Tec Family Kinases Modulate Thresholds for Thymocyte Development and Selection

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

LAT

1998 • 1,251 citations

Altered Peptide Ligand–Induced Partial T Cell Activation: Molecular Mechanisms and Role in T Cell Biology

1996 • 698 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity

1998 • 643 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

SELECTION OF THE T CELL REPERTOIRE

1999 • 507 citations

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1996 • 494 citations

Selective Events in T Cell Development

1994 • 486 citations

LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway

1998 • 486 citations

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

1998 • 436 citations

Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell

1998 • 412 citations

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

1998 • 410 citations

Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity

1999 • 399 citations

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1996 • 378 citations

Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

1991 • 351 citations

T Cell Receptor–initiated Calcium Release Is Uncoupled from Capacitative Calcium Entry in Itk-deficient T Cells

1998 • 336 citations

Vav and SLP-76 Interact and Functionally Cooperate in IL-2 Gene Activation

1996 • 335 citations

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk

1995 • 313 citations

Activation of the c-Raf protein kinase by protein kinase C phosphorylation.

1992 • 288 citations

Phosphoinositide-specific phospholipase C and mitogenic signaling

1995 • 286 citations

Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade

2000 • 278 citations

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

1994 • 257 citations

A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells.

1994 • 246 citations

Positive and negative selection invoke distinct signaling pathways.

1996 • 234 citations

How Many Thymocytes Audition for Selection?

1997 • 222 citations

PtdIns-3,4,5-P3

1998 • 220 citations

MHC Class II–Specific T Cells Can Develop in the CD8 Lineage When CD4 Is Absent

1996 • 218 citations

Differential Roles of ERK and p38 MAP Kinase Pathways in Positive and Negative Selection of T Lymphocytes

1998 • 217 citations

The Influence of the MAPK Pathway on T Cell Lineage Commitment

1997 • 217 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

Quantitative Impact of Thymic Clonal Deletion on the T Cell Repertoire

1997 • 198 citations

Lck Activity Controls CD4/CD8 T Cell Lineage Commitment

2000 • 194 citations

Btk function in B cell development and response

1998 • 181 citations

Tec family of protein-tyrosine kinases: an overview of their structure and function

1999 • 147 citations

Thymic Selection by a Single MHC/Peptide Ligand Produces a Semidiverse Repertoire of CD4+ T Cells

1997 • 134 citations

Role of the Multiple T Cell Receptor (TCR)-ζ Chain Signaling Motifs in Selection of the T Cell Repertoire

1997 • 116 citations

T Cells Can Be Activated by Peptides That Are Unrelated in Sequence to Their Selecting Peptide

1997 • 116 citations

Surface Molecules That Drive T Cell Development In Vitro in the Absence of Thymic Epithelium and in the Absence of Lineage-Specific Signals

1997 • 110 citations

REGULATION OF T CELL FATE BY NOTCH

1999 • 105 citations

Itk/Emt/Tsk Activation in Response to CD3 Cross-linking in Jurkat T Cells Requires ZAP-70 and Lat and Is Independent of Membrane Recruitment

1999 • 101 citations

Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation

1996 • 99 citations

Activation of the Extracellular Signal-Related Kinase/Mitogen-Activated Protein Kinase Pathway Discriminates CD4 Versus CD8 Lineage Commitment in the Thymus

1999 • 86 citations

In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor-activated protein tyrosine kinase.

1994 • 75 citations

Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes

1998 • 71 citations

Reconstitution of Btk Signaling by the Atypical Tec Family Tyrosine Kinases Bmx and Txk

1999 • 69 citations

A Role for the Tec Family Tyrosine Kinase Txk in T Cell Activation and Thymocyte Selection

1999 • 58 citations

Resting Lymphocyte Kinase (Rlk/Txk) Targets Lymphoid Adaptor SLP-76 in the Cooperative Activation of Interleukin-2 Transcription in T-cells

2000 • 58 citations

A shift from negative to positive selection of autoreactive T cells by the reduced level of TCR signal in TCR-transgenic CD3 zeta-deficient mice.

1997 • 57 citations

CD4/CD8 lineage commitment: back to instruction?

1996 • 57 citations

9 Role of calcium in T-lymphocyte activation

1995 • 30 citations

BTK the tyrosine kinase affected in X-linked agammaglobulinemia

1997 • 30 citations