Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.

1983 • 701 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Positive Selection of Thymocytes

1995 • 604 citations

Cellular Interactions in Thymocyte Development

1996 • 503 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

α/β–T Cell Receptor (TCR)+CD4−CD8− (NKT) Thymocytes Prevent Insulin-dependent Diabetes Mellitus in Nonobese Diabetic (NOD)/Lt Mice by the Influence of Interleukin (IL)-4 and/or IL-10

1998 • 473 citations

Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo

1997 • 459 citations

Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression

2000 • 448 citations

NKT cells derive from double-positive thymocytes that are positively selected by CD1d

2001 • 421 citations

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1996 • 378 citations

MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

1993 • 359 citations

Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response.

1995 • 271 citations

Regulatory T cells and inflammatory bowel disease

1999 • 270 citations

The Influence of Thymus H-2 Antigens on the Specificity of Maturing Killer and Helper Cells

1978 • 257 citations

NK1.1+ T Cells in the Liver Arise in the Thymus and Are Selected by Interactions with Class I Molecules on CD4+CD8+ Cells

2000 • 217 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

Receptor editing in developing T cells

2000 • 157 citations

Several Different Cell Surface Molecules Control Negative Selection of Medullary Thymocytes

1999 • 127 citations

The minimal number of antigen‐major histocompatibility complex class II complexes required for activation of naive and primed T cells

1997 • 100 citations

Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice.

1993 • 92 citations

Differential T cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses.

1997 • 89 citations

Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists.

1994 • 88 citations

Double Negative (CD4⁻CD8⁻αβ⁺) T Cells Which Promote Tolerance Induction and Regulate Autoimmunity

1996 • 88 citations

CD2-CD4-CD8- lymph node T lymphocytes in MRL lpr/lpr mice are derived from a CD2+CD4+CD8+ thymic precursor.

1993 • 82 citations

Clonal deletion of V beta 5+ T cells by transgenic I-E restricted to thymic medullary epithelium.

1993 • 76 citations

Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage.

1996 • 63 citations

Presentation of self and microbial lipids by CD1 molecules

2001 • 62 citations

Modulation of Naive CD4 T Cell Activation with Altered Peptide Ligands: The Nature of the Peptide and Presentation in the Context of Costimulation Are Critical for a Sustained Response

1998 • 57 citations

The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells

1998 • 31 citations

In Vivo Biological Effect of Allogeneic Cultured Thymic Epithelium on Thymus‐Dependent Immunity in Athymic Nude Rats

1985 • 23 citations

Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide

2001 • 16 citations

Transplantation of cultured thymus fragments. III. Induction of allotolerance.

1982 • 13 citations

In vitro positive selection and anergy induction of class II-restricted TCR transgenic thymocytes by a cortical thymic epithelial cell line

1998 • 11 citations

Role of thymic stromal cells in thymocyte education: a comparitive analysis of different models.

1994 • 9 citations