Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide.

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.

1975 • 1,734 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

T-Lymphocyte Recognition of Antigen in Association with Gene Products of the Major Histocompatibility Complex

1985 • 942 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

1988 • 491 citations

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

1987 • 391 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Correlations between T-cell specificity and the structure of the antigen receptor

1986 • 375 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

The effect of thymus environment on T cell development and tolerance

1988 • 330 citations

Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid.

1983 • 293 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes

1987 • 248 citations

The fine specificity of antigen and la determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c

1982 • 244 citations

T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E

1989 • 238 citations

Peripheral Clonal Elimination of Functional T Cells

1990 • 213 citations

The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells.

1991 • 190 citations

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.

1990 • 190 citations

T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.

1989 • 182 citations

Thymic Epithelium Tolerizes for Histocompatibility Antigens

1990 • 179 citations

Thymocyte subpopulations: an experimental review, including flow cytometric cross-correlations between the major murine thymocyte markers.

1983 • 178 citations

Deletion of self-reactive T cells before entry into the thymus medulla

1988 • 171 citations

Interleukin 2 receptor gene expression in normal human T lymphocytes.

1985 • 164 citations

Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection

1989 • 147 citations

Development of the CD4 and CD8 lineage of T cells: instruction versus selection.

1991 • 144 citations

Successful transplantation across major histocompatibility barrier of deoxyguanosine-treated embryonic thymus expressing class II antigens

1984 • 138 citations

Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities

1990 • 136 citations

Transgenic Mice with I-A on Islet Cells Are Normoglycemic But Immunologically Intolerant

1989 • 135 citations

T-cell differentiation in thymus organ cultures.

1990 • 100 citations

Peripheral tolerance to allogeneic class II histocompatibility antigens expressed in transgenic mice: evidence against a clonal-deletion mechanism.

1989 • 91 citations

Early Deletion and Late Positive Selection of T-Cells Expressing a Male-Specific Receptor in T-Cell Receptor Transgenic Mice

1989 • 83 citations

Alpha beta T cell receptor and CD3 transduce different signals in immature T cells. Implications for selection and tolerance.

1989 • 72 citations

Thymic epithelium and the induction of transplantation tolerance in nude mice

1985 • 64 citations

A simple screening method for transgenic mice using the polymerase chain reaction.

1990 • 58 citations

Thymic epithelium tolerizes for histocompatibility antigens

1990 • 53 citations

T-Lymphocyte Recognition of Antigen in Association with Gene Products of the Major Histocompatibility Complex

1985 • 37 citations

Generation of cells expressing cytoplasmic and/or surface T-cell receptor beta chains during the development of mouse fetal thymus.

1986 • 22 citations

Newly generated thymocytes are not refractory to deletion when the α/β component of the T cell receptor is engaged by the superantigen staphylococcal enterotoxin B

1990 • 20 citations

T-cell Repertoire and Thymus

1989 • 8 citations