Precursors of Functional MHC Class I- or Class II-Restricted CD8αα+ T Cells Are Positively Selected in the Thymus by Agonist Self-Peptides

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation.

1991 • 599 citations

Correlations between T-cell specificity and the structure of the antigen receptor

1986 • 375 citations

The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation.

1991 • 345 citations

Thymus-independent development and negative selection of T cells expressing T cell receptor alpha/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes.

1992 • 268 citations

Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta.

1991 • 262 citations

T Cell Responses Modulated Through Interaction Between CD8αα and the Nonclassical MHC Class I Molecule, TL

2001 • 257 citations

The fine specificity of antigen and la determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c

1982 • 244 citations

MHC Class II–Specific T Cells Can Develop in the CD8 Lineage When CD4 Is Absent

1996 • 218 citations

Thymic and extrathymic origins of gut intraepithelial lymphocyte populations in mice.

1994 • 208 citations

Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial T lymphocytes is induced locally. Correlation between functional assays, presence of perforin and granzyme transcripts, and cytoplasmic granules.

1991 • 183 citations

Essential Role of CD8 Palmitoylation in CD8 Coreceptor Function

2000 • 178 citations

The extrathymic T-cell development pathway

1992 • 169 citations

The αβ T Cell Receptor Can Replace the γδ Receptor in the Development of γδ Lineage Cells

1996 • 161 citations

Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor

2000 • 161 citations

Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition.

1992 • 159 citations

Gut Cryptopatches

2000 • 147 citations

Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals.

1993 • 117 citations

Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 β chain

1994 • 115 citations

Positive Selection Through a Motif in the αβ T Cell Receptor

1998 • 111 citations

Selection and Expansion of CD8α/α1 T Cell Receptor α/β1 Intestinal Intraepithelial Lymphocytes in the Absence of Both Classical Major Histocompatibility Complex Class I and Nonclassical Cd1 Molecules

1999 • 97 citations

Thymus influences the development of extrathymically derived intestinal intraepithelial lymphocytes

1993 • 86 citations

Expression of the CD28 costimulatory molecule on subsets of murine intestinal intraepithelial lymphocytes correlates with lineage and responsiveness

1993 • 80 citations

Role of Gut Cryptopatches in Early Extrathymic Maturation of Intestinal Intraepithelial T Cells

2000 • 75 citations

Cutting edge: TCR alpha beta+ CD8 alpha alpha+ T cells are found in intestinal intraepithelial lymphocytes of mice that lack classical MHC class I molecules.

1999 • 70 citations

A novel pathway of thymus-directed T lymphocyte maturation.

1994 • 69 citations

Development of Cd8α/α and Cd8α/β T Cells in Major Histocompatibility Complex Class I–Deficient Mice

1999 • 68 citations

Analysis of the intra-epithelial lymphocyte compartment in SCID mice that received co-isogenic CD4+ T cells. Evidence that mature post-thymic CD4+ T cells can be induced to express CD8 alpha in vivo.

1995 • 67 citations

An Opposite Pattern of Selection of a Single T Cell Antigen Receptor in the Thymus and among Intraepithelial Lymphocytes

1998 • 67 citations

Cutting Edge: TCRαβ+ CD8αα+ T Cells Are Found in Intestinal Intraepithelial Lymphocytes of Mice That Lack Classical MHC Class I Molecules

1999 • 65 citations

TAP-independent selection of CD8+ intestinal intraepithelial lymphocytes.

1996 • 61 citations

High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8αα and CD8αβ T lymphocytes

1999 • 48 citations

Down-Modulation of CD8 β-Chain in Response to an Altered Peptide Ligand Enables Developing Thymocytes to Escape Negative Selection

1997 • 36 citations

Immune deviation of 2C transgenic intraepithelial lymphocytes in antigen-bearing hosts.

1996 • 35 citations

Differential Appearance of T Cell Subsets in the Large and Small Intestine of Neonatal Mice

2001 • 35 citations

Contribution of double-negative thymic precursors to CD8α α+ intraepithelial lymphocytes of the gut in mice bearing TCR transgenes

2001 • 30 citations

An analysis of sequence variation in the β chain framework and complementarity determining regions of an allo-reactive T cell receptor

1994 • 23 citations

A critical role for the T cell receptor α-chain connecting peptide domain in positive selection of CD1-independent NKT cells

2001 • 18 citations

Selection of intestinal intraepithelial lymphocyte T cell receptors: evidence for a dynamic tissue-specific process

1993 • 15 citations

Structurally similar TCRs differ in their efficiency of positive selection.

1997 • 13 citations