The lack of NF-κB transactivation and PKCε expression in CD4+CD8+ thymocytes correlates with negative selection

Apoptosis by Death Factor

1997 • 5,038 citations

NF-κB: Ten Years After

1996 • 3,008 citations

AP-1 function and regulation

1997 • 2,833 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Inhibition of NF-κB by Sodium Salicylate and Aspirin

1994 • 1,743 citations

Control of apoptosis by Rel/NF-κB transcription factors

1999 • 1,204 citations

How NF-κB is activated: the role of the IκB kinase (IKK) complex

1999 • 1,133 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent Mechanism

1997 • 820 citations

T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

1996 • 692 citations

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.

1996 • 604 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

1993 • 546 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

A Functional Role for Mitochondrial Protein Kinase Cα in Bcl2 Phosphorylation and Suppression of Apoptosis

1998 • 446 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

The interaction of p62 with RIP links the atypical PKCs to NF-kappa B activation

1999 • 394 citations

Inhibition of TNF-induced apoptosis by NF-κB

1998 • 370 citations

NAK is an IκB kinase-activating kinase

2000 • 365 citations

Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells.

1993 • 306 citations

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

1994 • 299 citations

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

1994 • 288 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control Points

1994 • 252 citations

Protein Kinase C-θ Isoenzyme Selective Stimulation of the Transcription Factor Complex AP-1 in T Lymphocytes

1996 • 251 citations

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

1990 • 235 citations

Positive and negative selection invoke distinct signaling pathways.

1996 • 234 citations

The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes

1998 • 221 citations

Differential Roles of ERK and p38 MAP Kinase Pathways in Positive and Negative Selection of T Lymphocytes

1998 • 217 citations

Diverse agents act at multiple levels to inhibit the Rel/NF-κB signal transduction pathway

1999 • 211 citations

An Essential Role for Nuclear Factor κB in Promoting Double Positive Thymocyte Apoptosis

1999 • 207 citations

Analysis of the Role of Protein Kinase C-α, -ε, and -ζ in T Cell Activation

1995 • 184 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific.

1991 • 142 citations

bcl-2 proto-oncogene expression during human T cell development. Evidence for biphasic regulation.

1993 • 140 citations

Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death.

1999 • 131 citations

Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases

1999 • 120 citations

Activation of protein kinase Cdelta in human myeloid leukemia cells treated with 1-beta-D-arabinofuranosylcytosine

1996 • 119 citations

Overexpression of Protein Kinase C Isoform  but not δ in Human Interleukin-3–Dependent Cells Suppresses Apoptosis and Induces bcl-2 Expression

1998 • 114 citations

CD30 Overexpression Enhances Negative Selection in the Thymus and Mediates Programmed Cell Death Via a Bcl-2-Sensitive Pathway

1999 • 109 citations

Distinct mechanisms of regulation of protein kinase C epsilon by hormones and phorbol diesters.

1991 • 107 citations

Protein Kinase Cθ Cooperates with Calcineurin to Induce Fas Ligand Expression During Activation-Induced T Cell Death

1999 • 105 citations

Selective Involvement Of Protein Kinase C Isozymes In Differentiation And Neoplastic Transformation

1994 • 104 citations

Vav Regulates Peptide-specific Apoptosis in Thymocytes

1998 • 104 citations

Molecular basis for developmental changes in interleukin-2 gene inducibility.

1993 • 96 citations

NF-κB regulates Fas / APO-1 / CD95- and TCR-mediated apoptosis of T lymphocytes

1999 • 87 citations

Human T cell activation by phorbol esters and diacylglycerol analogues.

1989 • 84 citations

Regulation of AP-1 and NFAT Transcription Factors during Thymic Selection of T Cells

1996 • 74 citations

T Cell Receptor Signals Enhance Susceptibility to Fas-mediated Apoptosis

1997 • 72 citations

Evidence That Protein Kinase Cε Mediates Phorbol Ester Inhibition of Calphostin C- and Tumor Necrosis Factor-α-induced Apoptosis in U937 Histiocytic Lymphoma Cells

1998 • 70 citations

Induction of Thymocyte Apoptosis by Ca2+-independent Protein Kinase C (nPKC) Activation and Its Regulation by Calcineurin Activation

1998 • 66 citations

A NF-kappa B/c-myc-dependent survival pathway is targeted by corticosteroids in immature thymocytes.

1999 • 49 citations

A role for calcium influx in setting the threshold for CD4+CD8+ thymocyte negative selection.

1996 • 44 citations

A NF-κB/c-myc-Dependent Survival Pathway Is Targeted by Corticosteroids in Immature Thymocytes

1999 • 41 citations

Signals involved in thymocyte positive and negative selection

1999 • 39 citations

Regulation of thymocyte lineage commitment by the level of classical protein kinase C activity.

1997 • 34 citations

Protein kinase C is not a downstream effector of p21^ras in activated T cells

1995 • 26 citations

Antigen-induced TCR–CD3 down-modulation does not require CD3δ or CD3γ cytoplasmic domains, necessary in response to anti-CD3 antibody

1999 • 17 citations

Developmental control of antigen-induced thymic transcription factors

1996 • 14 citations

The balance between deletion and activation of CD4⁺8⁺ thymocytes is controlled by T cell receptor‐antigen interactions and is affected by cyclosporin A

1994 • 11 citations

Cellular interactions in the thymus regulate the protein kinase C signaling pathway

1998 • 7 citations