Calcineurin Aα plays an exclusive role in TCR signaling in mature but not in immature T cells

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Calcineurin: Form and Function

2000 • 1,336 citations

Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells

1996 • 1,299 citations

Ca ²⁺ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

1999 • 1,136 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

Generic Signals and Specific Outcomes

1999 • 732 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

A Role for CD5 in TCR-Mediated Signal Transduction and Thymocyte Selection

1995 • 437 citations

Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.

1997 • 403 citations

Effects of Cyclosporine A on T Cell Development and Clonal Deletion

1988 • 354 citations

Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

1994 • 334 citations

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk

1995 • 313 citations

Abnormal differentiation of thymocytes in mice treated with cyclosporin A

1988 • 281 citations

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

1998 • 270 citations

NF-AT activation requires suppression of Crm1-dependent export by calcineurin

1999 • 179 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

Negative Regulation of T Cell Proliferation and Interleukin 2 Production by the Serine Threonine Kinase Gsk-3

2000 • 162 citations

Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF‐κB activation

1997 • 154 citations

T cell responses in calcineurin A alpha-deficient mice.

1996 • 149 citations

Mature T cell reactivity altered by peptide agonist that induces positive selection.

1996 • 148 citations

Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death.

1999 • 131 citations

T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection.

1995 • 97 citations

Distinct tissue and cellular distribution of two major isoforms of calcineurin

1997 • 90 citations

TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditions

2000 • 75 citations

Immune down-regulation and peripheral deletion of CD8 T cells does not require TNF receptor-ligand interactions nor CD95 (Fas, APO-1)

2000 • 70 citations

Differential expression of calmodulin-binding proteins in B, T lymphocytes and thymocytes

1987 • 70 citations

Cyclosporin A inhibits positive selection and delays negative selection in alpha beta TCR transgenic mice.

1994 • 64 citations

Molecular and Functional Evidence for Calcineurin-A α and β Isoforms in the Osteoclast: Novel Insights into Cyclosporin A Action on Bone Resorption

1999 • 54 citations

A role for calcium influx in setting the threshold for CD4+CD8+ thymocyte negative selection.

1996 • 44 citations

Effects of a Constitutively Active Form of Calcineurin on T Cell Activation and Thymic Selection

2000 • 40 citations

Distribution of calcineurin A isoenzyme mRNAs in rat thymus and kidney

1995 • 38 citations

FKBP12-FK506 Complex Inhibits Phosphatase Activity of Two Mammalian Isoforms of Calcineurin Irrespective of Their Substrates or Activation Mechanisms11

1993 • 38 citations

Regulation of cell surface expression of Fas (CD95) ligand and susceptibility to Fas (CD95)-mediated apoptosis in activation-induced T cell death involves calcineurin and protein kinase C, respectively

1999 • 32 citations

FK506 and Cyclosporin A Each Inhibit Antigen-Specific Signaling in the T Cell Line 171 in the Absence of a Calcium Signal

1994 • 23 citations