T cell receptor editing

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Receptor editing in self-reactive bone marrow B cells.

1993 • 1,026 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Receptor editing: an approach by autoreactive B cells to escape tolerance.

1993 • 920 citations

Organ-Specific Disease Provoked by Systemic Autoimmunity

1996 • 880 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus

1998 • 654 citations

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1996 • 378 citations

Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.

1994 • 353 citations

Receptor Editing in a Transgenic Mouse Model: Site, Efficiency, and Role in B Cell Tolerance and Antibody Diversification

1997 • 291 citations

Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

1991 • 270 citations

Receptor Selection in B and T Lymphocytes

2000 • 226 citations

Editing Disease-Associated Autoantibodies

1997 • 217 citations

Deletion of self-reactive T cells before entry into the thymus medulla

1988 • 171 citations

T Lymphocyte Tolerance: From Thymic Deletion to Peripheral Control Mechanisms

1998 • 158 citations

Receptor editing in developing T cells

2000 • 157 citations

Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection

1989 • 147 citations

Thymic microenvironments, 3-D versus 2-D?

1999 • 139 citations

Allelic Inclusion of T Cell Receptor α Genes Poses an Autoimmune Hazard Due to Low-Level Expression of Autospecific Receptors

1998 • 129 citations

RAG Reexpression and DNA Recombination at T Cell Receptor Loci in Peripheral CD4+ T Cells

1998 • 124 citations

Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function.

1996 • 121 citations

Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens.

1988 • 117 citations

Immune Receptor Editing

1998 • 113 citations

Regulation of RAG‐1 and CD69 expression in the thymus during positive and negative selection

1994 • 112 citations

Antigen presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen

1997 • 109 citations

Rapid deletion of rearranged T cell antigen receptor (TCR) Vα-Jα segment by secondary rearrangement in the thymus: Role of continuous rearrangement of TCR α chain gene and positive selection in the T cell repertoire formation

1998 • 104 citations

Clonal deletion of specific thymocytes by an immunoglobulin idiotype.

1993 • 100 citations

Antigen‐specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection

1997 • 95 citations

Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen.

1997 • 93 citations

Thymocyte selection: not by TCR alone

1998 • 88 citations

Posttranslational regulation of TCR Valpha allelic exclusion during T cell differentiation.

1998 • 71 citations

Negative Selection of T Cells Occurs Throughout Thymic Development

1999 • 70 citations

Antigen compartmentation and T helper cell tolerance induction.

1996 • 68 citations

Deletion of high-avidity T cells by thymic epithelium.

1995 • 67 citations

Posttranslational Regulation of TCR Vα Allelic Exclusion During T Cell Differentiation

1998 • 64 citations

Using thymus anatomy to dissect T cell repertoire selection

1999 • 62 citations

Thymic stromal cell specialization and the T-cell receptor repertoire

1997 • 51 citations

The Avidity Spectrum of T Cell Receptor Interactions Accounts for T Cell Anergy in a Double Transgenic Model

1999 • 51 citations

Direct Visualization of thymocyte apoptosis in neglect, acute and steady-state negative selection

1996 • 41 citations

Negative selection by endogenous antigen and superantigen occurs at multiple thymic sites

1996 • 40 citations

Tolerance in TCR/Cognate Antigen Double-Transgenic Mice Mediated by Incomplete Thymic Deletion and Peripheral Receptor Downregulation

1995 • 31 citations

Expression of two structurally identical viral superantigens results in thymic elimination at distinct developmental stages.

1994 • 24 citations

Quantitative Analysis of the Efficiency of Clonal Deletion in the Thymus

1993 • 16 citations

Inhibition of intrathymic T cell development by expression of a transgenic antagonist peptide

1998 • 15 citations

Kinetics of clonal deletion varies with tolerizing antigen.

1992 • 2 citations