Caspase Enzyme Activity Is Not Essential for Apoptosis During Thymocyte Development

Caspases: Enemies Within

1998 • 6,923 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

Proteases to die for

1998 • 1,241 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 • 1,224 citations

Apoptotic Pathways

1998 • 1,193 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

1998 • 843 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

The central executioners of apoptosis: caspases or mitochondria?

1998 • 772 citations

Defects in regulation of apoptosis in caspase-2-deficient mice

1998 • 688 citations

Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE

1998 • 687 citations

Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35

1995 • 645 citations

Caspases and caspase inhibitors

1997 • 573 citations

SELECTION OF THE T CELL REPERTOIRE

1999 • 507 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

1999 • 485 citations

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1995 • 467 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis

1995 • 366 citations

The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques

1996 • 332 citations

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control Points

1994 • 252 citations

A Role for FADD in T Cell Activation and Development

1998 • 241 citations

Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases

1997 • 237 citations

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

1990 • 235 citations

Interaction of the Baculovirus Anti-apoptotic Protein p35 with Caspases. Specificity, Kinetics, and Characterization of the Caspase/p35 Complex

1998 • 212 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

Pleiotropic changes controlled by the pre-T-cell receptor

1999 • 199 citations

CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.

1996 • 174 citations

Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease

1996 • 170 citations

T-cell selection

1998 • 168 citations

Divergent transcription of early 35- and 94-kilodalton protein genes encoded by the HindIII K genome fragment of the baculovirus Autographa californica nuclear polyhedrosis virus

1987 • 138 citations

Developmental regulation of lck gene expression in T lymphocytes.

1991 • 124 citations

Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR

1999 • 110 citations

Crystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibition

1999 • 107 citations

p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.

1996 • 106 citations

Specific Activation of the Cysteine Protease CPP32 during the Negative Selection of T Cells in the Thymus

1997 • 92 citations

Disruption of thymocyte development and lymphomagenesis induced by SV4O T-antigen

1990 • 91 citations

T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection

1997 • 88 citations

Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor

1999 • 70 citations

Antigen-Induced Coreceptor Down-Regulation on Thymocytes Is Not a Result of Apoptosis

1999 • 24 citations