Thymocyte Selection Is Regulated by the Helix-Loop-Helix Inhibitor Protein, Id3

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2

1999 • 841 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins.

1991 • 601 citations

Positive selection of lymphocytes

1994 • 563 citations

Selective Events in T Cell Development

1994 • 486 citations

Two Distinct Transcription Factors that Bind the Immunoglobulin Enhancer μE5/κE2 Motif

1990 • 478 citations

E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell Lymphomas

1997 • 400 citations

An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene.

1991 • 352 citations

B-Lymphocyte Development Is Regulated by the Combined Dosage of Three Basic Helix-Loop-Helix Genes, E2A, E2-2, and HEB†

1996 • 339 citations

Activation events during thymic selection.

1992 • 326 citations

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

1996 • 316 citations

HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.

1992 • 312 citations

Inhibition of T Cell and Promotion of Natural Killer Cell Development by the Dominant Negative Helix Loop Helix Factor Id3

1997 • 279 citations

The expression pattern ofId4, a novel dominant negative helix-loop-helix protein, is distinct fromId1,1d2andId3

1994 • 274 citations

Constitutive expression of the Id1 gene impairs mouse B cell development

1994 • 266 citations

High Incidence of T-Cell Tumors in E2A-Null Mice and E2A/Id1 Double-Knockout Mice

1997 • 238 citations

CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection

1993 • 225 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

Each member of the Id gene family exhibits a unique expression pattern in mouse gastrulation and neurogenesis

1997 • 213 citations

Coupling of Cell Growth Control and Apoptosis Functions of Id Proteins

1998 • 187 citations

A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines.

1993 • 173 citations

Positive and Negative Regulation of V(D)J Recombination by the E2A Proteins

1999 • 126 citations

Thymocyte Maturation Is Regulated by the Activity of the Helix-Loop-Helix Protein, E47

1999 • 125 citations

Id2 Promotes Apoptosis by a Novel Mechanism Independent of Dimerization to Basic Helix-Loop-Helix Factors

1998 • 113 citations

Regulation of RAG‐1 and CD69 expression in the thymus during positive and negative selection

1994 • 112 citations

Regulation of Id3 Cell Cycle Function by Cdk-2-Dependent Phosphorylation

1997 • 103 citations

An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types.

1993 • 98 citations

Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection.

1995 • 84 citations

Functional analysis of the murine T-cell receptor beta enhancer and characteristics of its DNA-binding proteins.

1990 • 75 citations

E2A Basic-Helix-Loop-Helix Transcription Factors are Negatively Regulated by Serum Growth Factors and by the Id3 Protein

1996 • 70 citations

Asymmetric Redundancy in CD4 Silencer Function

1996 • 42 citations

Lymphoid-specific Expression of the Id3 Gene in Hematopoietic Cells

1998 • 39 citations

Inhibition of muscle-specific gene expression by Id3: requirement of the C-terminal region of the protein for stable expression and function

1997 • 39 citations

Physical and Functional Interactions between the Transcriptional Inhibitors Id3 and ITF-2b

1997 • 26 citations

Dual MHC Class I and Class II Restriction of a Single T Cell Receptor: Distinct Modes of Tolerance Induction by Two Classes of Autoantigens

1999 • 21 citations