The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

The somatic generation of immune recognition

1971 • 974 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Superantigens: Mechanism of T-Cell Stimulation and Role in Immune Responses

1991 • 783 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

Positive Selection of Thymocytes

1995 • 604 citations

Selective Events in T Cell Development

1994 • 486 citations

Why do so many lymphocytes respond to major histocompatibility antigens?

1977 • 462 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1996 • 378 citations

Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors.

1977 • 357 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

Two better cell lines for making hybridomas expressing specific T cell receptors.

1989 • 300 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

1991 • 263 citations

Mice lacking major histocompatibility complex class I and class II molecules.

1993 • 259 citations

Precursors of T cell growth factor producing cells in the thymus: ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5.

1983 • 237 citations

The Specificity and Orientation of a TCR to its Peptide–MHC Class II Ligands

1996 • 177 citations

High frequency and nonrandom distribution of alloreactivity in T cell clones selected for recognition of foreign antigen in association with self class II molecules.

1986 • 158 citations

Killer cells reactive to altered-self antigens can also be alloreactive.

1977 • 155 citations

Control of MHC Restriction by TCR V _α CDR1 and CDR2

1996 • 152 citations

Functionally conformed free class I heavy chains exist on the surface of beta 2 microglobulin negative cells.

1992 • 146 citations

Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells.

1989 • 146 citations

Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoire

1995 • 143 citations

The T cell repertoire may be biased in favor of MHC recognition

1986 • 121 citations

An MHC interaction site maps to the amino-terminal half of the T cell receptor α chain variable domain

1992 • 100 citations

T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen.

1993 • 97 citations

Positive selection of CD4+T cells by TCR ligation without aggregation even in the absence of MHC

1994 • 83 citations

Molecular basis for the recognition of two structurally different major histocompatibility complex/peptide complexes by a single T-cell receptor

1996 • 71 citations

The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire.

1995 • 64 citations

More efficient positive selection of thymocytes in mice lacking terminal deoxynucleotidyl transferase

1994 • 54 citations

Histocompatibility-2 system in wild mice. X. Frequencies of H-2 and Ia antigens in wild mice from Europe and Africa.

1980 • 46 citations

T cell receptor Vβ repertoire in mice lacking endogenous mouse mammary tumor provirus

1995 • 16 citations

CD4+/CD8- thymocytes dominate the fetal thymus treated with a combination of anti-T cell receptor-beta and anti-CD4 antibodies.

1993 • 7 citations

Limiting dilution analysis of ontogeny of self- and allo-reactive thymocytes of C57BL/6J mouse.

1990 • 1 citations