Inhibition of I‐A^d‐, but not D^b‐restricted peptide‐induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

The Fas Death Factor

1995 • 4,070 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation

1994 • 1,604 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Natural history of the major histo-compatibility complex

1987 • 1,274 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Apoptosis

1993 • 972 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

Fundamental Immunology

1994 • 903 citations

Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action.

1985 • 816 citations

Negative selection of lymphocytes

1994 • 810 citations

Positive selection of lymphocytes

1994 • 563 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

The natural history of the major histocompatibility complex

1987 • 500 citations

Control points in early T-cell development

1993 • 429 citations

RU 38486: Potent antiglucocorticoid activity correlated with strong binding to the cytosolic glucocorticoid receptor followed by an impaired activation

1984 • 372 citations

Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.

1994 • 353 citations

Steroid production in the thymus: implications for thymocyte selection.

1994 • 351 citations

Possible underlying mechanisms of sexual dimorphism in the immune response, fact and hypothesis

1989 • 346 citations

Effect of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: Application in the production of chimeric thymus rudiments

1982 • 324 citations

Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids.

1993 • 306 citations

Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance

1994 • 286 citations

Distinct roles for CD4 and CD8 as co-receptors in antigen receptor signalling

1993 • 274 citations

Early Events in T-Cell Maturation

1987 • 242 citations

Transcriptional control by nuclear receptors

1991 • 234 citations

The steroid receptor superfamily: mechanisms of diversity

1991 • 202 citations

In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes.

1991 • 199 citations

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody.

1995 • 197 citations

HORMONE RESPONSE DOMAINS IN GENE TRANSCRIPTION

1992 • 185 citations

Glucocorticoid-mediated control of the activation and clonal deletion of peripheral T cells in vivo.

1993 • 163 citations

Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice.

1992 • 149 citations

Delivery and Transport of Glucocorticoids to Target Cells

1979 • 140 citations

The roles of CD8 in cytotoxic T lymphocyte function

1993 • 132 citations

Thymocyte apoptosis induced by elevated endogenous corticosterone levels

1994 • 126 citations

9-cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte development.

1993 • 124 citations

Structure and function of the glucocorticoid receptor

1993 • 100 citations

Killing of immature CD4⁺CD8⁺ thymocytes in vivo by anti‐CD3 or 5′‐(N‐ethyl)‐carboxamido‐adenosine is blocked by glucocorticoid receptor antagonist RU‐486

1993 • 79 citations

Signaling for death of lymphoid cells

1993 • 71 citations

Evidence for differential intracellular signaling via CD4 and CD8 molecules.

1994 • 69 citations

Steroid hormone action

1993 • 69 citations

Functional recognition of in vivo processed self antigen

1994 • 53 citations

Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide.

1992 • 50 citations

Stimulation of T-cells with OKT3 antibodies increases forskolin binding and cyclic AMP accumulation

1990 • 31 citations

Expression of the mouse glucocorticoid receptor and its role during development

1993 • 21 citations

Thymocyte Apoptosis by Glucocorticoids and cAMP

1995 • 20 citations

Activation of protein kinase C via the T-cell receptor complex potentiates cyclic AMP responses in T-cells

1989 • 18 citations

Immature thymocytes are protected from deletion early in ontogeny.

1992 • 16 citations

Activation of Thymocyte Deoxyribonucleic Acid Degradation by Endogenous Glucocorticoids

1991 • 16 citations

Fruitful outcomes of intracellular cross-talk

1992 • 14 citations

Role of heat-shock proteins in steroid receptor function

1993 • 8 citations

T-cell differentiation under control

1993 • 4 citations