Mapping Precursor Movement through the Postnatal Thymus Reveals Specific Microenvironments Supporting Defined Stages of Early Lymphoid Development

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

A Light and Electron Microscopic Study

1976 • 1,232 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1985 • 613 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Tracing of cells of the avian thymus through embryonic life in interspecific chimeras.

1975 • 409 citations

Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny.

1996 • 405 citations

Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.

1996 • 343 citations

Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation.

1994 • 334 citations

The generation and fate of thymocytes.

1990 • 309 citations

T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice

1994 • 305 citations

Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes

1995 • 295 citations

Developmental potential of the earliest precursor cells from the adult mouse thymus.

1991 • 294 citations

Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

1998 • 292 citations

NF-κB Activation by the Pre-T Cell Receptor Serves as a Selective Survival Signal in T Lymphocyte Development

2000 • 280 citations

EVIDENCE FOR A BLOOD-THYMUS BARRIER USING ELECTRON-OPAQUE TRACERS

1972 • 258 citations

Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice.

1995 • 245 citations

Pax1 is expressed during development of the thymus epithelium and is required for normal T-cell maturation

1996 • 228 citations

Rearrangement of T-cell receptor beta-chain genes during T-cell development.

1985 • 200 citations

Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development

1999 • 197 citations

Pro-Thymocyte Expansion by c-kit and the Common Cytokine Receptor γ Chain Is Essential for Repertoire Formation

1997 • 195 citations

A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor.

1989 • 185 citations

T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production.

1995 • 180 citations

Characterization of TCR Gene Rearrangements During Adult Murine T Cell Development

1999 • 160 citations

Bone marrow cells give rise to distinct cell clones within the thymus

1984 • 146 citations

Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro.

1990 • 143 citations

T Cell Receptor (TCR)-β Gene Recombination: Dissociation from Cell Cycle Regulation and Developmental Progression During T Cell Ontogeny

1997 • 128 citations

Migration of bone marrow lymphocytes demonstrated by selective bone marrow labeling with thymidine‐H³

1970 • 126 citations

Transient expression of IL-2 receptor precedes the differentiation of immature thymocytes

1987 • 112 citations

Seeding of thymic microenvironments defined by distinct thymocyte-stromal cell interactions is developmentally controlled.

1987 • 112 citations

Commitment to the T cell receptor‐αβ or ‐γδ lineages can occur just prior to the onset of CD4 and CD8 expression among immature thymocytes

1992 • 110 citations

Two rare populations of mouse Thy-1lo bone marrow cells repopulate the thymus.

1988 • 98 citations

Clonal Characterization of a Bipotent T Cell and NK Cell Progenitor in the Mouse Fetal Thymus

2000 • 92 citations

Early progression of thymocytes along the CD4/CD8 developmental pathway is regulated by a subset of thymic epithelial cells expressing transforming growth factor beta.

1994 • 82 citations

A scanning electron-microscopic study of the rat thymus with special reference to cell types and migration of lymphocytes into the general circulation

1986 • 74 citations

Cell surface topography of thymic microenvironments.

1988 • 69 citations

Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells.

1994 • 63 citations

Thymic vasculature: organizer of the medullary epithelial compartment?

2000 • 61 citations

The majority of postselection CD4+ single-positive thymocytes requires the thymus to produce long-lived, functional T cells.

1995 • 55 citations

Characterization of the subset of immature thymocytes which can undergo rapid in vitro differentiation

1989 • 54 citations

Migration of Cells to the Thymus Demonstrated by Parabiosis.

1967 • 45 citations

Two distinct pathways of positive selection for thymocytes

1998 • 45 citations

Precursor Thymocyte Proliferation and Differentiation Are Controlled by Signals Unrelated to the Pre-TCR

2000 • 43 citations

Localization and phenotype of cycling and post-cycling murine thymocytes studied by simultaneous detection of bromodeoxyuridine and surface antigens.

1988 • 42 citations

Studies on the phenotype of migrant thymic stem cells

1999 • 41 citations

Microvasculature of Normal and Involuted Mouse Thymus

1989 • 41 citations

Phenotypic analysis of the early events during repopulation of the thymus by the bone marrow prothymocyte

1990 • 35 citations

CD4+8- and CD4-8+ mature thymocytes require different post-selection processing for final development.

1993 • 34 citations

Immunohistochemical localization of host and donor-derived cells in the regenerating thymus of radiation bone marrow chimeras.

1984 • 31 citations