The CD3γ chain is essential for development of both the TCRαβ and TCRγδ lineages

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

1992 • 540 citations

T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

1993 • 528 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Early T Lymphocyte Progenitors

1996 • 473 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.

1995 • 393 citations

The T Cell Antigen Receptor: Insights into Organelle Biology

1990 • 361 citations

Failure to synthesize the T Cell CD3-? chain: Structure and function of a partial T cell receptor complex

1988 • 351 citations

Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.

1996 • 343 citations

CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus

1991 • 343 citations

Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation.

1994 • 334 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice

1994 • 305 citations

Cross-linking of human T cell receptor proteins: association between the T cell idiotype β subunit and the T3 glycoprotein heavy subunit

1985 • 303 citations

Molecular Cloning of the Zeta Chain of the T Cell Antigen Receptor

1988 • 275 citations

Two waves of recombinase gene expression in developing thymocytes.

1994 • 268 citations

Early αβ T cell development in the thymus of normal and genetically altered mice

1997 • 249 citations

T cell development in mice lacking the CD3-zeta/eta gene.

1993 • 235 citations

Building a multichain receptor: synthesis, degradation, and assembly of the T-cell antigen receptor.

1987 • 232 citations

Primary Immunodeficiency Caused by Mutations in the Gene Encoding the CD3-γ Subunit of the T-Lymphocyte Receptor

1992 • 225 citations

Transmembrane Helical Interactions and the Assembly of the T Cell Receptor Complex

1990 • 217 citations

T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex

1993 • 217 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

CD3delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

1997 • 209 citations

CD3ε-mediated signals rescue the development of CD4⁺CD8⁺ thymocytes in RAG-2^−/− mice in the absence of TCR β chain expression

1994 • 205 citations

The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans

1984 • 204 citations

Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.

1993 • 164 citations

CD3 components at the surface of pro‐T cells can mediate pre‐T cell development in vivo

1994 • 156 citations

Identification of a Novel Developmental Stage Marking Lineage Commitment of Progenitor Thymocytes

1997 • 146 citations

Assembly of the human T cell receptor-CD3 complex takes place in the endoplasmic reticulum and involves intermediary complexes between the CD3-gamma.delta.epsilon core and single T cell receptor alpha or beta chains.

1988 • 142 citations

Role of TCR ζ Chain in T Cell Development and Selection

1994 • 141 citations

The implications of subunit interactions for the structure of the T cell receptor‐CD3 complex

1990 • 130 citations

The protein interactions of the immunoglobulin receptor family tyrosine‐based activation motifs present in the T cell receptor ζ subunits and the CD3 γ,δ and ϵ chains

1996 • 114 citations

Intrathymic δ Selection Events in γδ Cell Development

1997 • 112 citations

Role of Different T Cell Receptors in the Development of Pre–T Cells

1997 • 108 citations

Restoration of Thymopoiesis in pTα−/− Mice by Anti-CD3ε Antibody Treatment or with Transgenes Encoding Activated Lck or Tailless pTα

1997 • 106 citations

The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit.

1995 • 98 citations

Requirements for cell surface expression of the human TCR/CD3 complex in non-T cells

1991 • 92 citations

Receptors and signals in early thymic selection

1995 • 90 citations

Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein

1985 • 86 citations

Subunit interactions within the T-cell antigen receptor: clues from the study of partial complexes.

1988 • 84 citations

Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes

1996 • 82 citations

Subunit Composition of Pre–T Cell Receptor Complexes Expressed by Primary Thymocytes: CD3δ Is Physically Associated but Not Functionally Required

1997 • 80 citations

T cell receptor‐negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway

1990 • 79 citations

Functions of TCR and pre-TCR subunits: lessons from gene ablation

1996 • 77 citations

Failure to synthesize the CD3-gamma chain. Consequences for T cell antigen receptor assembly, processing, and expression.

1992 • 76 citations

Regulation of T cell receptor (TCR)‐β locus allelic exclusion and initiation of TCR‐α locus rearrangement in immature thymocytes by signaling through the CD3 complex

1995 • 73 citations

Role of CD3 gamma in T cell receptor assembly.

1996 • 71 citations

TCRα-CD3δϵ association is the initial step in αβ dimer formation in murine T cells and is limiting in immature CD4+CD8+ thymocytes

1995 • 71 citations

Expression of genes encoding the pre-TCR and CD3 complex during thymus development

1995 • 71 citations

Expression and function of a variant T cell receptor complex lacking CD3-gamma.

1991 • 68 citations

Surface expression of alternative forms of the TCR/CD3 complex.

1991 • 68 citations

Role of CD3 delta in surface expression of the TCR/CD3 complex and in activation for killing analyzed with a CD3 delta-negative cytotoxic T lymphocyte variant.

1992 • 67 citations

Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes.

1994 • 64 citations

Positive selection of CD4+ and CD8+ T cells

1996 • 55 citations

Double-negative thymocyte subsets in CD3′ chain-deficient mice: Absence of HSA+CD44−CD25− cells

1994 • 53 citations

Exit of the Pre-TCR from the ER/cis-Golgi Is Necessary for Signaling Differentiation, Proliferation, and Allelic Exclusion in Immature Thymocytes

1997 • 51 citations

Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements.

1987 • 47 citations

Negative selection of thymocytes. A novel polymerase chain reaction-based molecular analysis detects requirements for macromolecular synthesis.

1992 • 42 citations

Distinct Domains of the CD3-γ Chain Are Involved in Surface Expression and Function of the T Cell Antigen Receptor

1995 • 42 citations

Surface expression of CD3 in the absence of T cell receptor (TcR): evidence for sorting of partial TcR/CD3 complexes in a post‐endoplasmic reticulum compartment

1989 • 37 citations

_γδ T cells promote CD4 and CD8 expression by SCID thymocytes

1993 • 35 citations

Oncogenic potential of a pre-T cell receptor lacking the TCR beta variable domain.

1996 • 25 citations

Characterization and expression of the murine CD3-epsilon gene.

1988 • 25 citations

The T Cell Antigen Receptor: Insights Into Organelle Biology

1990 • 20 citations

Cloning and sequencing of murine T3 gamma cDNA from a subtractive cDNA library.

1987 • 17 citations

Biochemical basis of a novel T lymphocyte receptor immunodeficiency by immunohistochemistry. A possible CD3 gamma abnormality.

1991 • 14 citations

Deleted Work

1955 • 0 citations