

Comparison of peptides bound to spleen and thymus class II.

1993 • 168 citations

Tolerance Induced by Thymic Epithelial Grafts in Birds

1987 • 167 citations

Studies on Tolerance of the Y Chromosome Antigen in Mice

1960 • 161 citations

Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

1995 • 161 citations

Neonatal Thymectomy Results in a Repertoire Enriched in T Cells Deleted in Adult Thymus

1989 • 146 citations

Inefficient positive selection of T cells directed by haematopoietic cells

1992 • 132 citations

Tolerance induction by thymic medullary epithelium.

1992 • 121 citations

Establishment of tissue‐specific tolerance is driven by regulatory T cells selected by thymic epithelium

1996 • 110 citations

Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype.

1995 • 109 citations

Postnatal disappearance of self-reactive (V beta 6+) cells from the thymus of Mlsa mice. Implications for T cell development and autoimmunity.

1989 • 108 citations

Failure of clonal deletion in neonatally thymectomized mice: tolerance is preserved through clonal anergy.

1990 • 102 citations

Organ‐specific autoimmunity induced by adult thymectomy and cyclophosphamide‐induced lymphopenia

1995 • 84 citations

Cellular Mechanisms in Neonatal and Adult Tolerance

1989 • 71 citations

Natural effector T lymphocytes in normal mice.

1985 • 70 citations

The Role of Thymic Epithelium in the Establishment of Transplantation Tolerance

1993 • 66 citations

MHC restriction, alloreactivity, and thymic education: A common link?

1989 • 60 citations

Function of the MHC.

1988 • 58 citations

Autoimmunity: the moving boundaries between physiology and pathology

1988 • 54 citations

Differential contribution of thymic outputs and peripheral expansion in the development of peripheral T cell pools

1994 • 48 citations

Peripheral tolerance mechanisms prevent the development of autoreactive T cells in chimeras grafted with two minor incompatible thymuses

1989 • 44 citations

Tolerize one, tolerize them all: tolerance is self-assertion

1989 • 44 citations

Implants of quail thymic epithelium generate permanent tolerance in embryonically constructed quail/chick chimeras

1988 • 42 citations

Regulatory T cells in thymic epithelium‐induced tolerance. I. Suppression of mature peripheral non‐tolerant T cells

1995 • 38 citations

Split tolerance induced by chick embryo thymic epithelium allografted to embryonic recipients.

1986 • 37 citations

“In vivo” activated splenic T cells are refractory to interleukin 2 growth “in vitro”

1987 • 34 citations

Altered thymocyte development resulting from expressing a deleting ligand on selecting thymic epithelium.

1992 • 33 citations

Thymic epithelium tolerizes chickens to embryonic grafts of quail bursa of Fabricius

1989 • 33 citations

Thymic epithelium induces full tolerance to skin and heart but not to B lymphocyte grafts

1995 • 29 citations

The ontogeny of class-regulation of CD4⁺ T lymphocyte populations

1995 • 24 citations

Some reasons why deletion and anergy do not satisfactorily account for natural tolerance

1992 • 23 citations

Thymic epithelium induces neither clonal deletion nor anergy to Mls 1^a antigens

1992 • 19 citations

Natural lymphocyte activation in postnatal development of germ-free and conventional mice

1988 • 18 citations

A study of peripheral tolerance through embryonic grafts of the bursal epithelial rudiment between MHC-distinct chick embryos

1994 • 11 citations

The Identity of the Cells that Positively Select Thymocytes

1993 • 10 citations