Self-antigen presentation by thymic stromal cells: a subtle division of labor

Changes in thymic function with age and during the treatment of HIV infection

1998 • 1,887 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus

1998 • 654 citations

The T Cell Receptor

1987 • 554 citations

Low-Affinity Ligands for the TCR Drive Proliferation of Mature CD8+ T Cells in Lymphopenic Hosts

1999 • 548 citations

Cellular Interactions in Thymocyte Development

1996 • 503 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

2000 • 399 citations

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1996 • 378 citations

Generation of Functional Thymocytes in the Human Adult

1999 • 370 citations

Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.

1994 • 353 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

1994 • 309 citations

Control of immune pathology by regulatory T cells

1998 • 289 citations

Dendritic Cells

1999 • 269 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.

1993 • 221 citations

Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides

1997 • 214 citations

Towards an integrated view of thymopoiesis

1991 • 205 citations

Quantitative Impact of Thymic Clonal Deletion on the T Cell Repertoire

1997 • 198 citations

Thymic Function Can Be Accurately Monitored by the Level of Recent T Cell Emigrants in the Circulation

1998 • 193 citations

Identification of a Naturally Occurring Ligand for Thymic Positive Selection

1997 • 193 citations

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

1998 • 188 citations

Thymic emigration: conveyor belts or lucky dips?

1995 • 186 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

Transcription of a Broad Range of Self-Antigens in Human Thymus Suggests a Role for Central Mechanisms in Tolerance Toward Peripheral Antigens

1998 • 173 citations

T-cell selection

1998 • 168 citations

Comparison of peptides bound to spleen and thymus class II.

1993 • 168 citations

CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium

1998 • 162 citations

T Lymphocyte Tolerance: From Thymic Deletion to Peripheral Control Mechanisms

1998 • 158 citations

Cd4+ T Cell Division in Irradiated Mice Requires Peptides Distinct from Those Responsible for Thymic Selection

1999 • 157 citations

Intrathymic Expression of Genes Involved in Organ Specific Autoimmune Disease

1998 • 155 citations

Requirement for Diverse, Low-Abundance Peptides in Positive Selection of T Cells

1999 • 151 citations

Thymic Selection by a Single MHC/Peptide Ligand Produces a Semidiverse Repertoire of CD4+ T Cells

1997 • 134 citations

Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation.

1986 • 126 citations

Selection of a Broad Repertoire of CD4+ T Cells in H-2Ma0/0 Mice

1997 • 122 citations

Medullary Thymic Epithelium: A Mosaic of Epithelial “Self”?

1998 • 114 citations

Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus

1997 • 112 citations

Seeding of thymic microenvironments defined by distinct thymocyte-stromal cell interactions is developmentally controlled.

1987 • 112 citations

Thymus epithelium induces tissue-specific tolerance.

1993 • 111 citations

Antigen presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen

1997 • 109 citations

Thymic cortical epithelial cells can present self-antigens in vivo

1989 • 108 citations

The Imprint of Intrathymic Self-Peptides on the Mature T Cell Receptor Repertoire

1997 • 105 citations

Tolerance induction by clonal deletion of CD4⁺8⁺ thymocytes in vitro does not require dedicated antigen‐presenting cells

1993 • 97 citations

Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen.

1997 • 93 citations

CD4 T Cell Tolerance to Nuclear Proteins Induced by Medullary Thymic Epithelium

1996 • 83 citations

Evidence for a single-niche model of positive selection.

1994 • 76 citations

Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein

1995 • 74 citations

Negative Selection of T Cells Occurs Throughout Thymic Development

1999 • 70 citations

The transcapsular route: a new way for (self-) antigens to by-pass the blood-thymus barrier?

1988 • 67 citations

Self-Reactive T Cells Selected on Thymic Cortical Epithelium Are Polyclonal and Are Pathogenic In Vivo

1999 • 65 citations

Differential Effects of Peptide Diversity and Stromal Cell Type in Positive and Negative Selection in the Thymus

1998 • 64 citations

Medullary thymic epithelial cells induce tolerance to intracellular proteins.

1996 • 63 citations

Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide.

1992 • 50 citations

Thymic Selection by a Single MHC/Peptide Ligand

1999 • 50 citations

An acetylcholine receptor alpha subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis.

1998 • 49 citations

The nature of the peptide/MHC ligand involved in positive selection

1996 • 44 citations

Presentation and intercellular transfer of self antigen within the thymic microenvironment: expression of the Eα peptide-l-A^b complex by isolated thymic stromal cells

1994 • 41 citations

Direct Visualization of thymocyte apoptosis in neglect, acute and steady-state negative selection

1996 • 41 citations

Tracing interactions of thymocytes with individual stromal cell partners

1996 • 40 citations

Aberrant Expression of Tissue‐Specific Proteins in the Thymus: A Hypothesis for the Development of Central Tolerance

1998 • 39 citations

Timing and Casting for Actors of Thymic Negative Selection

1999 • 39 citations

The thymus and self-tolerance: co-existence of encephalitogenic S100 beta-specific T cells and their nominal autoantigen in the normal adult rat thymus

1997 • 35 citations

Selectivity of the major histocompatibility complex class II presentation pathway of cortical thymic epithelial cell lines

1997 • 34 citations

On the intrathymic intercellular transfer of self-determinants

1999 • 29 citations

T-cell development: A role for self-peptides in positive selection

1999 • 26 citations

The antigen presentation pathway in medullary thymic epithelial cells, but not that in cortical thymic epithelial cells, conforms to the endocytic pathway

1998 • 26 citations

In Vivo T-Lymphocyte Tolerance in the Absence of Thymic Clonal Deletion Mediated by Hematopoietic Cells

1999 • 25 citations

Intrathymic deletion of MHC class I-restricted cytotoxic T cell precursors by constitutive cross-presentation of exogenous antigen

1999 • 22 citations

Self major histocompatibility complex class I antigens expressed solely in lymphoid cells do not induce tolerance in the CD4+ T cell compartment.

1996 • 18 citations

Unexpected Reactivities of T Cells Selected by a Single MHC-Peptide Ligand

1999 • 14 citations

Thymocyte Antigens Do Not Induce Tolerance in the CD4+ T Cell Compartment

1999 • 10 citations