Cutting Edge: Positive Selection Induced by a Self-Peptide with TCR Antagonist Activity

Atlas of protein sequence and structure

1965 • 4,462 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

SYFPEITHI: database for MHC ligands and peptide motifs

1999 • 2,307 citations

Profile analysis: detection of distantly related proteins.

1987 • 1,308 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1992 • 501 citations

Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro

1990 • 418 citations

Appendix 5. Nomenclature for peptide fragment ions (positive ions)

1990 • 406 citations

Role of self-peptides in positively selecting the T-cell repertoire

1990 • 300 citations

A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein

1992 • 286 citations

Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells.

1993 • 266 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

Identification of a Naturally Occurring Ligand for Thymic Positive Selection

1997 • 193 citations

Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules

1998 • 186 citations

Mature T cell reactivity altered by peptide agonist that induces positive selection.

1996 • 148 citations

Positive selection of T-lymphocytes induced by intrathymic injection of a thymic epithelial cell line

1992 • 103 citations

Specific Recognition of Thymic Self-Peptides Induces the Positive Selection of Cytotoxic T Lymphocytes

1997 • 95 citations

Enhanced Intracellular Dissociation of Major Histocompatibility Complex Class I–associated Peptides: A Mechanism for Optimizing the Spectrum of Cell Surface–Presented Cytotoxic T Lymphocyte Epitopes

1997 • 89 citations

CD3 Ligation on Immature Thymocytes Generates Antagonist-like Signals Appropriate for CD8 Lineage Commitment, Independently of T Cell Receptor Specificity

1998 • 59 citations

Positive Selection of an H2-M3 Restricted T Cell Receptor

1999 • 49 citations

Modulation of T cell development by an endogenous altered peptide ligand.

1995 • 45 citations

The Selection of M3-Restricted T Cells Is Dependent on M3 Expression and Presentation of N-Formylated Peptides in the Thymus

1999 • 44 citations

In vivoantagonism of a T cell response by an endogenously expressed ligand

1998 • 42 citations

Identification of a cross-reactive self ligand in virus-mediated autoimmunity

1999 • 41 citations

A unified model for T cell antigen recognition and thymic selection of the T cell repertoire

1991 • 36 citations

The agonist-antagonist balance in positive selection

1997 • 35 citations

In Vivo Expression of a TCR Antagonist: T Cells Escape Central Tolerance But Are Antagonized in the Periphery

1998 • 34 citations

A Naturally Processed Mitochondrial Self-Peptide in Complex with Thymic Mhc Molecules Functions as a Selecting Ligand for a Viral-Specific T Cell Receptor

2001 • 32 citations

Positive Selection of Cd4+ T Cells Is Induced in Vivo by Agonist and Inhibited by Antagonist Peptides

2001 • 31 citations

Antagonist Peptide Selects Thymocytes Expressing a Class II Major Histocompatibility Complex–restricted T Cell Receptor into the CD8 Lineage

1998 • 23 citations

High fives or hand clasps?

1992 • 22 citations

Modulation of CD8+ T Cell Response to Antigen by the Levels of Self MHC Class I

2001 • 17 citations