The function of E- and id proteins in lymphocyte development

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms

2000 • 1,761 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

1999 • 1,139 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2

1999 • 841 citations

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1994 • 807 citations

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

1994 • 766 citations

The helix-loop-helix gene E2A is required for B cell formation

1994 • 679 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

Failure of B-cell differentiation in mice lacking the transcription factor EBF

1995 • 667 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

1999 • 641 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

Control points in early T-cell development

1993 • 429 citations

Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

1997 • 411 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny.

1996 • 405 citations

E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell Lymphomas

1997 • 400 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

B-Lymphocyte Development Is Regulated by the Combined Dosage of Three Basic Helix-Loop-Helix Genes, E2A, E2-2, and HEB†

1996 • 339 citations

Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation.

1994 • 334 citations

Id2 and Id3 Inhibit Development of Cd34+ Stem Cells into Predendritic Cell (Pre-Dc)2 but Not into Pre-Dc1

2000 • 324 citations

HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.

1992 • 312 citations

Inhibition of T Cell and Promotion of Natural Killer Cell Development by the Dominant Negative Helix Loop Helix Factor Id3

1997 • 279 citations

Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

2001 • 276 citations

Induction of Early B Cell Factor (EBF) and Multiple B Lineage Genes by the Basic Helix-Loop-Helix Transcription Factor E12

1998 • 268 citations

Notch Inhibition of E47 Supports the Existence of a Novel Signaling Pathway

1998 • 261 citations

E2A and EBF Act in Synergy with the V(D)J Recombinase to Generate a Diverse Immunoglobulin Repertoire in Nonlymphoid Cells

2000 • 227 citations

Thymocyte Selection Is Regulated by the Helix-Loop-Helix Inhibitor Protein, Id3

2000 • 220 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-Tα chain expression

2000 • 210 citations

CD3ε-mediated signals rescue the development of CD4⁺CD8⁺ thymocytes in RAG-2^−/− mice in the absence of TCR β chain expression

1994 • 205 citations

Early Thymocyte Development Is Regulated by Modulation of E2a Protein Activity

2001 • 190 citations

B-Cell-Specific DNA Binding by an E47 Homodimer

1995 • 187 citations

B cell development: signal transduction by antigen receptors and their surrogates

1999 • 186 citations

Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells

2001 • 182 citations

Regulation of thymocyte development from immature progenitors

1996 • 182 citations

T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production.

1995 • 180 citations

Functions of E2A-HEB Heterodimers in T-Cell Development Revealed by a Dominant Negative Mutation of HEB

2000 • 180 citations

A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines.

1993 • 173 citations

Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-β

2001 • 166 citations

Impaired Immune Responses and B-Cell Proliferation in Mice Lacking the Id3 Gene

1999 • 163 citations

Expression of pT mRNA in a Committed Dendritic Cell Precursor in the Human Thymus

1999 • 153 citations

E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination

1999 • 137 citations

A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis.

1999 • 133 citations

Massive Apoptosis of Thymocytes in T-Cell-Deficient Id1 Transgenic Mice

1999 • 133 citations

Positive and Negative Regulation of V(D)J Recombination by the E2A Proteins

1999 • 126 citations

Thymocyte Maturation Is Regulated by the Activity of the Helix-Loop-Helix Protein, E47

1999 • 125 citations

Functional Replacement of the Mouse E2A Gene with a Human HEB cDNA

1998 • 112 citations

Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas

1999 • 108 citations

Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers

1991 • 104 citations

Phosphorylation of E47 as a Potential Determinant of B-Cell-Specific Activity

1996 • 103 citations

A Novel Role for HEB Downstream or Parallel to the Pre-TCR Signaling Pathway During αβ Thymopoiesis

1999 • 101 citations

Disruption of αβ but not of γδ T cell development by overexpression of the helix–loop–helix protein Id3 in committed T cell progenitors

1999 • 96 citations

Growth Inhibition and Apoptosis Due to Restoration of E2A Activity in T Cell Acute Lymphoblastic Leukemia Cells

1999 • 75 citations

Serine/Threonine Kinases 3pK and MAPK-activated Protein Kinase 2 Interact with the Basic Helix-Loop-Helix Transcription Factor E47 and Repress Its Transcriptional Activity

2000 • 73 citations

E2A and HEB Activate the Pre-TCRα Promoter During Immature T Cell Development

2001 • 56 citations

The Upstream Enhancer Is Necessary and Sufficient for the Expression of the Pre-T Cell Receptor α Gene in Immature T Lymphocytes

2001 • 53 citations

Expression of the Mouse Pre-T Cell Receptor α Gene Is Controlled by an Upstream Region Containing a Transcriptional Enhancer

1999 • 53 citations

Induction of a Diverse T Cell Receptor γ/δ Repertoire by the Helix-Loop-Helix Proteins E2a and Heb in Nonlymphoid Cells

2001 • 50 citations

Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor

1990 • 37 citations

Identification of the E2A Gene Products as Regulatory Targets of the G1 Cyclin-dependent Kinases

2001 • 21 citations