Dual receptor T cells extend the immune repertoire for foreign antigens

Immunobiology: the immune system in health and disease

1995 • 3,893 citations

The clonal selection theory of acquired immunity

1959 • 2,008 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

The clonal selection theory of acquired immunity

1959 • 1,576 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics

1992 • 531 citations

Expression of Two T Cell Receptor α Chains: Dual Receptor T Cells

1993 • 527 citations

Quantifying the Frequency of Alloreactive T Cells In Vivo: New Answers to an Old Question

2001 • 519 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire.

1991 • 323 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

1993 • 247 citations

Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides

1997 • 214 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

Differential Tolerance Is Induced in T Cells Recognizing Distinct Epitopes of Myelin Basic Protein

1998 • 182 citations

The Specificity and Orientation of a TCR to its Peptide–MHC Class II Ligands

1996 • 177 citations

Cassette vectors directing expression of T cell receptor genes in transgenic mice

1995 • 159 citations

Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression.

1992 • 152 citations

Requirement for Diverse, Low-Abundance Peptides in Positive Selection of T Cells

1999 • 151 citations

Evolution of Antigen-specific T Cell Receptors In Vivo: Preimmune and Antigen-driven Selection of Preferred Complementarity-determining Region 3 (CDR3) Motifs

1999 • 151 citations

Thymic Selection by a Single MHC/Peptide Ligand Produces a Semidiverse Repertoire of CD4+ T Cells

1997 • 134 citations

Normal T lymphocytes can express two different T cell receptor beta chains: implications for the mechanism of allelic exclusion.

1995 • 132 citations

Expression of two T cell receptor α chains on the surface of normal murine T cells

1995 • 131 citations

Allelic Inclusion of T Cell Receptor α Genes Poses an Autoimmune Hazard Due to Low-Level Expression of Autospecific Receptors

1998 • 129 citations

Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function.

1996 • 121 citations

Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell‐mediated responses in mice of distinct MHC genotype

1992 • 120 citations

T cells with two functional antigen-specific receptors.

1995 • 119 citations

T Cells Can Be Activated by Peptides That Are Unrelated in Sequence to Their Selecting Peptide

1997 • 116 citations

Dual T cell receptor beta chain expression on human T lymphocytes.

1995 • 106 citations

The Imprint of Intrathymic Self-Peptides on the Mature T Cell Receptor Repertoire

1997 • 105 citations

A Molecular Map of T Cell Development

1998 • 94 citations

Dual T cell receptor alpha chain T cells in autoimmunity.

1995 • 82 citations

T Cell Receptor (Tcr)-Mediated Repertoire Selection and Loss of Tcr Vβ Diversity during the Initiation of a Cd4+ T Cell Response in Vivo

2000 • 77 citations

Posttranslational regulation of TCR Valpha allelic exclusion during T cell differentiation.

1998 • 71 citations

Incomplete T cell receptor V beta allelic exclusion and dual V beta-expressing cells.

1995 • 71 citations

Posttranslational Regulation of TCR Vα Allelic Exclusion During T Cell Differentiation

1998 • 64 citations

Following Antigen Challenge, T Cells Up-Regulate Cell Surface Expression of CD4 In Vitro and In Vivo

1998 • 61 citations

TCR transgenic mice in which usage of transgenic alpha- and beta-chains is highly dependent on the level of selecting ligand.

1998 • 56 citations

TCR Transgenic Mice in Which Usage of Transgenic α- and β-Chains Is Highly Dependent on the Level of Selecting Ligand

1998 • 49 citations

The influence of positive selection on RAG expression in thymocytes

1995 • 46 citations

Visualizing Memory Phenotype Development afterin VitroStimulation of CD4+T Cells

1998 • 44 citations

Competition for Specific Intrathymic Ligands Limits Positive Selection in a TCR Transgenic Model of CD4+ T Cell Development

2000 • 39 citations

Dual Receptor T‐Cells

1995 • 34 citations

Triggering a Second T Cell Receptor on Diabetogenic T Cells Can Prevent Induction of Diabetes

1999 • 27 citations

Highly Restricted T Cell Repertoire Shaped by a Single Major Histocompatibility Complex–Peptide Ligand in the Presence of a Single Rearranged T Cell Receptor β Chain

1998 • 26 citations

Allelic exclusion of α chains in TCRs

1994 • 26 citations

Non‐obese diabetic mice hemizygous at the T cell receptor α locus are susceptible to diabetes and sialitis

1996 • 25 citations

T cells with dual antigen specificity in T cell receptor transgenic mice rejecting allografts

1995 • 20 citations

αβTCRs Differ in the Degree of Their Specificity for the Positively Selecting MHC/Peptide Ligand

2001 • 19 citations

Selection of dual Vα T cells

1998 • 16 citations

Self-Restricted Dual Receptor Memory T Cells

1998 • 13 citations

The alternative approach.

1991 • 12 citations

A NK1.1+ Thymocyte-Derived TCR β-Chain Transgene Promotes Positive Selection of Thymic NK1.1+ αβ T Cells

2000 • 10 citations