Negative Selection of Precursor Thymocytes Before their Differentiation into CD4 ⁺ CD8 ⁺ Cells

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

The House Mouse: Atlas of Embryonic Development

1972 • 689 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1985 • 613 citations

The House Mouse

1989 • 559 citations

Molecular and Cellular Events of T Cell Development

1989 • 466 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function.

1989 • 356 citations

Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage

1988 • 265 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

Positive selection of the T cell repertoire: Where and when does it occur?

1989 • 242 citations

Programmed death of autoreactive thymocytes

1990 • 224 citations

Peripheral Clonal Elimination of Functional T Cells

1990 • 213 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

A cd3⁻ subset of cd4⁻8⁺ thymocytes: a rapidly cycling intermediate in the generation of cd4⁺8⁺ cells

1988 • 152 citations

Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection

1989 • 147 citations

An intermediate cell in thymocyte differentiation that expresses CD8 but not CD4 antigen.

1987 • 145 citations

Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro.

1990 • 143 citations

Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene

1987 • 127 citations

Immature CD4− CD8+ murine thymocytes

1988 • 93 citations

T cell receptor expression on immature thymocytes with in vivo and in vitro precursor potential

1989 • 39 citations

Cross‐linking of the T cell antigen receptor interferes with the generation of CD4⁺8⁺ thymocytes from their immediate CD4⁻8⁺ precursors

1988 • 37 citations