αβTCRs Differ in the Degree of Their Specificity for the Positively Selecting MHC/Peptide Ligand

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

Organ-Specific Disease Provoked by Systemic Autoimmunity

1996 • 880 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells

1992 • 726 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Positive Selection of Thymocytes

1995 • 604 citations

Low-Affinity Ligands for the TCR Drive Proliferation of Mature CD8+ T Cells in Lymphopenic Hosts

1999 • 548 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Two Human T Cell Receptors Bind in a Similar Diagonal Mode to the HLA-A2/Tax Peptide Complex Using Different TCR Amino Acids

1998 • 438 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

The Crystal Structure of a T Cell Receptor in Complex with Peptide and MHC Class II

1999 • 400 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice

1995 • 273 citations

Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

1993 • 266 citations

Antigen Presentation and T Cell Development in H2-M-Deficient Mice

1996 • 263 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

A differential-avidity model for T-cell selection

1994 • 239 citations

How Many Thymocytes Audition for Selection?

1997 • 222 citations

MHC Class II–Specific T Cells Can Develop in the CD8 Lineage When CD4 Is Absent

1996 • 218 citations

Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides

1997 • 214 citations

The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.

1994 • 196 citations

Identification of a Naturally Occurring Ligand for Thymic Positive Selection

1997 • 193 citations

A novel MHC class II epitope expressed in thymic medulla but not cortex

1989 • 175 citations

Cassette vectors directing expression of T cell receptor genes in transgenic mice

1995 • 159 citations

Peptides in positive and negative selection: A delicate balance

1994 • 153 citations

Requirement for Diverse, Low-Abundance Peptides in Positive Selection of T Cells

1999 • 151 citations

Thymic Selection by a Single MHC/Peptide Ligand Produces a Semidiverse Repertoire of CD4+ T Cells

1997 • 134 citations

Inefficient positive selection of T cells directed by haematopoietic cells

1992 • 132 citations

Selection of a Broad Repertoire of CD4+ T Cells in H-2Ma0/0 Mice

1997 • 122 citations

T Cells Can Be Activated by Peptides That Are Unrelated in Sequence to Their Selecting Peptide

1997 • 116 citations

Diversity of Endogenous Epitopes Bound to MHC Class II Molecules Limited by Invariant Chain

1994 • 116 citations

Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus

1997 • 112 citations

Specific Recognition of Thymic Self-Peptides Induces the Positive Selection of Cytotoxic T Lymphocytes

1997 • 95 citations

Peptide Recognition by Two HLA-A2/Tax11–19-Specific T Cell Clones in Relationship to Their MHC/Peptide/TCR Crystal Structures

1999 • 90 citations

Inactivation of Misselected CD8 T Cells by CD8 Gene Methylation and Cell Death

1999 • 87 citations

Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms

1995 • 80 citations

Evidence for a single-niche model of positive selection.

1994 • 76 citations

Molecular genetic analysis of 178 I-Abm12-reactive T cells.

1989 • 76 citations

Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire.

1995 • 75 citations

Weak positive selection of transgenic T cell receptor‐bearing thymocytes: importance of major histocompatibility complex class II, T cell receptor and CD4 surface molecule densities

1992 • 65 citations

Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage.

1996 • 63 citations

TCR transgenic mice in which usage of transgenic alpha- and beta-chains is highly dependent on the level of selecting ligand.

1998 • 56 citations

Selection of Antigen-specific T Cells by a Single IEk Peptide Combination

1997 • 52 citations

Permissive recognition during positive selection

1996 • 52 citations

TCR Transgenic Mice in Which Usage of Transgenic α- and β-Chains Is Highly Dependent on the Level of Selecting Ligand

1998 • 49 citations

The influence of invariant chain on the positive selection of single T cell receptor specificities

1995 • 49 citations

MHC Class II Expression in Double Mutant Mice Lacking Invariant Chain and DM Functions

1998 • 47 citations

Presentation and intercellular transfer of self antigen within the thymic microenvironment: expression of the Eα peptide-l-A^b complex by isolated thymic stromal cells

1994 • 41 citations

Regulation of T cell production in T cell receptor transgenic mice

1993 • 36 citations

Molecular requirements for lineage commitment in the thymus – antibody‐mediated receptor engagements reveal a central role for lck in lineage decisions

1998 • 31 citations

Determination of amino acids on agretopes of pigeon cytochrome c‐related peptides specifically bound to I‐A allelic products

1994 • 29 citations

Invariant Chain Can Bind MHC Class II at a Site Other Than the Peptide Binding Groove

1998 • 29 citations

In the Normal Repertoire of CD4+ T Cells, a Single Class II MHC/Peptide Complex Positively Selects TCRs with Various Antigen Specificities

1999 • 24 citations

Antagonist Peptide Selects Thymocytes Expressing a Class II Major Histocompatibility Complex–restricted T Cell Receptor into the CD8 Lineage

1998 • 23 citations

An endogenously processed self peptide and the corresponding exogenous peptide bound to the same MHC class II molecule could be distinct ligands for TCR with different kinetic stability

1998 • 15 citations

Inhibition of intrathymic T cell development by expression of a transgenic antagonist peptide

1998 • 15 citations

In vitro construction of graded thymus chimeras

1994 • 12 citations

The allogeneic effect in vitro: activation of antibody synthesis in aggressor and target lymphocyte populations by allogeneic interaction

1973 • 6 citations