Identification of a Naturally Occurring Ligand for Thymic Positive Selection

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

Method to Correlate Tandem Mass Spectra of Modified Peptides to Amino Acid Sequences in the Protein Database

1995 • 1,269 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells

1992 • 726 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides.

1996 • 410 citations

Structure of Peptides Associated with Class I and Class II MHC Molecules

1994 • 381 citations

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1996 • 378 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

H-2 antigens of the thymus determinelymphocyte specificity

1978 • 321 citations

Role of self-peptides in positively selecting the T-cell repertoire

1990 • 300 citations

Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells.

1993 • 266 citations

Antigen Presentation and T Cell Development in H2-M-Deficient Mice

1996 • 263 citations

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

1991 • 263 citations

Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove.

1995 • 254 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses.

1992 • 230 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

Specific T cell recognition of minimally homologous peptides: Evidence for multiple endogenous Ligands

1995 • 209 citations

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage

1991 • 209 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

Comparison of peptides bound to spleen and thymus class II.

1993 • 168 citations

Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

1995 • 161 citations

Alloreactive cytotoxic T lymphocytes generated in the presence of viral-derived peptides show exquisite peptide and MHC specificity.

1993 • 150 citations

Mature T cell reactivity altered by peptide agonist that induces positive selection.

1996 • 148 citations

Two signals are required for negative selection of CD4+CD8+ thymocytes.

1993 • 143 citations

Differential localization and sequence analysis of capping protein beta-subunit isoforms of vertebrates.

1994 • 139 citations

Ligands for the T-cell receptor: hard times for avidity models

1995 • 138 citations

The level of CD8 expression can determine the outcome of thymic selection

1992 • 134 citations

Dissection of major histocompatibility complex (MHC) and T cell receptor contact residues in a K^b‐restricted ovalbumin peptide and an assessment of the predictive power of MHC‐binding motifs

1992 • 134 citations

A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity.

1996 • 131 citations

CD8 surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice.

1992 • 119 citations

Consensus motifs and peptide ligands of MHC class I molecules

1993 • 118 citations

Identification of conserved T cell receptor CDR3 residues contacting known exposed peptide side chains from a major histocompatibility complex class I‐bound determinant

1993 • 116 citations

Positive selection of T-lymphocytes induced by intrathymic injection of a thymic epithelial cell line

1992 • 103 citations

Vesicular stomatitis virus antigenic octapeptide N52-59 is anchored into the groove of the H-2Kb molecule by the side chains of three amino acids and the main-chain atoms of the amino terminus.

1992 • 86 citations

Recognition of multiple peptide cores by a single T cell receptor.

1995 • 84 citations

Selecting the T Cell Receptor Repertoire

1994 • 71 citations

Changes at peptide residues buried in the major histocompatibility complex (MHC) class I binding cleft influence T cell recognition: a possible role for indirect conformational alterations in the MHC class I or bound peptide in determining T cell recognition.

1993 • 69 citations

A Strategy for Sequencing Peptides from Dilute Mixtures at the Low Femtomole Level Using Membrane Preconcentration-Capillary Electro-Phoresis-Tandem Mass Spectrometry (MPC-CE-MS/MS)

1995 • 67 citations

Are MHC-bound peptides a nuisance for positive selection?

1994 • 61 citations

Permissive recognition during positive selection

1996 • 52 citations

On‐line preconcentration‐capillary electrophoresis‐mass spectrometry (PC‐CE‐MS)

1994 • 50 citations

Peptide variants reveal how antibodies recognize major histocompatibility complex class I

1993 • 49 citations

Strategy for isolating and sequencing biologically derived MHC class I peptides

1996 • 45 citations

Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion

1994 • 33 citations

Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene.

1995 • 28 citations

Systematic development of on-line membrane preconcentration-capillary electrophoresis-mass spectrometry for the analysis of peptide mixtures.

1995 • 28 citations