Divergent Changes in the Sensitivity of Maturing T Cells to Structurally Related Ligands Underlies Formation of a Useful T Cell Repertoire

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus

1998 • 654 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Selective Events in T Cell Development

1994 • 486 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

1997 • 419 citations

Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

1997 • 402 citations

Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling

1996 • 390 citations

The thymus selects the useful, neglects the useless and destroys the harmful

1989 • 378 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.

1995 • 355 citations

Fidelity of T Cell Activation Through Multistep T Cell Receptor ζ Phosphorylation

1998 • 338 citations

High- and Low-Potency Ligands with Similar Affinities for the TCR

1998 • 322 citations

H-2 antigens of the thymus determinelymphocyte specificity

1978 • 321 citations

Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn.

1993 • 307 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

1991 • 263 citations

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

1994 • 257 citations

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

1994 • 254 citations

Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.

1994 • 248 citations

Short Related Sequences in the Cytoplasmic Domains of CD4 and CD8 Mediate Binding to the Amino-Terminal Domain of the p56^lck Tyrosine Protein Kinase

1990 • 245 citations

CD 69 expression during selection and maturation of CD4⁺8⁺ thymocytes

1993 • 242 citations

Positive and negative selection invoke distinct signaling pathways.

1996 • 234 citations

CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection

1993 • 225 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens

1989 • 219 citations

Differential Roles of ERK and p38 MAP Kinase Pathways in Positive and Negative Selection of T Lymphocytes

1998 • 217 citations

Preselection Thymocytes Are More Sensitive to T Cell Receptor Stimulation Than Mature T Cells

1998 • 208 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.

1990 • 190 citations

Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules

1998 • 186 citations

The Efficiency of CD4 Recruitment to Ligand-engaged TCR Controls the Agonist/Partial Agonist Properties of Peptide–MHC Molecule Ligands

1997 • 183 citations

Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70

1995 • 183 citations

Positive selection of CD4+ thymocytes controlled by MHC class II gene products

1988 • 174 citations

Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

1995 • 161 citations

Peptides in positive and negative selection: A delicate balance

1994 • 153 citations

Mature T cell reactivity altered by peptide agonist that induces positive selection.

1996 • 148 citations

Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase.

1990 • 145 citations

The mouse CD69 gene. Structure, expression, and mapping to the NK gene complex.

1994 • 135 citations

Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus

1996 • 135 citations

Isolation of the murine intercellular adhesion molecule 1 (ICAM-1) gene. ICAM-1 enhances antigen-specific T cell activation.

1989 • 118 citations

CD4 Augments the Response of a T Cell to Agonist but Not to Antagonist Ligands

1997 • 114 citations

Production, selection, and maturation of thymocytes with high surface density of TCR.

1994 • 113 citations

Partial signaling by CD8+ T cells in response to antagonist ligands.

1996 • 111 citations

Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement.

1994 • 109 citations

Positive selection of T cells

1995 • 106 citations

Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor.

1995 • 104 citations

Positive Selection of Thymocytes

1995 • 103 citations

Differential T cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses.

1997 • 89 citations

Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists.

1994 • 88 citations

A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes.

1994 • 86 citations

Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes.

1996 • 84 citations

A Spontaneously Arising Mutation in the DLAARN Motif of Murine ZAP-70 Abrogates Kinase Activity and Arrests Thymocyte Development

1997 • 81 citations

Demonstration of opsonic activity and in vivo protection against group B streptococci type III by Streptococcus pneumoniae type 14 antisera.

1978 • 74 citations

Selective Induction of Apoptosis in Mature T Lymphocytes by Variant T Cell Receptor Ligands

1998 • 72 citations

Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes

1998 • 71 citations

Positive selection of thymocytes involves sustained interactions with the thymic microenvironment.

1995 • 70 citations

Endogenous altered peptide ligands can affect peripheral T cell responses.

1996 • 59 citations

Autologous rat myelin basic protein is a partial agonist that is converted into a full antagonist upon blockade of CD4. Evidence for the integration of efficacious and nonefficacious signals during T cell antigen recognition.

1995 • 55 citations

Intracellular signals that mediate thymic negative selection

1994 • 54 citations

Limits to the differential avidity model of T cell selection in the thymus.

1997 • 48 citations

CD28-B7 interactions function to co-stimulate clonal deletion of double-positive thymocytes

1996 • 43 citations

Induction of thymocyte deletion by purified single peptide/major histocompatibility complex ligands.

1997 • 17 citations

Two separable T cell receptor signals reconstitute positive selection of CD4 lineage T cells in vivo

1997 • 12 citations

CD4‐dependent and ‐independent association of protein tyrosine kinases to the T cell receptor/CD3 complex of CD4⁺ mouse T lymphocytes

1996 • 6 citations