SEK1/MKK4 Is Required for Maintenance of a Normal Peripheral Lymphoid Compartment but Not for Lymphocyte Development

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease

1989 • 870 citations

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

1997 • 797 citations

Mitogen-activated protein kinase cascades and regulation of gene expression

1996 • 759 citations

Protein kinase cascades activated by stress and inflammatory cytokines

1996 • 722 citations

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

1995 • 710 citations

Neutrophil and B Cell Expansion in Mice That Lack the Murine IL-8 Receptor Homolog

1994 • 666 citations

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

1995 • 475 citations

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

1996 • 457 citations

Characterization of the B Lymphocyte Populations in Lyn-Deficient Mice and the Role of Lyn in Signal Initiation and Down-Regulation

1997 • 451 citations

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

1997 • 424 citations

Generalized autoimmune disease in interleukin‐2‐deficient mice is triggered by an uncontrolled activation and proliferation of CD4⁺ T cells

1995 • 423 citations

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice.

1995 • 418 citations

IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice

1990 • 410 citations

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

1993 • 393 citations

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH ₂ -terminal kinase

1997 • 382 citations

Fas and Fas Ligand: A Death Factor and Its Receptor

1994 • 354 citations

Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice.

1990 • 338 citations

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

1997 • 330 citations

Defective activation and survival of T cells lacking the Ets-1 transcription factor

1995 • 329 citations

MEKKs, GCKs, MLKs, PAKs, TAKs, and Tpls: upstream regulators of the c-Jun amino-terminal kinases?

1997 • 318 citations

Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene

1995 • 313 citations

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

1994 • 288 citations

Interleukin-6 Inhibits Fas-Induced Apoptosis and Stress-Activated Protein Kinase Activation in Multiple Myeloma Cells

1997 • 278 citations

Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway

1997 • 268 citations

Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH ₂ -terminal kinase activation, and defects in AP-1 transcriptional activity

1997 • 266 citations

Cutaneous lymphoproliferation and lymphomas in interleukin 7 transgenic mice.

1993 • 255 citations

Lack of a Role for Jun Kinase and AP-1 in Fas-Induced Apoptosis

1997 • 253 citations

Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population.

1990 • 223 citations

"Viable motheaten," a new allele at the motheaten locus. I. Pathology.

1984 • 205 citations

MKK7 Is A Stress-activated Mitogen-activated Protein Kinase Kinase Functionally Related to hemipterous

1997 • 182 citations

Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins.

1976 • 177 citations

Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases.

1996 • 175 citations

Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes

1996 • 166 citations

Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice.

1996 • 152 citations

Thymocyte development is normal in CTLA-4-deficient mice

1997 • 147 citations

Development and proliferation of lymphocytes in mice deficient for both interleukins‐2 and ‐4

1994 • 146 citations

Bruton’s tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity

1997 • 137 citations

Coagulation disorders associated with acute promyelocytic leukemia: corrective effect of all-trans retinoic acid treatment.

1993 • 130 citations

Abnormalities of the Immune System Induced by Dysregulated bcl-2 Expression in Transgenic Mice

1990 • 129 citations

Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes

1997 • 128 citations

Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells

1996 • 127 citations

Molecular Cloning and Characterization of Human JNKK2, a Novel Jun NH₂-Terminal Kinase-Specific Kinase

1997 • 108 citations

Motheaten, an Immunodeficient Mutant of the Mouse

1976 • 94 citations

Apoptosis: Does stress kill?

1996 • 45 citations

Targeted disruption of the CD3 eta locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand.

1994 • 37 citations

Lymphoproliferative disorders in an IL-7 transgenic mouse line.

1993 • 37 citations

Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse.

1994 • 34 citations

RAG-2-Deficient Blastocyst Complementation

1994 • 26 citations

Novel components of mammalian stress-activated protein kinase cascades

1997 • 9 citations